| MeSH term | MeSH ID | Detail |
|---|---|---|
| Trichostrongyloidiasis | D014252 | 7 associated lipids |
| Lice Infestations | D010373 | 9 associated lipids |
| Poisoning | D011041 | 9 associated lipids |
| Cleft Palate | D002972 | 9 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
Avermectin A1a
Avermectin A1a is a lipid of Polyketides (PK) class. Avermectin a1a is associated with abnormalities such as Ataxia with vitamin E deficiency, Strongyloidiasis, Congenital Transposition, Gigantism and Onchocerciasis. The involved functions are known as DNA Binding, Anabolism, Insertion Mutation, Process and physiological aspects. Avermectin a1a often locates in Chromosomes, Membrane, Clone, soluble and Tissue membrane. The associated genes with Avermectin A1a are Polypeptides, oxytocin, 1-desamino-(O-Et-Tyr)(2)-, Gene Feature, Genome and Gene Clusters. The related lipids are Propionate. The related experimental models are Mouse Model.
Cross Reference
Introduction
To understand associated biological information of Avermectin A1a, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Avermectin A1a?
Avermectin A1a is suspected in Ataxia with vitamin E deficiency, Gigantism, Strongyloidiasis, Congenital Transposition, Onchocerciasis, Tropical Disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Proc. Natl. Acad. Sci. U.S.A. (1)
- Stem Cell Reports (1)
- Antimicrob. Agents Chemother. (1)
- Others (3)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Avermectin A1a
PubChem Associated disorders and diseases
What pathways are associated with Avermectin A1a
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Avermectin A1a?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Avermectin A1a?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Avermectin A1a?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Avermectin A1a?
Related references are published most in these journals:
- Proc. Natl. Acad. Sci. U.S.A. (3)
- Appl. Environ. Microbiol. (3)
- Microbiology (Reading, Engl.) (1)
- Others (5)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Avermectin A1a?
Mouse Model
Mouse Model are used in the study 'Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the gamma-aminobutyric acid(A) receptor.' (Dawson GR et al., 2000).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Avermectin A1a
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sheehan LS et al. | Engineering of the spinosyn PKS: directing starter unit incorporation. | 2006 | J. Nat. Prod. | pmid:17190446 |
| Dong JY et al. | Ymf 1029A-E, preussomerin analogues from the fresh-water-derived fungus YMF 1.01029. | 2008 | J. Nat. Prod. | pmid:18479163 |
| Sun P et al. | 1,19-seco-Avermectin analogues from a ΔaveCDE mutant Streptomyces avermectinius strain. | 2015 | J. Nat. Prod. | pmid:25611131 |
| Barnes TM and Hekimi S | The Caenorhabditis elegans avermectin resistance and anesthetic response gene unc-9 encodes a member of a protein family implicated in electrical coupling of excitable cells. | 1997 | J. Neurochem. | pmid:9375655 |
| Iovchev M et al. | Altered drug resistance and recovery from paralysis in Drosophila melanogaster with a deficient histamine-gated chloride channel. | 2002 Oct-Dec | J. Neurogenet. | pmid:12745634 |
| Sha CK et al. | Anionic cyclization approach toward perhydrobenzofuranone: stereocontrolled synthesis of the hexahydrobenzofuran subunit of avermectin. | 2002 | J. Org. Chem. | pmid:11856026 |
| Luft JA et al. | Substituent effects on the rearrangements of cyclohexyl to cyclopentyl radicals involving avermectin-related radicals. | 2008 | J. Org. Chem. | pmid:18842059 |
| Campbell WC | The chemotherapy of parasitic infections. | 1986 | J. Parasitol. | pmid:3519918 |
| Arena JP et al. | The mechanism of action of avermectins in Caenorhabditis elegans: correlation between activation of glutamate-sensitive chloride current, membrane binding, and biological activity. | 1995 | J. Parasitol. | pmid:7707209 |
| Dawson GR et al. | Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the gamma-aminobutyric acid(A) receptor. | 2000 | J. Pharmacol. Exp. Ther. | pmid:11082440 |
| Tribble ND et al. | Identification of the genes encoding for putative gamma aminobutyric acid (GABA) and glutamate-gated chloride channel (GluCl) alpha receptor subunits in sea lice (Lepeophtheirus salmonis). | 2007 | J. Vet. Pharmacol. Ther. | pmid:17348903 |
| McKellar QA and Benchaoui HA | Avermectins and milbemycins. | 1996 | J. Vet. Pharmacol. Ther. | pmid:8905567 |
| Young KE et al. | Evaluation of anthelmintic activity in captive wild ruminants by fecal egg reduction tests and a larval development assay. | 2000 | J. Zoo Wildl. Med. | pmid:11237142 |
| Ikeda H | [Genetic analysis of biosynthesis of polyketide compound in Streptomyces avermitilis]. | 2001 | Jpn J Antibiot | pmid:11392681 |
| Venkatachalam MA et al. | Cytoprotection of kidney epithelial cells by compounds that target amino acid gated chloride channels. | 1996 | Kidney Int. | pmid:8821829 |
| BronshteÄn AM et al. | [Migrating subcutaneous myasis with systemic manifestations caused by gadfly larvae]. | 2004 | Klin Med (Mosk) | pmid:15656401 |
| Owens B | 2015 Nobel Prize goes to antiparasitic drug discoverers. | 2015 | Lancet | pmid:26466031 |
| Meng L et al. | Enhanced production of avermectin by deletion of type III polyketide synthases biosynthetic cluster rpp in Streptomyces avermitilis. | 2016 | Lett. Appl. Microbiol. | pmid:27538855 |
| BronshteÄn AM | [Praziquantel and other current preparations and chemotherapy methods in human trematodiases of the liver (opisthorchiasis and clonorchiasis) (a review of the literature)]. | 1984 Nov-Dec | Med Parazitol (Mosk) | pmid:6397686 |
| Lopatina IuV and Eremina OIu | [Comparative activity of different groups of insecticides against permethrin-resistant lice (anoplura: pediculidae)]. | 2013 Jan-Mar | Med Parazitol (Mosk) | pmid:23805484 |
| Denham DA | The effects of some avermectins on the growth of Brugia pahangi. | 1982 | Methods Find Exp Clin Pharmacol | pmid:7121142 |
| Kim MS et al. | Engineered biosynthesis of milbemycins in the avermectin high-producing strain Streptomyces avermitilis. | 2017 | Microb. Cell Fact. | pmid:28095865 |
| Zhang J et al. | Designed biosynthesis of 25-methyl and 25-ethyl ivermectin with enhanced insecticidal activity by domain swap of avermectin polyketide synthase. | 2015 | Microb. Cell Fact. | pmid:26400541 |
| Zhang YX et al. | Genes encoding acyl-CoA dehydrogenase (AcdH) homologues from Streptomyces coelicolor and Streptomyces avermitilis provide insights into the metabolism of small branched-chain fatty acids and macrolide antibiotic production. | 1999 | Microbiology (Reading, Engl.) | pmid:10517585 |
| Miyamoto KT et al. | The autoregulator receptor homologue AvaR3 plays a regulatory role in antibiotic production, mycelial aggregation and colony development of Streptomyces avermitilis. | 2011 | Microbiology (Reading, Engl.) | pmid:21622528 |
| Evans M et al. | Characterization of a Streptomyces-lividans-type site-specific DNA modification system in the avermectin-producer Streptomyces avermitilis permits investigation of two novel giant linear plasmids, pSA1 and pSA2. | 1994 | Microbiology (Reading, Engl.) | pmid:8081502 |
| Alves SN et al. | Alterations in the fat body and midgut of Culex quinquefasciatus larvae following exposure to different insecticides. | 2010 | Micron | pmid:20452779 |
| Iamborko NA and Pindrus AA | [Protective properties of avermectine complex and plant growth regulators]. | 2009 Mar-Apr | Mikrobiol. Z. | pmid:19938592 |
| Biliavs'ka LO et al. | [Effect of pyruvate and valine on avermectin biosynthesis by Streptomyces avermitilis UCM Ac-2179]. | 2007 Jul-Aug | Mikrobiol. Z. | pmid:17977447 |
| Petruk TV et al. | [Increasing biosynthesis of avermectins of Streptomyces avermitilis UCM Ac 2161 under the effect N-methyl-N'-nitro-N-nitrosoguanidine]. | 2004 Nov-Dec | Mikrobiol. Z. | pmid:15765867 |
| Beliavskaia LA et al. | [Biologically active substances of preparation avercom]. | 2012 May-Jun | Mikrobiol. Z. | pmid:22830191 |
| Iutynska GO | Elaboration of natural polyfunctional preparations with antiparasitic and biostimulating properties for plant growing. | 2012 Jul-Aug | Mikrobiol. Z. | pmid:23088094 |
| Delany NS et al. | Cloning and localisation of an avermectin receptor-related subunit from Haemonchus contortus. | 1998 | Mol. Biochem. Parasitol. | pmid:9879896 |
| Blackhall WJ et al. | Selection at a gamma-aminobutyric acid receptor gene in Haemonchus contortus resistant to avermectins/milbemycins. | 2003 | Mol. Biochem. Parasitol. | pmid:14511812 |
| Kass IS et al. | The effects of avermectin and drugs related to acetylcholine and 4-aminobutyric acid on neurotransmission in Ascaris suum. | 1984 | Mol. Biochem. Parasitol. | pmid:6096713 |
| Liu J et al. | Genomic organization of an avermectin receptor subunit from Haemonchus contortus and expression of its putative promoter region in Caenorhabditis elegans. | 2004 | Mol. Biochem. Parasitol. | pmid:15003846 |
| Kwon YJ et al. | Selective Inhibition of SIN3 Corepressor with Avermectins as a Novel Therapeutic Strategy in Triple-Negative Breast Cancer. | 2015 | Mol. Cancer Ther. | pmid:26078298 |
| Guo J et al. | The pathway-specific regulator AveR from Streptomyces avermitilis positively regulates avermectin production while it negatively affects oligomycin biosynthesis. | 2010 | Mol. Genet. Genomics | pmid:20012992 |
| Zhu J et al. | AvaR2, a pseudo γ-butyrolactone receptor homologue from Streptomyces avermitilis, is a pleiotropic repressor of avermectin and avenolide biosynthesis and cell growth. | 2016 | Mol. Microbiol. | pmid:27502190 |
| Yu Z et al. | Differential regulation of antibiotic biosynthesis by DraR-K, a novel two-component system in Streptomyces coelicolor. | 2012 | Mol. Microbiol. | pmid:22676800 |
| Arena JP et al. | Avermectin-sensitive chloride currents induced by Caenorhabditis elegans RNA in Xenopus oocytes. | 1991 | Mol. Pharmacol. | pmid:1716730 |
| Wang C et al. | A monoclonal antibody-based ELISA for multiresidue determination of avermectins in milk. | 2012 | Molecules | pmid:22706371 |
| Miakisheva SN et al. | [Proliferation and morphological differentiation of neurblastoma cells in cultured under the effect of avermectins]. | 2001 | Morfologiia | pmid:12016760 |
| Campbell WC | An introduction to the avermectins. | 1981 | N Z Vet J | pmid:7038568 |
| Davies HG and Green RH | Avermectins and milbemycins. | 1986 | Nat Prod Rep | pmid:3526202 |
| Walsh CT | Natural insights for chemical biologists. | 2005 | Nat. Chem. Biol. | pmid:16408011 |
| Cully DF et al. | Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans. | 1994 | Nature | pmid:7935817 |
| Schönrock B and Bormann J | Activation of Cl- channels by avermectin in rat cultured hippocampal neurons. | 1993 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:8133905 |
| Drexler G and Sieghart W | [35S]tert.-butylbicyclophosphorothionate and avermectin bind to different sites associated with the gamma- aminobutyric acid-benzodiazepine receptor complex. | 1984 | Neurosci. Lett. | pmid:6093013 |
| Chen LP et al. | Direct interaction of avermectin with epidermal growth factor receptor mediates the penetration resistance in Drosophila larvae. | 2016 | Open Biol | pmid:27249340 |