Avermectin A1a

Avermectin A1a is a lipid of Polyketides (PK) class. Avermectin a1a is associated with abnormalities such as Ataxia with vitamin E deficiency, Strongyloidiasis, Congenital Transposition, Gigantism and Onchocerciasis. The involved functions are known as DNA Binding, Anabolism, Insertion Mutation, Process and physiological aspects. Avermectin a1a often locates in Chromosomes, Membrane, Clone, soluble and Tissue membrane. The associated genes with Avermectin A1a are Polypeptides, oxytocin, 1-desamino-(O-Et-Tyr)(2)-, Gene Feature, Genome and Gene Clusters. The related lipids are Propionate. The related experimental models are Mouse Model.

Cross Reference

Introduction

To understand associated biological information of Avermectin A1a, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Avermectin A1a?

Avermectin A1a is suspected in Ataxia with vitamin E deficiency, Gigantism, Strongyloidiasis, Congenital Transposition, Onchocerciasis, Tropical Disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Avermectin A1a

MeSH term MeSH ID Detail
Inflammation D007249 119 associated lipids
Body Weight D001835 333 associated lipids
Dog Diseases D004283 5 associated lipids
Leukemia P388 D007941 43 associated lipids
Neuroblastoma D009447 66 associated lipids
Trichostrongyloidiasis D014252 7 associated lipids
Poisoning D011041 9 associated lipids
Cleft Palate D002972 9 associated lipids
Fish Diseases D005393 5 associated lipids
Neurotoxicity Syndromes D020258 34 associated lipids
Per page 10 20 | Total 19

PubChem Associated disorders and diseases

What pathways are associated with Avermectin A1a

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Avermectin A1a?

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What functions are associated with Avermectin A1a?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Avermectin A1a?

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What genes are associated with Avermectin A1a?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Avermectin A1a?

Mouse Model

Mouse Model are used in the study 'Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the gamma-aminobutyric acid(A) receptor.' (Dawson GR et al., 2000).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Avermectin A1a

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Authors Title Published Journal PubMed Link
pmid:
Sangster NC et al. Haemonchus contortus: sequence heterogeneity of internucleotide binding domains from P-glycoproteins. 1999 Exp. Parasitol. pmid:10072327
Turnipseed SB et al. Confirmation of avermectin residues in food matrices with negative-ion atmospheric pressure chemical ionization liquid chromatography/mass spectrometry. 1999 Rapid Commun. Mass Spectrom. pmid:10204245
Sangster NC and Gill J Pharmacology of anthelmintic resistance. 1999 Parasitol. Today (Regul. Ed.) pmid:10322335
Gopal RM et al. Resistance of field isolates of Trichostrongylus colubriformis and Ostertagia circumcincta to ivermectin. 1999 Int. J. Parasitol. pmid:10404276
Mosin VA et al. [Action of avermectins on lymphoid leukemia P-388 cells in vitro]. 1999 Antibiot. Khimioter. pmid:10422573
Roudaut B Multiresidue method for the determination of avermectin and moxidectin residues in the liver using HPLC with fluorescence detection. 1998 Analyst pmid:10435295
Ikeda H et al. Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:10449723
Geary TG et al. Frontiers in anthelmintic pharmacology. 1999 Vet. Parasitol. pmid:10456419
Sangster NC Pharmacology of anthelmintic resistance in cyathostomes: will it occur with the avermectin/milbemycins? 1999 Vet. Parasitol. pmid:10485365
Novik TS et al. [Assessment of the mutagenic activity of aversectin C]. 1999 Antibiot. Khimioter. pmid:10494378
Zhang YX et al. Genes encoding acyl-CoA dehydrogenase (AcdH) homologues from Streptomyces coelicolor and Streptomyces avermitilis provide insights into the metabolism of small branched-chain fatty acids and macrolide antibiotic production. 1999 Microbiology (Reading, Engl.) pmid:10517585
Smit JW et al. Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure. 1999 J. Clin. Invest. pmid:10562306
Le Jambre LF et al. Inheritance of avermectin resistance in Haemonchus contortus. 2000 Int. J. Parasitol. pmid:10675751
Kokoz YM et al. Selective cytostatic and neurotoxic effects of avermectins and activation of the GABAalpha receptors. 1999 Biosci. Rep. pmid:10841270
Gianelli L et al. Mass spectrometry of avermectins: structural determination of two new derivatives of Ivermectin B(1a). 2000 Rapid Commun. Mass Spectrom. pmid:10918377
Novotny MJ et al. Safety of selamectin in dogs. 2000 Vet. Parasitol. pmid:10940536
Krautmann MJ et al. Safety of selamectin in cats. 2000 Vet. Parasitol. pmid:10940537
Tsukamoto Y et al. Avermectin chemistry and action: ester- and ether-type candidate photoaffinity probes. 2000 Bioorg. Med. Chem. pmid:10968260
Banks BJ et al. Avermectins and flea control: structure-activity relationships and the selection of selamectin for development as an endectocide for companion animals. 2000 Bioorg. Med. Chem. pmid:11003146
Dawson GR et al. Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the gamma-aminobutyric acid(A) receptor. 2000 J. Pharmacol. Exp. Ther. pmid:11082440
Hoste H et al. A questionnaire survey on the practices adopted to control gastrointestinal nematode parasitism in dairy goat farms in France. 2000 Vet. Res. Commun. pmid:11085466
Jacobson M et al. Elimination of Sarcoptes scabiei in pig herds by single or double administrations of an avermectin. 2000 Acta Vet. Scand. pmid:11126572
Mosin VA et al. [Cytotoxic and cytostatic effect of avermectines on tumor cells in vitro]. 2000 Antibiot. Khimioter. pmid:11212393
Howells L and Sauer MJ Multi-residue analysis of avermectins and moxidectin by ion-trap LC-MSn. 2001 Analyst pmid:11235096
Young KE et al. Evaluation of anthelmintic activity in captive wild ruminants by fecal egg reduction tests and a larval development assay. 2000 J. Zoo Wildl. Med. pmid:11237142
Shao Y et al. [Determination of avermictin in avermictin tablet by high performance liquid chromatography]. 1998 Se Pu pmid:11324492
Barnes EH et al. Selection of different genotype larvae and adult worms for anthelmintic resistance by persistent and short-acting avermectin/milbemycins. 2001 Int. J. Parasitol. pmid:11336754
Ikeda H [Genetic analysis of biosynthesis of polyketide compound in Streptomyces avermitilis]. 2001 Jpn J Antibiot pmid:11392681
Wu Z et al. Multi-residue analysis of avermectins in swine liver by immunoaffinity extraction and liquid chromatography-mass spectrometry. 2001 J. Chromatogr. B Biomed. Sci. Appl. pmid:11393726
Danaher M et al. Development and optimisation of an improved derivatisation procedure for the determination of avermectins and milbemycins in bovine liver. 2001 Analyst pmid:11394296
Köhler P The biochemical basis of anthelmintic action and resistance. 2001 Int. J. Parasitol. pmid:11400692
Valenzuela AI et al. Comparison of various liquid chromatographic methods for the analysis of avermectin residues in citrus fruits. 2001 J Chromatogr A pmid:11403456
Drinyaev VA et al. Effect of avermectins on Ca2+-dependent Cl- currents in plasmalemma of Chara corallina cells. 2001 J. Membr. Biol. pmid:11426301
Wohlert S et al. Insights about the biosynthesis of the avermectin deoxysugar L-oleandrose through heterologous expression of Streptomyces avermitilis deoxysugar genes in Streptomyces lividans. 2001 Chem. Biol. pmid:11451669
Swarnkar CP et al. Anthelmintic resistance on an organized sheep farm in India. 2001 Trop Anim Health Prod pmid:11474864
Zakson-Aiken M et al. Systemic activity of the avermectins against the cat flea (Siphonaptera: Pulicidae). 2001 J. Med. Entomol. pmid:11476339
Anziani OS et al. Avermectin resistance in Cooperia pectinata in cattle in Argentina. 2001 Vet. Rec. pmid:11488345
Martins JR and Furlong J Avermectin resistance of the cattle tick Boophilus microplus in Brazil. 2001 Vet. Rec. pmid:11488352
Novik TS et al. [Acute toxicity of aversectin C : various routes of administration and dosage forms]. 2001 Mar-Apr Eksp Klin Farmakol pmid:11548452
Driniaev VA et al. [Selective cytostatic and cytotoxic effects of avermectins]. 2001 Antibiot. Khimioter. pmid:11558448
Driniaev VA et al. [Effect of avermectns on Ca(2+)-dependent chloride currents in plasmalemma of Chara corallina cells]. 2001 Antibiot. Khimioter. pmid:11558454
Danaher M et al. Extraction and isolation of avermectins and milbemycins from liver samples using unmodified supercritical CO2 with in-line trapping on basic alumina. 2001 J. Chromatogr. B Biomed. Sci. Appl. pmid:11585125
Ikeda H et al. Organization of biosynthetic gene cluster for avermectin in Streptomyces avermitilis: analysis of enzymatic domains in four polyketide synthases. 2001 J. Ind. Microbiol. Biotechnol. pmid:11780788
Sha CK et al. Anionic cyclization approach toward perhydrobenzofuranone: stereocontrolled synthesis of the hexahydrobenzofuran subunit of avermectin. 2002 J. Org. Chem. pmid:11856026
Miakisheva SN et al. [Proliferation and morphological differentiation of neurblastoma cells in cultured under the effect of avermectins]. 2001 Morfologiia pmid:12016760
Veale PI Resistance to macrocyclic lactones in nematodes of goats. 2002 Aust. Vet. J. pmid:12074315
Deger Y et al. Short communication serum copper, zinc, and calcium concentrations in lice-infested sheep. 2002 Biol Trace Elem Res pmid:12117268
Rehbein S et al. Efficacy of a new long-acting formulation of ivermectin and other injectable avermectins against induced Psoroptes ovis infestations in cattle. 2002 Parasitol. Res. pmid:12444456
Kim SB and Goodfellow M Streptomyces avermitilis sp. nov., nom. rev., a taxonomic home for the avermectin-producing streptomycetes. 2002 Int. J. Syst. Evol. Microbiol. pmid:12508861
Takahashi Y et al. Streptomyces avermectinius sp. nov., an avermectin-producing strain. 2002 Int. J. Syst. Evol. Microbiol. pmid:12508884
Argentine JA et al. Toxicities of emamectin benzoate homologues and photodegradates to Lepidoptera. 2002 J. Econ. Entomol. pmid:12539830
Chen Z et al. [Effect of gene disruption of aveD on avermectins production in Streptomyces avermitilis]. 2001 Wei Sheng Wu Xue Bao pmid:12552909
Hwang YS et al. Cloning and analysis of a DNA fragment stimulating avermectin production in various Streptomyces avermitilis strains. 2003 Appl. Environ. Microbiol. pmid:12571055
Martins JR et al. Partial strategic tick control within a herd of European breed cattle in the state of Rio Grande do Sul, southern Brazil. 2002 Exp. Appl. Acarol. pmid:12593589
Stutzman-Engwall K et al. Engineering the aveC gene to enhance the ratio of doramectin to its CHC-B2 analogue produced in Streptomyces avermitilis. 2003 Biotechnol. Bioeng. pmid:12599263
Mironov VA et al. [Dependence of the composition of the avermectin complex of Streptomyces avermitilis on glucose content of the growth medium]. 2003 Mar-Apr Prikl. Biokhim. Mikrobiol. pmid:12722656
Viktorov AV et al. [Comparative analysis of degradation of native avermectins and spinosyns by UV-HPLC]. 2002 Antibiot. Khimioter. pmid:12728628
Iovchev M et al. Altered drug resistance and recovery from paralysis in Drosophila melanogaster with a deficient histamine-gated chloride channel. 2002 Oct-Dec J. Neurogenet. pmid:12745634
Arena JP et al. Expression of a glutamate-activated chloride current in Xenopus oocytes injected with Caenorhabditis elegans RNA: evidence for modulation by avermectin. 1992 Brain Res. Mol. Brain Res. pmid:1279355
Sun Y et al. Identification of a gene cluster encoding meilingmycin biosynthesis among multiple polyketide synthase contigs isolated from Streptomyces nanchangensis NS3226. 2003 Arch. Microbiol. pmid:12811466
Lamb DC et al. Cytochrome p450 complement (CYPome) of the avermectin-producer Streptomyces avermitilis and comparison to that of Streptomyces coelicolor A3(2). 2003 Biochem. Biophys. Res. Commun. pmid:12893267
Gaisser S et al. Direct production of ivermectin-like drugs after domain exchange in the avermectin polyketide synthase of Streptomyces avermitilis ATCC31272. 2003 Org. Biomol. Chem. pmid:12968333
Rohrer SP et al. Photoaffinity labeling of avermectin binding sites from Caenorhabditis elegans and Drosophila melanogaster. 1992 Proc. Natl. Acad. Sci. U.S.A. pmid:1315055
Chartrain M et al. Bioconversion of avermectin into 27-OH avermectin. 1990 J. Ind. Microbiol. pmid:1366995
Yates DM et al. The avermectin receptors of Haemonchus contortus and Caenorhabditis elegans. 2003 Int. J. Parasitol. pmid:13678634
Stong JD et al. Radical-induced oxidation of oxahydrindene (hexahydrobenzofuran) portion of 22,23-dihydroavermectin B1a: identification of autooxidation products. 1992 J Pharm Sci pmid:1432608
Meinke PT et al. Affinity probes for the avermectin binding proteins. 1992 J. Med. Chem. pmid:1433197
Blackhall WJ et al. Selection at a gamma-aminobutyric acid receptor gene in Haemonchus contortus resistant to avermectins/milbemycins. 2003 Mol. Biochem. Parasitol. pmid:14511812
Nagai K et al. Synthesis and biological activities of novel 4"-alkylidene avermectin derivatives. 2003 Bioorg. Med. Chem. Lett. pmid:14592480
Yoon YJ et al. Avermectin: biochemical and molecular basis of its biosynthesis and regulation. 2004 Appl. Microbiol. Biotechnol. pmid:14689246
Strabel D et al. [The use of avermectins in two goats with demodicosis]. 2003 Schweiz. Arch. Tierheilkd. pmid:14725185
Shoop WL Resistance to avermectins and milbemycins. 1992 Vet. Rec. pmid:1496763
Chen J et al. Ethanol evolution rate: a new parameter to determine the feeding rate for the production of avermectins by Streptomyces avermitilis. 2004 Biotechnol. Lett. pmid:15000476
Liu J et al. Genomic organization of an avermectin receptor subunit from Haemonchus contortus and expression of its putative promoter region in Caenorhabditis elegans. 2004 Mol. Biochem. Parasitol. pmid:15003846
Korystov YN et al. Avermectins inhibit multidrug resistance of tumor cells. 2004 Eur. J. Pharmacol. pmid:15189764
Nagai K et al. Synthesis and biological evaluation of novel 4"-alkoxy avermectin derivatives. 2004 Bioorg. Med. Chem. Lett. pmid:15261257
Rezanka T et al. Influence of inhibitors of lipid biosynthesis on the production of avermectins in Streptomyces avermitilis. 1992 FEMS Microbiol. Lett. pmid:1526463
Drinyaev VA et al. Antitumor effect of avermectins. 2004 Eur. J. Pharmacol. pmid:15464058
MacNeil DJ et al. Analysis of Streptomyces avermitilis genes required for avermectin biosynthesis utilizing a novel integration vector. 1992 Gene pmid:1547955
Gong W et al. Improvement of transformation and electroduction in avermectin high-producer, Streptomyces avermitilis. 2004 Folia Microbiol. (Praha) pmid:15530004
Driniaev VA et al. [Antitumor effect of natural avermectins]. 2004 Antibiot. Khimioter. pmid:15573897
Shi ZH et al. Evaluation of selective toxicity of five pesticides against Plutella xylostella (Lep: Plutellidae) and their side-effects against Cotesia plutellae (Hym: Braconidae) and Oomyzus sokolowskii (Hym: Eulophidae). 2004 Pest Manag. Sci. pmid:15578602
Driniaev VA et al. [Modification of antitumor effect of vincristine by natural avermectins]. 2004 Antibiot. Khimioter. pmid:15628794
Li CL et al. [Differential acute mortality among the allozyme genotypes of Oxya chinensis by pesticide avermectin]. 2004 Yi Chuan Xue Bao pmid:15651676
BronshteÄ­n AM et al. [Migrating subcutaneous myasis with systemic manifestations caused by gadfly larvae]. 2004 Klin Med (Mosk) pmid:15656401
Wen LX et al. Controlled release of avermectin from porous hollow silica nanoparticles. 2005 Pest Manag. Sci. pmid:15714463
Petruk TV et al. [Increasing biosynthesis of avermectins of Streptomyces avermitilis UCM Ac 2161 under the effect N-methyl-N'-nitro-N-nitrosoguanidine]. 2004 Nov-Dec Mikrobiol. Z. pmid:15765867
Zhu HJ et al. [Effects of bkdAB interruption on avermectin biosynthesis]. 2004 Sheng Wu Gong Cheng Xue Bao pmid:15969120
Kuzmina TA et al. Analysis of the strongylid nematodes (Nematoda: Strongylidae) community after deworming of brood horses in Ukraine. 2005 Vet. Parasitol. pmid:15979240
Yong JH and Byeon WH Alternative production of avermectin components in Streptomyces avermitilis by gene replacement. 2005 J. Microbiol. pmid:15995647
Fisher MH and Mrozik H The chemistry and pharmacology of avermectins. 1992 Annu. Rev. Pharmacol. Toxicol. pmid:1605577
Orton CJ et al. Comparative effectiveness of avermectins and deltamethrin in suppressing oviposition in Lucilia cuprina (Diptera: Calliphoridae). 1992 J. Econ. Entomol. pmid:1607479
Bowen JM and Vitayavirasak B Contractile activity and motility responses of the dog heartworm Dirofilaria immitis to classical anthelmintics and other compounds. 2005 Vet. Parasitol. pmid:16076531
Novák J et al. Nitrogen regulation of fatty acids and avermectins biosynthesis in Streptomyces avermitilis. 1992 FEMS Microbiol. Lett. pmid:1612418
MacNeil DJ et al. Complex organization of the Streptomyces avermitilis genes encoding the avermectin polyketide synthase. 1992 Gene pmid:1612425
He J et al. Multiresidue analysis of avermectins in bovine liver by immunoaffinity column cleanup procedure and liquid chromatography with fluorescence detector. 2005 Jul-Aug J AOAC Int pmid:16152926
de Macedo DM et al. [Post-embrionic development of Stomoxys calcitrans (Linnaeus,1758) (Diptera: Muscidae)feed in feces of treated bovines with different avermectins]. 2005 Apr-Jun Rev Bras Parasitol Vet pmid:16153344
Erzen NK et al. Degradation of abamectin and doramectin on sheep grazed pasture. 2005 Ecotoxicology pmid:16215697
Jungmann V et al. Biocatalytic conversion of avermectin to 4"-oxo-avermectin: characterization of biocatalytically active bacterial strains and of cytochrome p450 monooxygenase enzymes and their genes. 2005 Appl. Environ. Microbiol. pmid:16269732