Avermectin is a lipid of Polyketides (PK) class. Avermectin is associated with abnormalities such as Parasitic infection, Parasitic Diseases, Scabies, Tropical Disease and Onchocerciasis. The involved functions are known as Anabolism, Binding (Molecular Function), physiological aspects, Saturated and Cell Growth. Avermectin often locates in receptor complex and cell body (neuron). The associated genes with Avermectin are Homologous Gene, Genome, Gene Clusters and Structural gene.
To understand associated biological information of Avermectin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Avermectin is suspected in Parasitic infection, Parasitic Diseases, Scabies, Tropical Disease, Onchocerciasis, Filarial Elephantiases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Avermectin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Trichostrongyloidiasis | D014252 | 7 associated lipids |
| Arteritis | D001167 | 2 associated lipids |
| Filariasis | D005368 | 6 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
| Trichostrongylosis | D014253 | 5 associated lipids |
| Tuberculosis, Multidrug-Resistant | D018088 | 6 associated lipids |
| Oesophagostomiasis | D009814 | 2 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Luft JA et al. | Substituent effects on the rearrangements of cyclohexyl to cyclopentyl radicals involving avermectin-related radicals. | 2008 | J. Org. Chem. | pmid:18842059 |
| Hu J et al. | Effects of insecticides on the fluidity of mitochondrial membranes of the diamondback moth, Plutella xylostella, resistant and susceptible to avermectin. | 2008 | J. Insect Sci. | pmid:20345311 |
| Brayden DJ and Griffin J | Avermectin transepithelial transport in MDR1- and MRP-transfected canine kidney monolayers. | 2008 | Vet. Res. Commun. | pmid:17578674 |
| Ayers S et al. | Anthelmintic macrolactams from Nonomuraea turkmeniaca MA7381. | 2008 | J. Antibiot. | pmid:18408323 |
| Macdonald N and Gledhill A | Potential impact of ABCB1 (p-glycoprotein) polymorphisms on avermectin toxicity in humans. | 2007 | Arch. Toxicol. | pmid:17354009 |
| Berendsen BJ et al. | The derivatisation of avermectins and milbemycins in milk: new insights and improvement of the procedure. | 2007 | Anal. Chim. Acta | pmid:17386656 |
| Lin YW et al. | Insecticide susceptibility of surviving Cotesia plutellae (Hym: Braconidae) and Diaeretiella rapae (M'Intosh) (Hym: Aphidiidae) as affected by sublethal insecticide dosages on host insects. | 2007 | Pest Manag. Sci. | pmid:17533655 |
| Hernando MD et al. | Fast separation liquid chromatography-tandem mass spectrometry for the confirmation and quantitative analysis of avermectin residues in food. | 2007 | J Chromatogr A | pmid:17524410 |
| Trefzer A et al. | Biocatalytic conversion of avermectin to 4''-oxo-avermectin: improvement of cytochrome p450 monooxygenase specificity by directed evolution. | 2007 | Appl. Environ. Microbiol. | pmid:17483257 |
| Li ZZ et al. | Adsorption of avermectin on porous hollow silica nanoparticles by supercritical technology. | 2007 | J Nanosci Nanotechnol | pmid:17450791 |
| Tribble ND et al. | Identification of the genes encoding for putative gamma aminobutyric acid (GABA) and glutamate-gated chloride channel (GluCl) alpha receptor subunits in sea lice (Lepeophtheirus salmonis). | 2007 | J. Vet. Pharmacol. Ther. | pmid:17348903 |
| Webb L et al. | Effects of avermectin residues in cattle dung on yellow dung fly Scathophaga stercoraria (Diptera: Scathophagidae) populations in grazed pastures. | 2007 | Bull. Entomol. Res. | pmid:17411477 |
| Rajkarnikar A et al. | Two threonine residues required for role of AfsKav in controlling morphogenesis and avermectin production in Streptomyces avermitilis. | 2007 | J. Microbiol. Biotechnol. | pmid:18062239 |
| Im JH et al. | Comparative transcriptome analysis for avermectin overproduction via Streptomyces avermitilis microarray system. | 2007 | J. Microbiol. Biotechnol. | pmid:18050961 |
| Artho R et al. | Avermectin-resistance in gastrointestinal nematodes of Boer goats and Dorper sheep in Switzerland. | 2007 | Vet. Parasitol. | pmid:17088023 |
| Li ZZ et al. | Study of UV-shielding properties of novel porous hollow silica nanoparticle carriers for avermectin. | 2007 | Pest Manag. Sci. | pmid:17177171 |
| Sheehan LS et al. | Engineering of the spinosyn PKS: directing starter unit incorporation. | 2006 | J. Nat. Prod. | pmid:17190446 |
| Li ZZ et al. | Controlled release of avermectin from porous hollow silica nanoparticles: influence of shell thickness on loading efficiency, UV-shielding property and release. | 2006 | J Control Release | pmid:16388871 |
| Shi W et al. | Determination of multiresidue of avermectins in bovine liver by an indirect competitive ELISA. | 2006 | J. Agric. Food Chem. | pmid:16910699 |
| Learmount J et al. | A computer model to simulate control of parasitic gastroenteritis in sheep on UK farms. | 2006 | Vet. Parasitol. | pmid:16930844 |
| Rajkarnikar A et al. | Catalytic domain of AfsKav modulates both secondary metabolism and morphologic differentiation in Streptomyces avermitilis ATCC 31272. | 2006 | Curr. Microbiol. | pmid:16874544 |
| Danaher M et al. | Review of methodology for the determination of macrocyclic lactone residues in biological matrices. | 2006 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:16950666 |
| Turnipseed SB et al. | No-discharge atmospheric pressure chemical ionization: evaluation and application to the analysis of animal drug residues in complex matrices. | 2006 | Rapid Commun. Mass Spectrom. | pmid:16541409 |
| Beasley CA et al. | Identification of impurities in ivermectin bulk material by mass spectrometry and NMR. | 2006 | J Pharm Biomed Anal | pmid:16554137 |
| Wei X et al. | Enhancement and selective production of oligomycin through inactivation of avermectin's starter unit in Streptomyces avermitilis. | 2006 | Biotechnol. Lett. | pmid:16786277 |
| Oremus G et al. | Effects of mid-season avermectin treatments on pyrethroid resistance in horn fly (Diptera: Muscidae) populations at three locations in Louisiana. | 2006 | Vet. Parasitol. | pmid:16769175 |
| Zhang X et al. | Construction of ivermectin producer by domain swaps of avermectin polyketide synthase in Streptomyces avermitilis. | 2006 | Appl. Microbiol. Biotechnol. | pmid:16708195 |
| Zhang C et al. | The in vitro characterization of the iterative avermectin glycosyltransferase AveBI reveals reaction reversibility and sugar nucleotide flexibility. | 2006 | J. Am. Chem. Soc. | pmid:17177349 |
| Shen J et al. | Bioconcentration and elimination of avermectin B1 in sturgeon. | 2005 | Environ. Toxicol. Chem. | pmid:15720000 |
| Wei L et al. | Synthesis of new, potent avermectin-like insecticidal agents. | 2005 | Carbohydr. Res. | pmid:15922315 |
| Sun Y et al. | Bioaccumulation and elimination of avermectin B1a in the earthworms (Eisenia fetida). | 2005 | Chemosphere | pmid:15963808 |
| Sun Y et al. | [Effects of avermectin B1a on soil microorganism and earthworm (Eisenia fetida)]. | 2005 | Ying Yong Sheng Tai Xue Bao | pmid:16471355 |
| Walsh CT | Natural insights for chemical biologists. | 2005 | Nat. Chem. Biol. | pmid:16408011 |
| Jungmann V et al. | Biocatalytic conversion of avermectin to 4"-oxo-avermectin: characterization of biocatalytically active bacterial strains and of cytochrome p450 monooxygenase enzymes and their genes. | 2005 | Appl. Environ. Microbiol. | pmid:16269732 |
| Molnár I et al. | Biocatalytic conversion of avermectin to 4"-oxo-avermectin: heterologous expression of the ema1 cytochrome P450 monooxygenase. | 2005 | Appl. Environ. Microbiol. | pmid:16269733 |
| Erzen NK et al. | Degradation of abamectin and doramectin on sheep grazed pasture. | 2005 | Ecotoxicology | pmid:16215697 |
| Bowen JM and Vitayavirasak B | Contractile activity and motility responses of the dog heartworm Dirofilaria immitis to classical anthelmintics and other compounds. | 2005 | Vet. Parasitol. | pmid:16076531 |
| Wen LX et al. | Controlled release of avermectin from porous hollow silica nanoparticles. | 2005 | Pest Manag. Sci. | pmid:15714463 |
| Yong JH and Byeon WH | Alternative production of avermectin components in Streptomyces avermitilis by gene replacement. | 2005 | J. Microbiol. | pmid:15995647 |
| Kuzmina TA et al. | Analysis of the strongylid nematodes (Nematoda: Strongylidae) community after deworming of brood horses in Ukraine. | 2005 | Vet. Parasitol. | pmid:15979240 |
| Wolstenholme AJ and Rogers AT | Glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics. | 2005 | Parasitology | pmid:16569295 |
| Korystov YN et al. | Avermectins inhibit multidrug resistance of tumor cells. | 2004 | Eur. J. Pharmacol. | pmid:15189764 |
| Nagai K et al. | Synthesis and biological evaluation of novel 4"-alkoxy avermectin derivatives. | 2004 | Bioorg. Med. Chem. Lett. | pmid:15261257 |
| Yoon YJ et al. | Avermectin: biochemical and molecular basis of its biosynthesis and regulation. | 2004 | Appl. Microbiol. Biotechnol. | pmid:14689246 |
| Brewer BN et al. | Determination of abamectin in soil samples using high-performance liquid chromatography with tandem mass spectrometry. | 2004 | Rapid Commun. Mass Spectrom. | pmid:15282767 |
| Shi ZH et al. | Evaluation of selective toxicity of five pesticides against Plutella xylostella (Lep: Plutellidae) and their side-effects against Cotesia plutellae (Hym: Braconidae) and Oomyzus sokolowskii (Hym: Eulophidae). | 2004 | Pest Manag. Sci. | pmid:15578602 |
| Chen J et al. | Ethanol evolution rate: a new parameter to determine the feeding rate for the production of avermectins by Streptomyces avermitilis. | 2004 | Biotechnol. Lett. | pmid:15000476 |
| Liu J et al. | Genomic organization of an avermectin receptor subunit from Haemonchus contortus and expression of its putative promoter region in Caenorhabditis elegans. | 2004 | Mol. Biochem. Parasitol. | pmid:15003846 |
| Drinyaev VA et al. | Antitumor effect of avermectins. | 2004 | Eur. J. Pharmacol. | pmid:15464058 |
| Sun Y et al. | Identification of a gene cluster encoding meilingmycin biosynthesis among multiple polyketide synthase contigs isolated from Streptomyces nanchangensis NS3226. | 2003 | Arch. Microbiol. | pmid:12811466 |
| Yates DM et al. | The avermectin receptors of Haemonchus contortus and Caenorhabditis elegans. | 2003 | Int. J. Parasitol. | pmid:13678634 |
| Stutzman-Engwall K et al. | Engineering the aveC gene to enhance the ratio of doramectin to its CHC-B2 analogue produced in Streptomyces avermitilis. | 2003 | Biotechnol. Bioeng. | pmid:12599263 |
| Lamb DC et al. | Cytochrome p450 complement (CYPome) of the avermectin-producer Streptomyces avermitilis and comparison to that of Streptomyces coelicolor A3(2). | 2003 | Biochem. Biophys. Res. Commun. | pmid:12893267 |
| Hwang YS et al. | Cloning and analysis of a DNA fragment stimulating avermectin production in various Streptomyces avermitilis strains. | 2003 | Appl. Environ. Microbiol. | pmid:12571055 |
| Blackhall WJ et al. | Selection at a gamma-aminobutyric acid receptor gene in Haemonchus contortus resistant to avermectins/milbemycins. | 2003 | Mol. Biochem. Parasitol. | pmid:14511812 |
| Nagai K et al. | Synthesis and biological activities of novel 4"-alkylidene avermectin derivatives. | 2003 | Bioorg. Med. Chem. Lett. | pmid:14592480 |
| Strabel D et al. | [The use of avermectins in two goats with demodicosis]. | 2003 | Schweiz. Arch. Tierheilkd. | pmid:14725185 |
| Sha CK et al. | Anionic cyclization approach toward perhydrobenzofuranone: stereocontrolled synthesis of the hexahydrobenzofuran subunit of avermectin. | 2002 | J. Org. Chem. | pmid:11856026 |
| Deger Y et al. | Short communication serum copper, zinc, and calcium concentrations in lice-infested sheep. | 2002 | Biol Trace Elem Res | pmid:12117268 |
| Veale PI | Resistance to macrocyclic lactones in nematodes of goats. | 2002 | Aust. Vet. J. | pmid:12074315 |
| Martins JR et al. | Partial strategic tick control within a herd of European breed cattle in the state of Rio Grande do Sul, southern Brazil. | 2002 | Exp. Appl. Acarol. | pmid:12593589 |
| Rehbein S et al. | Efficacy of a new long-acting formulation of ivermectin and other injectable avermectins against induced Psoroptes ovis infestations in cattle. | 2002 | Parasitol. Res. | pmid:12444456 |
| Kim SB and Goodfellow M | Streptomyces avermitilis sp. nov., nom. rev., a taxonomic home for the avermectin-producing streptomycetes. | 2002 | Int. J. Syst. Evol. Microbiol. | pmid:12508861 |
| Takahashi Y et al. | Streptomyces avermectinius sp. nov., an avermectin-producing strain. | 2002 | Int. J. Syst. Evol. Microbiol. | pmid:12508884 |
| Swarnkar CP et al. | Anthelmintic resistance on an organized sheep farm in India. | 2001 | Trop Anim Health Prod | pmid:11474864 |
| Barnes EH et al. | Selection of different genotype larvae and adult worms for anthelmintic resistance by persistent and short-acting avermectin/milbemycins. | 2001 | Int. J. Parasitol. | pmid:11336754 |
| Köhler P | The biochemical basis of anthelmintic action and resistance. | 2001 | Int. J. Parasitol. | pmid:11400692 |
| Valenzuela AI et al. | Comparison of various liquid chromatographic methods for the analysis of avermectin residues in citrus fruits. | 2001 | J Chromatogr A | pmid:11403456 |
| Wohlert S et al. | Insights about the biosynthesis of the avermectin deoxysugar L-oleandrose through heterologous expression of Streptomyces avermitilis deoxysugar genes in Streptomyces lividans. | 2001 | Chem. Biol. | pmid:11451669 |
| Young KE et al. | Evaluation of anthelmintic activity in captive wild ruminants by fecal egg reduction tests and a larval development assay. | 2000 | J. Zoo Wildl. Med. | pmid:11237142 |
| Dawson GR et al. | Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the gamma-aminobutyric acid(A) receptor. | 2000 | J. Pharmacol. Exp. Ther. | pmid:11082440 |
| Hoste H et al. | A questionnaire survey on the practices adopted to control gastrointestinal nematode parasitism in dairy goat farms in France. | 2000 | Vet. Res. Commun. | pmid:11085466 |
| Tsukamoto Y et al. | Avermectin chemistry and action: ester- and ether-type candidate photoaffinity probes. | 2000 | Bioorg. Med. Chem. | pmid:10968260 |
| Novotny MJ et al. | Safety of selamectin in dogs. | 2000 | Vet. Parasitol. | pmid:10940536 |
| Krautmann MJ et al. | Safety of selamectin in cats. | 2000 | Vet. Parasitol. | pmid:10940537 |
| Banks BJ et al. | Avermectins and flea control: structure-activity relationships and the selection of selamectin for development as an endectocide for companion animals. | 2000 | Bioorg. Med. Chem. | pmid:11003146 |
| Gianelli L et al. | Mass spectrometry of avermectins: structural determination of two new derivatives of Ivermectin B(1a). | 2000 | Rapid Commun. Mass Spectrom. | pmid:10918377 |
| Le Jambre LF et al. | Inheritance of avermectin resistance in Haemonchus contortus. | 2000 | Int. J. Parasitol. | pmid:10675751 |
| Kamijima M and Casida JE | Regional modification of [(3)H]Ethynylbicycloorthobenzoate binding in mouse brain GABA(A) receptor by endosulfan, fipronil, and avermectin B(1a). | 2000 | Toxicol. Appl. Pharmacol. | pmid:10698677 |
| Sangster NC et al. | Haemonchus contortus: sequence heterogeneity of internucleotide binding domains from P-glycoproteins. | 1999 | Exp. Parasitol. | pmid:10072327 |
| Zhang YX et al. | Genes encoding acyl-CoA dehydrogenase (AcdH) homologues from Streptomyces coelicolor and Streptomyces avermitilis provide insights into the metabolism of small branched-chain fatty acids and macrolide antibiotic production. | 1999 | Microbiology (Reading, Engl.) | pmid:10517585 |
| Sangster NC | Pharmacology of anthelmintic resistance in cyathostomes: will it occur with the avermectin/milbemycins? | 1999 | Vet. Parasitol. | pmid:10485365 |
| Geary TG et al. | Frontiers in anthelmintic pharmacology. | 1999 | Vet. Parasitol. | pmid:10456419 |
| Ikeda H et al. | Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10449723 |
| Smit JW et al. | Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure. | 1999 | J. Clin. Invest. | pmid:10562306 |
| Kokoz YM et al. | Selective cytostatic and neurotoxic effects of avermectins and activation of the GABAalpha receptors. | 1999 | Biosci. Rep. | pmid:10841270 |
| Sangster NC and Gill J | Pharmacology of anthelmintic resistance. | 1999 | Parasitol. Today (Regul. Ed.) | pmid:10322335 |
| Gopal RM et al. | Resistance of field isolates of Trichostrongylus colubriformis and Ostertagia circumcincta to ivermectin. | 1999 | Int. J. Parasitol. | pmid:10404276 |
| Turnipseed SB et al. | Confirmation of avermectin residues in food matrices with negative-ion atmospheric pressure chemical ionization liquid chromatography/mass spectrometry. | 1999 | Rapid Commun. Mass Spectrom. | pmid:10204245 |
| Lankas GR et al. | Placental P-glycoprotein deficiency enhances susceptibility to chemically induced birth defects in mice. | 1998 Jul-Aug | Reprod. Toxicol. | pmid:9717696 |
| Meinke PT et al. | Synthesis of gem-difluoro-avermectin derivatives: potent anthelmintic and anticonvulsant agents. | 1998 | Bioorg. Med. Chem. Lett. | pmid:9934486 |
| Delany NS et al. | Cloning and localisation of an avermectin receptor-related subunit from Haemonchus contortus. | 1998 | Mol. Biochem. Parasitol. | pmid:9879896 |
| Ikeda H et al. | Cloning of the gene encoding avermectin B 5-O-methyltransferase in avermectin-producing Streptomyces avermitilis. | 1998 | Gene | pmid:9469930 |
| Marsden AF et al. | Engineering broader specificity into an antibiotic-producing polyketide synthase. | 1998 | Science | pmid:9422686 |
| Gill JH and Lacey E | Avermectin/milbemycin resistance in trichostrongyloid nematodes. | 1998 | Int. J. Parasitol. | pmid:9673866 |
| Gill JH et al. | Evidence of multiple mechanisms of avermectin resistance in haemonchus contortus--comparison of selection protocols. | 1998 | Int. J. Parasitol. | pmid:9650059 |
| Lonneux JF et al. | The relationship between parasite counts, lesions, antibody titres and daily weight gains in Psoroptes ovis infested cattle. | 1998 | Vet. Parasitol. | pmid:9653998 |
| Lonneux JF et al. | Antibody response after treatment in cattle infected with Psoroptes ovis. | 1997 Jul-Aug | Res. Vet. Sci. | pmid:9368957 |
| Vassilatis DK et al. | Genetic and biochemical evidence for a novel avermectin-sensitive chloride channel in Caenorhabditis elegans. Isolation and characterization. | 1997 | J. Biol. Chem. | pmid:9407104 |
| Pomes A et al. | Target size analysis of an avermectin binding site from Drosophila melanogaster. | 1997 | Biochim. Biophys. Acta | pmid:9187243 |