| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
| Lice Infestations | D010373 | 9 associated lipids |
| Poisoning | D011041 | 9 associated lipids |
| Cleft Palate | D002972 | 9 associated lipids |
| Trichostrongyloidiasis | D014252 | 7 associated lipids |
| Tuberculosis, Multidrug-Resistant | D018088 | 6 associated lipids |
Avermectin A1a
Avermectin A1a is a lipid of Polyketides (PK) class. Avermectin a1a is associated with abnormalities such as Ataxia with vitamin E deficiency, Strongyloidiasis, Congenital Transposition, Gigantism and Onchocerciasis. The involved functions are known as DNA Binding, Anabolism, Insertion Mutation, Process and physiological aspects. Avermectin a1a often locates in Chromosomes, Membrane, Clone, soluble and Tissue membrane. The associated genes with Avermectin A1a are Polypeptides, oxytocin, 1-desamino-(O-Et-Tyr)(2)-, Gene Feature, Genome and Gene Clusters. The related lipids are Propionate. The related experimental models are Mouse Model.
Cross Reference
Introduction
To understand associated biological information of Avermectin A1a, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Avermectin A1a?
Avermectin A1a is suspected in Ataxia with vitamin E deficiency, Gigantism, Strongyloidiasis, Congenital Transposition, Onchocerciasis, Tropical Disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Avermectin A1a
PubChem Associated disorders and diseases
What pathways are associated with Avermectin A1a
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Avermectin A1a?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Avermectin A1a?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Avermectin A1a?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Avermectin A1a?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Avermectin A1a?
Mouse Model
Mouse Model are used in the study 'Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the gamma-aminobutyric acid(A) receptor.' (Dawson GR et al., 2000).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Avermectin A1a
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| BronshteÄn AM | [Praziquantel and other current preparations and chemotherapy methods in human trematodiases of the liver (opisthorchiasis and clonorchiasis) (a review of the literature)]. | 1984 Nov-Dec | Med Parazitol (Mosk) | pmid:6397686 |
| Parrish MD and Roberts RB | Toxicity of avermectin B1 to larval yellowjackets, Vespula maculifrons (Hymenoptera: Vespidae). | 1984 | J. Econ. Entomol. | pmid:6480980 |
| Pivnichny JV et al. | Direct determination of avermectins in plasma at nanogram levels by high-performance liquid chromatography. | 1983 | J Pharm Sci | pmid:6663483 |
| Calcott PH and Fatig RO | Inhibition of chitin metabolism by avermectin in susceptible organisms. | 1984 | J. Antibiot. | pmid:6725140 |
| Bowen JM | The avermectin complex: a new horizon in anthelmintic therapy. | 1981 | Vet Med Small Anim Clin | pmid:6908751 |
| Campbell WC | An introduction to the avermectins. | 1981 | N Z Vet J | pmid:7038568 |
| Denham DA | The effects of some avermectins on the growth of Brugia pahangi. | 1982 | Methods Find Exp Clin Pharmacol | pmid:7121142 |
| Wilkins CA et al. | Treatment of psoroptic mange with avermectins. | 1980 | Am. J. Vet. Res. | pmid:7212445 |
| Ostlind DA and Cifelli S | Efficacy of thiabendazole, levamisole hydrochloride and the major natural avermectins against Trichostrongylus colubriformis in the gerbil (Meriones unguiculatus). | 1981 | Res. Vet. Sci. | pmid:7323472 |
| James PS et al. | Insecticidal activity of the avermectins. | 1980 | Vet. Rec. | pmid:7361432 |
| Tolan JW et al. | Determination of avermectins in plasma at nanogram levels using high-performance liquid chromatography with fluorescence detection. | 1980 | J. Chromatogr. | pmid:7380953 |
| Shoop WL et al. | Structure and activity of avermectins and milbemycins in animal health. | 1995 | Vet. Parasitol. | pmid:7483237 |
| Ikeda H et al. | Construction of a single component producer from the wild type avermectin producer Streptomyces avermitilis. | 1995 | J. Antibiot. | pmid:7622445 |
| Gill JH et al. | Avermectin inhibition of larval development in Haemonchus contortus--effects of ivermectin resistance. | 1995 | Int. J. Parasitol. | pmid:7635622 |
| Ikeda H and Omura S | Control of avermectin biosynthesis in Streptomyces avermitilis for the selective production of a useful component. | 1995 | J. Antibiot. | pmid:7649850 |
| Le Jambre LF et al. | Characterisation of an avermectin resistant strain of Australian Haemonchus contortus. | 1995 | Int. J. Parasitol. | pmid:7657454 |
| Arena JP et al. | The mechanism of action of avermectins in Caenorhabditis elegans: correlation between activation of glutamate-sensitive chloride current, membrane binding, and biological activity. | 1995 | J. Parasitol. | pmid:7707209 |
| Denoya CD et al. | A second branched-chain alpha-keto acid dehydrogenase gene cluster (bkdFGH) from Streptomyces avermitilis: its relationship to avermectin biosynthesis and the construction of a bkdF mutant suitable for the production of novel antiparasitic avermectins. | 1995 | J. Bacteriol. | pmid:7768860 |
| Clark JM et al. | Resistance to avermectins: extent, mechanisms, and management implications. | 1995 | Annu. Rev. Entomol. | pmid:7810984 |
| Khalkova Zh | [An experimental evaluation of the cutaneous action of the preparation Bulmektin]. | 1994 | Probl Khig | pmid:7845982 |
| Pang CH et al. | Production of 6,8a-seco-6,8a-deoxy derivatives of avermectins by a mutant strain of Streptomyces avermitilis. | 1995 | J. Antibiot. | pmid:7868391 |
| Pang CH et al. | Production of a new methylated 6,8a-seco-6,8a-deoxy derivative of the avermectins by a transformant strain of Streptomyces avermitilis. | 1995 | J. Antibiot. | pmid:7868398 |
| Ikeda H et al. | Direct production of 5-oxo derivatives of avermectins by a recombinant strain of Streptomyces avermitilis. | 1995 | J. Antibiot. | pmid:7868399 |
| Cully DF et al. | Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans. | 1994 | Nature | pmid:7935817 |
| MacNeil DJ et al. | Correlation of the avermectin polyketide synthase genes to the avermectin structure. Implications for designing novel avermectins. | 1994 | Ann. N. Y. Acad. Sci. | pmid:8010663 |
| Roos MH et al. | Molecular aspects of drug resistance in parasitic helminths. | 1993 | Pharmacol. Ther. | pmid:8022863 |
| Evans M et al. | Characterization of a Streptomyces-lividans-type site-specific DNA modification system in the avermectin-producer Streptomyces avermitilis permits investigation of two novel giant linear plasmids, pSA1 and pSA2. | 1994 | Microbiology (Reading, Engl.) | pmid:8081502 |
| Rohrer SP et al. | Immunoaffinity purification of avermectin-binding proteins from the free-living nematode Caenorhabditis elegans and the fruitfly Drosophila melanogaster. | 1994 | Biochem. J. | pmid:8092985 |
| Schönrock B and Bormann J | Activation of Cl- channels by avermectin in rat cultured hippocampal neurons. | 1993 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:8133905 |
| Naito S et al. | Milbemycin derivatives: modification at the C-5 position. | 1994 | J. Antibiot. | pmid:8150720 |
| Schulman M et al. | Microbial conversion of avermectins by Saccharopolyspora erythraea: hydroxylation at C-27. | 1994 | J. Antibiot. | pmid:8175491 |
| Schulman M et al. | Microbial conversion of avermectins by Saccharopolyspora erythraea: glycosylation at C-4' and C-4''. | 1993 | Antimicrob. Agents Chemother. | pmid:8239577 |
| Special issue: Environmental impact of avermectin usage in livestock. | 1993 | Vet. Parasitol. | pmid:8346625 | |
| Ridsdill-Smith TJ | Effects of avermectin residues in cattle dung on dung beetle (Coleoptera: Scarabaeidae) reproduction and survival. | 1993 | Vet. Parasitol. | pmid:8346627 |
| King KL | The potential for avermectins to affect the nutrient economy of grazed pastures. | 1993 | Vet. Parasitol. | pmid:8346639 |
| McCracken DI | The potential for avermectins to affect wildlife. | 1993 | Vet. Parasitol. | pmid:8346640 |
| Waller PJ et al. | Regional and temporal use of avermectins for ruminants in Australia. | 1993 | Vet. Parasitol. | pmid:8346642 |
| Strong L | Overview: the impact of avermectins on pastureland ecology. | 1993 | Vet. Parasitol. | pmid:8346644 |
| Herd R et al. | Research recommendations. | 1993 | Vet. Parasitol. | pmid:8346647 |
| Sams R | Chemical assay of avermectins by high performance liquid chromatography with fluorescence detection. | 1993 | Vet. Parasitol. | pmid:8346649 |
| Ikeda H et al. | Transposon mutagenesis by Tn4560 and applications with avermectin-producing Streptomyces avermitilis. | 1993 | J. Bacteriol. | pmid:8384619 |
| Novák J et al. | Instability of the production of avermectins, sporulation, and pigmentation in Streptomyces avermitilis. | 1993 | Can. J. Microbiol. | pmid:8467423 |
| MacNeil T et al. | Deletion analysis of the avermectin biosynthetic genes of Streptomyces avermitilis by gene cluster displacement. | 1993 | J. Bacteriol. | pmid:8478321 |
| Sergeev AV et al. | [Effect of nitrogen-containing compounds on the biosynthesis of avermectins]. | 1995 | Antibiot. Khimioter. | pmid:8645056 |
| Nari A et al. | The prevalence of anthelmintic resistance in nematode parasites of sheep in southern Latin America: Uruguay. | 1996 | Vet. Parasitol. | pmid:8686167 |
| MacNeil DJ | Avermectins. | 1995 | Biotechnology | pmid:8688633 |
| Löwenstein M et al. | Histology of the skin and determination of blood and serum parameters during the recovery phase of sarcoptic manage in cattle after avermectin (Ivomec) treatment. | 1996 | Appl. Parasitol. | pmid:8688864 |
| Vercruysse J and Claerebout E | Effect of chemoprophylaxis on immunity to gastrointestinal nematodes in cattle. | 1996 | Verh. K. Acad. Geneeskd. Belg. | pmid:8701602 |
| Cully DF et al. | Identification of a Drosophila melanogaster glutamate-gated chloride channel sensitive to the antiparasitic agent avermectin. | 1996 | J. Biol. Chem. | pmid:8702744 |
| Mironov VA et al. | [Activity of threonine deaminase and biosynthesis of avermectins in the culture of Streptomyces avermitilis]. | 1995 | Antibiot. Khimioter. | pmid:8713429 |