| MeSH term | MeSH ID | Detail |
|---|---|---|
| Parasitic Diseases, Animal | D010273 | 1 associated lipids |
| Larva Migrans | D007815 | 1 associated lipids |
| Ectoparasitic Infestations | D004478 | 2 associated lipids |
| Scabies | D012532 | 2 associated lipids |
| Ostertagiasis | D010029 | 2 associated lipids |
| Fish Diseases | D005393 | 5 associated lipids |
| Dog Diseases | D004283 | 5 associated lipids |
| Strongylida Infections | D017206 | 5 associated lipids |
| Trichostrongylosis | D014253 | 5 associated lipids |
| Tuberculosis, Multidrug-Resistant | D018088 | 6 associated lipids |
Avermectin A1a
Avermectin A1a is a lipid of Polyketides (PK) class. Avermectin a1a is associated with abnormalities such as Ataxia with vitamin E deficiency, Strongyloidiasis, Congenital Transposition, Gigantism and Onchocerciasis. The involved functions are known as DNA Binding, Anabolism, Insertion Mutation, Process and physiological aspects. Avermectin a1a often locates in Chromosomes, Membrane, Clone, soluble and Tissue membrane. The associated genes with Avermectin A1a are Polypeptides, oxytocin, 1-desamino-(O-Et-Tyr)(2)-, Gene Feature, Genome and Gene Clusters. The related lipids are Propionate. The related experimental models are Mouse Model.
Cross Reference
Introduction
To understand associated biological information of Avermectin A1a, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Avermectin A1a?
Avermectin A1a is suspected in Ataxia with vitamin E deficiency, Gigantism, Strongyloidiasis, Congenital Transposition, Onchocerciasis, Tropical Disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Avermectin A1a
PubChem Associated disorders and diseases
What pathways are associated with Avermectin A1a
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Avermectin A1a?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Avermectin A1a?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Avermectin A1a?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Avermectin A1a?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Avermectin A1a?
Mouse Model
Mouse Model are used in the study 'Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the gamma-aminobutyric acid(A) receptor.' (Dawson GR et al., 2000).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Avermectin A1a
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Duong CT et al. | Functional expression of SAV3818, a putative TetR-family transcriptional regulatory gene from Streptomyces avermitilis, stimulates antibiotic production in Streptomyces species. | 2009 | J. Microbiol. Biotechnol. | pmid:19307761 |
| Kitani S et al. | Characterization of a regulatory gene, aveR, for the biosynthesis of avermectin in Streptomyces avermitilis. | 2009 | Appl. Microbiol. Biotechnol. | pmid:19148632 |
| Wang H et al. | Rapid method for multi-residue determination of avermectins in bovine liver using high-performance liquid chromatography with fluorescence detection. | 2009 | Bull Environ Contam Toxicol | pmid:19159053 |
| Thompson TS et al. | Large volume injection for the direct analysis of ionophores and avermectins in surface water by liquid chromatography-electrospray ionization tandem mass spectrometry. | 2009 | Anal. Chim. Acta | pmid:19110126 |
| dos Santos AR et al. | Ivermectin-derived leishmanicidal compounds. | 2009 | Bioorg. Med. Chem. | pmid:19114308 |
| Boina DR et al. | Influence of posttreatment temperature on the toxicity of insecticides against Diaphorina citri (Hemiptera: Psyllidae). | 2009 | J. Econ. Entomol. | pmid:19449650 |
| Ci X et al. | Avermectin exerts anti-inflammatory effect by downregulating the nuclear transcription factor kappa-B and mitogen-activated protein kinase activation pathway. | 2009 | Fundam Clin Pharmacol | pmid:19453757 |
| Shiwen X et al. | Preparation and characterization of monoclonal antibodies against avermectin. | 2009 | Hybridoma (Larchmt) | pmid:19519244 |
| Yang F et al. | [Determination of avermectin residues in tea by ultra-performance liquid chromatography-electrospray tandem mass spectrometry]. | 2009 | Se Pu | pmid:19626840 |
| Sung YF et al. | Avermectin intoxication with coma, myoclonus, and polyneuropathy. | 2009 | Clin Toxicol (Phila) | pmid:19640241 |
| Zhao X et al. | Construction of a doramectin producer mutant from an avermectin-overproducing industrial strain of Streptomyces avermitilis. | 2009 | Can. J. Microbiol. | pmid:20029527 |
| Ji P et al. | [Clinical analysis of acute Avermectins poisoning]. | 2009 | Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi | pmid:20039548 |
| Krogh KA et al. | Development of an analytical method to determine avermectins in water, sediments and soils using liquid chromatography-tandem mass spectrometry. | 2008 | J Chromatogr A | pmid:18929364 |
| Li M et al. | Engineering of avermectin biosynthetic genes to improve production of ivermectin in Streptomyces avermitilis. | 2008 | Bioorg. Med. Chem. Lett. | pmid:18824353 |
| Luft JA et al. | Substituent effects on the rearrangements of cyclohexyl to cyclopentyl radicals involving avermectin-related radicals. | 2008 | J. Org. Chem. | pmid:18842059 |
| Zhu J and Tao M | [Effect on production of avermectins of spore pigment biosynthesis in Streptomyces avermitilis NRRL8165]. | 2008 | Sheng Wu Gong Cheng Xue Bao | pmid:19149180 |
| Hu J et al. | Effects of insecticides on the fluidity of mitochondrial membranes of the diamondback moth, Plutella xylostella, resistant and susceptible to avermectin. | 2008 | J. Insect Sci. | pmid:20345311 |
| Brayden DJ and Griffin J | Avermectin transepithelial transport in MDR1- and MRP-transfected canine kidney monolayers. | 2008 | Vet. Res. Commun. | pmid:17578674 |
| Ayers S et al. | Anthelmintic macrolactams from Nonomuraea turkmeniaca MA7381. | 2008 | J. Antibiot. | pmid:18408323 |
| Dong JY et al. | Ymf 1029A-E, preussomerin analogues from the fresh-water-derived fungus YMF 1.01029. | 2008 | J. Nat. Prod. | pmid:18479163 |
| Kessabi FM et al. | Rearrangement of a cyclohexyl radical to a cyclopentylmethyl radical on the avermectin skeleton. | 2008 | Org. Lett. | pmid:18461948 |
| Chen L et al. | Characterization of a negative regulator AveI for avermectin biosynthesis in Streptomyces avermitilis NRRL8165. | 2008 | Appl. Microbiol. Biotechnol. | pmid:18560830 |
| Biliavs'ka LO et al. | [Effect of pyruvate and valine on avermectin biosynthesis by Streptomyces avermitilis UCM Ac-2179]. | 2007 Jul-Aug | Mikrobiol. Z. | pmid:17977447 |
| Wang XJ et al. | [Effect of Avermectins on the secretion function of cultured granulosa cells from rat ovary in vitro.]. | 2007 | Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi | pmid:17945112 |
| Macdonald N and Gledhill A | Potential impact of ABCB1 (p-glycoprotein) polymorphisms on avermectin toxicity in humans. | 2007 | Arch. Toxicol. | pmid:17354009 |
| Berendsen BJ et al. | The derivatisation of avermectins and milbemycins in milk: new insights and improvement of the procedure. | 2007 | Anal. Chim. Acta | pmid:17386656 |
| Rezanka T et al. | Relationship between volatile odorous substances and production of avermectins by Streptomyces avermitilis. | 2007 | Folia Microbiol. (Praha) | pmid:17571791 |
| Lin YW et al. | Insecticide susceptibility of surviving Cotesia plutellae (Hym: Braconidae) and Diaeretiella rapae (M'Intosh) (Hym: Aphidiidae) as affected by sublethal insecticide dosages on host insects. | 2007 | Pest Manag. Sci. | pmid:17533655 |
| Hernando MD et al. | Fast separation liquid chromatography-tandem mass spectrometry for the confirmation and quantitative analysis of avermectin residues in food. | 2007 | J Chromatogr A | pmid:17524410 |
| Trefzer A et al. | Biocatalytic conversion of avermectin to 4''-oxo-avermectin: improvement of cytochrome p450 monooxygenase specificity by directed evolution. | 2007 | Appl. Environ. Microbiol. | pmid:17483257 |
| Li ZZ et al. | Adsorption of avermectin on porous hollow silica nanoparticles by supercritical technology. | 2007 | J Nanosci Nanotechnol | pmid:17450791 |
| Tribble ND et al. | Identification of the genes encoding for putative gamma aminobutyric acid (GABA) and glutamate-gated chloride channel (GluCl) alpha receptor subunits in sea lice (Lepeophtheirus salmonis). | 2007 | J. Vet. Pharmacol. Ther. | pmid:17348903 |
| Webb L et al. | Effects of avermectin residues in cattle dung on yellow dung fly Scathophaga stercoraria (Diptera: Scathophagidae) populations in grazed pastures. | 2007 | Bull. Entomol. Res. | pmid:17411477 |
| Rajkarnikar A et al. | Two threonine residues required for role of AfsKav in controlling morphogenesis and avermectin production in Streptomyces avermitilis. | 2007 | J. Microbiol. Biotechnol. | pmid:18062239 |
| Im JH et al. | Comparative transcriptome analysis for avermectin overproduction via Streptomyces avermitilis microarray system. | 2007 | J. Microbiol. Biotechnol. | pmid:18050961 |
| Sollai G et al. | Effects of avermectins on olfactory responses of Culicoides imicola (Diptera: Ceratopogonidae). | 2007 | J. Med. Entomol. | pmid:17695021 |
| Tao WX et al. | [Cloning of bldAa and the effect on morphological differentiation and avermectins production in Streptomyces avermitilis NRRL8165]. | 2007 | Wei Sheng Wu Xue Bao | pmid:17436620 |
| Artho R et al. | Avermectin-resistance in gastrointestinal nematodes of Boer goats and Dorper sheep in Switzerland. | 2007 | Vet. Parasitol. | pmid:17088023 |
| Li ZZ et al. | Study of UV-shielding properties of novel porous hollow silica nanoparticle carriers for avermectin. | 2007 | Pest Manag. Sci. | pmid:17177171 |
| Hou X et al. | Multiresidue analysis of avermectins in cattle liver by liquid chromatography/tandem mass spectrometry. | 2006 Jul-Aug | J AOAC Int | pmid:16915852 |
| Sheehan LS et al. | Engineering of the spinosyn PKS: directing starter unit incorporation. | 2006 | J. Nat. Prod. | pmid:17190446 |
| Li ZZ et al. | Controlled release of avermectin from porous hollow silica nanoparticles: influence of shell thickness on loading efficiency, UV-shielding property and release. | 2006 | J Control Release | pmid:16388871 |
| Rajkarnikar A et al. | Catalytic domain of AfsKav modulates both secondary metabolism and morphologic differentiation in Streptomyces avermitilis ATCC 31272. | 2006 | Curr. Microbiol. | pmid:16874544 |
| Danaher M et al. | Review of methodology for the determination of macrocyclic lactone residues in biological matrices. | 2006 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:16950666 |
| Turnipseed SB et al. | No-discharge atmospheric pressure chemical ionization: evaluation and application to the analysis of animal drug residues in complex matrices. | 2006 | Rapid Commun. Mass Spectrom. | pmid:16541409 |
| Beasley CA et al. | Identification of impurities in ivermectin bulk material by mass spectrometry and NMR. | 2006 | J Pharm Biomed Anal | pmid:16554137 |
| Wei X et al. | Enhancement and selective production of oligomycin through inactivation of avermectin's starter unit in Streptomyces avermitilis. | 2006 | Biotechnol. Lett. | pmid:16786277 |
| Oremus G et al. | Effects of mid-season avermectin treatments on pyrethroid resistance in horn fly (Diptera: Muscidae) populations at three locations in Louisiana. | 2006 | Vet. Parasitol. | pmid:16769175 |
| Zhang X et al. | Construction of ivermectin producer by domain swaps of avermectin polyketide synthase in Streptomyces avermitilis. | 2006 | Appl. Microbiol. Biotechnol. | pmid:16708195 |
| Zhang C et al. | The in vitro characterization of the iterative avermectin glycosyltransferase AveBI reveals reaction reversibility and sugar nucleotide flexibility. | 2006 | J. Am. Chem. Soc. | pmid:17177349 |