| MeSH term | MeSH ID | Detail |
|---|---|---|
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
| Tuberculosis, Multidrug-Resistant | D018088 | 6 associated lipids |
| Strongylida Infections | D017206 | 5 associated lipids |
| Trichostrongylosis | D014253 | 5 associated lipids |
| Trichostrongyloidiasis | D014252 | 7 associated lipids |
| Scabies | D012532 | 2 associated lipids |
| Poisoning | D011041 | 9 associated lipids |
| Lice Infestations | D010373 | 9 associated lipids |
| Parasitic Diseases, Animal | D010273 | 1 associated lipids |
| Ostertagiasis | D010029 | 2 associated lipids |
Avermectin A1a
Avermectin A1a is a lipid of Polyketides (PK) class. Avermectin a1a is associated with abnormalities such as Ataxia with vitamin E deficiency, Strongyloidiasis, Congenital Transposition, Gigantism and Onchocerciasis. The involved functions are known as DNA Binding, Anabolism, Insertion Mutation, Process and physiological aspects. Avermectin a1a often locates in Chromosomes, Membrane, Clone, soluble and Tissue membrane. The associated genes with Avermectin A1a are Polypeptides, oxytocin, 1-desamino-(O-Et-Tyr)(2)-, Gene Feature, Genome and Gene Clusters. The related lipids are Propionate. The related experimental models are Mouse Model.
Cross Reference
Introduction
To understand associated biological information of Avermectin A1a, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Avermectin A1a?
Avermectin A1a is suspected in Ataxia with vitamin E deficiency, Gigantism, Strongyloidiasis, Congenital Transposition, Onchocerciasis, Tropical Disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Avermectin A1a
PubChem Associated disorders and diseases
What pathways are associated with Avermectin A1a
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Avermectin A1a?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Avermectin A1a?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Avermectin A1a?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Avermectin A1a?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Avermectin A1a?
Mouse Model
Mouse Model are used in the study 'Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the gamma-aminobutyric acid(A) receptor.' (Dawson GR et al., 2000).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with Avermectin A1a
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Guo J et al. | Two adjacent and similar TetR family transcriptional regulator genes, SAV577 and SAV576, co-regulate avermectin production in Streptomyces avermitilis. | 2014 | PLoS ONE | pmid:24915523 |
| Li M et al. | Exploring the electron transfer pathway in the oxidation of avermectin by CYP107Z13 in Streptomyces ahygroscopicus ZB01. | 2014 | PLoS ONE | pmid:24905717 |
| Huang WK et al. | Efficacy evaluation of fungus Syncephalastrum racemosum and nematicide avermectin against the root-knot nematode Meloidogyne incognita on cucumber. | 2014 | PLoS ONE | pmid:24586982 |
| Liu M et al. | Magnetic field is the dominant factor to induce the response of Streptomyces avermitilis in altered gravity simulated by diamagnetic levitation. | 2011 | PLoS ONE | pmid:22039402 |
| Omansen TF et al. | In-vitro activity of avermectins against Mycobacterium ulcerans. | 2015 | PLoS Negl Trop Dis | pmid:25742173 |
| Efferth T et al. | Nobel Prize for artemisinin brings phytotherapy into the spotlight. | 2015 | Phytomedicine | pmid:26563851 |
| Roos MH et al. | Molecular aspects of drug resistance in parasitic helminths. | 1993 | Pharmacol. Ther. | pmid:8022863 |
| Liu C et al. | Avermectin induced global DNA hypomethylation and over-expression of heat shock proteins in cardiac tissues of pigeon. | 2017 | Pestic Biochem Physiol | pmid:28043331 |
| Chen LJ et al. | The effects of avermectin on amino acid neurotransmitters and their receptors in the pigeon brain. | 2014 | Pestic Biochem Physiol | pmid:24759046 |
| Li HB et al. | Combined effects of temperature and avermectins on life history and stress response of the western flower thrips, Frankliniella occidentalis. | 2014 | Pestic Biochem Physiol | pmid:24485314 |
| Mermans C et al. | A G326E substitution in the glutamate-gated chloride channel 3 (GluCl3) of the two-spotted spider mite Tetranychus urticae abolishes the agonistic activity of macrocyclic lactones. | 2017 | Pest Manag. Sci. | pmid:28736919 |
| Jin T et al. | Insecticide resistance of the oriental fruit fly, Bactrocera dorsalis (Hendel) (Diptera: Tephritidae), in mainland China. | 2011 | Pest Manag. Sci. | pmid:21308963 |
| Lin YW et al. | Insecticide susceptibility of surviving Cotesia plutellae (Hym: Braconidae) and Diaeretiella rapae (M'Intosh) (Hym: Aphidiidae) as affected by sublethal insecticide dosages on host insects. | 2007 | Pest Manag. Sci. | pmid:17533655 |
| Shi ZH et al. | Evaluation of selective toxicity of five pesticides against Plutella xylostella (Lep: Plutellidae) and their side-effects against Cotesia plutellae (Hym: Braconidae) and Oomyzus sokolowskii (Hym: Eulophidae). | 2004 | Pest Manag. Sci. | pmid:15578602 |
| Wen LX et al. | Controlled release of avermectin from porous hollow silica nanoparticles. | 2005 | Pest Manag. Sci. | pmid:15714463 |
| Li ZZ et al. | Study of UV-shielding properties of novel porous hollow silica nanoparticle carriers for avermectin. | 2007 | Pest Manag. Sci. | pmid:17177171 |
| Byrne FJ et al. | Evaluation of neonicotinoid, organophosphate and avermectin trunk injections for the management of avocado thrips in California avocado groves. | 2012 | Pest Manag. Sci. | pmid:22396314 |
| Holden-Dye L and Walker RJ | Avermectin and avermectin derivatives are antagonists at the 4-aminobutyric acid (GABA) receptor on the somatic muscle cells of Ascaris; is this the site of anthelmintic action? | 1990 | Parasitology | pmid:2175874 |
| Wolstenholme AJ and Rogers AT | Glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics. | 2005 | Parasitology | pmid:16569295 |
| Demeler J et al. | Measuring the effect of avermectins and milbemycins on somatic muscle contraction of adult Haemonchus contortus and on motility of Ostertagia circumcincta in vitro. | 2014 | Parasitology | pmid:24576444 |
| Sangster NC and Gill J | Pharmacology of anthelmintic resistance. | 1999 | Parasitol. Today (Regul. Ed.) | pmid:10322335 |
| Rehbein S et al. | Efficacy of a new long-acting formulation of ivermectin and other injectable avermectins against induced Psoroptes ovis infestations in cattle. | 2002 | Parasitol. Res. | pmid:12444456 |
| Godoy P et al. | Characterisation of P-glycoprotein-9.1 in Haemonchus contortus. | 2016 | Parasit Vectors | pmid:26822677 |
| Kessabi FM et al. | Rearrangement of a cyclohexyl radical to a cyclopentylmethyl radical on the avermectin skeleton. | 2008 | Org. Lett. | pmid:18461948 |
| Brady PB et al. | Stereodivergent approach to the avermectins based on "super silyl" directed aldol reactions. | 2014 | Org. Lett. | pmid:25025525 |
| Gaisser S et al. | Direct production of ivermectin-like drugs after domain exchange in the avermectin polyketide synthase of Streptomyces avermitilis ATCC31272. | 2003 | Org. Biomol. Chem. | pmid:12968333 |
| Sperry J et al. | Synthesis of natural products containing spiroketals via intramolecular hydrogen abstraction. | 2010 | Org. Biomol. Chem. | pmid:20024126 |
| Chen LP et al. | Direct interaction of avermectin with epidermal growth factor receptor mediates the penetration resistance in Drosophila larvae. | 2016 | Open Biol | pmid:27249340 |
| Drexler G and Sieghart W | [35S]tert.-butylbicyclophosphorothionate and avermectin bind to different sites associated with the gamma- aminobutyric acid-benzodiazepine receptor complex. | 1984 | Neurosci. Lett. | pmid:6093013 |
| Schönrock B and Bormann J | Activation of Cl- channels by avermectin in rat cultured hippocampal neurons. | 1993 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:8133905 |
| Cully DF et al. | Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans. | 1994 | Nature | pmid:7935817 |
| Walsh CT | Natural insights for chemical biologists. | 2005 | Nat. Chem. Biol. | pmid:16408011 |
| Davies HG and Green RH | Avermectins and milbemycins. | 1986 | Nat Prod Rep | pmid:3526202 |
| Campbell WC | An introduction to the avermectins. | 1981 | N Z Vet J | pmid:7038568 |
| Miakisheva SN et al. | [Proliferation and morphological differentiation of neurblastoma cells in cultured under the effect of avermectins]. | 2001 | Morfologiia | pmid:12016760 |
| Wang C et al. | A monoclonal antibody-based ELISA for multiresidue determination of avermectins in milk. | 2012 | Molecules | pmid:22706371 |
| Arena JP et al. | Avermectin-sensitive chloride currents induced by Caenorhabditis elegans RNA in Xenopus oocytes. | 1991 | Mol. Pharmacol. | pmid:1716730 |
| Zhu J et al. | AvaR2, a pseudo γ-butyrolactone receptor homologue from Streptomyces avermitilis, is a pleiotropic repressor of avermectin and avenolide biosynthesis and cell growth. | 2016 | Mol. Microbiol. | pmid:27502190 |
| Yu Z et al. | Differential regulation of antibiotic biosynthesis by DraR-K, a novel two-component system in Streptomyces coelicolor. | 2012 | Mol. Microbiol. | pmid:22676800 |
| Guo J et al. | The pathway-specific regulator AveR from Streptomyces avermitilis positively regulates avermectin production while it negatively affects oligomycin biosynthesis. | 2010 | Mol. Genet. Genomics | pmid:20012992 |
| Kwon YJ et al. | Selective Inhibition of SIN3 Corepressor with Avermectins as a Novel Therapeutic Strategy in Triple-Negative Breast Cancer. | 2015 | Mol. Cancer Ther. | pmid:26078298 |
| Delany NS et al. | Cloning and localisation of an avermectin receptor-related subunit from Haemonchus contortus. | 1998 | Mol. Biochem. Parasitol. | pmid:9879896 |
| Blackhall WJ et al. | Selection at a gamma-aminobutyric acid receptor gene in Haemonchus contortus resistant to avermectins/milbemycins. | 2003 | Mol. Biochem. Parasitol. | pmid:14511812 |
| Kass IS et al. | The effects of avermectin and drugs related to acetylcholine and 4-aminobutyric acid on neurotransmission in Ascaris suum. | 1984 | Mol. Biochem. Parasitol. | pmid:6096713 |
| Liu J et al. | Genomic organization of an avermectin receptor subunit from Haemonchus contortus and expression of its putative promoter region in Caenorhabditis elegans. | 2004 | Mol. Biochem. Parasitol. | pmid:15003846 |
| Iamborko NA and Pindrus AA | [Protective properties of avermectine complex and plant growth regulators]. | 2009 Mar-Apr | Mikrobiol. Z. | pmid:19938592 |
| Biliavs'ka LO et al. | [Effect of pyruvate and valine on avermectin biosynthesis by Streptomyces avermitilis UCM Ac-2179]. | 2007 Jul-Aug | Mikrobiol. Z. | pmid:17977447 |
| Petruk TV et al. | [Increasing biosynthesis of avermectins of Streptomyces avermitilis UCM Ac 2161 under the effect N-methyl-N'-nitro-N-nitrosoguanidine]. | 2004 Nov-Dec | Mikrobiol. Z. | pmid:15765867 |
| Beliavskaia LA et al. | [Biologically active substances of preparation avercom]. | 2012 May-Jun | Mikrobiol. Z. | pmid:22830191 |
| Iutynska GO | Elaboration of natural polyfunctional preparations with antiparasitic and biostimulating properties for plant growing. | 2012 Jul-Aug | Mikrobiol. Z. | pmid:23088094 |
| Alves SN et al. | Alterations in the fat body and midgut of Culex quinquefasciatus larvae following exposure to different insecticides. | 2010 | Micron | pmid:20452779 |
| Zhang YX et al. | Genes encoding acyl-CoA dehydrogenase (AcdH) homologues from Streptomyces coelicolor and Streptomyces avermitilis provide insights into the metabolism of small branched-chain fatty acids and macrolide antibiotic production. | 1999 | Microbiology (Reading, Engl.) | pmid:10517585 |
| Miyamoto KT et al. | The autoregulator receptor homologue AvaR3 plays a regulatory role in antibiotic production, mycelial aggregation and colony development of Streptomyces avermitilis. | 2011 | Microbiology (Reading, Engl.) | pmid:21622528 |
| Evans M et al. | Characterization of a Streptomyces-lividans-type site-specific DNA modification system in the avermectin-producer Streptomyces avermitilis permits investigation of two novel giant linear plasmids, pSA1 and pSA2. | 1994 | Microbiology (Reading, Engl.) | pmid:8081502 |
| Kim MS et al. | Engineered biosynthesis of milbemycins in the avermectin high-producing strain Streptomyces avermitilis. | 2017 | Microb. Cell Fact. | pmid:28095865 |
| Zhang J et al. | Designed biosynthesis of 25-methyl and 25-ethyl ivermectin with enhanced insecticidal activity by domain swap of avermectin polyketide synthase. | 2015 | Microb. Cell Fact. | pmid:26400541 |
| Denham DA | The effects of some avermectins on the growth of Brugia pahangi. | 1982 | Methods Find Exp Clin Pharmacol | pmid:7121142 |
| BronshteÄn AM | [Praziquantel and other current preparations and chemotherapy methods in human trematodiases of the liver (opisthorchiasis and clonorchiasis) (a review of the literature)]. | 1984 Nov-Dec | Med Parazitol (Mosk) | pmid:6397686 |
| Lopatina IuV and Eremina OIu | [Comparative activity of different groups of insecticides against permethrin-resistant lice (anoplura: pediculidae)]. | 2013 Jan-Mar | Med Parazitol (Mosk) | pmid:23805484 |
| Meng L et al. | Enhanced production of avermectin by deletion of type III polyketide synthases biosynthetic cluster rpp in Streptomyces avermitilis. | 2016 | Lett. Appl. Microbiol. | pmid:27538855 |
| Owens B | 2015 Nobel Prize goes to antiparasitic drug discoverers. | 2015 | Lancet | pmid:26466031 |
| BronshteÄn AM et al. | [Migrating subcutaneous myasis with systemic manifestations caused by gadfly larvae]. | 2004 | Klin Med (Mosk) | pmid:15656401 |
| Venkatachalam MA et al. | Cytoprotection of kidney epithelial cells by compounds that target amino acid gated chloride channels. | 1996 | Kidney Int. | pmid:8821829 |
| Ikeda H | [Genetic analysis of biosynthesis of polyketide compound in Streptomyces avermitilis]. | 2001 | Jpn J Antibiot | pmid:11392681 |
| Young KE et al. | Evaluation of anthelmintic activity in captive wild ruminants by fecal egg reduction tests and a larval development assay. | 2000 | J. Zoo Wildl. Med. | pmid:11237142 |
| Tribble ND et al. | Identification of the genes encoding for putative gamma aminobutyric acid (GABA) and glutamate-gated chloride channel (GluCl) alpha receptor subunits in sea lice (Lepeophtheirus salmonis). | 2007 | J. Vet. Pharmacol. Ther. | pmid:17348903 |
| McKellar QA and Benchaoui HA | Avermectins and milbemycins. | 1996 | J. Vet. Pharmacol. Ther. | pmid:8905567 |
| Dawson GR et al. | Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the gamma-aminobutyric acid(A) receptor. | 2000 | J. Pharmacol. Exp. Ther. | pmid:11082440 |
| Campbell WC | The chemotherapy of parasitic infections. | 1986 | J. Parasitol. | pmid:3519918 |
| Arena JP et al. | The mechanism of action of avermectins in Caenorhabditis elegans: correlation between activation of glutamate-sensitive chloride current, membrane binding, and biological activity. | 1995 | J. Parasitol. | pmid:7707209 |
| Sha CK et al. | Anionic cyclization approach toward perhydrobenzofuranone: stereocontrolled synthesis of the hexahydrobenzofuran subunit of avermectin. | 2002 | J. Org. Chem. | pmid:11856026 |
| Luft JA et al. | Substituent effects on the rearrangements of cyclohexyl to cyclopentyl radicals involving avermectin-related radicals. | 2008 | J. Org. Chem. | pmid:18842059 |
| Iovchev M et al. | Altered drug resistance and recovery from paralysis in Drosophila melanogaster with a deficient histamine-gated chloride channel. | 2002 Oct-Dec | J. Neurogenet. | pmid:12745634 |
| Barnes TM and Hekimi S | The Caenorhabditis elegans avermectin resistance and anesthetic response gene unc-9 encodes a member of a protein family implicated in electrical coupling of excitable cells. | 1997 | J. Neurochem. | pmid:9375655 |
| Sheehan LS et al. | Engineering of the spinosyn PKS: directing starter unit incorporation. | 2006 | J. Nat. Prod. | pmid:17190446 |
| Dong JY et al. | Ymf 1029A-E, preussomerin analogues from the fresh-water-derived fungus YMF 1.01029. | 2008 | J. Nat. Prod. | pmid:18479163 |
| Sun P et al. | 1,19-seco-Avermectin analogues from a ΔaveCDE mutant Streptomyces avermectinius strain. | 2015 | J. Nat. Prod. | pmid:25611131 |
| Vassilatis DK et al. | Evolutionary relationship of the ligand-gated ion channels and the avermectin-sensitive, glutamate-gated chloride channels. | 1997 | J. Mol. Evol. | pmid:9115174 |
| Wang YS et al. | A spectrophotometric screening method for avermectin oxidizing microorganisms. | 2017 | J. Microbiol. Methods | pmid:28215961 |
| Godinez O et al. | Targeting the Osmotic Stress Response for Strain Improvement of an Industrial Producer of Secondary Metabolites. | 2015 | J. Microbiol. Biotechnol. | pmid:26139611 |
| Duong CT et al. | Functional expression of SAV3818, a putative TetR-family transcriptional regulatory gene from Streptomyces avermitilis, stimulates antibiotic production in Streptomyces species. | 2009 | J. Microbiol. Biotechnol. | pmid:19307761 |
| Rajkarnikar A et al. | Two threonine residues required for role of AfsKav in controlling morphogenesis and avermectin production in Streptomyces avermitilis. | 2007 | J. Microbiol. Biotechnol. | pmid:18062239 |
| Im JH et al. | Comparative transcriptome analysis for avermectin overproduction via Streptomyces avermitilis microarray system. | 2007 | J. Microbiol. Biotechnol. | pmid:18050961 |
| Yong JH and Byeon WH | Alternative production of avermectin components in Streptomyces avermitilis by gene replacement. | 2005 | J. Microbiol. | pmid:15995647 |
| Drinyaev VA et al. | Effect of avermectins on Ca2+-dependent Cl- currents in plasmalemma of Chara corallina cells. | 2001 | J. Membr. Biol. | pmid:11426301 |
| Zakson-Aiken M et al. | Systemic activity of the avermectins against the cat flea (Siphonaptera: Pulicidae). | 2001 | J. Med. Entomol. | pmid:11476339 |
| Sollai G et al. | Effects of avermectins on olfactory responses of Culicoides imicola (Diptera: Ceratopogonidae). | 2007 | J. Med. Entomol. | pmid:17695021 |
| Fritz ML et al. | Lethal and sublethal effects of avermectin/milbemycin parasiticides on the African malaria vector, Anopheles arabiensis. | 2012 | J. Med. Entomol. | pmid:22493850 |
| Meinke PT et al. | Affinity probes for the avermectin binding proteins. | 1992 | J. Med. Chem. | pmid:1433197 |
| Tomilova OG et al. | Immune-physiological aspects of synergy between avermectins and the entomopathogenic fungus Metarhizium robertsii in Colorado potato beetle larvae. | 2016 | J. Invertebr. Pathol. | pmid:27546865 |
| Hu J et al. | Effects of insecticides on the fluidity of mitochondrial membranes of the diamondback moth, Plutella xylostella, resistant and susceptible to avermectin. | 2008 | J. Insect Sci. | pmid:20345311 |
| Zou CS et al. | Purification, characterization, and sensitivity to pesticides of carboxylesterase from Dendrolimus superans (Lepidoptera: Lasiocampidae). | 2014 | J. Insect Sci. | pmid:25525114 |
| Ikeda H et al. | Organization of biosynthetic gene cluster for avermectin in Streptomyces avermitilis: analysis of enzymatic domains in four polyketide synthases. | 2001 | J. Ind. Microbiol. Biotechnol. | pmid:11780788 |
| Li L et al. | Overexpression of ribosome recycling factor causes increased production of avermectin in Streptomyces avermitilis strains. | 2010 | J. Ind. Microbiol. Biotechnol. | pmid:20352288 |
| Tian P et al. | Comparative metabolomics reveals the mechanism of avermectin production enhancement by S-adenosylmethionine. | 2017 | J. Ind. Microbiol. Biotechnol. | pmid:27988821 |
| Baltz RH et al. | Introduction to the Special Issue: "Natural Product Discovery and Development in the Genomic Era". | 2016 | J. Ind. Microbiol. Biotechnol. | pmid:26660315 |
| Hopwood DA | Satoshi ÅŒmura. | 2016 | J. Ind. Microbiol. Biotechnol. | pmid:26186906 |
| Zhang X et al. | Deletion of ku homologs increases gene targeting frequency in Streptomyces avermitilis. | 2012 | J. Ind. Microbiol. Biotechnol. | pmid:22350115 |
| Chartrain M et al. | Bioconversion of avermectin into 27-OH avermectin. | 1990 | J. Ind. Microbiol. | pmid:1366995 |
| Wang Y et al. | Ternary toxicological interactions of insecticides, herbicides, and a heavy metal on the earthworm Eisenia fetida. | 2015 | J. Hazard. Mater. | pmid:25463238 |