| MeSH term | MeSH ID | Detail |
|---|---|---|
| Ostertagiasis | D010029 | 2 associated lipids |
| Strongylida Infections | D017206 | 5 associated lipids |
| Trichostrongylosis | D014253 | 5 associated lipids |
| Lice Infestations | D010373 | 9 associated lipids |
| Ectoparasitic Infestations | D004478 | 2 associated lipids |
| Tuberculosis, Multidrug-Resistant | D018088 | 6 associated lipids |
| Parasitic Diseases, Animal | D010273 | 1 associated lipids |
| Scabies | D012532 | 2 associated lipids |
| Larva Migrans | D007815 | 1 associated lipids |
Avermectin A1a
Avermectin A1a is a lipid of Polyketides (PK) class. Avermectin a1a is associated with abnormalities such as Ataxia with vitamin E deficiency, Strongyloidiasis, Congenital Transposition, Gigantism and Onchocerciasis. The involved functions are known as DNA Binding, Anabolism, Insertion Mutation, Process and physiological aspects. Avermectin a1a often locates in Chromosomes, Membrane, Clone, soluble and Tissue membrane. The associated genes with Avermectin A1a are Polypeptides, oxytocin, 1-desamino-(O-Et-Tyr)(2)-, Gene Feature, Genome and Gene Clusters. The related lipids are Propionate. The related experimental models are Mouse Model.
Cross Reference
Introduction
To understand associated biological information of Avermectin A1a, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Avermectin A1a?
Avermectin A1a is suspected in Ataxia with vitamin E deficiency, Gigantism, Strongyloidiasis, Congenital Transposition, Onchocerciasis, Tropical Disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Avermectin A1a
PubChem Associated disorders and diseases
What pathways are associated with Avermectin A1a
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Avermectin A1a?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Avermectin A1a?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Avermectin A1a?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Avermectin A1a?
Related references are published most in these journals:
- Proc. Natl. Acad. Sci. U.S.A. (3)
- Appl. Environ. Microbiol. (3)
- J. Pharmacol. Exp. Ther. (1)
- Others (5)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Avermectin A1a?
Mouse Model
Mouse Model are used in the study 'Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the gamma-aminobutyric acid(A) receptor.' (Dawson GR et al., 2000).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with Avermectin A1a
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Rezanka T et al. | Pivalic acid acts as a starter unit in a fatty acid and antibiotic biosynthetic pathway in Alicyclobacillus, Rhodococcus and Streptomyces. | 2011 | Environ. Microbiol. | pmid:21450004 |
| Sargison ND et al. | Effects of age and immune suppression of sheep on fecundity, hatching and larval feeding of different strains of Haemonchus contortus. | 2011 | Vet. J. | pmid:20822936 |
| Guan HN et al. | Novel photodegradable insecticide W/TiO(2)/Avermectin nanocomposites obtained by polyelectrolytes assembly. | 2011 | Colloids Surf B Biointerfaces | pmid:21131183 |
| Sherman JG | Understanding the impact of P-glycoprotein mutation on canine health. | 2011 | Vet. J. | pmid:21106417 |
| Miyamoto KT et al. | The autoregulator receptor homologue AvaR3 plays a regulatory role in antibiotic production, mycelial aggregation and colony development of Streptomyces avermitilis. | 2011 | Microbiology (Reading, Engl.) | pmid:21622528 |
| Qiu J et al. | Overexpression of the ABC transporter AvtAB increases avermectin production in Streptomyces avermitilis. | 2011 | Appl. Microbiol. Biotechnol. | pmid:21713508 |
| Jiang L et al. | Inactivation of the extracytoplasmic function sigma factor Sig6 stimulates avermectin production in Streptomyces avermitilis. | 2011 | Biotechnol. Lett. | pmid:21691838 |
| Wang XX et al. | Yeast screening from avermectins wastewater and investigation on the ability of its fermentation. | 2011 | Bioprocess Biosyst Eng | pmid:21698347 |
| Gong X et al. | [Determination of avermectin, diclazuril, toltrazuril and metabolite residues in pork by high performance liquid chromatography-tandem mass spectrometry]. | 2011 | Se Pu | pmid:21657050 |
| Wang JB et al. | Production of doramectin by rational engineering of the avermectin biosynthetic pathway. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21514826 |
| Wang F et al. | Multi-residue method for the confirmation of four avermectin residues in food products of animal origin by ultra-performance liquid chromatography-tandem mass spectrometry. | 2011 | Food Addit Contam Part A Chem Anal Control Expo Risk Assess | pmid:21598143 |
| Jin T et al. | Insecticide resistance of the oriental fruit fly, Bactrocera dorsalis (Hendel) (Diptera: Tephritidae), in mainland China. | 2011 | Pest Manag. Sci. | pmid:21308963 |
| He HG et al. | [Resistance realized heritability and risk assessment of Panonychus citri to avermectin and fenpropathrin]. | 2011 | Ying Yong Sheng Tai Xue Bao | pmid:22097380 |
| Liu M et al. | Magnetic field is the dominant factor to induce the response of Streptomyces avermitilis in altered gravity simulated by diamagnetic levitation. | 2011 | PLoS ONE | pmid:22039402 |
| Kitani S et al. | Avenolide, a Streptomyces hormone controlling antibiotic production in Streptomyces avermitilis. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:21930904 |
| Liu C et al. | [Analysis of methanogenic community of anaerobic granular sludge based on mcrA gene]. | 2011 | Huan Jing Ke Xue | pmid:21717756 |
| Gao Y et al. | Species displacements are common to two invasive species of leafminer fly in China, Japan, and the United States. | 2011 | J. Econ. Entomol. | pmid:22299335 |
| Huang J et al. | Molecular characterization of the sigma class gutathione S-transferase from Chilo suppressalis and expression analysis upon bacterial and insecticidal challenge. | 2011 | J. Econ. Entomol. | pmid:22299369 |
| Alves SN et al. | [Susceptibility of Culex quinquefasciatus larvae to different insecticides]. | 2011 Jul-Aug | Rev. Soc. Bras. Med. Trop. | pmid:21860896 |
| Mandzynets SM et al. | [Avermectin effects on ultrastructure characteristics of the loach embryos]. | 2011 Sep-Oct | Tsitol. Genet. | pmid:22168050 |
| Campbell WC | History of avermectin and ivermectin, with notes on the history of other macrocyclic lactone antiparasitic agents. | 2012 | Curr Pharm Biotechnol | pmid:22039784 |
| Danaher M et al. | Recent developments in the analysis of avermectin and milbemycin residues in food safety and the environment. | 2012 | Curr Pharm Biotechnol | pmid:22039790 |
| Horsberg TE | Avermectin use in aquaculture. | 2012 | Curr Pharm Biotechnol | pmid:22039799 |
| Jiang X et al. | Expression of CYP107Z13 in Streptomyces lividans TK54 catalyzes the oxidation of avermectin to 4″-oxo-avermectin. | 2012 | Appl. Microbiol. Biotechnol. | pmid:21842154 |
| Lopes RP et al. | Development and validation of a multiclass method for the determination of veterinary drug residues in chicken by ultra high performance liquid chromatography-tandem mass spectrometry. | 2012 | Talanta | pmid:22284481 |
| Erban T et al. | The efficacy of four avermectins on the synanthropic mite Lepidoglyphus destructor under laboratory conditions. | 2012 | Exp. Appl. Acarol. | pmid:22527833 |
| Tao Y et al. | Determination of 17 macrolide antibiotics and avermectins residues in meat with accelerated solvent extraction by liquid chromatography-tandem mass spectrometry. | 2012 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:22542398 |
| Lin YY et al. | Differential susceptibilities of Brontispa longissima (Coleoptera: Hispidae) to insecticides in Southeast Asia. | 2012 | J. Econ. Entomol. | pmid:22812140 |
| Liu GD et al. | [Hemoperfusion in the treatment of an acute avermectin poisoning patient with liver cirrhosis]. | 2012 | Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi | pmid:22730696 |
| Fritz ML et al. | Lethal and sublethal effects of avermectin/milbemycin parasiticides on the African malaria vector, Anopheles arabiensis. | 2012 | J. Med. Entomol. | pmid:22493850 |
| Molento MB et al. | Resistance to avermectin/milbemycin anthelmintics in equine cyathostomins - current situation. | 2012 | Vet. Parasitol. | pmid:22047763 |
| Wang C et al. | A monoclonal antibody-based ELISA for multiresidue determination of avermectins in milk. | 2012 | Molecules | pmid:22706371 |
| Yu Z et al. | Differential regulation of antibiotic biosynthesis by DraR-K, a novel two-component system in Streptomyces coelicolor. | 2012 | Mol. Microbiol. | pmid:22676800 |
| Gao Y et al. | Insecticide-mediated apparent displacement between two invasive species of leafminer fly. | 2012 | PLoS ONE | pmid:22662122 |
| Byrne FJ et al. | Evaluation of neonicotinoid, organophosphate and avermectin trunk injections for the management of avocado thrips in California avocado groves. | 2012 | Pest Manag. Sci. | pmid:22396314 |
| Zhang X et al. | Deletion of ku homologs increases gene targeting frequency in Streptomyces avermitilis. | 2012 | J. Ind. Microbiol. Biotechnol. | pmid:22350115 |
| Merola VM and Eubig PA | Toxicology of avermectins and milbemycins (macrocylic lactones) and the role of P-glycoprotein in dogs and cats. | 2012 | Vet. Clin. North Am. Small Anim. Pract. | pmid:22381182 |
| Awasthi A et al. | An overview on chemical derivatization and stability aspects of selected avermectin derivatives. | 2012 | Chem. Pharm. Bull. | pmid:22863694 |
| Iutynska GO | Elaboration of natural polyfunctional preparations with antiparasitic and biostimulating properties for plant growing. | 2012 Jul-Aug | Mikrobiol. Z. | pmid:23088094 |
| Beliavskaia LA et al. | [Biologically active substances of preparation avercom]. | 2012 May-Jun | Mikrobiol. Z. | pmid:22830191 |
| McMahon C et al. | Anthelmintic resistance in Northern Ireland (I): prevalence of resistance in ovine gastrointestinal nematodes, as determined through faecal egg count reduction testing. | 2013 | Vet. Parasitol. | pmid:23398988 |
| Park JH et al. | Application of hollow-fiber-assisted liquid-phase microextraction to identify avermectins in stream water using MS/MS. | 2013 | J Sep Sci | pmid:23504817 |
| Sun P et al. | Spiroketal formation and modification in avermectin biosynthesis involves a dual activity of AveC. | 2013 | J. Am. Chem. Soc. | pmid:23294008 |
| Yin P et al. | Direct proteomic mapping of Streptomyces avermitilis wild and industrial strain and insights into avermectin production. | 2013 | J Proteomics | pmid:23201115 |
| Park JH et al. | Development of an extraction method for the determination of avermectins in soil using supercritical CO2 modified with ethanol and liquid chromatography-tandem mass spectrometry. | 2013 | J Sep Sci | pmid:23109286 |
| Lim LE et al. | Anthelmintic avermectins kill Mycobacterium tuberculosis, including multidrug-resistant clinical strains. | 2013 | Antimicrob. Agents Chemother. | pmid:23165468 |
| Yan Y et al. | Utilization of environmental waste cyanobacteria as a pesticide carrier: studies on controlled release and photostability of avermectin. | 2013 | Colloids Surf B Biointerfaces | pmid:23006573 |
| Zhao X et al. | Overexpression of metK shows different effects on avermectin production in various Streptomyces avermitilis strains. | 2013 | World J. Microbiol. Biotechnol. | pmid:23579768 |
| Luo L et al. | Avermectin induces P-glycoprotein expression in S2 cells via the calcium/calmodulin/NF-κB pathway. | 2013 | Chem. Biol. Interact. | pmid:23523950 |
| Guo J et al. | A novel TetR family transcriptional regulator, SAV576, negatively controls avermectin biosynthesis in Streptomyces avermitilis. | 2013 | PLoS ONE | pmid:23967193 |
| Liu Y et al. | Characterization of SAV7471, a TetR-family transcriptional regulator involved in the regulation of coenzyme A metabolism in Streptomyces avermitilis. | 2013 | J. Bacteriol. | pmid:23893108 |
| Li M et al. | Antioxidant response and histopathological changes in brain tissue of pigeon exposed to avermectin. | 2013 | Ecotoxicology | pmid:23943211 |
| Chen LJ et al. | Avermectin induced inflammation damage in king pigeon brain. | 2013 | Chemosphere | pmid:24134892 |
| Zhu WJ et al. | Avermectin induced liver injury in pigeon: mechanisms of apoptosis and oxidative stress. | 2013 | Ecotoxicol. Environ. Saf. | pmid:24138898 |
| Doan HT et al. | The efficacy of avermectins (ivermectin, doramectin and abamectin) as treatments for infestation with the tick Haemaphysalis longicornis on rabbits in Korea. | 2013 | Vet. Parasitol. | pmid:24140165 |
| Komatsu M et al. | Engineered Streptomyces avermitilis host for heterologous expression of biosynthetic gene cluster for secondary metabolites. | 2013 | ACS Synth Biol | pmid:23654282 |
| Lopatina IuV and Eremina OIu | [Comparative activity of different groups of insecticides against permethrin-resistant lice (anoplura: pediculidae)]. | 2013 Jan-Mar | Med Parazitol (Mosk) | pmid:23805484 |
| Cornejo I et al. | Identification and functional expression of a glutamate- and avermectin-gated chloride channel from Caligus rogercresseyi, a southern Hemisphere sea louse affecting farmed fish. | 2014 | PLoS Pathog. | pmid:25255455 |
| Guo J et al. | Two adjacent and similar TetR family transcriptional regulator genes, SAV577 and SAV576, co-regulate avermectin production in Streptomyces avermitilis. | 2014 | PLoS ONE | pmid:24915523 |
| Li M et al. | Exploring the electron transfer pathway in the oxidation of avermectin by CYP107Z13 in Streptomyces ahygroscopicus ZB01. | 2014 | PLoS ONE | pmid:24905717 |
| Huang WK et al. | Efficacy evaluation of fungus Syncephalastrum racemosum and nematicide avermectin against the root-knot nematode Meloidogyne incognita on cucumber. | 2014 | PLoS ONE | pmid:24586982 |
| Zou CS et al. | Purification, characterization, and sensitivity to pesticides of carboxylesterase from Dendrolimus superans (Lepidoptera: Lasiocampidae). | 2014 | J. Insect Sci. | pmid:25525114 |
| Liu C et al. | Effects of avermectin on heat shock proteins expression and histopathology in spleen tissues of pigeon. | 2014 | Chem. Biol. Interact. | pmid:25446859 |
| Jia X et al. | Adhesive polydopamine coated avermectin microcapsules for prolonging foliar pesticide retention. | 2014 | ACS Appl Mater Interfaces | pmid:25390545 |
| Li M et al. | The change in heat shock protein expression in avermectin induced neurotoxicity of the pigeon (Columba livia) both in vivo and in vitro. | 2014 | Ecotoxicol. Environ. Saf. | pmid:25202854 |
| Zhu WJ et al. | Effects of avermectin on microsomal cytochrome P450 enzymes in the liver and kidneys of pigeons. | 2014 | Environ. Toxicol. Pharmacol. | pmid:25194326 |
| Mahieu M et al. | Fifteen years later, anthelmintic resistances have dramatically spread over goat farms in Guadeloupe. | 2014 | Vet. Parasitol. | pmid:25149098 |
| Guo H et al. | Reversal of meticillin resistance in Staphylococcus aureus by the anthelmintic avermectin. | 2014 | Int. J. Antimicrob. Agents | pmid:25123810 |
| Thuan NH et al. | Recent advances in biochemistry and biotechnological synthesis of avermectins and their derivatives. | 2014 | Appl. Microbiol. Biotechnol. | pmid:25104027 |
| Shen W et al. | [Study on the inclusion compound of avermectin by infrared spectroscopy]. | 2014 | Guang Pu Xue Yu Guang Pu Fen Xi | pmid:25095407 |
| Cao Y et al. | Global DNA hypomethylation: a potential mechanism in King pigeon nerve tissue damage induced by avermectin. | 2014 | Chem. Biol. Interact. | pmid:24858076 |
| Luo S et al. | An extracytoplasmic function sigma factor, σ(25), differentially regulates avermectin and oligomycin biosynthesis in Streptomyces avermitilis. | 2014 | Appl. Microbiol. Biotechnol. | pmid:24811406 |
| Chen LJ et al. | The effects of avermectin on amino acid neurotransmitters and their receptors in the pigeon brain. | 2014 | Pestic Biochem Physiol | pmid:24759046 |
| Demeler J et al. | Measuring the effect of avermectins and milbemycins on somatic muscle contraction of adult Haemonchus contortus and on motility of Ostertagia circumcincta in vitro. | 2014 | Parasitology | pmid:24576444 |
| Sun P et al. | Effect of stereochemistry of avermectin-like 6,6-spiroketals on biological activities and endogenous biotransformations in Streptomyces avermectinius. | 2014 | Chembiochem | pmid:24573905 |
| Zhuo Y et al. | Synthetic biology of avermectin for production improvement and structure diversification. | 2014 | Biotechnol J | pmid:24478271 |
| Brady PB et al. | Stereodivergent approach to the avermectins based on "super silyl" directed aldol reactions. | 2014 | Org. Lett. | pmid:25025525 |
| Li HB et al. | Combined effects of temperature and avermectins on life history and stress response of the western flower thrips, Frankliniella occidentalis. | 2014 | Pestic Biochem Physiol | pmid:24485314 |
| Liu C et al. | Effects of avermectin on immune function and oxidative stress in the pigeon spleen. | 2014 | Chem. Biol. Interact. | pmid:24412236 |
| Kennedy CJ et al. | Inhibition of P-glycoprotein in the blood-brain barrier alters avermectin neurotoxicity and swimming performance in rainbow trout. | 2014 | Aquat. Toxicol. | pmid:24316435 |
| He F et al. | Engineering of the TetR family transcriptional regulator SAV151 and its target genes increases avermectin production in Streptomyces avermitilis. | 2014 | Appl. Microbiol. Biotechnol. | pmid:24220792 |
| Wang JB et al. | Characterization of AvaR1, an autoregulator receptor that negatively controls avermectins production in a high avermectin-producing strain. | 2014 | Biotechnol. Lett. | pmid:24322771 |
| Długońska H | The Nobel Prize 2015 in physiology or medicine for highly effective antiparasitic drugs. | 2015 | Ann Parasitol | pmid:26878630 |
| Tambo E et al. | Nobel prize for the artemisinin and ivermectin discoveries: a great boost towards elimination of the global infectious diseases of poverty. | 2015 | Infect Dis Poverty | pmid:26708575 |
| Shen B | A New Golden Age of Natural Products Drug Discovery. | 2015 | Cell | pmid:26638061 |
| Jin L et al. | Selective targeting of nuclear receptor FXR by avermectin analogues with therapeutic effects on nonalcoholic fatty liver disease. | 2015 | Sci Rep | pmid:26620317 |
| Zhang J et al. | Designed biosynthesis of 25-methyl and 25-ethyl ivermectin with enhanced insecticidal activity by domain swap of avermectin polyketide synthase. | 2015 | Microb. Cell Fact. | pmid:26400541 |
| Godinez O et al. | Targeting the Osmotic Stress Response for Strain Improvement of an Industrial Producer of Secondary Metabolites. | 2015 | J. Microbiol. Biotechnol. | pmid:26139611 |
| Kwon YJ et al. | Selective Inhibition of SIN3 Corepressor with Avermectins as a Novel Therapeutic Strategy in Triple-Negative Breast Cancer. | 2015 | Mol. Cancer Ther. | pmid:26078298 |
| Wang F et al. | Structural and functional analysis of the loading acyltransferase from avermectin modular polyketide synthase. | 2015 | ACS Chem. Biol. | pmid:25581064 |
| Yang R et al. | The PhoP transcription factor negatively regulates avermectin biosynthesis in Streptomyces avermitilis. | 2015 | Appl. Microbiol. Biotechnol. | pmid:26298701 |
| Dalzell AM et al. | Characterization of multidrug transporter-mediated efflux of avermectins in human and mouse neuroblastoma cell lines. | 2015 | Toxicol. Lett. | pmid:25865432 |
| Li X et al. | Fast and Online Determination of Five Avermectin Residues in Foodstuffs of Plant and Animal Origin Using Reusable Polymeric Monolithic Extractor Coupled with LC-MS/MS. | 2015 | J. Agric. Food Chem. | pmid:25865176 |
| Rúbies A et al. | Determination of avermectins: a QuEChERS approach to the analysis of food samples. | 2015 | Food Chem | pmid:25794721 |
| Li D et al. | Synergistic effect of non-ionic surfactants Tween 80 and PEG6000 on cytotoxicity of insecticides. | 2015 | Environ. Toxicol. Pharmacol. | pmid:25699500 |
| Chen C et al. | The synergistic toxicity of the multiple chemical mixtures: implications for risk assessment in the terrestrial environment. | 2015 | Environ Int | pmid:25667058 |
| Sun P et al. | 1,19-seco-Avermectin analogues from a ΔaveCDE mutant Streptomyces avermectinius strain. | 2015 | J. Nat. Prod. | pmid:25611131 |
| Woerde DJ et al. | Susceptibility of rapidly growing mycobacteria isolated from Australian cats to ivermectin, moxidectin, ceftiofur and florfenicol. | 2015 | J. Feline Med. Surg. | pmid:25572306 |
| Qu J et al. | Autophagy is upregulated in brain tissues of pigeons exposed to avermectin. | 2015 | Ecotoxicol. Environ. Saf. | pmid:25497772 |
| Wang Y et al. | Ternary toxicological interactions of insecticides, herbicides, and a heavy metal on the earthworm Eisenia fetida. | 2015 | J. Hazard. Mater. | pmid:25463238 |