| MeSH term | MeSH ID | Detail |
|---|---|---|
| Larva Migrans | D007815 | 1 associated lipids |
| Parasitic Diseases, Animal | D010273 | 1 associated lipids |
| Scabies | D012532 | 2 associated lipids |
| Ostertagiasis | D010029 | 2 associated lipids |
| Ectoparasitic Infestations | D004478 | 2 associated lipids |
| Dog Diseases | D004283 | 5 associated lipids |
| Strongylida Infections | D017206 | 5 associated lipids |
| Trichostrongylosis | D014253 | 5 associated lipids |
| Fish Diseases | D005393 | 5 associated lipids |
| Tuberculosis, Multidrug-Resistant | D018088 | 6 associated lipids |
Avermectin A1a
Avermectin A1a is a lipid of Polyketides (PK) class. Avermectin a1a is associated with abnormalities such as Ataxia with vitamin E deficiency, Strongyloidiasis, Congenital Transposition, Gigantism and Onchocerciasis. The involved functions are known as DNA Binding, Anabolism, Insertion Mutation, Process and physiological aspects. Avermectin a1a often locates in Chromosomes, Membrane, Clone, soluble and Tissue membrane. The associated genes with Avermectin A1a are Polypeptides, oxytocin, 1-desamino-(O-Et-Tyr)(2)-, Gene Feature, Genome and Gene Clusters. The related lipids are Propionate. The related experimental models are Mouse Model.
Cross Reference
Introduction
To understand associated biological information of Avermectin A1a, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Avermectin A1a?
Avermectin A1a is suspected in Ataxia with vitamin E deficiency, Gigantism, Strongyloidiasis, Congenital Transposition, Onchocerciasis, Tropical Disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Avermectin A1a
PubChem Associated disorders and diseases
What pathways are associated with Avermectin A1a
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Avermectin A1a?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Avermectin A1a?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Avermectin A1a?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Avermectin A1a?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Avermectin A1a?
Mouse Model
Mouse Model are used in the study 'Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the gamma-aminobutyric acid(A) receptor.' (Dawson GR et al., 2000).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Avermectin A1a
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Arena JP et al. | Avermectin-sensitive chloride currents induced by Caenorhabditis elegans RNA in Xenopus oocytes. | 1991 | Mol. Pharmacol. | pmid:1716730 |
| Payne GT and Soderlund DM | Activation of gamma-aminobutyric acid insensitive chloride channels in mouse brain synaptic vesicles by avermectin B1a. | 1991 | J. Biochem. Toxicol. | pmid:1663556 |
| Gill JH et al. | Detection of resistance to ivermectin in Haemonchus contortus. | 1991 | Int. J. Parasitol. | pmid:1774112 |
| Hafner EW et al. | Branched-chain fatty acid requirement for avermectin production by a mutant of Streptomyces avermitilis lacking branched-chain 2-oxo acid dehydrogenase activity. | 1991 | J. Antibiot. | pmid:2026560 |
| Dutton CJ et al. | Novel avermectins produced by mutational biosynthesis. | 1991 | J. Antibiot. | pmid:2026561 |
| Lasota JA and Dybas RA | Avermectins, a novel class of compounds: implications for use in arthropod pest control. | 1991 | Annu. Rev. Entomol. | pmid:2006872 |
| Haber CL et al. | Development of a mechanism of action-based screen for anthelmintic microbial metabolites with avermectinlike activity and isolation of milbemycin-producing Streptomyces strains. | 1991 | Antimicrob. Agents Chemother. | pmid:1719935 |
| ChermenskiÄ DN et al. | [Avermectins: biotechnological features of the producing strain of Streptomyces avermitilis VKM As 1301]. | 1991 Nov-Dec | Prikl. Biokhim. Mikrobiol. | pmid:1796092 |
| Fisher MH and Mrozik H | The chemistry and pharmacology of avermectins. | 1992 | Annu. Rev. Pharmacol. Toxicol. | pmid:1605577 |
| Orton CJ et al. | Comparative effectiveness of avermectins and deltamethrin in suppressing oviposition in Lucilia cuprina (Diptera: Calliphoridae). | 1992 | J. Econ. Entomol. | pmid:1607479 |
| MacNeil DJ et al. | Analysis of Streptomyces avermitilis genes required for avermectin biosynthesis utilizing a novel integration vector. | 1992 | Gene | pmid:1547955 |
| Rezanka T et al. | Influence of inhibitors of lipid biosynthesis on the production of avermectins in Streptomyces avermitilis. | 1992 | FEMS Microbiol. Lett. | pmid:1526463 |
| Arena JP et al. | Expression of a glutamate-activated chloride current in Xenopus oocytes injected with Caenorhabditis elegans RNA: evidence for modulation by avermectin. | 1992 | Brain Res. Mol. Brain Res. | pmid:1279355 |
| Rohrer SP et al. | Photoaffinity labeling of avermectin binding sites from Caenorhabditis elegans and Drosophila melanogaster. | 1992 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1315055 |
| Shoop WL | Resistance to avermectins and milbemycins. | 1992 | Vet. Rec. | pmid:1496763 |
| Stong JD et al. | Radical-induced oxidation of oxahydrindene (hexahydrobenzofuran) portion of 22,23-dihydroavermectin B1a: identification of autooxidation products. | 1992 | J Pharm Sci | pmid:1432608 |
| Meinke PT et al. | Affinity probes for the avermectin binding proteins. | 1992 | J. Med. Chem. | pmid:1433197 |
| Novák J et al. | Nitrogen regulation of fatty acids and avermectins biosynthesis in Streptomyces avermitilis. | 1992 | FEMS Microbiol. Lett. | pmid:1612418 |
| MacNeil DJ et al. | Complex organization of the Streptomyces avermitilis genes encoding the avermectin polyketide synthase. | 1992 | Gene | pmid:1612425 |
| Roos MH et al. | Molecular aspects of drug resistance in parasitic helminths. | 1993 | Pharmacol. Ther. | pmid:8022863 |
| Schönrock B and Bormann J | Activation of Cl- channels by avermectin in rat cultured hippocampal neurons. | 1993 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:8133905 |
| Schulman M et al. | Microbial conversion of avermectins by Saccharopolyspora erythraea: glycosylation at C-4' and C-4''. | 1993 | Antimicrob. Agents Chemother. | pmid:8239577 |
| Ikeda H et al. | Transposon mutagenesis by Tn4560 and applications with avermectin-producing Streptomyces avermitilis. | 1993 | J. Bacteriol. | pmid:8384619 |
| MacNeil T et al. | Deletion analysis of the avermectin biosynthetic genes of Streptomyces avermitilis by gene cluster displacement. | 1993 | J. Bacteriol. | pmid:8478321 |
| Novák J et al. | Instability of the production of avermectins, sporulation, and pigmentation in Streptomyces avermitilis. | 1993 | Can. J. Microbiol. | pmid:8467423 |
| Special issue: Environmental impact of avermectin usage in livestock. | 1993 | Vet. Parasitol. | pmid:8346625 | |
| Ridsdill-Smith TJ | Effects of avermectin residues in cattle dung on dung beetle (Coleoptera: Scarabaeidae) reproduction and survival. | 1993 | Vet. Parasitol. | pmid:8346627 |
| King KL | The potential for avermectins to affect the nutrient economy of grazed pastures. | 1993 | Vet. Parasitol. | pmid:8346639 |
| McCracken DI | The potential for avermectins to affect wildlife. | 1993 | Vet. Parasitol. | pmid:8346640 |
| Waller PJ et al. | Regional and temporal use of avermectins for ruminants in Australia. | 1993 | Vet. Parasitol. | pmid:8346642 |
| Strong L | Overview: the impact of avermectins on pastureland ecology. | 1993 | Vet. Parasitol. | pmid:8346644 |
| Herd R et al. | Research recommendations. | 1993 | Vet. Parasitol. | pmid:8346647 |
| Sams R | Chemical assay of avermectins by high performance liquid chromatography with fluorescence detection. | 1993 | Vet. Parasitol. | pmid:8346649 |
| MacNeil DJ et al. | Correlation of the avermectin polyketide synthase genes to the avermectin structure. Implications for designing novel avermectins. | 1994 | Ann. N. Y. Acad. Sci. | pmid:8010663 |
| Cully DF et al. | Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans. | 1994 | Nature | pmid:7935817 |
| Rohrer SP et al. | Immunoaffinity purification of avermectin-binding proteins from the free-living nematode Caenorhabditis elegans and the fruitfly Drosophila melanogaster. | 1994 | Biochem. J. | pmid:8092985 |
| Evans M et al. | Characterization of a Streptomyces-lividans-type site-specific DNA modification system in the avermectin-producer Streptomyces avermitilis permits investigation of two novel giant linear plasmids, pSA1 and pSA2. | 1994 | Microbiology (Reading, Engl.) | pmid:8081502 |
| Schulman M et al. | Microbial conversion of avermectins by Saccharopolyspora erythraea: hydroxylation at C-27. | 1994 | J. Antibiot. | pmid:8175491 |
| Khalkova Zh | [An experimental evaluation of the cutaneous action of the preparation Bulmektin]. | 1994 | Probl Khig | pmid:7845982 |
| Naito S et al. | Milbemycin derivatives: modification at the C-5 position. | 1994 | J. Antibiot. | pmid:8150720 |
| Clark JM et al. | Resistance to avermectins: extent, mechanisms, and management implications. | 1995 | Annu. Rev. Entomol. | pmid:7810984 |
| Le Jambre LF et al. | Characterisation of an avermectin resistant strain of Australian Haemonchus contortus. | 1995 | Int. J. Parasitol. | pmid:7657454 |
| Ikeda H and Omura S | Control of avermectin biosynthesis in Streptomyces avermitilis for the selective production of a useful component. | 1995 | J. Antibiot. | pmid:7649850 |
| Arena JP et al. | The mechanism of action of avermectins in Caenorhabditis elegans: correlation between activation of glutamate-sensitive chloride current, membrane binding, and biological activity. | 1995 | J. Parasitol. | pmid:7707209 |
| Shoop WL et al. | Structure and activity of avermectins and milbemycins in animal health. | 1995 | Vet. Parasitol. | pmid:7483237 |
| Ikeda H et al. | Construction of a single component producer from the wild type avermectin producer Streptomyces avermitilis. | 1995 | J. Antibiot. | pmid:7622445 |
| Gill JH et al. | Avermectin inhibition of larval development in Haemonchus contortus--effects of ivermectin resistance. | 1995 | Int. J. Parasitol. | pmid:7635622 |
| Pang CH et al. | Production of a new methylated 6,8a-seco-6,8a-deoxy derivative of the avermectins by a transformant strain of Streptomyces avermitilis. | 1995 | J. Antibiot. | pmid:7868398 |
| Ikeda H et al. | Direct production of 5-oxo derivatives of avermectins by a recombinant strain of Streptomyces avermitilis. | 1995 | J. Antibiot. | pmid:7868399 |
| Denoya CD et al. | A second branched-chain alpha-keto acid dehydrogenase gene cluster (bkdFGH) from Streptomyces avermitilis: its relationship to avermectin biosynthesis and the construction of a bkdF mutant suitable for the production of novel antiparasitic avermectins. | 1995 | J. Bacteriol. | pmid:7768860 |