Avermectin is a lipid of Polyketides (PK) class. Avermectin is associated with abnormalities such as Parasitic infection, Parasitic Diseases, Scabies, Tropical Disease and Onchocerciasis. The involved functions are known as Anabolism, Binding (Molecular Function), physiological aspects, Saturated and Cell Growth. Avermectin often locates in receptor complex and cell body (neuron). The associated genes with Avermectin are Homologous Gene, Genome, Gene Clusters and Structural gene.
To understand associated biological information of Avermectin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Avermectin is suspected in Parasitic infection, Parasitic Diseases, Scabies, Tropical Disease, Onchocerciasis, Filarial Elephantiases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Avermectin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Trichostrongyloidiasis | D014252 | 7 associated lipids |
| Arteritis | D001167 | 2 associated lipids |
| Filariasis | D005368 | 6 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
| Trichostrongylosis | D014253 | 5 associated lipids |
| Tuberculosis, Multidrug-Resistant | D018088 | 6 associated lipids |
| Oesophagostomiasis | D009814 | 2 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
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| Chen TS and Inamine ES | Studies on the biosynthesis of avermectins. | 1989 | Arch. Biochem. Biophys. | pmid:2705778 |
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| Schaeffer JM et al. | A chemiluminescent assay for measuring avermectin binding sites. | 1989 | Anal. Biochem. | pmid:2729548 |
| Zhang J et al. | Synthesis, biological activities and structure-activity relationships for new avermectin analogues. | 2016 | Eur J Med Chem | pmid:27318119 |
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| Li M et al. | Effects of in vitro and in vivo avermectin exposure on alpha synuclein expression and proteasomal activity in pigeons. | 2017 | Ecotoxicol. Environ. Saf. | pmid:27677079 |
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| de Oliveira Ferreira F et al. | On-line solid-phase extraction-ultra high performance liquid chromatography-tandem mass spectrometry for the determination of avermectins and milbemycin in soils. | 2016 | J Chromatogr A | pmid:27745927 |
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| Sun D et al. | SAV742, a Novel AraC-Family Regulator from Streptomyces avermitilis, Controls Avermectin Biosynthesis, Cell Growth and Development. | 2016 | Sci Rep | pmid:27841302 |
| Zhang Y et al. | Cytotoxic effects of Avermectin on human HepG2 cells in vitro bioassays. | 2017 | Environ. Pollut. | pmid:27852506 |
| You X et al. | Preparation of magnetic molecularly imprinted polymers by atom transfer radical polymerization for the rapid extraction of avermectin from fish samples. | 2017 | J Sep Sci | pmid:27860252 |
| He JM et al. | Direct Involvement of the Master Nitrogen Metabolism Regulator GlnR in Antibiotic Biosynthesis in Streptomyces. | 2016 | J. Biol. Chem. | pmid:27875313 |
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| Takahashi Y | Continuing fascination of exploration in natural substances from microorganisms. | 2017 | Biosci. Biotechnol. Biochem. | pmid:27885930 |
| Iwai Y | Anecdote of the ÅŒmura laboratory and the discovery of avermectin. | 2017 | Biosci. Biotechnol. Biochem. | pmid:27885935 |
| Mendes AM et al. | Inhibition of Plasmodium Liver Infection by Ivermectin. | 2017 | Antimicrob. Agents Chemother. | pmid:27895022 |
| Tian P et al. | Comparative metabolomics reveals the mechanism of avermectin production enhancement by S-adenosylmethionine. | 2017 | J. Ind. Microbiol. Biotechnol. | pmid:27988821 |
| Liu C et al. | Avermectin induced global DNA hypomethylation and over-expression of heat shock proteins in cardiac tissues of pigeon. | 2017 | Pestic Biochem Physiol | pmid:28043331 |
| Maynard MS and Maynard HD | HPLC assay for avermectin B1a and its two photoisomers using a photo diode array detector. | 1989 | Bull Environ Contam Toxicol | pmid:2804390 |
| Neszmélyi A et al. | Solution conformation of the disaccharide of avermectin B1a examined by NMR spectroscopy and nuclear Overhauser enhancement restrained hard-sphere exo-anomeric effect calculation. | 1989 | J. Antibiot. | pmid:2808137 |
| Zhao X et al. | Pesticide-mediated interspecific competition between local and invasive thrips pests. | 2017 | Sci Rep | pmid:28084404 |
| Kim MS et al. | Engineered biosynthesis of milbemycins in the avermectin high-producing strain Streptomyces avermitilis. | 2017 | Microb. Cell Fact. | pmid:28095865 |
| Wang YS et al. | A spectrophotometric screening method for avermectin oxidizing microorganisms. | 2017 | J. Microbiol. Methods | pmid:28215961 |
| Brownjohn PW et al. | Phenotypic Screening Identifies Modulators of Amyloid Precursor Protein Processing in Human Stem Cell Models of Alzheimer's Disease. | 2017 | Stem Cell Reports | pmid:28285880 |
| Liu X et al. | Redox-sensing regulator Rex regulates aerobic metabolism, morphological differentiation, and avermectin production in Streptomyces avermitilis. | 2017 | Sci Rep | pmid:28303934 |
| Zhang Y et al. | New Avermectin Analogues from a Mutant Streptomyces avermectinius Strain. | 2017 | Chem. Biodivers. | pmid:28387012 |
| Qin Y et al. | Analysis of sulfonamides, tilmicosin and avermectins residues in typical animal matrices with multi-plug filtration cleanup by liquid chromatography-tandem mass spectrometry detection. | 2017 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:28410479 |
| Kirkness EF and Turner AJ | The stimulatory effects of secobarbital and pregnanolone on the GABAA receptor can be blocked selectively. | 1988 | Eur. J. Pharmacol. | pmid:2843385 |
| Falkenberg LJ et al. | Low sensitivity of reproductive life-stages in the Pacific oyster (Crassostrea gigas) to abamectin. | 2017 | Chemosphere | pmid:28528312 |
| Silva GRD et al. | Multiresidue method for identification and quantification of avermectins, benzimidazoles and nitroimidazoles residues in bovine muscle tissue by ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) using a QuEChERS approach. | 2017 | Talanta | pmid:28551144 |
| Zhang H et al. | Preparation and Characterization of Controlled-Release Avermectin/Castor Oil-Based Polyurethane Nanoemulsions. | 2018 | J. Agric. Food Chem. | pmid:28562041 |