Avermectin is a lipid of Polyketides (PK) class. Avermectin is associated with abnormalities such as Parasitic infection, Parasitic Diseases, Scabies, Tropical Disease and Onchocerciasis. The involved functions are known as Anabolism, Binding (Molecular Function), physiological aspects, Saturated and Cell Growth. Avermectin often locates in receptor complex and cell body (neuron). The associated genes with Avermectin are Homologous Gene, Genome, Gene Clusters and Structural gene.
To understand associated biological information of Avermectin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Avermectin is suspected in Parasitic infection, Parasitic Diseases, Scabies, Tropical Disease, Onchocerciasis, Filarial Elephantiases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Avermectin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Trichostrongyloidiasis | D014252 | 7 associated lipids |
| Arteritis | D001167 | 2 associated lipids |
| Filariasis | D005368 | 6 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
| Trichostrongylosis | D014253 | 5 associated lipids |
| Tuberculosis, Multidrug-Resistant | D018088 | 6 associated lipids |
| Oesophagostomiasis | D009814 | 2 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Novotny MJ et al. | Safety of selamectin in dogs. | 2000 | Vet. Parasitol. | pmid:10940536 |
| Krautmann MJ et al. | Safety of selamectin in cats. | 2000 | Vet. Parasitol. | pmid:10940537 |
| Bowen JM and Vitayavirasak B | Contractile activity and motility responses of the dog heartworm Dirofilaria immitis to classical anthelmintics and other compounds. | 2005 | Vet. Parasitol. | pmid:16076531 |
| Agbedanu PN et al. | Doxycycline as an inhibitor of p-glycoprotein in the alpaca for the purpose of maintaining avermectins in the CNS during treatment for parelaphostrongylosis. | 2015 | Vet. Parasitol. | pmid:26371853 |
| Sargison ND et al. | Effects of age and immune suppression of sheep on fecundity, hatching and larval feeding of different strains of Haemonchus contortus. | 2011 | Vet. J. | pmid:20822936 |
| Sherman JG | Understanding the impact of P-glycoprotein mutation on canine health. | 2011 | Vet. J. | pmid:21106417 |
| Merola VM and Eubig PA | Toxicology of Avermectins and Milbemycins (Macrocyclic Lactones) and the Role of P-Glycoprotein in Dogs and Cats. | 2018 | Vet. Clin. North Am. Small Anim. Pract. | pmid:30139545 |
| Merola VM and Eubig PA | Toxicology of avermectins and milbemycins (macrocylic lactones) and the role of P-glycoprotein in dogs and cats. | 2012 | Vet. Clin. North Am. Small Anim. Pract. | pmid:22381182 |
| Yazwinski TA et al. | The effectiveness of ivermectin for reducing bovine gastrointestinal helminthiasis. | 1981 | Vet Med Small Anim Clin | pmid:6911919 |
| Hassan MU et al. | Bovine hypodermosis--a global aspect. | 2010 | Trop Anim Health Prod | pmid:20607401 |