Avermectin is a lipid of Polyketides (PK) class. Avermectin is associated with abnormalities such as Parasitic infection, Parasitic Diseases, Scabies, Tropical Disease and Onchocerciasis. The involved functions are known as Anabolism, Binding (Molecular Function), physiological aspects, Saturated and Cell Growth. Avermectin often locates in receptor complex and cell body (neuron). The associated genes with Avermectin are Homologous Gene, Genome, Gene Clusters and Structural gene.
To understand associated biological information of Avermectin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Avermectin is suspected in Parasitic infection, Parasitic Diseases, Scabies, Tropical Disease, Onchocerciasis, Filarial Elephantiases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Avermectin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Trichostrongyloidiasis | D014252 | 7 associated lipids |
| Arteritis | D001167 | 2 associated lipids |
| Filariasis | D005368 | 6 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
| Trichostrongylosis | D014253 | 5 associated lipids |
| Tuberculosis, Multidrug-Resistant | D018088 | 6 associated lipids |
| Oesophagostomiasis | D009814 | 2 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Schulman MD et al. | Biosynthesis of the avermectins by Streptomyces avermitilis. Incorporation of labeled precursors. | 1986 | J. Antibiot. | pmid:3086265 |
| Seaman JT et al. | Avermectin B1 toxicity in a herd of Murray Grey cattle. | 1987 | Aust. Vet. J. | pmid:3426470 |
| Wright DJ | Avermectins: action on target pest species. | 1987 | Biochem. Soc. Trans. | pmid:2435585 |
| Gordnier PM et al. | Chitin metabolism: not a target of avermectin/milbemycin activity in insects. | 1987 | J. Antibiot. | pmid:2951358 |
| Ikeda H et al. | Genetic studies of avermectin biosynthesis in Streptomyces avermitilis. | 1987 | J. Bacteriol. | pmid:3680172 |
| Schulman MD et al. | "Streptomyces avermitilis" mutants defective in methylation of avermectins. | 1987 | Antimicrob. Agents Chemother. | pmid:3606074 |
| Kirkness EF and Turner AJ | The stimulatory effects of secobarbital and pregnanolone on the GABAA receptor can be blocked selectively. | 1988 | Eur. J. Pharmacol. | pmid:2843385 |
| Wislocki PG et al. | Dermal penetration of avermectin B1a in the rhesus monkey. | 1988 | Toxicol. Appl. Pharmacol. | pmid:3388421 |
| De Chaneet GC et al. | Effect of avermectin B1 and benzimidazole anthelmintics on worm egg output of treated cattle. | 1988 | Aust. Vet. J. | pmid:3401149 |
| Button C et al. | Avermectin toxicity in calves and an evaluation of picrotoxin as an antidote. | 1988 | Aust. Vet. J. | pmid:3401165 |