| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Cleft Palate | D002972 | 9 associated lipids |
| Dog Diseases | D004283 | 5 associated lipids |
| Ectoparasitic Infestations | D004478 | 2 associated lipids |
| Fish Diseases | D005393 | 5 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Larva Migrans | D007815 | 1 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Ostertagiasis | D010029 | 2 associated lipids |
Avermectin A1a
Avermectin A1a is a lipid of Polyketides (PK) class. Avermectin a1a is associated with abnormalities such as Ataxia with vitamin E deficiency, Strongyloidiasis, Congenital Transposition, Gigantism and Onchocerciasis. The involved functions are known as DNA Binding, Anabolism, Insertion Mutation, Process and physiological aspects. Avermectin a1a often locates in Chromosomes, Membrane, Clone, soluble and Tissue membrane. The associated genes with Avermectin A1a are Polypeptides, oxytocin, 1-desamino-(O-Et-Tyr)(2)-, Gene Feature, Genome and Gene Clusters. The related lipids are Propionate. The related experimental models are Mouse Model.
Cross Reference
Introduction
To understand associated biological information of Avermectin A1a, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Avermectin A1a?
Avermectin A1a is suspected in Ataxia with vitamin E deficiency, Gigantism, Strongyloidiasis, Congenital Transposition, Onchocerciasis, Tropical Disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Avermectin A1a
PubChem Associated disorders and diseases
What pathways are associated with Avermectin A1a
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Avermectin A1a?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Avermectin A1a?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Avermectin A1a?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Avermectin A1a?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Avermectin A1a?
Mouse Model
Mouse Model are used in the study 'Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the gamma-aminobutyric acid(A) receptor.' (Dawson GR et al., 2000).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with Avermectin A1a
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Meinke PT et al. | Synthesis of gem-difluoro-avermectin derivatives: potent anthelmintic and anticonvulsant agents. | 1998 | Bioorg. Med. Chem. Lett. | pmid:9934486 |
| Windelspecht M et al. | Survey of malathion resistance and avermectin susceptibility in field populations of Drosophila melanogaster (Diptera: Drosophilidae) and D. simulans. | 1998 | J. Econ. Entomol. | pmid:9887681 |
| Delany NS et al. | Cloning and localisation of an avermectin receptor-related subunit from Haemonchus contortus. | 1998 | Mol. Biochem. Parasitol. | pmid:9879896 |
| Lankas GR et al. | Placental P-glycoprotein deficiency enhances susceptibility to chemically induced birth defects in mice. | 1998 Jul-Aug | Reprod. Toxicol. | pmid:9717696 |
| Gill JH and Lacey E | Avermectin/milbemycin resistance in trichostrongyloid nematodes. | 1998 | Int. J. Parasitol. | pmid:9673866 |
| Lonneux JF et al. | The relationship between parasite counts, lesions, antibody titres and daily weight gains in Psoroptes ovis infested cattle. | 1998 | Vet. Parasitol. | pmid:9653998 |
| Gill JH et al. | Evidence of multiple mechanisms of avermectin resistance in haemonchus contortus--comparison of selection protocols. | 1998 | Int. J. Parasitol. | pmid:9650059 |
| Ikeda H et al. | Cloning of the gene encoding avermectin B 5-O-methyltransferase in avermectin-producing Streptomyces avermitilis. | 1998 | Gene | pmid:9469930 |
| Marsden AF et al. | Engineering broader specificity into an antibiotic-producing polyketide synthase. | 1998 | Science | pmid:9422686 |
| Vassilatis DK et al. | Genetic and biochemical evidence for a novel avermectin-sensitive chloride channel in Caenorhabditis elegans. Isolation and characterization. | 1997 | J. Biol. Chem. | pmid:9407104 |
| Barnes TM and Hekimi S | The Caenorhabditis elegans avermectin resistance and anesthetic response gene unc-9 encodes a member of a protein family implicated in electrical coupling of excitable cells. | 1997 | J. Neurochem. | pmid:9375655 |
| Lonneux JF et al. | Antibody response after treatment in cattle infected with Psoroptes ovis. | 1997 Jul-Aug | Res. Vet. Sci. | pmid:9368957 |
| Mironov VA et al. | [Biosynthesis of avermectins: physiological and technological aspects]. | 1997 | Antibiot. Khimioter. | pmid:9265465 |
| Doody GM | Avermectin toxicity in the dog. | 1997 | Vet. Rec. | pmid:9203324 |
| Laughton DL et al. | Reporter gene constructs suggest that the Caenorhabditis elegans avermectin receptor beta-subunit is expressed solely in the pharynx. | 1997 | J. Exp. Biol. | pmid:9192499 |
| Pomes A et al. | Target size analysis of an avermectin binding site from Drosophila melanogaster. | 1997 | Biochim. Biophys. Acta | pmid:9187243 |
| Scarff DH | Avermectin toxicity in the dog. | 1997 | Vet. Rec. | pmid:9185317 |
| Gray AK | Avermectin toxicity in the dog. | 1997 | Vet. Rec. | pmid:9185316 |
| Vassilatis DK et al. | Evolutionary relationship of the ligand-gated ion channels and the avermectin-sensitive, glutamate-gated chloride channels. | 1997 | J. Mol. Evol. | pmid:9115174 |
| Krieger RI et al. | Adult and infant abamectin exposures following Avert 310 and pressurized gel crack and crevice treatment. | 1997 | Bull Environ Contam Toxicol | pmid:9115128 |
| Shoop WL et al. | Eprinomectin: a novel avermectin for use as a topical endectocide for cattle. | 1996 | Int. J. Parasitol. | pmid:9024867 |
| Shoop WL et al. | Efficacy in sheep and pharmacokinetics in cattle that led to the selection of eprinomectin as a topical endectocide for cattle. | 1996 | Int. J. Parasitol. | pmid:9024866 |
| McKellar QA and Benchaoui HA | Avermectins and milbemycins. | 1996 | J. Vet. Pharmacol. Ther. | pmid:8905567 |
| Titchener RN and Purnell RE | Duration of persistence of injectable avermectins against sucking lice of cattle. | 1996 | Vet. Rec. | pmid:8903014 |
| Venkatachalam MA et al. | Cytoprotection of kidney epithelial cells by compounds that target amino acid gated chloride channels. | 1996 | Kidney Int. | pmid:8821829 |
| Herd R | Ecotoxicity of the avermectins: a reply to Forbes. | 1996 | Int. J. Parasitol. | pmid:8818740 |
| Gill JH and Redwin JM | Cryopreservation of the first-stage larvae of trichostrongylid nematode parasites. | 1995 | Int. J. Parasitol. | pmid:8719953 |
| Mironov VA et al. | [Activity of threonine deaminase and biosynthesis of avermectins in the culture of Streptomyces avermitilis]. | 1995 | Antibiot. Khimioter. | pmid:8713429 |
| Cully DF et al. | Identification of a Drosophila melanogaster glutamate-gated chloride channel sensitive to the antiparasitic agent avermectin. | 1996 | J. Biol. Chem. | pmid:8702744 |
| Vercruysse J and Claerebout E | Effect of chemoprophylaxis on immunity to gastrointestinal nematodes in cattle. | 1996 | Verh. K. Acad. Geneeskd. Belg. | pmid:8701602 |
| Löwenstein M et al. | Histology of the skin and determination of blood and serum parameters during the recovery phase of sarcoptic manage in cattle after avermectin (Ivomec) treatment. | 1996 | Appl. Parasitol. | pmid:8688864 |
| MacNeil DJ | Avermectins. | 1995 | Biotechnology | pmid:8688633 |
| Nari A et al. | The prevalence of anthelmintic resistance in nematode parasites of sheep in southern Latin America: Uruguay. | 1996 | Vet. Parasitol. | pmid:8686167 |
| Sergeev AV et al. | [Effect of nitrogen-containing compounds on the biosynthesis of avermectins]. | 1995 | Antibiot. Khimioter. | pmid:8645056 |
| MacNeil T et al. | Deletion analysis of the avermectin biosynthetic genes of Streptomyces avermitilis by gene cluster displacement. | 1993 | J. Bacteriol. | pmid:8478321 |
| Novák J et al. | Instability of the production of avermectins, sporulation, and pigmentation in Streptomyces avermitilis. | 1993 | Can. J. Microbiol. | pmid:8467423 |
| Ikeda H et al. | Transposon mutagenesis by Tn4560 and applications with avermectin-producing Streptomyces avermitilis. | 1993 | J. Bacteriol. | pmid:8384619 |
| Sams R | Chemical assay of avermectins by high performance liquid chromatography with fluorescence detection. | 1993 | Vet. Parasitol. | pmid:8346649 |
| Herd R et al. | Research recommendations. | 1993 | Vet. Parasitol. | pmid:8346647 |
| Strong L | Overview: the impact of avermectins on pastureland ecology. | 1993 | Vet. Parasitol. | pmid:8346644 |
| Waller PJ et al. | Regional and temporal use of avermectins for ruminants in Australia. | 1993 | Vet. Parasitol. | pmid:8346642 |
| McCracken DI | The potential for avermectins to affect wildlife. | 1993 | Vet. Parasitol. | pmid:8346640 |
| King KL | The potential for avermectins to affect the nutrient economy of grazed pastures. | 1993 | Vet. Parasitol. | pmid:8346639 |
| Ridsdill-Smith TJ | Effects of avermectin residues in cattle dung on dung beetle (Coleoptera: Scarabaeidae) reproduction and survival. | 1993 | Vet. Parasitol. | pmid:8346627 |
| Special issue: Environmental impact of avermectin usage in livestock. | 1993 | Vet. Parasitol. | pmid:8346625 | |
| Schulman M et al. | Microbial conversion of avermectins by Saccharopolyspora erythraea: glycosylation at C-4' and C-4''. | 1993 | Antimicrob. Agents Chemother. | pmid:8239577 |
| Schulman M et al. | Microbial conversion of avermectins by Saccharopolyspora erythraea: hydroxylation at C-27. | 1994 | J. Antibiot. | pmid:8175491 |
| Naito S et al. | Milbemycin derivatives: modification at the C-5 position. | 1994 | J. Antibiot. | pmid:8150720 |
| Schönrock B and Bormann J | Activation of Cl- channels by avermectin in rat cultured hippocampal neurons. | 1993 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:8133905 |
| Rohrer SP et al. | Immunoaffinity purification of avermectin-binding proteins from the free-living nematode Caenorhabditis elegans and the fruitfly Drosophila melanogaster. | 1994 | Biochem. J. | pmid:8092985 |
| Evans M et al. | Characterization of a Streptomyces-lividans-type site-specific DNA modification system in the avermectin-producer Streptomyces avermitilis permits investigation of two novel giant linear plasmids, pSA1 and pSA2. | 1994 | Microbiology (Reading, Engl.) | pmid:8081502 |
| Roos MH et al. | Molecular aspects of drug resistance in parasitic helminths. | 1993 | Pharmacol. Ther. | pmid:8022863 |
| MacNeil DJ et al. | Correlation of the avermectin polyketide synthase genes to the avermectin structure. Implications for designing novel avermectins. | 1994 | Ann. N. Y. Acad. Sci. | pmid:8010663 |
| Cully DF et al. | Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans. | 1994 | Nature | pmid:7935817 |
| Ikeda H et al. | Direct production of 5-oxo derivatives of avermectins by a recombinant strain of Streptomyces avermitilis. | 1995 | J. Antibiot. | pmid:7868399 |
| Pang CH et al. | Production of a new methylated 6,8a-seco-6,8a-deoxy derivative of the avermectins by a transformant strain of Streptomyces avermitilis. | 1995 | J. Antibiot. | pmid:7868398 |
| Pang CH et al. | Production of 6,8a-seco-6,8a-deoxy derivatives of avermectins by a mutant strain of Streptomyces avermitilis. | 1995 | J. Antibiot. | pmid:7868391 |
| Khalkova Zh | [An experimental evaluation of the cutaneous action of the preparation Bulmektin]. | 1994 | Probl Khig | pmid:7845982 |
| Clark JM et al. | Resistance to avermectins: extent, mechanisms, and management implications. | 1995 | Annu. Rev. Entomol. | pmid:7810984 |
| Denoya CD et al. | A second branched-chain alpha-keto acid dehydrogenase gene cluster (bkdFGH) from Streptomyces avermitilis: its relationship to avermectin biosynthesis and the construction of a bkdF mutant suitable for the production of novel antiparasitic avermectins. | 1995 | J. Bacteriol. | pmid:7768860 |
| Arena JP et al. | The mechanism of action of avermectins in Caenorhabditis elegans: correlation between activation of glutamate-sensitive chloride current, membrane binding, and biological activity. | 1995 | J. Parasitol. | pmid:7707209 |
| Le Jambre LF et al. | Characterisation of an avermectin resistant strain of Australian Haemonchus contortus. | 1995 | Int. J. Parasitol. | pmid:7657454 |
| Ikeda H and Omura S | Control of avermectin biosynthesis in Streptomyces avermitilis for the selective production of a useful component. | 1995 | J. Antibiot. | pmid:7649850 |
| Gill JH et al. | Avermectin inhibition of larval development in Haemonchus contortus--effects of ivermectin resistance. | 1995 | Int. J. Parasitol. | pmid:7635622 |
| Ikeda H et al. | Construction of a single component producer from the wild type avermectin producer Streptomyces avermitilis. | 1995 | J. Antibiot. | pmid:7622445 |
| Shoop WL et al. | Structure and activity of avermectins and milbemycins in animal health. | 1995 | Vet. Parasitol. | pmid:7483237 |
| Tolan JW et al. | Determination of avermectins in plasma at nanogram levels using high-performance liquid chromatography with fluorescence detection. | 1980 | J. Chromatogr. | pmid:7380953 |
| James PS et al. | Insecticidal activity of the avermectins. | 1980 | Vet. Rec. | pmid:7361432 |
| Ostlind DA and Cifelli S | Efficacy of thiabendazole, levamisole hydrochloride and the major natural avermectins against Trichostrongylus colubriformis in the gerbil (Meriones unguiculatus). | 1981 | Res. Vet. Sci. | pmid:7323472 |
| Wilkins CA et al. | Treatment of psoroptic mange with avermectins. | 1980 | Am. J. Vet. Res. | pmid:7212445 |
| Denham DA | The effects of some avermectins on the growth of Brugia pahangi. | 1982 | Methods Find Exp Clin Pharmacol | pmid:7121142 |
| Campbell WC | An introduction to the avermectins. | 1981 | N Z Vet J | pmid:7038568 |
| Bowen JM | The avermectin complex: a new horizon in anthelmintic therapy. | 1981 | Vet Med Small Anim Clin | pmid:6908751 |
| Calcott PH and Fatig RO | Inhibition of chitin metabolism by avermectin in susceptible organisms. | 1984 | J. Antibiot. | pmid:6725140 |
| Pivnichny JV et al. | Direct determination of avermectins in plasma at nanogram levels by high-performance liquid chromatography. | 1983 | J Pharm Sci | pmid:6663483 |
| Parrish MD and Roberts RB | Toxicity of avermectin B1 to larval yellowjackets, Vespula maculifrons (Hymenoptera: Vespidae). | 1984 | J. Econ. Entomol. | pmid:6480980 |
| BronshteÄn AM | [Praziquantel and other current preparations and chemotherapy methods in human trematodiases of the liver (opisthorchiasis and clonorchiasis) (a review of the literature)]. | 1984 Nov-Dec | Med Parazitol (Mosk) | pmid:6397686 |
| Goodwin LG | Recent advances in research on filariasis. Chemotherapy. | 1984 | Trans. R. Soc. Trop. Med. Hyg. | pmid:6382706 |
| Williams M and Risley EA | Interaction of avermectins with [3H]beta-carboline-3-carboxylate ethyl ester and [3H]diazepam binding sites in rat brain cortical membranes. | 1982 | Eur. J. Pharmacol. | pmid:6277673 |
| Miwa GT et al. | The metabolism of avermectins B1a, H2B1a, and H2B1b by liver microsomes. | 1982 May-Jun | Drug Metab. Dispos. | pmid:6125361 |
| Kass IS et al. | The effects of avermectin and drugs related to acetylcholine and 4-aminobutyric acid on neurotransmission in Ascaris suum. | 1984 | Mol. Biochem. Parasitol. | pmid:6096713 |
| Drexler G and Sieghart W | [35S]tert.-butylbicyclophosphorothionate and avermectin bind to different sites associated with the gamma- aminobutyric acid-benzodiazepine receptor complex. | 1984 | Neurosci. Lett. | pmid:6093013 |
| Calcott PH and Fatig RO | Avermectin modulation of GABA binding to membranes of rat brain, brine shrimp and a fungus, Mucor miehei. | 1984 | J. Antibiot. | pmid:6088460 |
| Drexler G and Sieghart W | Evidence for association of a high affinity avermectin binding site with the benzodiazepine receptor. | 1984 | Eur. J. Pharmacol. | pmid:6088254 |
| Onishi JC and Miller TW | The lack of antifungal activity by avermectin B1a. | 1985 | J. Antibiot. | pmid:4077735 |
| Schulman MD et al. | Demethylavermectins. Biosynthesis, isolation and characterization. | 1985 | J. Antibiot. | pmid:4077729 |
| Marriner S | Anthelmintic drugs. | 1986 | Vet. Rec. | pmid:3962132 |
| Schulman MD et al. | Avermectin B2 O-methyltransferase activity in "Streptomyces avermitilis" mutants that produce increased amounts of the avermectins. | 1986 | Antimicrob. Agents Chemother. | pmid:3707112 |
| Ikeda H et al. | Genetic studies of avermectin biosynthesis in Streptomyces avermitilis. | 1987 | J. Bacteriol. | pmid:3680172 |
| Schulman MD et al. | "Streptomyces avermitilis" mutants defective in methylation of avermectins. | 1987 | Antimicrob. Agents Chemother. | pmid:3606074 |
| Davies HG and Green RH | Avermectins and milbemycins. | 1986 | Nat Prod Rep | pmid:3526202 |
| Campbell WC | The chemotherapy of parasitic infections. | 1986 | J. Parasitol. | pmid:3519918 |
| Seaman JT et al. | Avermectin B1 toxicity in a herd of Murray Grey cattle. | 1987 | Aust. Vet. J. | pmid:3426470 |
| Button C et al. | Avermectin toxicity in calves and an evaluation of picrotoxin as an antidote. | 1988 | Aust. Vet. J. | pmid:3401165 |
| De Chaneet GC et al. | Effect of avermectin B1 and benzimidazole anthelmintics on worm egg output of treated cattle. | 1988 | Aust. Vet. J. | pmid:3401149 |
| Ikeda H et al. | Involvement of glucose catabolism in avermectin production by Streptomyces avermitilis. | 1988 | Antimicrob. Agents Chemother. | pmid:3364948 |
| Chang V | Toxic baiting of the Western yellowjacket (Hymenoptera: Vespidae) in Hawaii. | 1988 | J. Econ. Entomol. | pmid:3351079 |
| Ammendola D et al. | Anticonvulsant effects of avermectin in DBA/2 mice and rat. | 1988 | Exp Biol | pmid:3268424 |
| Schulman MD et al. | Biosynthesis of the avermectins by Streptomyces avermitilis. Incorporation of labeled precursors. | 1986 | J. Antibiot. | pmid:3086265 |
| Matsumoto K et al. | Actions of avermectins on cultured neurons. | 1988 | Gen. Pharmacol. | pmid:3044917 |