Avermectin A1a

Avermectin A1a is a lipid of Polyketides (PK) class. Avermectin a1a is associated with abnormalities such as Ataxia with vitamin E deficiency, Strongyloidiasis, Congenital Transposition, Gigantism and Onchocerciasis. The involved functions are known as DNA Binding, Anabolism, Insertion Mutation, Process and physiological aspects. Avermectin a1a often locates in Chromosomes, Membrane, Clone, soluble and Tissue membrane. The associated genes with Avermectin A1a are Polypeptides, oxytocin, 1-desamino-(O-Et-Tyr)(2)-, Gene Feature, Genome and Gene Clusters. The related lipids are Propionate. The related experimental models are Mouse Model.

Cross Reference

Introduction

To understand associated biological information of Avermectin A1a, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Avermectin A1a?

Avermectin A1a is suspected in Ataxia with vitamin E deficiency, Gigantism, Strongyloidiasis, Congenital Transposition, Onchocerciasis, Tropical Disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Avermectin A1a

MeSH term MeSH ID Detail
Fish Diseases D005393 5 associated lipids
Dog Diseases D004283 5 associated lipids
Strongylida Infections D017206 5 associated lipids
Trichostrongylosis D014253 5 associated lipids
Scabies D012532 2 associated lipids
Ostertagiasis D010029 2 associated lipids
Ectoparasitic Infestations D004478 2 associated lipids
Parasitic Diseases, Animal D010273 1 associated lipids
Larva Migrans D007815 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Avermectin A1a

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Avermectin A1a?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Avermectin A1a?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Avermectin A1a?

Related references are published most in these journals:

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What genes are associated with Avermectin A1a?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Avermectin A1a?

Mouse Model

Mouse Model are used in the study 'Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the gamma-aminobutyric acid(A) receptor.' (Dawson GR et al., 2000).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Avermectin A1a

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Authors Title Published Journal PubMed Link
Chen LJ et al. The effects of avermectin on amino acid neurotransmitters and their receptors in the pigeon brain. 2014 Pestic Biochem Physiol pmid:24759046
Demeler J et al. Measuring the effect of avermectins and milbemycins on somatic muscle contraction of adult Haemonchus contortus and on motility of Ostertagia circumcincta in vitro. 2014 Parasitology pmid:24576444
Sun P et al. Effect of stereochemistry of avermectin-like 6,6-spiroketals on biological activities and endogenous biotransformations in Streptomyces avermectinius. 2014 Chembiochem pmid:24573905
Zhuo Y et al. Synthetic biology of avermectin for production improvement and structure diversification. 2014 Biotechnol J pmid:24478271
Brady PB et al. Stereodivergent approach to the avermectins based on "super silyl" directed aldol reactions. 2014 Org. Lett. pmid:25025525
Li HB et al. Combined effects of temperature and avermectins on life history and stress response of the western flower thrips, Frankliniella occidentalis. 2014 Pestic Biochem Physiol pmid:24485314
Liu C et al. Effects of avermectin on immune function and oxidative stress in the pigeon spleen. 2014 Chem. Biol. Interact. pmid:24412236
Kennedy CJ et al. Inhibition of P-glycoprotein in the blood-brain barrier alters avermectin neurotoxicity and swimming performance in rainbow trout. 2014 Aquat. Toxicol. pmid:24316435
He F et al. Engineering of the TetR family transcriptional regulator SAV151 and its target genes increases avermectin production in Streptomyces avermitilis. 2014 Appl. Microbiol. Biotechnol. pmid:24220792
Wang JB et al. Characterization of AvaR1, an autoregulator receptor that negatively controls avermectins production in a high avermectin-producing strain. 2014 Biotechnol. Lett. pmid:24322771