Avermectin is a lipid of Polyketides (PK) class. Avermectin is associated with abnormalities such as Parasitic infection, Parasitic Diseases, Scabies, Tropical Disease and Onchocerciasis. The involved functions are known as Anabolism, Binding (Molecular Function), physiological aspects, Saturated and Cell Growth. Avermectin often locates in receptor complex and cell body (neuron). The associated genes with Avermectin are Homologous Gene, Genome, Gene Clusters and Structural gene.
To understand associated biological information of Avermectin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Avermectin is suspected in Parasitic infection, Parasitic Diseases, Scabies, Tropical Disease, Onchocerciasis, Filarial Elephantiases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Avermectin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Trichostrongyloidiasis | D014252 | 7 associated lipids |
| Arteritis | D001167 | 2 associated lipids |
| Filariasis | D005368 | 6 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
| Trichostrongylosis | D014253 | 5 associated lipids |
| Tuberculosis, Multidrug-Resistant | D018088 | 6 associated lipids |
| Oesophagostomiasis | D009814 | 2 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Boden R | Editorial: on artemisinin, avermectins and Nobel Prizes. | 2015 | FEMS Microbiol. Lett. | pmid:26486159 |
| Novák J et al. | Nitrogen regulation of fatty acids and avermectins biosynthesis in Streptomyces avermitilis. | 1992 | FEMS Microbiol. Lett. | pmid:1612418 |
| Zhao Y et al. | Isolation, characterization, and tissue-specific expression of GABA A receptor α1 subunit gene of Carassius auratus gibelio after avermectin treatment. | 2016 | Fish Physiol. Biochem. | pmid:26318443 |
| Wang F et al. | Multi-residue method for the confirmation of four avermectin residues in food products of animal origin by ultra-performance liquid chromatography-tandem mass spectrometry. | 2011 | Food Addit Contam Part A Chem Anal Control Expo Risk Assess | pmid:21598143 |
| Dos Anjos MR et al. | Multiresidue method for simultaneous analysis of aflatoxin M1, avermectins, organophosphate pesticides and milbemycin in milk by ultra-performance liquid chromatography coupled to tandem mass spectrometry. | 2016 | Food Addit Contam Part A Chem Anal Control Expo Risk Assess | pmid:27144891 |
| Rúbies A et al. | Determination of avermectins: a QuEChERS approach to the analysis of food samples. | 2015 | Food Chem | pmid:25794721 |
| Ci X et al. | Avermectin exerts anti-inflammatory effect by downregulating the nuclear transcription factor kappa-B and mitogen-activated protein kinase activation pathway. | 2009 | Fundam Clin Pharmacol | pmid:19453757 |
| Matsumoto K et al. | Actions of avermectins on cultured neurons. | 1988 | Gen. Pharmacol. | pmid:3044917 |
| MacNeil DJ et al. | Analysis of Streptomyces avermitilis genes required for avermectin biosynthesis utilizing a novel integration vector. | 1992 | Gene | pmid:1547955 |
| Ikeda H et al. | Cloning of the gene encoding avermectin B 5-O-methyltransferase in avermectin-producing Streptomyces avermitilis. | 1998 | Gene | pmid:9469930 |
| MacNeil DJ et al. | Complex organization of the Streptomyces avermitilis genes encoding the avermectin polyketide synthase. | 1992 | Gene | pmid:1612425 |
| Shen W et al. | [Study on the inclusion compound of avermectin by infrared spectroscopy]. | 2014 | Guang Pu Xue Yu Guang Pu Fen Xi | pmid:25095407 |
| Shiwen X et al. | Preparation and characterization of monoclonal antibodies against avermectin. | 2009 | Hybridoma (Larchmt) | pmid:19519244 |
| Tambo E et al. | Nobel prize for the artemisinin and ivermectin discoveries: a great boost towards elimination of the global infectious diseases of poverty. | 2015 | Infect Dis Poverty | pmid:26708575 |
| Guo H et al. | Reversal of meticillin resistance in Staphylococcus aureus by the anthelmintic avermectin. | 2014 | Int. J. Antimicrob. Agents | pmid:25123810 |
| Liang W et al. | Chitosan-based nanoparticles of avermectin to control pine wood nematodes. | 2018 | Int. J. Biol. Macromol. | pmid:29382581 |
| Barnes EH et al. | Selection of different genotype larvae and adult worms for anthelmintic resistance by persistent and short-acting avermectin/milbemycins. | 2001 | Int. J. Parasitol. | pmid:11336754 |
| Köhler P | The biochemical basis of anthelmintic action and resistance. | 2001 | Int. J. Parasitol. | pmid:11400692 |
| Yates DM et al. | The avermectin receptors of Haemonchus contortus and Caenorhabditis elegans. | 2003 | Int. J. Parasitol. | pmid:13678634 |
| Le Jambre LF et al. | Inheritance of avermectin resistance in Haemonchus contortus. | 2000 | Int. J. Parasitol. | pmid:10675751 |
| Ishii AI et al. | Studies on chemotherapy of parasitic helminths: effects of avermectin B1a on Angiostrongylus cantonensis in rats. | 1983 | Int. J. Parasitol. | pmid:6685712 |
| Gill JH et al. | Detection of resistance to ivermectin in Haemonchus contortus. | 1991 | Int. J. Parasitol. | pmid:1774112 |
| Le Jambre LF et al. | Characterisation of an avermectin resistant strain of Australian Haemonchus contortus. | 1995 | Int. J. Parasitol. | pmid:7657454 |
| Herd R | Ecotoxicity of the avermectins: a reply to Forbes. | 1996 | Int. J. Parasitol. | pmid:8818740 |
| Gill JH and Redwin JM | Cryopreservation of the first-stage larvae of trichostrongylid nematode parasites. | 1995 | Int. J. Parasitol. | pmid:8719953 |
| Gill JH et al. | Avermectin inhibition of larval development in Haemonchus contortus--effects of ivermectin resistance. | 1995 | Int. J. Parasitol. | pmid:7635622 |
| Shoop WL et al. | Efficacy in sheep and pharmacokinetics in cattle that led to the selection of eprinomectin as a topical endectocide for cattle. | 1996 | Int. J. Parasitol. | pmid:9024866 |
| Shoop WL et al. | Eprinomectin: a novel avermectin for use as a topical endectocide for cattle. | 1996 | Int. J. Parasitol. | pmid:9024867 |
| Gopal RM et al. | Resistance of field isolates of Trichostrongylus colubriformis and Ostertagia circumcincta to ivermectin. | 1999 | Int. J. Parasitol. | pmid:10404276 |
| Gill JH and Lacey E | Avermectin/milbemycin resistance in trichostrongyloid nematodes. | 1998 | Int. J. Parasitol. | pmid:9673866 |
| Gill JH et al. | Evidence of multiple mechanisms of avermectin resistance in haemonchus contortus--comparison of selection protocols. | 1998 | Int. J. Parasitol. | pmid:9650059 |
| Kim SB and Goodfellow M | Streptomyces avermitilis sp. nov., nom. rev., a taxonomic home for the avermectin-producing streptomycetes. | 2002 | Int. J. Syst. Evol. Microbiol. | pmid:12508861 |
| Takahashi Y et al. | Streptomyces avermectinius sp. nov., an avermectin-producing strain. | 2002 | Int. J. Syst. Evol. Microbiol. | pmid:12508884 |
| Wolstenholme AJ | Recent progress in understanding the interaction between avermectins and ligand-gated ion channels: putting the pests to sleep. | 2010 | Invert. Neurosci. | pmid:20953673 |
| Valenzuela AI et al. | Comparison of various liquid chromatographic methods for the analysis of avermectin residues in citrus fruits. | 2001 | J Chromatogr A | pmid:11403456 |
| Krogh KA et al. | Development of an analytical method to determine avermectins in water, sediments and soils using liquid chromatography-tandem mass spectrometry. | 2008 | J Chromatogr A | pmid:18929364 |
| Whelan M et al. | Determination of anthelmintic drug residues in milk using ultra high performance liquid chromatography-tandem mass spectrometry with rapid polarity switching. | 2010 | J Chromatogr A | pmid:20564781 |
| Hernando MD et al. | Fast separation liquid chromatography-tandem mass spectrometry for the confirmation and quantitative analysis of avermectin residues in food. | 2007 | J Chromatogr A | pmid:17524410 |
| de Oliveira Ferreira F et al. | On-line solid-phase extraction-ultra high performance liquid chromatography-tandem mass spectrometry for the determination of avermectins and milbemycin in soils. | 2016 | J Chromatogr A | pmid:27745927 |
| Li ZZ et al. | Controlled release of avermectin from porous hollow silica nanoparticles: influence of shell thickness on loading efficiency, UV-shielding property and release. | 2006 | J Control Release | pmid:16388871 |
| Kose LP et al. | The effects of some avermectins on bovine carbonic anhydrase enzyme. | 2016 | J Enzyme Inhib Med Chem | pmid:26207514 |
| Li ZZ et al. | Adsorption of avermectin on porous hollow silica nanoparticles by supercritical technology. | 2007 | J Nanosci Nanotechnol | pmid:17450791 |
| Beasley CA et al. | Identification of impurities in ivermectin bulk material by mass spectrometry and NMR. | 2006 | J Pharm Biomed Anal | pmid:16554137 |
| Stong JD et al. | Radical-induced oxidation of oxahydrindene (hexahydrobenzofuran) portion of 22,23-dihydroavermectin B1a: identification of autooxidation products. | 1992 | J Pharm Sci | pmid:1432608 |
| Pivnichny JV et al. | Direct determination of avermectins in plasma at nanogram levels by high-performance liquid chromatography. | 1983 | J Pharm Sci | pmid:6663483 |
| Yin P et al. | Direct proteomic mapping of Streptomyces avermitilis wild and industrial strain and insights into avermectin production. | 2013 | J Proteomics | pmid:23201115 |
| Inoue K et al. | Simultaneous determination of avermectins in bovine tissues by LC-MS/MS. | 2009 | J Sep Sci | pmid:19877150 |
| You X et al. | Preparation of magnetic molecularly imprinted polymers by atom transfer radical polymerization for the rapid extraction of avermectin from fish samples. | 2017 | J Sep Sci | pmid:27860252 |
| Park JH et al. | Application of hollow-fiber-assisted liquid-phase microextraction to identify avermectins in stream water using MS/MS. | 2013 | J Sep Sci | pmid:23504817 |
| Park JH et al. | Development of an extraction method for the determination of avermectins in soil using supercritical CO2 modified with ethanol and liquid chromatography-tandem mass spectrometry. | 2013 | J Sep Sci | pmid:23109286 |