| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
| Lice Infestations | D010373 | 9 associated lipids |
| Poisoning | D011041 | 9 associated lipids |
| Cleft Palate | D002972 | 9 associated lipids |
| Trichostrongyloidiasis | D014252 | 7 associated lipids |
| Tuberculosis, Multidrug-Resistant | D018088 | 6 associated lipids |
Avermectin A1a
Avermectin A1a is a lipid of Polyketides (PK) class. Avermectin a1a is associated with abnormalities such as Ataxia with vitamin E deficiency, Strongyloidiasis, Congenital Transposition, Gigantism and Onchocerciasis. The involved functions are known as DNA Binding, Anabolism, Insertion Mutation, Process and physiological aspects. Avermectin a1a often locates in Chromosomes, Membrane, Clone, soluble and Tissue membrane. The associated genes with Avermectin A1a are Polypeptides, oxytocin, 1-desamino-(O-Et-Tyr)(2)-, Gene Feature, Genome and Gene Clusters. The related lipids are Propionate. The related experimental models are Mouse Model.
Cross Reference
Introduction
To understand associated biological information of Avermectin A1a, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Avermectin A1a?
Avermectin A1a is suspected in Ataxia with vitamin E deficiency, Gigantism, Strongyloidiasis, Congenital Transposition, Onchocerciasis, Tropical Disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Avermectin A1a
PubChem Associated disorders and diseases
What pathways are associated with Avermectin A1a
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Avermectin A1a?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Avermectin A1a?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Avermectin A1a?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Avermectin A1a?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Avermectin A1a?
Mouse Model
Mouse Model are used in the study 'Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the gamma-aminobutyric acid(A) receptor.' (Dawson GR et al., 2000).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Avermectin A1a
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Nagai K et al. | Synthesis and biological evaluation of novel 4"-alkoxy avermectin derivatives. | 2004 | Bioorg. Med. Chem. Lett. | pmid:15261257 |
| Korystov YN et al. | Avermectins inhibit multidrug resistance of tumor cells. | 2004 | Eur. J. Pharmacol. | pmid:15189764 |
| Liu J et al. | Genomic organization of an avermectin receptor subunit from Haemonchus contortus and expression of its putative promoter region in Caenorhabditis elegans. | 2004 | Mol. Biochem. Parasitol. | pmid:15003846 |
| Chen J et al. | Ethanol evolution rate: a new parameter to determine the feeding rate for the production of avermectins by Streptomyces avermitilis. | 2004 | Biotechnol. Lett. | pmid:15000476 |
| Shoop WL | Resistance to avermectins and milbemycins. | 1992 | Vet. Rec. | pmid:1496763 |
| Strabel D et al. | [The use of avermectins in two goats with demodicosis]. | 2003 | Schweiz. Arch. Tierheilkd. | pmid:14725185 |
| Yoon YJ et al. | Avermectin: biochemical and molecular basis of its biosynthesis and regulation. | 2004 | Appl. Microbiol. Biotechnol. | pmid:14689246 |
| Nagai K et al. | Synthesis and biological activities of novel 4"-alkylidene avermectin derivatives. | 2003 | Bioorg. Med. Chem. Lett. | pmid:14592480 |
| Blackhall WJ et al. | Selection at a gamma-aminobutyric acid receptor gene in Haemonchus contortus resistant to avermectins/milbemycins. | 2003 | Mol. Biochem. Parasitol. | pmid:14511812 |
| Meinke PT et al. | Affinity probes for the avermectin binding proteins. | 1992 | J. Med. Chem. | pmid:1433197 |
| Stong JD et al. | Radical-induced oxidation of oxahydrindene (hexahydrobenzofuran) portion of 22,23-dihydroavermectin B1a: identification of autooxidation products. | 1992 | J Pharm Sci | pmid:1432608 |
| Yates DM et al. | The avermectin receptors of Haemonchus contortus and Caenorhabditis elegans. | 2003 | Int. J. Parasitol. | pmid:13678634 |
| Chartrain M et al. | Bioconversion of avermectin into 27-OH avermectin. | 1990 | J. Ind. Microbiol. | pmid:1366995 |
| Rohrer SP et al. | Photoaffinity labeling of avermectin binding sites from Caenorhabditis elegans and Drosophila melanogaster. | 1992 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1315055 |
| Gaisser S et al. | Direct production of ivermectin-like drugs after domain exchange in the avermectin polyketide synthase of Streptomyces avermitilis ATCC31272. | 2003 | Org. Biomol. Chem. | pmid:12968333 |
| Lamb DC et al. | Cytochrome p450 complement (CYPome) of the avermectin-producer Streptomyces avermitilis and comparison to that of Streptomyces coelicolor A3(2). | 2003 | Biochem. Biophys. Res. Commun. | pmid:12893267 |
| Sun Y et al. | Identification of a gene cluster encoding meilingmycin biosynthesis among multiple polyketide synthase contigs isolated from Streptomyces nanchangensis NS3226. | 2003 | Arch. Microbiol. | pmid:12811466 |
| Arena JP et al. | Expression of a glutamate-activated chloride current in Xenopus oocytes injected with Caenorhabditis elegans RNA: evidence for modulation by avermectin. | 1992 | Brain Res. Mol. Brain Res. | pmid:1279355 |
| Iovchev M et al. | Altered drug resistance and recovery from paralysis in Drosophila melanogaster with a deficient histamine-gated chloride channel. | 2002 Oct-Dec | J. Neurogenet. | pmid:12745634 |
| Viktorov AV et al. | [Comparative analysis of degradation of native avermectins and spinosyns by UV-HPLC]. | 2002 | Antibiot. Khimioter. | pmid:12728628 |
| Mironov VA et al. | [Dependence of the composition of the avermectin complex of Streptomyces avermitilis on glucose content of the growth medium]. | 2003 Mar-Apr | Prikl. Biokhim. Mikrobiol. | pmid:12722656 |
| Stutzman-Engwall K et al. | Engineering the aveC gene to enhance the ratio of doramectin to its CHC-B2 analogue produced in Streptomyces avermitilis. | 2003 | Biotechnol. Bioeng. | pmid:12599263 |
| Martins JR et al. | Partial strategic tick control within a herd of European breed cattle in the state of Rio Grande do Sul, southern Brazil. | 2002 | Exp. Appl. Acarol. | pmid:12593589 |
| Hwang YS et al. | Cloning and analysis of a DNA fragment stimulating avermectin production in various Streptomyces avermitilis strains. | 2003 | Appl. Environ. Microbiol. | pmid:12571055 |
| Chen Z et al. | [Effect of gene disruption of aveD on avermectins production in Streptomyces avermitilis]. | 2001 | Wei Sheng Wu Xue Bao | pmid:12552909 |
| Argentine JA et al. | Toxicities of emamectin benzoate homologues and photodegradates to Lepidoptera. | 2002 | J. Econ. Entomol. | pmid:12539830 |
| Takahashi Y et al. | Streptomyces avermectinius sp. nov., an avermectin-producing strain. | 2002 | Int. J. Syst. Evol. Microbiol. | pmid:12508884 |
| Kim SB and Goodfellow M | Streptomyces avermitilis sp. nov., nom. rev., a taxonomic home for the avermectin-producing streptomycetes. | 2002 | Int. J. Syst. Evol. Microbiol. | pmid:12508861 |
| Rehbein S et al. | Efficacy of a new long-acting formulation of ivermectin and other injectable avermectins against induced Psoroptes ovis infestations in cattle. | 2002 | Parasitol. Res. | pmid:12444456 |
| Deger Y et al. | Short communication serum copper, zinc, and calcium concentrations in lice-infested sheep. | 2002 | Biol Trace Elem Res | pmid:12117268 |
| Veale PI | Resistance to macrocyclic lactones in nematodes of goats. | 2002 | Aust. Vet. J. | pmid:12074315 |
| Miakisheva SN et al. | [Proliferation and morphological differentiation of neurblastoma cells in cultured under the effect of avermectins]. | 2001 | Morfologiia | pmid:12016760 |
| Sha CK et al. | Anionic cyclization approach toward perhydrobenzofuranone: stereocontrolled synthesis of the hexahydrobenzofuran subunit of avermectin. | 2002 | J. Org. Chem. | pmid:11856026 |
| Ikeda H et al. | Organization of biosynthetic gene cluster for avermectin in Streptomyces avermitilis: analysis of enzymatic domains in four polyketide synthases. | 2001 | J. Ind. Microbiol. Biotechnol. | pmid:11780788 |
| Danaher M et al. | Extraction and isolation of avermectins and milbemycins from liver samples using unmodified supercritical CO2 with in-line trapping on basic alumina. | 2001 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:11585125 |
| Driniaev VA et al. | [Effect of avermectns on Ca(2+)-dependent chloride currents in plasmalemma of Chara corallina cells]. | 2001 | Antibiot. Khimioter. | pmid:11558454 |
| Driniaev VA et al. | [Selective cytostatic and cytotoxic effects of avermectins]. | 2001 | Antibiot. Khimioter. | pmid:11558448 |
| Novik TS et al. | [Acute toxicity of aversectin C : various routes of administration and dosage forms]. | 2001 Mar-Apr | Eksp Klin Farmakol | pmid:11548452 |
| Martins JR and Furlong J | Avermectin resistance of the cattle tick Boophilus microplus in Brazil. | 2001 | Vet. Rec. | pmid:11488352 |
| Anziani OS et al. | Avermectin resistance in Cooperia pectinata in cattle in Argentina. | 2001 | Vet. Rec. | pmid:11488345 |
| Zakson-Aiken M et al. | Systemic activity of the avermectins against the cat flea (Siphonaptera: Pulicidae). | 2001 | J. Med. Entomol. | pmid:11476339 |
| Swarnkar CP et al. | Anthelmintic resistance on an organized sheep farm in India. | 2001 | Trop Anim Health Prod | pmid:11474864 |
| Wohlert S et al. | Insights about the biosynthesis of the avermectin deoxysugar L-oleandrose through heterologous expression of Streptomyces avermitilis deoxysugar genes in Streptomyces lividans. | 2001 | Chem. Biol. | pmid:11451669 |
| Drinyaev VA et al. | Effect of avermectins on Ca2+-dependent Cl- currents in plasmalemma of Chara corallina cells. | 2001 | J. Membr. Biol. | pmid:11426301 |
| Valenzuela AI et al. | Comparison of various liquid chromatographic methods for the analysis of avermectin residues in citrus fruits. | 2001 | J Chromatogr A | pmid:11403456 |
| Köhler P | The biochemical basis of anthelmintic action and resistance. | 2001 | Int. J. Parasitol. | pmid:11400692 |
| Danaher M et al. | Development and optimisation of an improved derivatisation procedure for the determination of avermectins and milbemycins in bovine liver. | 2001 | Analyst | pmid:11394296 |
| Wu Z et al. | Multi-residue analysis of avermectins in swine liver by immunoaffinity extraction and liquid chromatography-mass spectrometry. | 2001 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:11393726 |
| Ikeda H | [Genetic analysis of biosynthesis of polyketide compound in Streptomyces avermitilis]. | 2001 | Jpn J Antibiot | pmid:11392681 |
| Barnes EH et al. | Selection of different genotype larvae and adult worms for anthelmintic resistance by persistent and short-acting avermectin/milbemycins. | 2001 | Int. J. Parasitol. | pmid:11336754 |