Avermectin A1a

Avermectin A1a is a lipid of Polyketides (PK) class. Avermectin a1a is associated with abnormalities such as Ataxia with vitamin E deficiency, Strongyloidiasis, Congenital Transposition, Gigantism and Onchocerciasis. The involved functions are known as DNA Binding, Anabolism, Insertion Mutation, Process and physiological aspects. Avermectin a1a often locates in Chromosomes, Membrane, Clone, soluble and Tissue membrane. The associated genes with Avermectin A1a are Polypeptides, oxytocin, 1-desamino-(O-Et-Tyr)(2)-, Gene Feature, Genome and Gene Clusters. The related lipids are Propionate. The related experimental models are Mouse Model.

Cross Reference

Introduction

To understand associated biological information of Avermectin A1a, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Avermectin A1a?

Avermectin A1a is suspected in Ataxia with vitamin E deficiency, Gigantism, Strongyloidiasis, Congenital Transposition, Onchocerciasis, Tropical Disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Avermectin A1a

MeSH term MeSH ID Detail
Larva Migrans D007815 1 associated lipids
Parasitic Diseases, Animal D010273 1 associated lipids
Scabies D012532 2 associated lipids
Ostertagiasis D010029 2 associated lipids
Ectoparasitic Infestations D004478 2 associated lipids
Dog Diseases D004283 5 associated lipids
Strongylida Infections D017206 5 associated lipids
Trichostrongylosis D014253 5 associated lipids
Fish Diseases D005393 5 associated lipids
Tuberculosis, Multidrug-Resistant D018088 6 associated lipids
Per page 10 20 | Total 19

PubChem Associated disorders and diseases

What pathways are associated with Avermectin A1a

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Avermectin A1a?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Avermectin A1a?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Avermectin A1a?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Avermectin A1a?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Avermectin A1a?

Mouse Model

Mouse Model are used in the study 'Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the gamma-aminobutyric acid(A) receptor.' (Dawson GR et al., 2000).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with Avermectin A1a

Download all related citations
Per page 10 20 50 100 | Total 477
Authors Title Published Journal PubMed Link
Wang H et al. Rapid method for multi-residue determination of avermectins in bovine liver using high-performance liquid chromatography with fluorescence detection. 2009 Bull Environ Contam Toxicol pmid:19159053
Pitterna T et al. New ventures in the chemistry of avermectins. 2009 Bioorg. Med. Chem. pmid:19168364
Duong CT et al. Functional expression of SAV3818, a putative TetR-family transcriptional regulatory gene from Streptomyces avermitilis, stimulates antibiotic production in Streptomyces species. 2009 J. Microbiol. Biotechnol. pmid:19307761
Boina DR et al. Influence of posttreatment temperature on the toxicity of insecticides against Diaphorina citri (Hemiptera: Psyllidae). 2009 J. Econ. Entomol. pmid:19449650
Ci X et al. Avermectin exerts anti-inflammatory effect by downregulating the nuclear transcription factor kappa-B and mitogen-activated protein kinase activation pathway. 2009 Fundam Clin Pharmacol pmid:19453757
Shiwen X et al. Preparation and characterization of monoclonal antibodies against avermectin. 2009 Hybridoma (Larchmt) pmid:19519244
Webb L et al. Field-scale dispersal of Aphodius dung beetles (Coleoptera: Scarabaeidae) in response to avermectin treatments on pastured cattle. 2010 Bull. Entomol. Res. pmid:19586576
Yang F et al. [Determination of avermectin residues in tea by ultra-performance liquid chromatography-electrospray tandem mass spectrometry]. 2009 Se Pu pmid:19626840
Sung YF et al. Avermectin intoxication with coma, myoclonus, and polyneuropathy. 2009 Clin Toxicol (Phila) pmid:19640241
Inoue K et al. Simultaneous determination of avermectins in bovine tissues by LC-MS/MS. 2009 J Sep Sci pmid:19877150
Iamborko NA and Pindrus AA [Protective properties of avermectine complex and plant growth regulators]. 2009 Mar-Apr Mikrobiol. Z. pmid:19938592
Gao H et al. Identification of avermectin-high-producing strains by high-throughput screening methods. 2010 Appl. Microbiol. Biotechnol. pmid:19957083
Guo J et al. The pathway-specific regulator AveR from Streptomyces avermitilis positively regulates avermectin production while it negatively affects oligomycin biosynthesis. 2010 Mol. Genet. Genomics pmid:20012992
Sperry J et al. Synthesis of natural products containing spiroketals via intramolecular hydrogen abstraction. 2010 Org. Biomol. Chem. pmid:20024126
Zhao X et al. Construction of a doramectin producer mutant from an avermectin-overproducing industrial strain of Streptomyces avermitilis. 2009 Can. J. Microbiol. pmid:20029527
Ji P et al. [Clinical analysis of acute Avermectins poisoning]. 2009 Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi pmid:20039548
Lasota JA and Dybas RA Avermectins, a novel class of compounds: implications for use in arthropod pest control. 1991 Annu. Rev. Entomol. pmid:2006872
Hafner EW et al. Branched-chain fatty acid requirement for avermectin production by a mutant of Streptomyces avermitilis lacking branched-chain 2-oxo acid dehydrogenase activity. 1991 J. Antibiot. pmid:2026560
Dutton CJ et al. Novel avermectins produced by mutational biosynthesis. 1991 J. Antibiot. pmid:2026561
Hu J et al. Effects of insecticides on the fluidity of mitochondrial membranes of the diamondback moth, Plutella xylostella, resistant and susceptible to avermectin. 2008 J. Insect Sci. pmid:20345311
Li L et al. Overexpression of ribosome recycling factor causes increased production of avermectin in Streptomyces avermitilis strains. 2010 J. Ind. Microbiol. Biotechnol. pmid:20352288
Liu C et al. [Analysis of methanogenic community of anaerobic granular sludge in a full-scale UASB treating avermectin wastewater]. 2010 Huan Jing Ke Xue pmid:20358834
Molinari G et al. New ventures in the genotoxic and cytotoxic effects of macrocyclic lactones, abamectin and ivermectin. 2010 Cytogenet. Genome Res. pmid:20389039
Jiao YL et al. Function analysis of a new type I PKS-SAT domain by SAT-EAT domain replacement. 2010 Mar-Apr Prikl. Biokhim. Mikrobiol. pmid:20391758
Yang YN et al. [Avermectin poisoning in a child]. 2010 Zhongguo Dang Dai Er Ke Za Zhi pmid:20416232
Alves SN et al. Alterations in the fat body and midgut of Culex quinquefasciatus larvae following exposure to different insecticides. 2010 Micron pmid:20452779
Gao H et al. Assessing the potential of an induced-mutation strategy for avermectin overproducers. 2010 Appl. Environ. Microbiol. pmid:20453119
Sargison ND et al. Characterisation of milbemycin-, avermectin-, imidazothiazole- and benzimidazole-resistant Teladorsagia circumcincta from a sheep flock. 2010 Vet. Rec. pmid:20511651
Zhuo Y et al. Reverse biological engineering of hrdB to enhance the production of avermectins in an industrial strain of Streptomyces avermitilis. 2010 Proc. Natl. Acad. Sci. U.S.A. pmid:20534557
Whelan M et al. Determination of anthelmintic drug residues in milk using ultra high performance liquid chromatography-tandem mass spectrometry with rapid polarity switching. 2010 J Chromatogr A pmid:20564781
Hassan MU et al. Bovine hypodermosis--a global aspect. 2010 Trop Anim Health Prod pmid:20607401
Omura S et al. Selective production of specific components of avermectins in Streptomyces avermitilis. 1991 J. Antibiot. pmid:2061197
Orpin P Potential avermectin resistance in a cattle herd. 2010 Vet. Rec. pmid:20622213
Wu ZX et al. [Determination of avermectin and ivermectin in swine muscular tissues using high performance liquid chromatography-tandem mass spectrometry]. 2010 Sichuan Da Xue Xue Bao Yi Xue Ban pmid:20629337
Li M et al. Enhancement of avermectin and ivermectin production by overexpression of the maltose ATP-binding cassette transporter in Streptomyces avermitilis. 2010 Bioresour. Technol. pmid:20655739
Sargison ND et al. Effects of age and immune suppression of sheep on fecundity, hatching and larval feeding of different strains of Haemonchus contortus. 2011 Vet. J. pmid:20822936
Wolstenholme AJ Recent progress in understanding the interaction between avermectins and ligand-gated ion channels: putting the pests to sleep. 2010 Invert. Neurosci. pmid:20953673
Tom LA and Foster N Development of a molecularly imprinted polymer for the analysis of avermectin. 2010 Anal. Chim. Acta pmid:20969995
Sherman JG Understanding the impact of P-glycoprotein mutation on canine health. 2011 Vet. J. pmid:21106417
Guan HN et al. Novel photodegradable insecticide W/TiO(2)/Avermectin nanocomposites obtained by polyelectrolytes assembly. 2011 Colloids Surf B Biointerfaces pmid:21131183
Jin T et al. Insecticide resistance of the oriental fruit fly, Bactrocera dorsalis (Hendel) (Diptera: Tephritidae), in mainland China. 2011 Pest Manag. Sci. pmid:21308963
Rezanka T et al. Pivalic acid acts as a starter unit in a fatty acid and antibiotic biosynthetic pathway in Alicyclobacillus, Rhodococcus and Streptomyces. 2011 Environ. Microbiol. pmid:21450004
Wang JB et al. Production of doramectin by rational engineering of the avermectin biosynthetic pathway. 2011 Bioorg. Med. Chem. Lett. pmid:21514826
Wang F et al. Multi-residue method for the confirmation of four avermectin residues in food products of animal origin by ultra-performance liquid chromatography-tandem mass spectrometry. 2011 Food Addit Contam Part A Chem Anal Control Expo Risk Assess pmid:21598143
Miyamoto KT et al. The autoregulator receptor homologue AvaR3 plays a regulatory role in antibiotic production, mycelial aggregation and colony development of Streptomyces avermitilis. 2011 Microbiology (Reading, Engl.) pmid:21622528
Gong X et al. [Determination of avermectin, diclazuril, toltrazuril and metabolite residues in pork by high performance liquid chromatography-tandem mass spectrometry]. 2011 Se Pu pmid:21657050
Jiang L et al. Inactivation of the extracytoplasmic function sigma factor Sig6 stimulates avermectin production in Streptomyces avermitilis. 2011 Biotechnol. Lett. pmid:21691838
Wang XX et al. Yeast screening from avermectins wastewater and investigation on the ability of its fermentation. 2011 Bioprocess Biosyst Eng pmid:21698347
Qiu J et al. Overexpression of the ABC transporter AvtAB increases avermectin production in Streptomyces avermitilis. 2011 Appl. Microbiol. Biotechnol. pmid:21713508
Liu C et al. [Analysis of methanogenic community of anaerobic granular sludge based on mcrA gene]. 2011 Huan Jing Ke Xue pmid:21717756