Avermectin is a lipid of Polyketides (PK) class. Avermectin is associated with abnormalities such as Parasitic infection, Parasitic Diseases, Scabies, Tropical Disease and Onchocerciasis. The involved functions are known as Anabolism, Binding (Molecular Function), physiological aspects, Saturated and Cell Growth. Avermectin often locates in receptor complex and cell body (neuron). The associated genes with Avermectin are Homologous Gene, Genome, Gene Clusters and Structural gene.
To understand associated biological information of Avermectin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Avermectin is suspected in Parasitic infection, Parasitic Diseases, Scabies, Tropical Disease, Onchocerciasis, Filarial Elephantiases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Avermectin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Trichostrongyloidiasis | D014252 | 7 associated lipids |
| Arteritis | D001167 | 2 associated lipids |
| Filariasis | D005368 | 6 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
| Trichostrongylosis | D014253 | 5 associated lipids |
| Tuberculosis, Multidrug-Resistant | D018088 | 6 associated lipids |
| Oesophagostomiasis | D009814 | 2 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Demeler J et al. | Measuring the effect of avermectins and milbemycins on somatic muscle contraction of adult Haemonchus contortus and on motility of Ostertagia circumcincta in vitro. | 2014 | Parasitology | pmid:24576444 |
| Huang WK et al. | Efficacy evaluation of fungus Syncephalastrum racemosum and nematicide avermectin against the root-knot nematode Meloidogyne incognita on cucumber. | 2014 | PLoS ONE | pmid:24586982 |
| Chen LJ et al. | The effects of avermectin on amino acid neurotransmitters and their receptors in the pigeon brain. | 2014 | Pestic Biochem Physiol | pmid:24759046 |
| Robertson B | Actions of anaesthetics and avermectin on GABAA chloride channels in mammalian dorsal root ganglion neurones. | 1989 | Br. J. Pharmacol. | pmid:2478243 |
| Luo S et al. | An extracytoplasmic function sigma factor, σ(25), differentially regulates avermectin and oligomycin biosynthesis in Streptomyces avermitilis. | 2014 | Appl. Microbiol. Biotechnol. | pmid:24811406 |
| Cao Y et al. | Global DNA hypomethylation: a potential mechanism in King pigeon nerve tissue damage induced by avermectin. | 2014 | Chem. Biol. Interact. | pmid:24858076 |
| Li M et al. | Exploring the electron transfer pathway in the oxidation of avermectin by CYP107Z13 in Streptomyces ahygroscopicus ZB01. | 2014 | PLoS ONE | pmid:24905717 |
| Guo J et al. | Two adjacent and similar TetR family transcriptional regulator genes, SAV577 and SAV576, co-regulate avermectin production in Streptomyces avermitilis. | 2014 | PLoS ONE | pmid:24915523 |
| Brady PB et al. | Stereodivergent approach to the avermectins based on "super silyl" directed aldol reactions. | 2014 | Org. Lett. | pmid:25025525 |
| Shen W et al. | [Study on the inclusion compound of avermectin by infrared spectroscopy]. | 2014 | Guang Pu Xue Yu Guang Pu Fen Xi | pmid:25095407 |
| Thuan NH et al. | Recent advances in biochemistry and biotechnological synthesis of avermectins and their derivatives. | 2014 | Appl. Microbiol. Biotechnol. | pmid:25104027 |
| Guo H et al. | Reversal of meticillin resistance in Staphylococcus aureus by the anthelmintic avermectin. | 2014 | Int. J. Antimicrob. Agents | pmid:25123810 |
| Mahieu M et al. | Fifteen years later, anthelmintic resistances have dramatically spread over goat farms in Guadeloupe. | 2014 | Vet. Parasitol. | pmid:25149098 |
| Zhu WJ et al. | Effects of avermectin on microsomal cytochrome P450 enzymes in the liver and kidneys of pigeons. | 2014 | Environ. Toxicol. Pharmacol. | pmid:25194326 |
| Li M et al. | The change in heat shock protein expression in avermectin induced neurotoxicity of the pigeon (Columba livia) both in vivo and in vitro. | 2014 | Ecotoxicol. Environ. Saf. | pmid:25202854 |
| Cornejo I et al. | Identification and functional expression of a glutamate- and avermectin-gated chloride channel from Caligus rogercresseyi, a southern Hemisphere sea louse affecting farmed fish. | 2014 | PLoS Pathog. | pmid:25255455 |
| Jia X et al. | Adhesive polydopamine coated avermectin microcapsules for prolonging foliar pesticide retention. | 2014 | ACS Appl Mater Interfaces | pmid:25390545 |
| Liu C et al. | Effects of avermectin on heat shock proteins expression and histopathology in spleen tissues of pigeon. | 2014 | Chem. Biol. Interact. | pmid:25446859 |
| Wang Y et al. | Ternary toxicological interactions of insecticides, herbicides, and a heavy metal on the earthworm Eisenia fetida. | 2015 | J. Hazard. Mater. | pmid:25463238 |
| Qu J et al. | Autophagy is upregulated in brain tissues of pigeons exposed to avermectin. | 2015 | Ecotoxicol. Environ. Saf. | pmid:25497772 |
| Zou CS et al. | Purification, characterization, and sensitivity to pesticides of carboxylesterase from Dendrolimus superans (Lepidoptera: Lasiocampidae). | 2014 | J. Insect Sci. | pmid:25525114 |
| Woerde DJ et al. | Susceptibility of rapidly growing mycobacteria isolated from Australian cats to ivermectin, moxidectin, ceftiofur and florfenicol. | 2015 | J. Feline Med. Surg. | pmid:25572306 |
| Wang F et al. | Structural and functional analysis of the loading acyltransferase from avermectin modular polyketide synthase. | 2015 | ACS Chem. Biol. | pmid:25581064 |
| Sun P et al. | 1,19-seco-Avermectin analogues from a ΔaveCDE mutant Streptomyces avermectinius strain. | 2015 | J. Nat. Prod. | pmid:25611131 |
| Chen C et al. | The synergistic toxicity of the multiple chemical mixtures: implications for risk assessment in the terrestrial environment. | 2015 | Environ Int | pmid:25667058 |
| Li D et al. | Synergistic effect of non-ionic surfactants Tween 80 and PEG6000 on cytotoxicity of insecticides. | 2015 | Environ. Toxicol. Pharmacol. | pmid:25699500 |
| Omansen TF et al. | In-vitro activity of avermectins against Mycobacterium ulcerans. | 2015 | PLoS Negl Trop Dis | pmid:25742173 |
| Rúbies A et al. | Determination of avermectins: a QuEChERS approach to the analysis of food samples. | 2015 | Food Chem | pmid:25794721 |
| Li X et al. | Fast and Online Determination of Five Avermectin Residues in Foodstuffs of Plant and Animal Origin Using Reusable Polymeric Monolithic Extractor Coupled with LC-MS/MS. | 2015 | J. Agric. Food Chem. | pmid:25865176 |
| Dalzell AM et al. | Characterization of multidrug transporter-mediated efflux of avermectins in human and mouse neuroblastoma cell lines. | 2015 | Toxicol. Lett. | pmid:25865432 |
| Meyers JI et al. | Mosquitocidal properties of IgG targeting the glutamate-gated chloride channel in three mosquito disease vectors (Diptera: Culicidae). | 2015 | J. Exp. Biol. | pmid:25994632 |
| Liu W et al. | Increasing Avermectin Production in Streptomyces avermitilis by Manipulating the Expression of a Novel TetR-Family Regulator and Its Target Gene Product. | 2015 | Appl. Environ. Microbiol. | pmid:26002902 |
| Huang J et al. | Gene Replacement for the Generation of Designed Novel Avermectin Derivatives with Enhanced Acaricidal and Nematicidal Activities. | 2015 | Appl. Environ. Microbiol. | pmid:26025902 |
| Kwon YJ et al. | Selective Inhibition of SIN3 Corepressor with Avermectins as a Novel Therapeutic Strategy in Triple-Negative Breast Cancer. | 2015 | Mol. Cancer Ther. | pmid:26078298 |
| Godinez O et al. | Targeting the Osmotic Stress Response for Strain Improvement of an Industrial Producer of Secondary Metabolites. | 2015 | J. Microbiol. Biotechnol. | pmid:26139611 |
| Curdová E et al. | The effect of inorganic phosphate on the production of avermectin in Streptomyces avermitilis. | 1989 | J. Basic Microbiol. | pmid:2614673 |
| Hopwood DA | Satoshi ÅŒmura. | 2016 | J. Ind. Microbiol. Biotechnol. | pmid:26186906 |
| Kose LP et al. | The effects of some avermectins on bovine carbonic anhydrase enzyme. | 2016 | J Enzyme Inhib Med Chem | pmid:26207514 |
| Yang R et al. | The PhoP transcription factor negatively regulates avermectin biosynthesis in Streptomyces avermitilis. | 2015 | Appl. Microbiol. Biotechnol. | pmid:26298701 |
| Zhao Y et al. | Isolation, characterization, and tissue-specific expression of GABA A receptor α1 subunit gene of Carassius auratus gibelio after avermectin treatment. | 2016 | Fish Physiol. Biochem. | pmid:26318443 |
| Agbedanu PN et al. | Doxycycline as an inhibitor of p-glycoprotein in the alpaca for the purpose of maintaining avermectins in the CNS during treatment for parelaphostrongylosis. | 2015 | Vet. Parasitol. | pmid:26371853 |
| Zhang J et al. | Designed biosynthesis of 25-methyl and 25-ethyl ivermectin with enhanced insecticidal activity by domain swap of avermectin polyketide synthase. | 2015 | Microb. Cell Fact. | pmid:26400541 |
| Owens B | 2015 Nobel Prize goes to antiparasitic drug discoverers. | 2015 | Lancet | pmid:26466031 |
| Boden R | Editorial: on artemisinin, avermectins and Nobel Prizes. | 2015 | FEMS Microbiol. Lett. | pmid:26486159 |
| Tatsuta K | Celebrating the 2015 Nobel Prize in Physiology or Medicine of Dr Satoshi ÅŒmura. | 2016 | J. Antibiot. | pmid:26486878 |
| Liu C et al. | Avermectin induced autophagy in pigeon spleen tissues. | 2015 | Chem. Biol. Interact. | pmid:26541719 |
| Molyneux DH and Ward SA | Reflections on the Nobel Prize for Medicine 2015--The Public Health Legacy and Impact of Avermectin and Artemisinin. | 2015 | Trends Parasitol. | pmid:26552892 |
| Efferth T et al. | Nobel Prize for artemisinin brings phytotherapy into the spotlight. | 2015 | Phytomedicine | pmid:26563851 |
| Li D et al. | Preparation of uniform starch microcapsules by premix membrane emulsion for controlled release of avermectin. | 2016 | Carbohydr Polym | pmid:26572364 |
| Jin L et al. | Selective targeting of nuclear receptor FXR by avermectin analogues with therapeutic effects on nonalcoholic fatty liver disease. | 2015 | Sci Rep | pmid:26620317 |