Avermectin is a lipid of Polyketides (PK) class. Avermectin is associated with abnormalities such as Parasitic infection, Parasitic Diseases, Scabies, Tropical Disease and Onchocerciasis. The involved functions are known as Anabolism, Binding (Molecular Function), physiological aspects, Saturated and Cell Growth. Avermectin often locates in receptor complex and cell body (neuron). The associated genes with Avermectin are Homologous Gene, Genome, Gene Clusters and Structural gene.
To understand associated biological information of Avermectin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Avermectin is suspected in Parasitic infection, Parasitic Diseases, Scabies, Tropical Disease, Onchocerciasis, Filarial Elephantiases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Avermectin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Trichostrongyloidiasis | D014252 | 7 associated lipids |
| Arteritis | D001167 | 2 associated lipids |
| Filariasis | D005368 | 6 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
| Trichostrongylosis | D014253 | 5 associated lipids |
| Tuberculosis, Multidrug-Resistant | D018088 | 6 associated lipids |
| Oesophagostomiasis | D009814 | 2 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wang XX et al. | Yeast screening from avermectins wastewater and investigation on the ability of its fermentation. | 2011 | Bioprocess Biosyst Eng | pmid:21698347 |
| Qiu J et al. | Overexpression of the ABC transporter AvtAB increases avermectin production in Streptomyces avermitilis. | 2011 | Appl. Microbiol. Biotechnol. | pmid:21713508 |
| Jiang X et al. | Expression of CYP107Z13 in Streptomyces lividans TK54 catalyzes the oxidation of avermectin to 4″-oxo-avermectin. | 2012 | Appl. Microbiol. Biotechnol. | pmid:21842154 |
| Alves SN et al. | [Susceptibility of Culex quinquefasciatus larvae to different insecticides]. | 2011 Jul-Aug | Rev. Soc. Bras. Med. Trop. | pmid:21860896 |
| Kitani S et al. | Avenolide, a Streptomyces hormone controlling antibiotic production in Streptomyces avermitilis. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:21930904 |
| Yamamuro D et al. | Screening for microbial metabolites affecting phenotype of Caenorhabditis elegans. | 2011 | Biol. Pharm. Bull. | pmid:21963505 |
| Liu M et al. | Magnetic field is the dominant factor to induce the response of Streptomyces avermitilis in altered gravity simulated by diamagnetic levitation. | 2011 | PLoS ONE | pmid:22039402 |
| Campbell WC | History of avermectin and ivermectin, with notes on the history of other macrocyclic lactone antiparasitic agents. | 2012 | Curr Pharm Biotechnol | pmid:22039784 |
| Danaher M et al. | Recent developments in the analysis of avermectin and milbemycin residues in food safety and the environment. | 2012 | Curr Pharm Biotechnol | pmid:22039790 |
| Horsberg TE | Avermectin use in aquaculture. | 2012 | Curr Pharm Biotechnol | pmid:22039799 |
| Molento MB et al. | Resistance to avermectin/milbemycin anthelmintics in equine cyathostomins - current situation. | 2012 | Vet. Parasitol. | pmid:22047763 |
| Schulman MD et al. | Purification and identification of dTDP-oleandrose, the precursor of the oleandrose units of the avermectins. | 1990 | J. Biol. Chem. | pmid:2211601 |
| Zufall F et al. | The insecticide avermectin b (la) activates a chloride channel in crayfish muscle membrane. | 1989 | J. Exp. Biol. | pmid:22135837 |
| Lopes RP et al. | Development and validation of a multiclass method for the determination of veterinary drug residues in chicken by ultra high performance liquid chromatography-tandem mass spectrometry. | 2012 | Talanta | pmid:22284481 |
| Zhang X et al. | Deletion of ku homologs increases gene targeting frequency in Streptomyces avermitilis. | 2012 | J. Ind. Microbiol. Biotechnol. | pmid:22350115 |
| Merola VM and Eubig PA | Toxicology of avermectins and milbemycins (macrocylic lactones) and the role of P-glycoprotein in dogs and cats. | 2012 | Vet. Clin. North Am. Small Anim. Pract. | pmid:22381182 |
| Byrne FJ et al. | Evaluation of neonicotinoid, organophosphate and avermectin trunk injections for the management of avocado thrips in California avocado groves. | 2012 | Pest Manag. Sci. | pmid:22396314 |
| Erban T et al. | The efficacy of four avermectins on the synanthropic mite Lepidoglyphus destructor under laboratory conditions. | 2012 | Exp. Appl. Acarol. | pmid:22527833 |
| Tao Y et al. | Determination of 17 macrolide antibiotics and avermectins residues in meat with accelerated solvent extraction by liquid chromatography-tandem mass spectrometry. | 2012 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:22542398 |
| Gao Y et al. | Insecticide-mediated apparent displacement between two invasive species of leafminer fly. | 2012 | PLoS ONE | pmid:22662122 |
| Yu Z et al. | Differential regulation of antibiotic biosynthesis by DraR-K, a novel two-component system in Streptomyces coelicolor. | 2012 | Mol. Microbiol. | pmid:22676800 |
| Wang C et al. | A monoclonal antibody-based ELISA for multiresidue determination of avermectins in milk. | 2012 | Molecules | pmid:22706371 |
| Awasthi A et al. | An overview on chemical derivatization and stability aspects of selected avermectin derivatives. | 2012 | Chem. Pharm. Bull. | pmid:22863694 |
| Yan Y et al. | Utilization of environmental waste cyanobacteria as a pesticide carrier: studies on controlled release and photostability of avermectin. | 2013 | Colloids Surf B Biointerfaces | pmid:23006573 |
| Park JH et al. | Development of an extraction method for the determination of avermectins in soil using supercritical CO2 modified with ethanol and liquid chromatography-tandem mass spectrometry. | 2013 | J Sep Sci | pmid:23109286 |
| Lim LE et al. | Anthelmintic avermectins kill Mycobacterium tuberculosis, including multidrug-resistant clinical strains. | 2013 | Antimicrob. Agents Chemother. | pmid:23165468 |
| Yin P et al. | Direct proteomic mapping of Streptomyces avermitilis wild and industrial strain and insights into avermectin production. | 2013 | J Proteomics | pmid:23201115 |
| Sun P et al. | Spiroketal formation and modification in avermectin biosynthesis involves a dual activity of AveC. | 2013 | J. Am. Chem. Soc. | pmid:23294008 |
| McMahon C et al. | Anthelmintic resistance in Northern Ireland (I): prevalence of resistance in ovine gastrointestinal nematodes, as determined through faecal egg count reduction testing. | 2013 | Vet. Parasitol. | pmid:23398988 |
| Park JH et al. | Application of hollow-fiber-assisted liquid-phase microextraction to identify avermectins in stream water using MS/MS. | 2013 | J Sep Sci | pmid:23504817 |
| Luo L et al. | Avermectin induces P-glycoprotein expression in S2 cells via the calcium/calmodulin/NF-κB pathway. | 2013 | Chem. Biol. Interact. | pmid:23523950 |
| Zhao X et al. | Overexpression of metK shows different effects on avermectin production in various Streptomyces avermitilis strains. | 2013 | World J. Microbiol. Biotechnol. | pmid:23579768 |
| Komatsu M et al. | Engineered Streptomyces avermitilis host for heterologous expression of biosynthetic gene cluster for secondary metabolites. | 2013 | ACS Synth Biol | pmid:23654282 |
| Mann J | Organic chemistry. New routes to natural products. | 1990 | Nature | pmid:2366859 |
| Liu Y et al. | Characterization of SAV7471, a TetR-family transcriptional regulator involved in the regulation of coenzyme A metabolism in Streptomyces avermitilis. | 2013 | J. Bacteriol. | pmid:23893108 |
| Li M et al. | Antioxidant response and histopathological changes in brain tissue of pigeon exposed to avermectin. | 2013 | Ecotoxicology | pmid:23943211 |
| Guo J et al. | A novel TetR family transcriptional regulator, SAV576, negatively controls avermectin biosynthesis in Streptomyces avermitilis. | 2013 | PLoS ONE | pmid:23967193 |
| Chen LJ et al. | Avermectin induced inflammation damage in king pigeon brain. | 2013 | Chemosphere | pmid:24134892 |
| Zhu WJ et al. | Avermectin induced liver injury in pigeon: mechanisms of apoptosis and oxidative stress. | 2013 | Ecotoxicol. Environ. Saf. | pmid:24138898 |
| Doan HT et al. | The efficacy of avermectins (ivermectin, doramectin and abamectin) as treatments for infestation with the tick Haemaphysalis longicornis on rabbits in Korea. | 2013 | Vet. Parasitol. | pmid:24140165 |
| He F et al. | Engineering of the TetR family transcriptional regulator SAV151 and its target genes increases avermectin production in Streptomyces avermitilis. | 2014 | Appl. Microbiol. Biotechnol. | pmid:24220792 |
| Wenjie W et al. | Nystagmus following acute avermectins poisoning. | 2016 | Toxicol Ind Health | pmid:24280654 |
| Chalmers AE et al. | The actions of avermectin on crayfish nerve and muscle. | 1986 | Eur. J. Pharmacol. | pmid:2430816 |
| Kennedy CJ et al. | Inhibition of P-glycoprotein in the blood-brain barrier alters avermectin neurotoxicity and swimming performance in rainbow trout. | 2014 | Aquat. Toxicol. | pmid:24316435 |
| Wang JB et al. | Characterization of AvaR1, an autoregulator receptor that negatively controls avermectins production in a high avermectin-producing strain. | 2014 | Biotechnol. Lett. | pmid:24322771 |
| Wright DJ | Avermectins: action on target pest species. | 1987 | Biochem. Soc. Trans. | pmid:2435585 |
| Liu C et al. | Effects of avermectin on immune function and oxidative stress in the pigeon spleen. | 2014 | Chem. Biol. Interact. | pmid:24412236 |
| Zhuo Y et al. | Synthetic biology of avermectin for production improvement and structure diversification. | 2014 | Biotechnol J | pmid:24478271 |
| Li HB et al. | Combined effects of temperature and avermectins on life history and stress response of the western flower thrips, Frankliniella occidentalis. | 2014 | Pestic Biochem Physiol | pmid:24485314 |
| Sun P et al. | Effect of stereochemistry of avermectin-like 6,6-spiroketals on biological activities and endogenous biotransformations in Streptomyces avermectinius. | 2014 | Chembiochem | pmid:24573905 |