Avermectin A1a

Avermectin A1a is a lipid of Polyketides (PK) class. Avermectin a1a is associated with abnormalities such as Ataxia with vitamin E deficiency, Strongyloidiasis, Congenital Transposition, Gigantism and Onchocerciasis. The involved functions are known as DNA Binding, Anabolism, Insertion Mutation, Process and physiological aspects. Avermectin a1a often locates in Chromosomes, Membrane, Clone, soluble and Tissue membrane. The associated genes with Avermectin A1a are Polypeptides, oxytocin, 1-desamino-(O-Et-Tyr)(2)-, Gene Feature, Genome and Gene Clusters. The related lipids are Propionate. The related experimental models are Mouse Model.

Cross Reference

Introduction

To understand associated biological information of Avermectin A1a, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Avermectin A1a?

Avermectin A1a is suspected in Ataxia with vitamin E deficiency, Gigantism, Strongyloidiasis, Congenital Transposition, Onchocerciasis, Tropical Disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Avermectin A1a

MeSH term MeSH ID Detail
Parasitic Diseases, Animal D010273 1 associated lipids
Larva Migrans D007815 1 associated lipids
Ectoparasitic Infestations D004478 2 associated lipids
Scabies D012532 2 associated lipids
Ostertagiasis D010029 2 associated lipids
Strongylida Infections D017206 5 associated lipids
Trichostrongylosis D014253 5 associated lipids
Fish Diseases D005393 5 associated lipids
Dog Diseases D004283 5 associated lipids
Tuberculosis, Multidrug-Resistant D018088 6 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Avermectin A1a

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Avermectin A1a?

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Location Cross reference Weighted score Related literatures
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What functions are associated with Avermectin A1a?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Avermectin A1a?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Avermectin A1a?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Avermectin A1a?

Mouse Model

Mouse Model are used in the study 'Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the gamma-aminobutyric acid(A) receptor.' (Dawson GR et al., 2000).

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NCBI Entrez Crosslinks

All references with Avermectin A1a

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Authors Title Published Journal PubMed Link
pmid:
Jia X et al. Adhesive polydopamine coated avermectin microcapsules for prolonging foliar pesticide retention. 2014 ACS Appl Mater Interfaces pmid:25390545
Wang F et al. Structural and functional analysis of the loading acyltransferase from avermectin modular polyketide synthase. 2015 ACS Chem. Biol. pmid:25581064
Komatsu M et al. Engineered Streptomyces avermitilis host for heterologous expression of biosynthetic gene cluster for secondary metabolites. 2013 ACS Synth Biol pmid:23654282
Jacobson M et al. Elimination of Sarcoptes scabiei in pig herds by single or double administrations of an avermectin. 2000 Acta Vet. Scand. pmid:11126572
Wilkins CA et al. Treatment of psoroptic mange with avermectins. 1980 Am. J. Vet. Res. pmid:7212445
Florez DHÂ et al. Pipette-tip solid-phase extraction using polypyrrole as efficient adsorbent for extraction of avermectins and milbemycins in milk. 2018 Anal Bioanal Chem pmid:29607449
Schaeffer JM et al. A chemiluminescent assay for measuring avermectin binding sites. 1989 Anal. Biochem. pmid:2729548
Thompson TS et al. Large volume injection for the direct analysis of ionophores and avermectins in surface water by liquid chromatography-electrospray ionization tandem mass spectrometry. 2009 Anal. Chim. Acta pmid:19110126
Berendsen BJ et al. The derivatisation of avermectins and milbemycins in milk: new insights and improvement of the procedure. 2007 Anal. Chim. Acta pmid:17386656