| MeSH term | MeSH ID | Detail |
|---|---|---|
| Inflammation | D007249 | 119 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Dog Diseases | D004283 | 5 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Trichostrongyloidiasis | D014252 | 7 associated lipids |
| Poisoning | D011041 | 9 associated lipids |
| Cleft Palate | D002972 | 9 associated lipids |
| Fish Diseases | D005393 | 5 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
Avermectin A1a
Avermectin A1a is a lipid of Polyketides (PK) class. Avermectin a1a is associated with abnormalities such as Ataxia with vitamin E deficiency, Strongyloidiasis, Congenital Transposition, Gigantism and Onchocerciasis. The involved functions are known as DNA Binding, Anabolism, Insertion Mutation, Process and physiological aspects. Avermectin a1a often locates in Chromosomes, Membrane, Clone, soluble and Tissue membrane. The associated genes with Avermectin A1a are Polypeptides, oxytocin, 1-desamino-(O-Et-Tyr)(2)-, Gene Feature, Genome and Gene Clusters. The related lipids are Propionate. The related experimental models are Mouse Model.
Cross Reference
Introduction
To understand associated biological information of Avermectin A1a, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Avermectin A1a?
Avermectin A1a is suspected in Ataxia with vitamin E deficiency, Gigantism, Strongyloidiasis, Congenital Transposition, Onchocerciasis, Tropical Disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Avermectin A1a
PubChem Associated disorders and diseases
What pathways are associated with Avermectin A1a
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Avermectin A1a?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Avermectin A1a?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Avermectin A1a?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Avermectin A1a?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Avermectin A1a?
Mouse Model
Mouse Model are used in the study 'Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the gamma-aminobutyric acid(A) receptor.' (Dawson GR et al., 2000).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Avermectin A1a
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Sangster NC et al. | Haemonchus contortus: sequence heterogeneity of internucleotide binding domains from P-glycoproteins. | 1999 | Exp. Parasitol. | pmid:10072327 |
| Turnipseed SB et al. | Confirmation of avermectin residues in food matrices with negative-ion atmospheric pressure chemical ionization liquid chromatography/mass spectrometry. | 1999 | Rapid Commun. Mass Spectrom. | pmid:10204245 |
| Sangster NC and Gill J | Pharmacology of anthelmintic resistance. | 1999 | Parasitol. Today (Regul. Ed.) | pmid:10322335 |
| Gopal RM et al. | Resistance of field isolates of Trichostrongylus colubriformis and Ostertagia circumcincta to ivermectin. | 1999 | Int. J. Parasitol. | pmid:10404276 |
| Mosin VA et al. | [Action of avermectins on lymphoid leukemia P-388 cells in vitro]. | 1999 | Antibiot. Khimioter. | pmid:10422573 |
| Roudaut B | Multiresidue method for the determination of avermectin and moxidectin residues in the liver using HPLC with fluorescence detection. | 1998 | Analyst | pmid:10435295 |
| Ikeda H et al. | Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10449723 |
| Geary TG et al. | Frontiers in anthelmintic pharmacology. | 1999 | Vet. Parasitol. | pmid:10456419 |
| Sangster NC | Pharmacology of anthelmintic resistance in cyathostomes: will it occur with the avermectin/milbemycins? | 1999 | Vet. Parasitol. | pmid:10485365 |
| Novik TS et al. | [Assessment of the mutagenic activity of aversectin C]. | 1999 | Antibiot. Khimioter. | pmid:10494378 |
| Zhang YX et al. | Genes encoding acyl-CoA dehydrogenase (AcdH) homologues from Streptomyces coelicolor and Streptomyces avermitilis provide insights into the metabolism of small branched-chain fatty acids and macrolide antibiotic production. | 1999 | Microbiology (Reading, Engl.) | pmid:10517585 |
| Smit JW et al. | Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure. | 1999 | J. Clin. Invest. | pmid:10562306 |
| Le Jambre LF et al. | Inheritance of avermectin resistance in Haemonchus contortus. | 2000 | Int. J. Parasitol. | pmid:10675751 |
| Kokoz YM et al. | Selective cytostatic and neurotoxic effects of avermectins and activation of the GABAalpha receptors. | 1999 | Biosci. Rep. | pmid:10841270 |
| Gianelli L et al. | Mass spectrometry of avermectins: structural determination of two new derivatives of Ivermectin B(1a). | 2000 | Rapid Commun. Mass Spectrom. | pmid:10918377 |
| Novotny MJ et al. | Safety of selamectin in dogs. | 2000 | Vet. Parasitol. | pmid:10940536 |
| Krautmann MJ et al. | Safety of selamectin in cats. | 2000 | Vet. Parasitol. | pmid:10940537 |
| Tsukamoto Y et al. | Avermectin chemistry and action: ester- and ether-type candidate photoaffinity probes. | 2000 | Bioorg. Med. Chem. | pmid:10968260 |
| Banks BJ et al. | Avermectins and flea control: structure-activity relationships and the selection of selamectin for development as an endectocide for companion animals. | 2000 | Bioorg. Med. Chem. | pmid:11003146 |
| Dawson GR et al. | Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the gamma-aminobutyric acid(A) receptor. | 2000 | J. Pharmacol. Exp. Ther. | pmid:11082440 |
| Hoste H et al. | A questionnaire survey on the practices adopted to control gastrointestinal nematode parasitism in dairy goat farms in France. | 2000 | Vet. Res. Commun. | pmid:11085466 |
| Jacobson M et al. | Elimination of Sarcoptes scabiei in pig herds by single or double administrations of an avermectin. | 2000 | Acta Vet. Scand. | pmid:11126572 |
| Mosin VA et al. | [Cytotoxic and cytostatic effect of avermectines on tumor cells in vitro]. | 2000 | Antibiot. Khimioter. | pmid:11212393 |
| Howells L and Sauer MJ | Multi-residue analysis of avermectins and moxidectin by ion-trap LC-MSn. | 2001 | Analyst | pmid:11235096 |
| Young KE et al. | Evaluation of anthelmintic activity in captive wild ruminants by fecal egg reduction tests and a larval development assay. | 2000 | J. Zoo Wildl. Med. | pmid:11237142 |
| Shao Y et al. | [Determination of avermictin in avermictin tablet by high performance liquid chromatography]. | 1998 | Se Pu | pmid:11324492 |
| Barnes EH et al. | Selection of different genotype larvae and adult worms for anthelmintic resistance by persistent and short-acting avermectin/milbemycins. | 2001 | Int. J. Parasitol. | pmid:11336754 |
| Ikeda H | [Genetic analysis of biosynthesis of polyketide compound in Streptomyces avermitilis]. | 2001 | Jpn J Antibiot | pmid:11392681 |
| Wu Z et al. | Multi-residue analysis of avermectins in swine liver by immunoaffinity extraction and liquid chromatography-mass spectrometry. | 2001 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:11393726 |
| Danaher M et al. | Development and optimisation of an improved derivatisation procedure for the determination of avermectins and milbemycins in bovine liver. | 2001 | Analyst | pmid:11394296 |
| Köhler P | The biochemical basis of anthelmintic action and resistance. | 2001 | Int. J. Parasitol. | pmid:11400692 |
| Valenzuela AI et al. | Comparison of various liquid chromatographic methods for the analysis of avermectin residues in citrus fruits. | 2001 | J Chromatogr A | pmid:11403456 |
| Drinyaev VA et al. | Effect of avermectins on Ca2+-dependent Cl- currents in plasmalemma of Chara corallina cells. | 2001 | J. Membr. Biol. | pmid:11426301 |
| Wohlert S et al. | Insights about the biosynthesis of the avermectin deoxysugar L-oleandrose through heterologous expression of Streptomyces avermitilis deoxysugar genes in Streptomyces lividans. | 2001 | Chem. Biol. | pmid:11451669 |
| Swarnkar CP et al. | Anthelmintic resistance on an organized sheep farm in India. | 2001 | Trop Anim Health Prod | pmid:11474864 |
| Zakson-Aiken M et al. | Systemic activity of the avermectins against the cat flea (Siphonaptera: Pulicidae). | 2001 | J. Med. Entomol. | pmid:11476339 |
| Anziani OS et al. | Avermectin resistance in Cooperia pectinata in cattle in Argentina. | 2001 | Vet. Rec. | pmid:11488345 |
| Martins JR and Furlong J | Avermectin resistance of the cattle tick Boophilus microplus in Brazil. | 2001 | Vet. Rec. | pmid:11488352 |
| Novik TS et al. | [Acute toxicity of aversectin C : various routes of administration and dosage forms]. | 2001 Mar-Apr | Eksp Klin Farmakol | pmid:11548452 |
| Driniaev VA et al. | [Selective cytostatic and cytotoxic effects of avermectins]. | 2001 | Antibiot. Khimioter. | pmid:11558448 |
| Driniaev VA et al. | [Effect of avermectns on Ca(2+)-dependent chloride currents in plasmalemma of Chara corallina cells]. | 2001 | Antibiot. Khimioter. | pmid:11558454 |
| Danaher M et al. | Extraction and isolation of avermectins and milbemycins from liver samples using unmodified supercritical CO2 with in-line trapping on basic alumina. | 2001 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:11585125 |
| Ikeda H et al. | Organization of biosynthetic gene cluster for avermectin in Streptomyces avermitilis: analysis of enzymatic domains in four polyketide synthases. | 2001 | J. Ind. Microbiol. Biotechnol. | pmid:11780788 |
| Sha CK et al. | Anionic cyclization approach toward perhydrobenzofuranone: stereocontrolled synthesis of the hexahydrobenzofuran subunit of avermectin. | 2002 | J. Org. Chem. | pmid:11856026 |
| Miakisheva SN et al. | [Proliferation and morphological differentiation of neurblastoma cells in cultured under the effect of avermectins]. | 2001 | Morfologiia | pmid:12016760 |
| Veale PI | Resistance to macrocyclic lactones in nematodes of goats. | 2002 | Aust. Vet. J. | pmid:12074315 |
| Deger Y et al. | Short communication serum copper, zinc, and calcium concentrations in lice-infested sheep. | 2002 | Biol Trace Elem Res | pmid:12117268 |
| Rehbein S et al. | Efficacy of a new long-acting formulation of ivermectin and other injectable avermectins against induced Psoroptes ovis infestations in cattle. | 2002 | Parasitol. Res. | pmid:12444456 |
| Kim SB and Goodfellow M | Streptomyces avermitilis sp. nov., nom. rev., a taxonomic home for the avermectin-producing streptomycetes. | 2002 | Int. J. Syst. Evol. Microbiol. | pmid:12508861 |