Avermectin is a lipid of Polyketides (PK) class. Avermectin is associated with abnormalities such as Parasitic infection, Parasitic Diseases, Scabies, Tropical Disease and Onchocerciasis. The involved functions are known as Anabolism, Binding (Molecular Function), physiological aspects, Saturated and Cell Growth. Avermectin often locates in receptor complex and cell body (neuron). The associated genes with Avermectin are Homologous Gene, Genome, Gene Clusters and Structural gene.
To understand associated biological information of Avermectin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Avermectin is suspected in Parasitic infection, Parasitic Diseases, Scabies, Tropical Disease, Onchocerciasis, Filarial Elephantiases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Avermectin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Trichostrongyloidiasis | D014252 | 7 associated lipids |
| Arteritis | D001167 | 2 associated lipids |
| Filariasis | D005368 | 6 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
| Trichostrongylosis | D014253 | 5 associated lipids |
| Tuberculosis, Multidrug-Resistant | D018088 | 6 associated lipids |
| Oesophagostomiasis | D009814 | 2 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kessabi FM et al. | Rearrangement of a cyclohexyl radical to a cyclopentylmethyl radical on the avermectin skeleton. | 2008 | Org. Lett. | pmid:18461948 |
| Dong JY et al. | Ymf 1029A-E, preussomerin analogues from the fresh-water-derived fungus YMF 1.01029. | 2008 | J. Nat. Prod. | pmid:18479163 |
| Chen L et al. | Characterization of a negative regulator AveI for avermectin biosynthesis in Streptomyces avermitilis NRRL8165. | 2008 | Appl. Microbiol. Biotechnol. | pmid:18560830 |
| Li M et al. | Engineering of avermectin biosynthetic genes to improve production of ivermectin in Streptomyces avermitilis. | 2008 | Bioorg. Med. Chem. Lett. | pmid:18824353 |
| Luft JA et al. | Substituent effects on the rearrangements of cyclohexyl to cyclopentyl radicals involving avermectin-related radicals. | 2008 | J. Org. Chem. | pmid:18842059 |
| Krogh KA et al. | Development of an analytical method to determine avermectins in water, sediments and soils using liquid chromatography-tandem mass spectrometry. | 2008 | J Chromatogr A | pmid:18929364 |
| Thompson TS et al. | Large volume injection for the direct analysis of ionophores and avermectins in surface water by liquid chromatography-electrospray ionization tandem mass spectrometry. | 2009 | Anal. Chim. Acta | pmid:19110126 |
| dos Santos AR et al. | Ivermectin-derived leishmanicidal compounds. | 2009 | Bioorg. Med. Chem. | pmid:19114308 |
| Kitani S et al. | Characterization of a regulatory gene, aveR, for the biosynthesis of avermectin in Streptomyces avermitilis. | 2009 | Appl. Microbiol. Biotechnol. | pmid:19148632 |
| Wang H et al. | Rapid method for multi-residue determination of avermectins in bovine liver using high-performance liquid chromatography with fluorescence detection. | 2009 | Bull Environ Contam Toxicol | pmid:19159053 |
| Pitterna T et al. | New ventures in the chemistry of avermectins. | 2009 | Bioorg. Med. Chem. | pmid:19168364 |
| Duong CT et al. | Functional expression of SAV3818, a putative TetR-family transcriptional regulatory gene from Streptomyces avermitilis, stimulates antibiotic production in Streptomyces species. | 2009 | J. Microbiol. Biotechnol. | pmid:19307761 |
| Gao H et al. | Medium optimization for the production of avermectin B1a by Streptomyces avermitilis 14-12A using response surface methodology. | 2009 | Bioresour. Technol. | pmid:19356927 |
| Ci X et al. | Avermectin exerts anti-inflammatory effect by downregulating the nuclear transcription factor kappa-B and mitogen-activated protein kinase activation pathway. | 2009 | Fundam Clin Pharmacol | pmid:19453757 |
| Shiwen X et al. | Preparation and characterization of monoclonal antibodies against avermectin. | 2009 | Hybridoma (Larchmt) | pmid:19519244 |
| Webb L et al. | Field-scale dispersal of Aphodius dung beetles (Coleoptera: Scarabaeidae) in response to avermectin treatments on pastured cattle. | 2010 | Bull. Entomol. Res. | pmid:19586576 |
| Sung YF et al. | Avermectin intoxication with coma, myoclonus, and polyneuropathy. | 2009 | Clin Toxicol (Phila) | pmid:19640241 |
| Wang LY et al. | Novel mutation breeding method for Streptomyces avermitilis using an atmospheric pressure glow discharge plasma. | 2010 | J. Appl. Microbiol. | pmid:19735332 |
| Inoue K et al. | Simultaneous determination of avermectins in bovine tissues by LC-MS/MS. | 2009 | J Sep Sci | pmid:19877150 |
| Gao H et al. | Identification of avermectin-high-producing strains by high-throughput screening methods. | 2010 | Appl. Microbiol. Biotechnol. | pmid:19957083 |
| Guo J et al. | The pathway-specific regulator AveR from Streptomyces avermitilis positively regulates avermectin production while it negatively affects oligomycin biosynthesis. | 2010 | Mol. Genet. Genomics | pmid:20012992 |
| Sperry J et al. | Synthesis of natural products containing spiroketals via intramolecular hydrogen abstraction. | 2010 | Org. Biomol. Chem. | pmid:20024126 |
| Zhao X et al. | Construction of a doramectin producer mutant from an avermectin-overproducing industrial strain of Streptomyces avermitilis. | 2009 | Can. J. Microbiol. | pmid:20029527 |
| Lasota JA and Dybas RA | Avermectins, a novel class of compounds: implications for use in arthropod pest control. | 1991 | Annu. Rev. Entomol. | pmid:2006872 |
| Hafner EW et al. | Branched-chain fatty acid requirement for avermectin production by a mutant of Streptomyces avermitilis lacking branched-chain 2-oxo acid dehydrogenase activity. | 1991 | J. Antibiot. | pmid:2026560 |
| Dutton CJ et al. | Novel avermectins produced by mutational biosynthesis. | 1991 | J. Antibiot. | pmid:2026561 |
| Hu J et al. | Effects of insecticides on the fluidity of mitochondrial membranes of the diamondback moth, Plutella xylostella, resistant and susceptible to avermectin. | 2008 | J. Insect Sci. | pmid:20345311 |
| Li L et al. | Overexpression of ribosome recycling factor causes increased production of avermectin in Streptomyces avermitilis strains. | 2010 | J. Ind. Microbiol. Biotechnol. | pmid:20352288 |
| Molinari G et al. | New ventures in the genotoxic and cytotoxic effects of macrocyclic lactones, abamectin and ivermectin. | 2010 | Cytogenet. Genome Res. | pmid:20389039 |
| Alves SN et al. | Alterations in the fat body and midgut of Culex quinquefasciatus larvae following exposure to different insecticides. | 2010 | Micron | pmid:20452779 |
| Gao H et al. | Assessing the potential of an induced-mutation strategy for avermectin overproducers. | 2010 | Appl. Environ. Microbiol. | pmid:20453119 |
| Sargison ND et al. | Characterisation of milbemycin-, avermectin-, imidazothiazole- and benzimidazole-resistant Teladorsagia circumcincta from a sheep flock. | 2010 | Vet. Rec. | pmid:20511651 |
| Zhuo Y et al. | Reverse biological engineering of hrdB to enhance the production of avermectins in an industrial strain of Streptomyces avermitilis. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:20534557 |
| Whelan M et al. | Determination of anthelmintic drug residues in milk using ultra high performance liquid chromatography-tandem mass spectrometry with rapid polarity switching. | 2010 | J Chromatogr A | pmid:20564781 |
| Hassan MU et al. | Bovine hypodermosis--a global aspect. | 2010 | Trop Anim Health Prod | pmid:20607401 |
| Omura S et al. | Selective production of specific components of avermectins in Streptomyces avermitilis. | 1991 | J. Antibiot. | pmid:2061197 |
| Orpin P | Potential avermectin resistance in a cattle herd. | 2010 | Vet. Rec. | pmid:20622213 |
| Li M et al. | Enhancement of avermectin and ivermectin production by overexpression of the maltose ATP-binding cassette transporter in Streptomyces avermitilis. | 2010 | Bioresour. Technol. | pmid:20655739 |
| Sargison ND et al. | Effects of age and immune suppression of sheep on fecundity, hatching and larval feeding of different strains of Haemonchus contortus. | 2011 | Vet. J. | pmid:20822936 |
| Mogg TD et al. | Efficacy of avermectin B1 given orally against equine intestinal strongyles and Onchocera microfilaria. | 1990 | Aust. Vet. J. | pmid:2085293 |
| Wolstenholme AJ | Recent progress in understanding the interaction between avermectins and ligand-gated ion channels: putting the pests to sleep. | 2010 | Invert. Neurosci. | pmid:20953673 |
| Tom LA and Foster N | Development of a molecularly imprinted polymer for the analysis of avermectin. | 2010 | Anal. Chim. Acta | pmid:20969995 |
| Sherman JG | Understanding the impact of P-glycoprotein mutation on canine health. | 2011 | Vet. J. | pmid:21106417 |
| Guan HN et al. | Novel photodegradable insecticide W/TiO(2)/Avermectin nanocomposites obtained by polyelectrolytes assembly. | 2011 | Colloids Surf B Biointerfaces | pmid:21131183 |
| Jin T et al. | Insecticide resistance of the oriental fruit fly, Bactrocera dorsalis (Hendel) (Diptera: Tephritidae), in mainland China. | 2011 | Pest Manag. Sci. | pmid:21308963 |
| Rezanka T et al. | Pivalic acid acts as a starter unit in a fatty acid and antibiotic biosynthetic pathway in Alicyclobacillus, Rhodococcus and Streptomyces. | 2011 | Environ. Microbiol. | pmid:21450004 |
| Wang JB et al. | Production of doramectin by rational engineering of the avermectin biosynthetic pathway. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21514826 |
| Wang F et al. | Multi-residue method for the confirmation of four avermectin residues in food products of animal origin by ultra-performance liquid chromatography-tandem mass spectrometry. | 2011 | Food Addit Contam Part A Chem Anal Control Expo Risk Assess | pmid:21598143 |
| Miyamoto KT et al. | The autoregulator receptor homologue AvaR3 plays a regulatory role in antibiotic production, mycelial aggregation and colony development of Streptomyces avermitilis. | 2011 | Microbiology (Reading, Engl.) | pmid:21622528 |
| Jiang L et al. | Inactivation of the extracytoplasmic function sigma factor Sig6 stimulates avermectin production in Streptomyces avermitilis. | 2011 | Biotechnol. Lett. | pmid:21691838 |