Avermectin A1a

Avermectin A1a is a lipid of Polyketides (PK) class. Avermectin a1a is associated with abnormalities such as Ataxia with vitamin E deficiency, Strongyloidiasis, Congenital Transposition, Gigantism and Onchocerciasis. The involved functions are known as DNA Binding, Anabolism, Insertion Mutation, Process and physiological aspects. Avermectin a1a often locates in Chromosomes, Membrane, Clone, soluble and Tissue membrane. The associated genes with Avermectin A1a are Polypeptides, oxytocin, 1-desamino-(O-Et-Tyr)(2)-, Gene Feature, Genome and Gene Clusters. The related lipids are Propionate. The related experimental models are Mouse Model.

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Introduction

To understand associated biological information of Avermectin A1a, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Avermectin A1a?

Avermectin A1a is suspected in Ataxia with vitamin E deficiency, Gigantism, Strongyloidiasis, Congenital Transposition, Onchocerciasis, Tropical Disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Avermectin A1a

MeSH term MeSH ID Detail
Fish Diseases D005393 5 associated lipids
Dog Diseases D004283 5 associated lipids
Strongylida Infections D017206 5 associated lipids
Trichostrongylosis D014253 5 associated lipids
Ectoparasitic Infestations D004478 2 associated lipids
Scabies D012532 2 associated lipids
Ostertagiasis D010029 2 associated lipids
Parasitic Diseases, Animal D010273 1 associated lipids
Larva Migrans D007815 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Avermectin A1a

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Avermectin A1a?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Avermectin A1a?


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What lipids are associated with Avermectin A1a?

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What genes are associated with Avermectin A1a?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Avermectin A1a?

Mouse Model

Mouse Model are used in the study 'Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the gamma-aminobutyric acid(A) receptor.' (Dawson GR et al., 2000).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Avermectin A1a

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Authors Title Published Journal PubMed Link
Molnár I et al. Biocatalytic conversion of avermectin to 4"-oxo-avermectin: heterologous expression of the ema1 cytochrome P450 monooxygenase. 2005 Appl. Environ. Microbiol. pmid:16269733
Li ZZ et al. Controlled release of avermectin from porous hollow silica nanoparticles: influence of shell thickness on loading efficiency, UV-shielding property and release. 2006 J Control Release pmid:16388871
Walsh CT Natural insights for chemical biologists. 2005 Nat. Chem. Biol. pmid:16408011
Turnipseed SB et al. No-discharge atmospheric pressure chemical ionization: evaluation and application to the analysis of animal drug residues in complex matrices. 2006 Rapid Commun. Mass Spectrom. pmid:16541409
Beasley CA et al. Identification of impurities in ivermectin bulk material by mass spectrometry and NMR. 2006 J Pharm Biomed Anal pmid:16554137
Wolstenholme AJ and Rogers AT Glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics. 2005 Parasitology pmid:16569295
Payne GT and Soderlund DM Activation of gamma-aminobutyric acid insensitive chloride channels in mouse brain synaptic vesicles by avermectin B1a. 1991 J. Biochem. Toxicol. pmid:1663556
Zhang X et al. Construction of ivermectin producer by domain swaps of avermectin polyketide synthase in Streptomyces avermitilis. 2006 Appl. Microbiol. Biotechnol. pmid:16708195
Oremus G et al. Effects of mid-season avermectin treatments on pyrethroid resistance in horn fly (Diptera: Muscidae) populations at three locations in Louisiana. 2006 Vet. Parasitol. pmid:16769175
Wei X et al. Enhancement and selective production of oligomycin through inactivation of avermectin's starter unit in Streptomyces avermitilis. 2006 Biotechnol. Lett. pmid:16786277