Avermectin A1a

Avermectin A1a is a lipid of Polyketides (PK) class. Avermectin a1a is associated with abnormalities such as Ataxia with vitamin E deficiency, Strongyloidiasis, Congenital Transposition, Gigantism and Onchocerciasis. The involved functions are known as DNA Binding, Anabolism, Insertion Mutation, Process and physiological aspects. Avermectin a1a often locates in Chromosomes, Membrane, Clone, soluble and Tissue membrane. The associated genes with Avermectin A1a are Polypeptides, oxytocin, 1-desamino-(O-Et-Tyr)(2)-, Gene Feature, Genome and Gene Clusters. The related lipids are Propionate. The related experimental models are Mouse Model.

Cross Reference

Introduction

To understand associated biological information of Avermectin A1a, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Avermectin A1a?

Avermectin A1a is suspected in Ataxia with vitamin E deficiency, Gigantism, Strongyloidiasis, Congenital Transposition, Onchocerciasis, Tropical Disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Avermectin A1a

MeSH term MeSH ID Detail
Inflammation D007249 119 associated lipids
Body Weight D001835 333 associated lipids
Dog Diseases D004283 5 associated lipids
Leukemia P388 D007941 43 associated lipids
Neuroblastoma D009447 66 associated lipids
Trichostrongyloidiasis D014252 7 associated lipids
Poisoning D011041 9 associated lipids
Cleft Palate D002972 9 associated lipids
Fish Diseases D005393 5 associated lipids
Neurotoxicity Syndromes D020258 34 associated lipids
Per page 10 20 | Total 19

PubChem Associated disorders and diseases

What pathways are associated with Avermectin A1a

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Avermectin A1a?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Avermectin A1a?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Avermectin A1a?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Avermectin A1a?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Avermectin A1a?

Mouse Model

Mouse Model are used in the study 'Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the gamma-aminobutyric acid(A) receptor.' (Dawson GR et al., 2000).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with Avermectin A1a

Download all related citations
Per page 10 20 50 100 | Total 477
Authors Title Published Journal PubMed Link
Yi Y et al. Effect of external resistance on the sensitivity of microbial fuel cell biosensor for detection of different types of pollutants. 2019 Bioelectrochemistry pmid:30273855
Rath S et al. Sorption behaviors of antimicrobial and antiparasitic veterinary drugs on subtropical soils. 2019 Chemosphere pmid:30261417
Zhang H et al. Preparation and Characterization of Controlled-Release Avermectin/Castor Oil-Based Polyurethane Nanoemulsions. 2018 J. Agric. Food Chem. pmid:28562041
Wang G et al. Development of Multifunctional Avermectin Poly(succinimide) Nanoparticles to Improve Bioactivity and Transportation in Rice. 2018 J. Agric. Food Chem. pmid:30299946
Merola VM and Eubig PA Toxicology of Avermectins and Milbemycins (Macrocyclic Lactones) and the Role of P-Glycoprotein in Dogs and Cats. 2018 Vet. Clin. North Am. Small Anim. Pract. pmid:30139545
Türkan F et al. The toxicological impact of some avermectins on human erythrocytes glutathione S-transferase enzyme. 2018 J. Biochem. Mol. Toxicol. pmid:30091233
Conforti S et al. Comparative effects of the parasiticide ivermectin on survival and reproduction of adult sepsid flies. 2018 Ecotoxicol. Environ. Saf. pmid:30055386
Guan W et al. Fabrication of an Effective Avermectin Nanoemulsion Using a Cleavable Succinic Ester Emulsifier. 2018 J. Agric. Food Chem. pmid:29976065
Dos Santos Moreira AM et al. Hydrophobic Nanoprecipitates of β-Cyclodextrin/Avermectins Inclusion Compounds Reveal Insecticide Activity against Aedes aegypti Larvae and Low Toxicity against Fibroblasts. 2018 J. Agric. Food Chem. pmid:29925239
Florez DHÂ et al. Pipette-tip solid-phase extraction using polypyrrole as efficient adsorbent for extraction of avermectins and milbemycins in milk. 2018 Anal Bioanal Chem pmid:29607449
Liang W et al. Chitosan-based nanoparticles of avermectin to control pine wood nematodes. 2018 Int. J. Biol. Macromol. pmid:29382581
Liang J et al. Bioinspired Development of P(St-MAA)-Avermectin Nanoparticles with High Affinity for Foliage To Enhance Folia Retention. 2018 J. Agric. Food Chem. pmid:28727420
Guan W et al. Fabrication of Novel Avermectin Nanoemulsion Using a Polyurethane Emulsifier with Cleavable Disulfide Bonds. 2018 J. Agric. Food Chem. pmid:28700229
Cui B et al. Characterization and evaluation of avermectin solid nanodispersion prepared by microprecipitation and lyophilisation techniques. 2018 PLoS ONE pmid:29360866
Li Y et al. Modified Lignin with Anionic Surfactant and Its Application in Controlled Release of Avermectin. 2018 J. Agric. Food Chem. pmid:29533641
Xu Z et al. From the Cover: Functional Analysis Reveals Glutamate and Gamma-Aminobutyric Acid-Gated Chloride Channels as Targets of Avermectins in the Carmine Spider Mite. 2017 Toxicol. Sci. pmid:27742867
Boukhrissa A et al. Study of the degradation in aqueous solution of a refractory organic compound: avermectin type used as pesticide in agriculture. 2017 Water Sci. Technol. pmid:29068328
Brownjohn PW et al. Phenotypic Screening Identifies Modulators of Amyloid Precursor Protein Processing in Human Stem Cell Models of Alzheimer's Disease. 2017 Stem Cell Reports pmid:28285880
Kim MS et al. Engineered biosynthesis of milbemycins in the avermectin high-producing strain Streptomyces avermitilis. 2017 Microb. Cell Fact. pmid:28095865
Mendes AM et al. Inhibition of Plasmodium Liver Infection by Ivermectin. 2017 Antimicrob. Agents Chemother. pmid:27895022
Cui Q et al. Avermectin biosynthesis: stable functional expression of branched chain α-keto acid dehydrogenase complex from Streptomyces avermitilis in Escherichia coli by selectively regulating individual subunit gene expression. 2017 Biotechnol. Lett. pmid:28664314
Zhang W et al. Determination of avermectins by the internal standard recovery correction - high performance liquid chromatography - quantitative Nuclear Magnetic Resonance method. 2017 Talanta pmid:28602306
Silva GRD et al. Multiresidue method for identification and quantification of avermectins, benzimidazoles and nitroimidazoles residues in bovine muscle tissue by ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) using a QuEChERS approach. 2017 Talanta pmid:28551144
Liu X et al. Redox-sensing regulator Rex regulates aerobic metabolism, morphological differentiation, and avermectin production in Streptomyces avermitilis. 2017 Sci Rep pmid:28303934
Zhao X et al. Pesticide-mediated interspecific competition between local and invasive thrips pests. 2017 Sci Rep pmid:28084404
Gao Q et al. Learn from microbial intelligence for avermectins overproduction. 2017 Curr. Opin. Biotechnol. pmid:29049952
Mermans C et al. A G326E substitution in the glutamate-gated chloride channel 3 (GluCl3) of the two-spotted spider mite Tetranychus urticae abolishes the agonistic activity of macrocyclic lactones. 2017 Pest Manag. Sci. pmid:28736919
Suroto DA et al. Activation of cryptic phthoxazolin A production in Streptomyces avermitilis by the disruption of autoregulator-receptor homologue AvaR3. 2017 J. Biosci. Bioeng. pmid:28728974
Falkenberg LJ et al. Low sensitivity of reproductive life-stages in the Pacific oyster (Crassostrea gigas) to abamectin. 2017 Chemosphere pmid:28528312
Zhang Y et al. New Avermectin Analogues from a Mutant Streptomyces avermectinius Strain. 2017 Chem. Biodivers. pmid:28387012
Wang YS et al. A spectrophotometric screening method for avermectin oxidizing microorganisms. 2017 J. Microbiol. Methods pmid:28215961
Liu C et al. Avermectin induced global DNA hypomethylation and over-expression of heat shock proteins in cardiac tissues of pigeon. 2017 Pestic Biochem Physiol pmid:28043331
Tian P et al. Comparative metabolomics reveals the mechanism of avermectin production enhancement by S-adenosylmethionine. 2017 J. Ind. Microbiol. Biotechnol. pmid:27988821
Iwai Y Anecdote of the ÅŒmura laboratory and the discovery of avermectin. 2017 Biosci. Biotechnol. Biochem. pmid:27885935
Takahashi Y Continuing fascination of exploration in natural substances from microorganisms. 2017 Biosci. Biotechnol. Biochem. pmid:27885930
Hotta K Epoch-making milestones in antibiotic exploratory researches in Japan. 2017 Biosci. Biotechnol. Biochem. pmid:27885928
You X et al. Preparation of magnetic molecularly imprinted polymers by atom transfer radical polymerization for the rapid extraction of avermectin from fish samples. 2017 J Sep Sci pmid:27860252
Zhang Y et al. Cytotoxic effects of Avermectin on human HepG2 cells in vitro bioassays. 2017 Environ. Pollut. pmid:27852506
Ohba M et al. Antiviral effect of theaflavins against caliciviruses. 2017 J. Antibiot. pmid:27756911
Li M et al. Effects of in vitro and in vivo avermectin exposure on alpha synuclein expression and proteasomal activity in pigeons. 2017 Ecotoxicol. Environ. Saf. pmid:27677079
Wang XS et al. Autophagy response in the liver of pigeon exposed to avermectin. 2017 Environ Sci Pollut Res Int pmid:26886445
Qin Y et al. Analysis of sulfonamides, tilmicosin and avermectins residues in typical animal matrices with multi-plug filtration cleanup by liquid chromatography-tandem mass spectrometry detection. 2017 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:28410479
Chen LP et al. Direct interaction of avermectin with epidermal growth factor receptor mediates the penetration resistance in Drosophila larvae. 2016 Open Biol pmid:27249340
Li Y et al. Preparation, Characterization, and Insecticidal Activity of Avermectin-Grafted-Carboxymethyl Chitosan. 2016 Biomed Res Int pmid:27213156
Godoy P et al. Characterisation of P-glycoprotein-9.1 in Haemonchus contortus. 2016 Parasit Vectors pmid:26822677
Sultan SP et al. Characterization of AvaR1, a butenolide-autoregulator receptor for biosynthesis of a Streptomyces hormone in Streptomyces avermitilis. 2016 Appl. Microbiol. Biotechnol. pmid:27541747
Zhu J et al. AvaR2, a pseudo γ-butyrolactone receptor homologue from Streptomyces avermitilis, is a pleiotropic repressor of avermectin and avenolide biosynthesis and cell growth. 2016 Mol. Microbiol. pmid:27502190
Guo J et al. Raising the avermectins production in Streptomyces avermitilis by utilizing nanosecond pulsed electric fields (nsPEFs). 2016 Sci Rep pmid:27181521
Sun D et al. SAV742, a Novel AraC-Family Regulator from Streptomyces avermitilis, Controls Avermectin Biosynthesis, Cell Growth and Development. 2016 Sci Rep pmid:27841302
He JM et al. Direct Involvement of the Master Nitrogen Metabolism Regulator GlnR in Antibiotic Biosynthesis in Streptomyces. 2016 J. Biol. Chem. pmid:27875313
de Oliveira Ferreira F et al. On-line solid-phase extraction-ultra high performance liquid chromatography-tandem mass spectrometry for the determination of avermectins and milbemycin in soils. 2016 J Chromatogr A pmid:27745927
Zhang Y et al. Avermectin Confers Its Cytotoxic Effects by Inducing DNA Damage and Mitochondria-Associated Apoptosis. 2016 J. Agric. Food Chem. pmid:27551889
Tomilova OG et al. Immune-physiological aspects of synergy between avermectins and the entomopathogenic fungus Metarhizium robertsii in Colorado potato beetle larvae. 2016 J. Invertebr. Pathol. pmid:27546865
Meng L et al. Enhanced production of avermectin by deletion of type III polyketide synthases biosynthetic cluster rpp in Streptomyces avermitilis. 2016 Lett. Appl. Microbiol. pmid:27538855
Lemos MA et al. Development, validation, and application of a method for selected avermectin determination in rural waters using high performance liquid chromatography and fluorescence detection. 2016 Ecotoxicol. Environ. Saf. pmid:27513222
Zhang J et al. Synthesis, biological activities and structure-activity relationships for new avermectin analogues. 2016 Eur J Med Chem pmid:27318119
Dos Anjos MR et al. Multiresidue method for simultaneous analysis of aflatoxin M1, avermectins, organophosphate pesticides and milbemycin in milk by ultra-performance liquid chromatography coupled to tandem mass spectrometry. 2016 Food Addit Contam Part A Chem Anal Control Expo Risk Assess pmid:27144891
Chen J et al. Different fates of avermectin and artemisinin in China. 2016 Sci China Life Sci pmid:27132020
Del Giudice P [Nobel prize for ivermectin]. 2016 Ann Dermatol Venereol pmid:27016202
Lewin H and Roberts M Introduction. 2016 Annu Rev Anim Biosci pmid:26884105
Baltz RH et al. Introduction to the Special Issue: "Natural Product Discovery and Development in the Genomic Era". 2016 J. Ind. Microbiol. Biotechnol. pmid:26660315
Li D et al. Preparation of uniform starch microcapsules by premix membrane emulsion for controlled release of avermectin. 2016 Carbohydr Polym pmid:26572364
Tatsuta K Celebrating the 2015 Nobel Prize in Physiology or Medicine of Dr Satoshi ÅŒmura. 2016 J. Antibiot. pmid:26486878
Zhao Y et al. Isolation, characterization, and tissue-specific expression of GABA A receptor α1 subunit gene of Carassius auratus gibelio after avermectin treatment. 2016 Fish Physiol. Biochem. pmid:26318443
Kose LP et al. The effects of some avermectins on bovine carbonic anhydrase enzyme. 2016 J Enzyme Inhib Med Chem pmid:26207514
Hopwood DA Satoshi ÅŒmura. 2016 J. Ind. Microbiol. Biotechnol. pmid:26186906
Wenjie W et al. Nystagmus following acute avermectins poisoning. 2016 Toxicol Ind Health pmid:24280654
Długońska H The Nobel Prize 2015 in physiology or medicine for highly effective antiparasitic drugs. 2015 Ann Parasitol pmid:26878630
Tambo E et al. Nobel prize for the artemisinin and ivermectin discoveries: a great boost towards elimination of the global infectious diseases of poverty. 2015 Infect Dis Poverty pmid:26708575
Shen B A New Golden Age of Natural Products Drug Discovery. 2015 Cell pmid:26638061
Jin L et al. Selective targeting of nuclear receptor FXR by avermectin analogues with therapeutic effects on nonalcoholic fatty liver disease. 2015 Sci Rep pmid:26620317
Zhang J et al. Designed biosynthesis of 25-methyl and 25-ethyl ivermectin with enhanced insecticidal activity by domain swap of avermectin polyketide synthase. 2015 Microb. Cell Fact. pmid:26400541
Godinez O et al. Targeting the Osmotic Stress Response for Strain Improvement of an Industrial Producer of Secondary Metabolites. 2015 J. Microbiol. Biotechnol. pmid:26139611
Kwon YJ et al. Selective Inhibition of SIN3 Corepressor with Avermectins as a Novel Therapeutic Strategy in Triple-Negative Breast Cancer. 2015 Mol. Cancer Ther. pmid:26078298
Huang J et al. Gene Replacement for the Generation of Designed Novel Avermectin Derivatives with Enhanced Acaricidal and Nematicidal Activities. 2015 Appl. Environ. Microbiol. pmid:26025902
Liu W et al. Increasing Avermectin Production in Streptomyces avermitilis by Manipulating the Expression of a Novel TetR-Family Regulator and Its Target Gene Product. 2015 Appl. Environ. Microbiol. pmid:26002902
Meyers JI et al. Mosquitocidal properties of IgG targeting the glutamate-gated chloride channel in three mosquito disease vectors (Diptera: Culicidae). 2015 J. Exp. Biol. pmid:25994632
Omansen TF et al. In-vitro activity of avermectins against Mycobacterium ulcerans. 2015 PLoS Negl Trop Dis pmid:25742173
Wang F et al. Structural and functional analysis of the loading acyltransferase from avermectin modular polyketide synthase. 2015 ACS Chem. Biol. pmid:25581064
Efferth T et al. Nobel Prize for artemisinin brings phytotherapy into the spotlight. 2015 Phytomedicine pmid:26563851
Molyneux DH and Ward SA Reflections on the Nobel Prize for Medicine 2015--The Public Health Legacy and Impact of Avermectin and Artemisinin. 2015 Trends Parasitol. pmid:26552892
Liu C et al. Avermectin induced autophagy in pigeon spleen tissues. 2015 Chem. Biol. Interact. pmid:26541719
Boden R Editorial: on artemisinin, avermectins and Nobel Prizes. 2015 FEMS Microbiol. Lett. pmid:26486159
Owens B 2015 Nobel Prize goes to antiparasitic drug discoverers. 2015 Lancet pmid:26466031
Agbedanu PN et al. Doxycycline as an inhibitor of p-glycoprotein in the alpaca for the purpose of maintaining avermectins in the CNS during treatment for parelaphostrongylosis. 2015 Vet. Parasitol. pmid:26371853
Yang R et al. The PhoP transcription factor negatively regulates avermectin biosynthesis in Streptomyces avermitilis. 2015 Appl. Microbiol. Biotechnol. pmid:26298701
Dalzell AM et al. Characterization of multidrug transporter-mediated efflux of avermectins in human and mouse neuroblastoma cell lines. 2015 Toxicol. Lett. pmid:25865432
Li X et al. Fast and Online Determination of Five Avermectin Residues in Foodstuffs of Plant and Animal Origin Using Reusable Polymeric Monolithic Extractor Coupled with LC-MS/MS. 2015 J. Agric. Food Chem. pmid:25865176
Rúbies A et al. Determination of avermectins: a QuEChERS approach to the analysis of food samples. 2015 Food Chem pmid:25794721
Li D et al. Synergistic effect of non-ionic surfactants Tween 80 and PEG6000 on cytotoxicity of insecticides. 2015 Environ. Toxicol. Pharmacol. pmid:25699500
Chen C et al. The synergistic toxicity of the multiple chemical mixtures: implications for risk assessment in the terrestrial environment. 2015 Environ Int pmid:25667058
Sun P et al. 1,19-seco-Avermectin analogues from a ΔaveCDE mutant Streptomyces avermectinius strain. 2015 J. Nat. Prod. pmid:25611131
Woerde DJ et al. Susceptibility of rapidly growing mycobacteria isolated from Australian cats to ivermectin, moxidectin, ceftiofur and florfenicol. 2015 J. Feline Med. Surg. pmid:25572306
Qu J et al. Autophagy is upregulated in brain tissues of pigeons exposed to avermectin. 2015 Ecotoxicol. Environ. Saf. pmid:25497772
Wang Y et al. Ternary toxicological interactions of insecticides, herbicides, and a heavy metal on the earthworm Eisenia fetida. 2015 J. Hazard. Mater. pmid:25463238
Zou CS et al. Purification, characterization, and sensitivity to pesticides of carboxylesterase from Dendrolimus superans (Lepidoptera: Lasiocampidae). 2014 J. Insect Sci. pmid:25525114
Liu C et al. Effects of avermectin on heat shock proteins expression and histopathology in spleen tissues of pigeon. 2014 Chem. Biol. Interact. pmid:25446859
Jia X et al. Adhesive polydopamine coated avermectin microcapsules for prolonging foliar pesticide retention. 2014 ACS Appl Mater Interfaces pmid:25390545
Li M et al. The change in heat shock protein expression in avermectin induced neurotoxicity of the pigeon (Columba livia) both in vivo and in vitro. 2014 Ecotoxicol. Environ. Saf. pmid:25202854
Zhu WJ et al. Effects of avermectin on microsomal cytochrome P450 enzymes in the liver and kidneys of pigeons. 2014 Environ. Toxicol. Pharmacol. pmid:25194326