Avermectin is a lipid of Polyketides (PK) class. Avermectin is associated with abnormalities such as Parasitic infection, Parasitic Diseases, Scabies, Tropical Disease and Onchocerciasis. The involved functions are known as Anabolism, Binding (Molecular Function), physiological aspects, Saturated and Cell Growth. Avermectin often locates in receptor complex and cell body (neuron). The associated genes with Avermectin are Homologous Gene, Genome, Gene Clusters and Structural gene.
To understand associated biological information of Avermectin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Avermectin is suspected in Parasitic infection, Parasitic Diseases, Scabies, Tropical Disease, Onchocerciasis, Filarial Elephantiases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Avermectin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Trichostrongyloidiasis | D014252 | 7 associated lipids |
| Arteritis | D001167 | 2 associated lipids |
| Filariasis | D005368 | 6 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
| Trichostrongylosis | D014253 | 5 associated lipids |
| Tuberculosis, Multidrug-Resistant | D018088 | 6 associated lipids |
| Oesophagostomiasis | D009814 | 2 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sun Y et al. | [Effects of avermectin B1a on soil microorganism and earthworm (Eisenia fetida)]. | 2005 | Ying Yong Sheng Tai Xue Bao | pmid:16471355 |
| Zhao X et al. | Overexpression of metK shows different effects on avermectin production in various Streptomyces avermitilis strains. | 2013 | World J. Microbiol. Biotechnol. | pmid:23579768 |
| Boukhrissa A et al. | Study of the degradation in aqueous solution of a refractory organic compound: avermectin type used as pesticide in agriculture. | 2017 | Water Sci. Technol. | pmid:29068328 |
| Hoste H et al. | A questionnaire survey on the practices adopted to control gastrointestinal nematode parasitism in dairy goat farms in France. | 2000 | Vet. Res. Commun. | pmid:11085466 |
| Campbell WC | Efficacy of the avermectins against filarial parasites: a short review. | 1982 | Vet. Res. Commun. | pmid:7051527 |
| Brayden DJ and Griffin J | Avermectin transepithelial transport in MDR1- and MRP-transfected canine kidney monolayers. | 2008 | Vet. Res. Commun. | pmid:17578674 |
| Orpin P | Potential avermectin resistance in a cattle herd. | 2010 | Vet. Rec. | pmid:20622213 |
| Sargison ND et al. | Characterisation of milbemycin-, avermectin-, imidazothiazole- and benzimidazole-resistant Teladorsagia circumcincta from a sheep flock. | 2010 | Vet. Rec. | pmid:20511651 |
| Sangster NC | Pharmacology of anthelmintic resistance in cyathostomes: will it occur with the avermectin/milbemycins? | 1999 | Vet. Parasitol. | pmid:10485365 |
| Geary TG et al. | Frontiers in anthelmintic pharmacology. | 1999 | Vet. Parasitol. | pmid:10456419 |
| Novotny MJ et al. | Safety of selamectin in dogs. | 2000 | Vet. Parasitol. | pmid:10940536 |
| Krautmann MJ et al. | Safety of selamectin in cats. | 2000 | Vet. Parasitol. | pmid:10940537 |
| Goudie AC et al. | Doramectin--a potent novel endectocide. | 1993 | Vet. Parasitol. | pmid:8236738 |
| Bowen JM and Vitayavirasak B | Contractile activity and motility responses of the dog heartworm Dirofilaria immitis to classical anthelmintics and other compounds. | 2005 | Vet. Parasitol. | pmid:16076531 |
| Kuzmina TA et al. | Analysis of the strongylid nematodes (Nematoda: Strongylidae) community after deworming of brood horses in Ukraine. | 2005 | Vet. Parasitol. | pmid:15979240 |
| Learmount J et al. | A computer model to simulate control of parasitic gastroenteritis in sheep on UK farms. | 2006 | Vet. Parasitol. | pmid:16930844 |
| Artho R et al. | Avermectin-resistance in gastrointestinal nematodes of Boer goats and Dorper sheep in Switzerland. | 2007 | Vet. Parasitol. | pmid:17088023 |
| Agbedanu PN et al. | Doxycycline as an inhibitor of p-glycoprotein in the alpaca for the purpose of maintaining avermectins in the CNS during treatment for parelaphostrongylosis. | 2015 | Vet. Parasitol. | pmid:26371853 |
| Oremus G et al. | Effects of mid-season avermectin treatments on pyrethroid resistance in horn fly (Diptera: Muscidae) populations at three locations in Louisiana. | 2006 | Vet. Parasitol. | pmid:16769175 |
| Nari A et al. | The prevalence of anthelmintic resistance in nematode parasites of sheep in southern Latin America: Uruguay. | 1996 | Vet. Parasitol. | pmid:8686167 |
| Mahieu M et al. | Fifteen years later, anthelmintic resistances have dramatically spread over goat farms in Guadeloupe. | 2014 | Vet. Parasitol. | pmid:25149098 |
| Molento MB et al. | Resistance to avermectin/milbemycin anthelmintics in equine cyathostomins - current situation. | 2012 | Vet. Parasitol. | pmid:22047763 |
| McMahon C et al. | Anthelmintic resistance in Northern Ireland (I): prevalence of resistance in ovine gastrointestinal nematodes, as determined through faecal egg count reduction testing. | 2013 | Vet. Parasitol. | pmid:23398988 |
| Shoop WL et al. | Structure and activity of avermectins and milbemycins in animal health. | 1995 | Vet. Parasitol. | pmid:7483237 |
| Doan HT et al. | The efficacy of avermectins (ivermectin, doramectin and abamectin) as treatments for infestation with the tick Haemaphysalis longicornis on rabbits in Korea. | 2013 | Vet. Parasitol. | pmid:24140165 |
| Special issue: Environmental impact of avermectin usage in livestock. | 1993 | Vet. Parasitol. | pmid:8346625 | |
| Ridsdill-Smith TJ | Effects of avermectin residues in cattle dung on dung beetle (Coleoptera: Scarabaeidae) reproduction and survival. | 1993 | Vet. Parasitol. | pmid:8346627 |
| King KL | The potential for avermectins to affect the nutrient economy of grazed pastures. | 1993 | Vet. Parasitol. | pmid:8346639 |
| McCracken DI | The potential for avermectins to affect wildlife. | 1993 | Vet. Parasitol. | pmid:8346640 |
| Waller PJ et al. | Regional and temporal use of avermectins for ruminants in Australia. | 1993 | Vet. Parasitol. | pmid:8346642 |
| Strong L | Overview: the impact of avermectins on pastureland ecology. | 1993 | Vet. Parasitol. | pmid:8346644 |
| Herd R et al. | Research recommendations. | 1993 | Vet. Parasitol. | pmid:8346647 |
| Sams R | Chemical assay of avermectins by high performance liquid chromatography with fluorescence detection. | 1993 | Vet. Parasitol. | pmid:8346649 |
| Lonneux JF et al. | The relationship between parasite counts, lesions, antibody titres and daily weight gains in Psoroptes ovis infested cattle. | 1998 | Vet. Parasitol. | pmid:9653998 |
| Sargison ND et al. | Effects of age and immune suppression of sheep on fecundity, hatching and larval feeding of different strains of Haemonchus contortus. | 2011 | Vet. J. | pmid:20822936 |
| Sherman JG | Understanding the impact of P-glycoprotein mutation on canine health. | 2011 | Vet. J. | pmid:21106417 |
| Merola VM and Eubig PA | Toxicology of Avermectins and Milbemycins (Macrocyclic Lactones) and the Role of P-Glycoprotein in Dogs and Cats. | 2018 | Vet. Clin. North Am. Small Anim. Pract. | pmid:30139545 |
| Merola VM and Eubig PA | Toxicology of avermectins and milbemycins (macrocylic lactones) and the role of P-glycoprotein in dogs and cats. | 2012 | Vet. Clin. North Am. Small Anim. Pract. | pmid:22381182 |
| Yazwinski TA et al. | The effectiveness of ivermectin for reducing bovine gastrointestinal helminthiasis. | 1981 | Vet Med Small Anim Clin | pmid:6911919 |
| Swarnkar CP et al. | Anthelmintic resistance on an organized sheep farm in India. | 2001 | Trop Anim Health Prod | pmid:11474864 |
| Hassan MU et al. | Bovine hypodermosis--a global aspect. | 2010 | Trop Anim Health Prod | pmid:20607401 |
| Molyneux DH and Ward SA | Reflections on the Nobel Prize for Medicine 2015--The Public Health Legacy and Impact of Avermectin and Artemisinin. | 2015 | Trends Parasitol. | pmid:26552892 |
| Pampiglione S et al. | Avermectins, MK-933 and MK-936, for mosquito control. | 1985 | Trans. R. Soc. Trop. Med. Hyg. | pmid:3832491 |
| Xu Z et al. | From the Cover: Functional Analysis Reveals Glutamate and Gamma-Aminobutyric Acid-Gated Chloride Channels as Targets of Avermectins in the Carmine Spider Mite. | 2017 | Toxicol. Sci. | pmid:27742867 |
| Dalzell AM et al. | Characterization of multidrug transporter-mediated efflux of avermectins in human and mouse neuroblastoma cell lines. | 2015 | Toxicol. Lett. | pmid:25865432 |
| Wislocki PG et al. | Dermal penetration of avermectin B1a in the rhesus monkey. | 1988 | Toxicol. Appl. Pharmacol. | pmid:3388421 |
| Kamijima M and Casida JE | Regional modification of [(3)H]Ethynylbicycloorthobenzoate binding in mouse brain GABA(A) receptor by endosulfan, fipronil, and avermectin B(1a). | 2000 | Toxicol. Appl. Pharmacol. | pmid:10698677 |
| Wenjie W et al. | Nystagmus following acute avermectins poisoning. | 2016 | Toxicol Ind Health | pmid:24280654 |
| Zhang W et al. | Determination of avermectins by the internal standard recovery correction - high performance liquid chromatography - quantitative Nuclear Magnetic Resonance method. | 2017 | Talanta | pmid:28602306 |
| Silva GRD et al. | Multiresidue method for identification and quantification of avermectins, benzimidazoles and nitroimidazoles residues in bovine muscle tissue by ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) using a QuEChERS approach. | 2017 | Talanta | pmid:28551144 |