Avermectin A1a

Avermectin A1a is a lipid of Polyketides (PK) class. Avermectin a1a is associated with abnormalities such as Ataxia with vitamin E deficiency, Strongyloidiasis, Congenital Transposition, Gigantism and Onchocerciasis. The involved functions are known as DNA Binding, Anabolism, Insertion Mutation, Process and physiological aspects. Avermectin a1a often locates in Chromosomes, Membrane, Clone, soluble and Tissue membrane. The associated genes with Avermectin A1a are Polypeptides, oxytocin, 1-desamino-(O-Et-Tyr)(2)-, Gene Feature, Genome and Gene Clusters. The related lipids are Propionate. The related experimental models are Mouse Model.

Cross Reference

Introduction

To understand associated biological information of Avermectin A1a, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Avermectin A1a?

Avermectin A1a is suspected in Ataxia with vitamin E deficiency, Gigantism, Strongyloidiasis, Congenital Transposition, Onchocerciasis, Tropical Disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Avermectin A1a

MeSH term MeSH ID Detail
Strongylida Infections D017206 5 associated lipids
Trichostrongylosis D014253 5 associated lipids
Fish Diseases D005393 5 associated lipids
Dog Diseases D004283 5 associated lipids
Ectoparasitic Infestations D004478 2 associated lipids
Scabies D012532 2 associated lipids
Ostertagiasis D010029 2 associated lipids
Parasitic Diseases, Animal D010273 1 associated lipids
Larva Migrans D007815 1 associated lipids
Per page 10 20 | Total 19

PubChem Associated disorders and diseases

What pathways are associated with Avermectin A1a

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Avermectin A1a?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Avermectin A1a?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Avermectin A1a?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Avermectin A1a?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Avermectin A1a?

Mouse Model

Mouse Model are used in the study 'Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the gamma-aminobutyric acid(A) receptor.' (Dawson GR et al., 2000).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Avermectin A1a

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Authors Title Published Journal PubMed Link
Xu Z et al. From the Cover: Functional Analysis Reveals Glutamate and Gamma-Aminobutyric Acid-Gated Chloride Channels as Targets of Avermectins in the Carmine Spider Mite. 2017 Toxicol. Sci. pmid:27742867
Mermans C et al. A G326E substitution in the glutamate-gated chloride channel 3 (GluCl3) of the two-spotted spider mite Tetranychus urticae abolishes the agonistic activity of macrocyclic lactones. 2017 Pest Manag. Sci. pmid:28736919
Chen LP et al. Direct interaction of avermectin with epidermal growth factor receptor mediates the penetration resistance in Drosophila larvae. 2016 Open Biol pmid:27249340
Li Y et al. Preparation, Characterization, and Insecticidal Activity of Avermectin-Grafted-Carboxymethyl Chitosan. 2016 Biomed Res Int pmid:27213156
Godoy P et al. Characterisation of P-glycoprotein-9.1 in Haemonchus contortus. 2016 Parasit Vectors pmid:26822677
Sultan SP et al. Characterization of AvaR1, a butenolide-autoregulator receptor for biosynthesis of a Streptomyces hormone in Streptomyces avermitilis. 2016 Appl. Microbiol. Biotechnol. pmid:27541747
Sun D et al. SAV742, a Novel AraC-Family Regulator from Streptomyces avermitilis, Controls Avermectin Biosynthesis, Cell Growth and Development. 2016 Sci Rep pmid:27841302
He JM et al. Direct Involvement of the Master Nitrogen Metabolism Regulator GlnR in Antibiotic Biosynthesis in Streptomyces. 2016 J. Biol. Chem. pmid:27875313
de Oliveira Ferreira F et al. On-line solid-phase extraction-ultra high performance liquid chromatography-tandem mass spectrometry for the determination of avermectins and milbemycin in soils. 2016 J Chromatogr A pmid:27745927
Dos Anjos MR et al. Multiresidue method for simultaneous analysis of aflatoxin M1, avermectins, organophosphate pesticides and milbemycin in milk by ultra-performance liquid chromatography coupled to tandem mass spectrometry. 2016 Food Addit Contam Part A Chem Anal Control Expo Risk Assess pmid:27144891
Chen J et al. Different fates of avermectin and artemisinin in China. 2016 Sci China Life Sci pmid:27132020
Del Giudice P [Nobel prize for ivermectin]. 2016 Ann Dermatol Venereol pmid:27016202
Lewin H and Roberts M Introduction. 2016 Annu Rev Anim Biosci pmid:26884105
Baltz RH et al. Introduction to the Special Issue: "Natural Product Discovery and Development in the Genomic Era". 2016 J. Ind. Microbiol. Biotechnol. pmid:26660315
Li D et al. Preparation of uniform starch microcapsules by premix membrane emulsion for controlled release of avermectin. 2016 Carbohydr Polym pmid:26572364
Tatsuta K Celebrating the 2015 Nobel Prize in Physiology or Medicine of Dr Satoshi ÅŒmura. 2016 J. Antibiot. pmid:26486878
Zhao Y et al. Isolation, characterization, and tissue-specific expression of GABA A receptor α1 subunit gene of Carassius auratus gibelio after avermectin treatment. 2016 Fish Physiol. Biochem. pmid:26318443
Kose LP et al. The effects of some avermectins on bovine carbonic anhydrase enzyme. 2016 J Enzyme Inhib Med Chem pmid:26207514
Hopwood DA Satoshi ÅŒmura. 2016 J. Ind. Microbiol. Biotechnol. pmid:26186906
Wenjie W et al. Nystagmus following acute avermectins poisoning. 2016 Toxicol Ind Health pmid:24280654