| MeSH term | MeSH ID | Detail |
|---|---|---|
| Inflammation | D007249 | 119 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Dog Diseases | D004283 | 5 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Trichostrongyloidiasis | D014252 | 7 associated lipids |
| Poisoning | D011041 | 9 associated lipids |
| Cleft Palate | D002972 | 9 associated lipids |
| Fish Diseases | D005393 | 5 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
| Ostertagiasis | D010029 | 2 associated lipids |
| Strongylida Infections | D017206 | 5 associated lipids |
| Trichostrongylosis | D014253 | 5 associated lipids |
| Lice Infestations | D010373 | 9 associated lipids |
| Ectoparasitic Infestations | D004478 | 2 associated lipids |
| Tuberculosis, Multidrug-Resistant | D018088 | 6 associated lipids |
| Parasitic Diseases, Animal | D010273 | 1 associated lipids |
| Scabies | D012532 | 2 associated lipids |
| Larva Migrans | D007815 | 1 associated lipids |
Avermectin A1a
Avermectin A1a is a lipid of Polyketides (PK) class. Avermectin a1a is associated with abnormalities such as Ataxia with vitamin E deficiency, Strongyloidiasis, Congenital Transposition, Gigantism and Onchocerciasis. The involved functions are known as DNA Binding, Anabolism, Insertion Mutation, Process and physiological aspects. Avermectin a1a often locates in Chromosomes, Membrane, Clone, soluble and Tissue membrane. The associated genes with Avermectin A1a are Polypeptides, oxytocin, 1-desamino-(O-Et-Tyr)(2)-, Gene Feature, Genome and Gene Clusters. The related lipids are Propionate. The related experimental models are Mouse Model.
Cross Reference
Introduction
To understand associated biological information of Avermectin A1a, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Avermectin A1a?
Avermectin A1a is suspected in Ataxia with vitamin E deficiency, Gigantism, Strongyloidiasis, Congenital Transposition, Onchocerciasis, Tropical Disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Avermectin A1a
PubChem Associated disorders and diseases
What pathways are associated with Avermectin A1a
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Avermectin A1a?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Avermectin A1a?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Avermectin A1a?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Avermectin A1a?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Avermectin A1a?
Mouse Model
Mouse Model are used in the study 'Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the gamma-aminobutyric acid(A) receptor.' (Dawson GR et al., 2000).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with Avermectin A1a
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Holden-Dye L and Walker RJ | Avermectin and avermectin derivatives are antagonists at the 4-aminobutyric acid (GABA) receptor on the somatic muscle cells of Ascaris; is this the site of anthelmintic action? | 1990 | Parasitology | pmid:2175874 |
| Jiang X et al. | Expression of CYP107Z13 in Streptomyces lividans TK54 catalyzes the oxidation of avermectin to 4″-oxo-avermectin. | 2012 | Appl. Microbiol. Biotechnol. | pmid:21842154 |
| Alves SN et al. | [Susceptibility of Culex quinquefasciatus larvae to different insecticides]. | 2011 Jul-Aug | Rev. Soc. Bras. Med. Trop. | pmid:21860896 |
| Kitani S et al. | Avenolide, a Streptomyces hormone controlling antibiotic production in Streptomyces avermitilis. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:21930904 |
| Liu M et al. | Magnetic field is the dominant factor to induce the response of Streptomyces avermitilis in altered gravity simulated by diamagnetic levitation. | 2011 | PLoS ONE | pmid:22039402 |
| Campbell WC | History of avermectin and ivermectin, with notes on the history of other macrocyclic lactone antiparasitic agents. | 2012 | Curr Pharm Biotechnol | pmid:22039784 |
| Danaher M et al. | Recent developments in the analysis of avermectin and milbemycin residues in food safety and the environment. | 2012 | Curr Pharm Biotechnol | pmid:22039790 |
| Horsberg TE | Avermectin use in aquaculture. | 2012 | Curr Pharm Biotechnol | pmid:22039799 |
| Molento MB et al. | Resistance to avermectin/milbemycin anthelmintics in equine cyathostomins - current situation. | 2012 | Vet. Parasitol. | pmid:22047763 |
| He HG et al. | [Resistance realized heritability and risk assessment of Panonychus citri to avermectin and fenpropathrin]. | 2011 | Ying Yong Sheng Tai Xue Bao | pmid:22097380 |
| Schulman MD et al. | Purification and identification of dTDP-oleandrose, the precursor of the oleandrose units of the avermectins. | 1990 | J. Biol. Chem. | pmid:2211601 |
| Mandzynets SM et al. | [Avermectin effects on ultrastructure characteristics of the loach embryos]. | 2011 Sep-Oct | Tsitol. Genet. | pmid:22168050 |
| Lopes RP et al. | Development and validation of a multiclass method for the determination of veterinary drug residues in chicken by ultra high performance liquid chromatography-tandem mass spectrometry. | 2012 | Talanta | pmid:22284481 |
| MalanÃková M et al. | Use of thin-layer chromatography for the testing of avermectins produced by Streptomyces avermitilis strains. | 1990 | J. Chromatogr. | pmid:2229244 |
| Gao Y et al. | Species displacements are common to two invasive species of leafminer fly in China, Japan, and the United States. | 2011 | J. Econ. Entomol. | pmid:22299335 |
| Huang J et al. | Molecular characterization of the sigma class gutathione S-transferase from Chilo suppressalis and expression analysis upon bacterial and insecticidal challenge. | 2011 | J. Econ. Entomol. | pmid:22299369 |
| Zhang X et al. | Deletion of ku homologs increases gene targeting frequency in Streptomyces avermitilis. | 2012 | J. Ind. Microbiol. Biotechnol. | pmid:22350115 |
| Merola VM and Eubig PA | Toxicology of avermectins and milbemycins (macrocylic lactones) and the role of P-glycoprotein in dogs and cats. | 2012 | Vet. Clin. North Am. Small Anim. Pract. | pmid:22381182 |
| Byrne FJ et al. | Evaluation of neonicotinoid, organophosphate and avermectin trunk injections for the management of avocado thrips in California avocado groves. | 2012 | Pest Manag. Sci. | pmid:22396314 |
| Fritz ML et al. | Lethal and sublethal effects of avermectin/milbemycin parasiticides on the African malaria vector, Anopheles arabiensis. | 2012 | J. Med. Entomol. | pmid:22493850 |
| Erban T et al. | The efficacy of four avermectins on the synanthropic mite Lepidoglyphus destructor under laboratory conditions. | 2012 | Exp. Appl. Acarol. | pmid:22527833 |
| Tao Y et al. | Determination of 17 macrolide antibiotics and avermectins residues in meat with accelerated solvent extraction by liquid chromatography-tandem mass spectrometry. | 2012 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:22542398 |
| Gao Y et al. | Insecticide-mediated apparent displacement between two invasive species of leafminer fly. | 2012 | PLoS ONE | pmid:22662122 |
| Yu Z et al. | Differential regulation of antibiotic biosynthesis by DraR-K, a novel two-component system in Streptomyces coelicolor. | 2012 | Mol. Microbiol. | pmid:22676800 |
| Wang C et al. | A monoclonal antibody-based ELISA for multiresidue determination of avermectins in milk. | 2012 | Molecules | pmid:22706371 |
| Liu GD et al. | [Hemoperfusion in the treatment of an acute avermectin poisoning patient with liver cirrhosis]. | 2012 | Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi | pmid:22730696 |
| Lin YY et al. | Differential susceptibilities of Brontispa longissima (Coleoptera: Hispidae) to insecticides in Southeast Asia. | 2012 | J. Econ. Entomol. | pmid:22812140 |
| Beliavskaia LA et al. | [Biologically active substances of preparation avercom]. | 2012 May-Jun | Mikrobiol. Z. | pmid:22830191 |
| Awasthi A et al. | An overview on chemical derivatization and stability aspects of selected avermectin derivatives. | 2012 | Chem. Pharm. Bull. | pmid:22863694 |
| Yan Y et al. | Utilization of environmental waste cyanobacteria as a pesticide carrier: studies on controlled release and photostability of avermectin. | 2013 | Colloids Surf B Biointerfaces | pmid:23006573 |
| Iutynska GO | Elaboration of natural polyfunctional preparations with antiparasitic and biostimulating properties for plant growing. | 2012 Jul-Aug | Mikrobiol. Z. | pmid:23088094 |
| Park JH et al. | Development of an extraction method for the determination of avermectins in soil using supercritical CO2 modified with ethanol and liquid chromatography-tandem mass spectrometry. | 2013 | J Sep Sci | pmid:23109286 |
| Lim LE et al. | Anthelmintic avermectins kill Mycobacterium tuberculosis, including multidrug-resistant clinical strains. | 2013 | Antimicrob. Agents Chemother. | pmid:23165468 |
| Yin P et al. | Direct proteomic mapping of Streptomyces avermitilis wild and industrial strain and insights into avermectin production. | 2013 | J Proteomics | pmid:23201115 |
| Sun P et al. | Spiroketal formation and modification in avermectin biosynthesis involves a dual activity of AveC. | 2013 | J. Am. Chem. Soc. | pmid:23294008 |
| McMahon C et al. | Anthelmintic resistance in Northern Ireland (I): prevalence of resistance in ovine gastrointestinal nematodes, as determined through faecal egg count reduction testing. | 2013 | Vet. Parasitol. | pmid:23398988 |
| Park JH et al. | Application of hollow-fiber-assisted liquid-phase microextraction to identify avermectins in stream water using MS/MS. | 2013 | J Sep Sci | pmid:23504817 |
| Luo L et al. | Avermectin induces P-glycoprotein expression in S2 cells via the calcium/calmodulin/NF-κB pathway. | 2013 | Chem. Biol. Interact. | pmid:23523950 |
| Zhao X et al. | Overexpression of metK shows different effects on avermectin production in various Streptomyces avermitilis strains. | 2013 | World J. Microbiol. Biotechnol. | pmid:23579768 |
| Komatsu M et al. | Engineered Streptomyces avermitilis host for heterologous expression of biosynthetic gene cluster for secondary metabolites. | 2013 | ACS Synth Biol | pmid:23654282 |
| Lopatina IuV and Eremina OIu | [Comparative activity of different groups of insecticides against permethrin-resistant lice (anoplura: pediculidae)]. | 2013 Jan-Mar | Med Parazitol (Mosk) | pmid:23805484 |
| Liu Y et al. | Characterization of SAV7471, a TetR-family transcriptional regulator involved in the regulation of coenzyme A metabolism in Streptomyces avermitilis. | 2013 | J. Bacteriol. | pmid:23893108 |
| Li M et al. | Antioxidant response and histopathological changes in brain tissue of pigeon exposed to avermectin. | 2013 | Ecotoxicology | pmid:23943211 |
| Guo J et al. | A novel TetR family transcriptional regulator, SAV576, negatively controls avermectin biosynthesis in Streptomyces avermitilis. | 2013 | PLoS ONE | pmid:23967193 |
| Chen LJ et al. | Avermectin induced inflammation damage in king pigeon brain. | 2013 | Chemosphere | pmid:24134892 |
| Zhu WJ et al. | Avermectin induced liver injury in pigeon: mechanisms of apoptosis and oxidative stress. | 2013 | Ecotoxicol. Environ. Saf. | pmid:24138898 |
| Doan HT et al. | The efficacy of avermectins (ivermectin, doramectin and abamectin) as treatments for infestation with the tick Haemaphysalis longicornis on rabbits in Korea. | 2013 | Vet. Parasitol. | pmid:24140165 |
| He F et al. | Engineering of the TetR family transcriptional regulator SAV151 and its target genes increases avermectin production in Streptomyces avermitilis. | 2014 | Appl. Microbiol. Biotechnol. | pmid:24220792 |
| Wenjie W et al. | Nystagmus following acute avermectins poisoning. | 2016 | Toxicol Ind Health | pmid:24280654 |
| Chalmers AE et al. | The actions of avermectin on crayfish nerve and muscle. | 1986 | Eur. J. Pharmacol. | pmid:2430816 |
| Kennedy CJ et al. | Inhibition of P-glycoprotein in the blood-brain barrier alters avermectin neurotoxicity and swimming performance in rainbow trout. | 2014 | Aquat. Toxicol. | pmid:24316435 |
| Wang JB et al. | Characterization of AvaR1, an autoregulator receptor that negatively controls avermectins production in a high avermectin-producing strain. | 2014 | Biotechnol. Lett. | pmid:24322771 |
| Wright DJ | Avermectins: action on target pest species. | 1987 | Biochem. Soc. Trans. | pmid:2435585 |
| Liu C et al. | Effects of avermectin on immune function and oxidative stress in the pigeon spleen. | 2014 | Chem. Biol. Interact. | pmid:24412236 |
| Zhuo Y et al. | Synthetic biology of avermectin for production improvement and structure diversification. | 2014 | Biotechnol J | pmid:24478271 |
| Li HB et al. | Combined effects of temperature and avermectins on life history and stress response of the western flower thrips, Frankliniella occidentalis. | 2014 | Pestic Biochem Physiol | pmid:24485314 |
| Sun P et al. | Effect of stereochemistry of avermectin-like 6,6-spiroketals on biological activities and endogenous biotransformations in Streptomyces avermectinius. | 2014 | Chembiochem | pmid:24573905 |
| Demeler J et al. | Measuring the effect of avermectins and milbemycins on somatic muscle contraction of adult Haemonchus contortus and on motility of Ostertagia circumcincta in vitro. | 2014 | Parasitology | pmid:24576444 |
| Huang WK et al. | Efficacy evaluation of fungus Syncephalastrum racemosum and nematicide avermectin against the root-knot nematode Meloidogyne incognita on cucumber. | 2014 | PLoS ONE | pmid:24586982 |
| Chen LJ et al. | The effects of avermectin on amino acid neurotransmitters and their receptors in the pigeon brain. | 2014 | Pestic Biochem Physiol | pmid:24759046 |
| Robertson B | Actions of anaesthetics and avermectin on GABAA chloride channels in mammalian dorsal root ganglion neurones. | 1989 | Br. J. Pharmacol. | pmid:2478243 |
| Luo S et al. | An extracytoplasmic function sigma factor, σ(25), differentially regulates avermectin and oligomycin biosynthesis in Streptomyces avermitilis. | 2014 | Appl. Microbiol. Biotechnol. | pmid:24811406 |
| Cao Y et al. | Global DNA hypomethylation: a potential mechanism in King pigeon nerve tissue damage induced by avermectin. | 2014 | Chem. Biol. Interact. | pmid:24858076 |
| Li M et al. | Exploring the electron transfer pathway in the oxidation of avermectin by CYP107Z13 in Streptomyces ahygroscopicus ZB01. | 2014 | PLoS ONE | pmid:24905717 |
| Guo J et al. | Two adjacent and similar TetR family transcriptional regulator genes, SAV577 and SAV576, co-regulate avermectin production in Streptomyces avermitilis. | 2014 | PLoS ONE | pmid:24915523 |
| Brady PB et al. | Stereodivergent approach to the avermectins based on "super silyl" directed aldol reactions. | 2014 | Org. Lett. | pmid:25025525 |
| Shen W et al. | [Study on the inclusion compound of avermectin by infrared spectroscopy]. | 2014 | Guang Pu Xue Yu Guang Pu Fen Xi | pmid:25095407 |
| Thuan NH et al. | Recent advances in biochemistry and biotechnological synthesis of avermectins and their derivatives. | 2014 | Appl. Microbiol. Biotechnol. | pmid:25104027 |
| Guo H et al. | Reversal of meticillin resistance in Staphylococcus aureus by the anthelmintic avermectin. | 2014 | Int. J. Antimicrob. Agents | pmid:25123810 |
| Mahieu M et al. | Fifteen years later, anthelmintic resistances have dramatically spread over goat farms in Guadeloupe. | 2014 | Vet. Parasitol. | pmid:25149098 |
| Zhu WJ et al. | Effects of avermectin on microsomal cytochrome P450 enzymes in the liver and kidneys of pigeons. | 2014 | Environ. Toxicol. Pharmacol. | pmid:25194326 |
| Li M et al. | The change in heat shock protein expression in avermectin induced neurotoxicity of the pigeon (Columba livia) both in vivo and in vitro. | 2014 | Ecotoxicol. Environ. Saf. | pmid:25202854 |
| Cornejo I et al. | Identification and functional expression of a glutamate- and avermectin-gated chloride channel from Caligus rogercresseyi, a southern Hemisphere sea louse affecting farmed fish. | 2014 | PLoS Pathog. | pmid:25255455 |
| Jia X et al. | Adhesive polydopamine coated avermectin microcapsules for prolonging foliar pesticide retention. | 2014 | ACS Appl Mater Interfaces | pmid:25390545 |
| Liu C et al. | Effects of avermectin on heat shock proteins expression and histopathology in spleen tissues of pigeon. | 2014 | Chem. Biol. Interact. | pmid:25446859 |
| Wang Y et al. | Ternary toxicological interactions of insecticides, herbicides, and a heavy metal on the earthworm Eisenia fetida. | 2015 | J. Hazard. Mater. | pmid:25463238 |
| Qu J et al. | Autophagy is upregulated in brain tissues of pigeons exposed to avermectin. | 2015 | Ecotoxicol. Environ. Saf. | pmid:25497772 |
| Zou CS et al. | Purification, characterization, and sensitivity to pesticides of carboxylesterase from Dendrolimus superans (Lepidoptera: Lasiocampidae). | 2014 | J. Insect Sci. | pmid:25525114 |
| Woerde DJ et al. | Susceptibility of rapidly growing mycobacteria isolated from Australian cats to ivermectin, moxidectin, ceftiofur and florfenicol. | 2015 | J. Feline Med. Surg. | pmid:25572306 |
| Wang F et al. | Structural and functional analysis of the loading acyltransferase from avermectin modular polyketide synthase. | 2015 | ACS Chem. Biol. | pmid:25581064 |
| Sun P et al. | 1,19-seco-Avermectin analogues from a ΔaveCDE mutant Streptomyces avermectinius strain. | 2015 | J. Nat. Prod. | pmid:25611131 |
| Chen C et al. | The synergistic toxicity of the multiple chemical mixtures: implications for risk assessment in the terrestrial environment. | 2015 | Environ Int | pmid:25667058 |
| Li D et al. | Synergistic effect of non-ionic surfactants Tween 80 and PEG6000 on cytotoxicity of insecticides. | 2015 | Environ. Toxicol. Pharmacol. | pmid:25699500 |
| Omansen TF et al. | In-vitro activity of avermectins against Mycobacterium ulcerans. | 2015 | PLoS Negl Trop Dis | pmid:25742173 |
| Rúbies A et al. | Determination of avermectins: a QuEChERS approach to the analysis of food samples. | 2015 | Food Chem | pmid:25794721 |
| Li X et al. | Fast and Online Determination of Five Avermectin Residues in Foodstuffs of Plant and Animal Origin Using Reusable Polymeric Monolithic Extractor Coupled with LC-MS/MS. | 2015 | J. Agric. Food Chem. | pmid:25865176 |
| Dalzell AM et al. | Characterization of multidrug transporter-mediated efflux of avermectins in human and mouse neuroblastoma cell lines. | 2015 | Toxicol. Lett. | pmid:25865432 |
| Meyers JI et al. | Mosquitocidal properties of IgG targeting the glutamate-gated chloride channel in three mosquito disease vectors (Diptera: Culicidae). | 2015 | J. Exp. Biol. | pmid:25994632 |
| Liu W et al. | Increasing Avermectin Production in Streptomyces avermitilis by Manipulating the Expression of a Novel TetR-Family Regulator and Its Target Gene Product. | 2015 | Appl. Environ. Microbiol. | pmid:26002902 |
| Huang J et al. | Gene Replacement for the Generation of Designed Novel Avermectin Derivatives with Enhanced Acaricidal and Nematicidal Activities. | 2015 | Appl. Environ. Microbiol. | pmid:26025902 |
| Kwon YJ et al. | Selective Inhibition of SIN3 Corepressor with Avermectins as a Novel Therapeutic Strategy in Triple-Negative Breast Cancer. | 2015 | Mol. Cancer Ther. | pmid:26078298 |
| Godinez O et al. | Targeting the Osmotic Stress Response for Strain Improvement of an Industrial Producer of Secondary Metabolites. | 2015 | J. Microbiol. Biotechnol. | pmid:26139611 |
| Curdová E et al. | The effect of inorganic phosphate on the production of avermectin in Streptomyces avermitilis. | 1989 | J. Basic Microbiol. | pmid:2614673 |
| Hopwood DA | Satoshi ÅŒmura. | 2016 | J. Ind. Microbiol. Biotechnol. | pmid:26186906 |
| Kose LP et al. | The effects of some avermectins on bovine carbonic anhydrase enzyme. | 2016 | J Enzyme Inhib Med Chem | pmid:26207514 |
| Yang R et al. | The PhoP transcription factor negatively regulates avermectin biosynthesis in Streptomyces avermitilis. | 2015 | Appl. Microbiol. Biotechnol. | pmid:26298701 |
| Zhao Y et al. | Isolation, characterization, and tissue-specific expression of GABA A receptor α1 subunit gene of Carassius auratus gibelio after avermectin treatment. | 2016 | Fish Physiol. Biochem. | pmid:26318443 |
| Agbedanu PN et al. | Doxycycline as an inhibitor of p-glycoprotein in the alpaca for the purpose of maintaining avermectins in the CNS during treatment for parelaphostrongylosis. | 2015 | Vet. Parasitol. | pmid:26371853 |
| Zhang J et al. | Designed biosynthesis of 25-methyl and 25-ethyl ivermectin with enhanced insecticidal activity by domain swap of avermectin polyketide synthase. | 2015 | Microb. Cell Fact. | pmid:26400541 |
| Owens B | 2015 Nobel Prize goes to antiparasitic drug discoverers. | 2015 | Lancet | pmid:26466031 |