| MeSH term | MeSH ID | Detail |
|---|---|---|
| Inflammation | D007249 | 119 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Dog Diseases | D004283 | 5 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Trichostrongyloidiasis | D014252 | 7 associated lipids |
| Poisoning | D011041 | 9 associated lipids |
| Cleft Palate | D002972 | 9 associated lipids |
| Fish Diseases | D005393 | 5 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
Avermectin A1a
Avermectin A1a is a lipid of Polyketides (PK) class. Avermectin a1a is associated with abnormalities such as Ataxia with vitamin E deficiency, Strongyloidiasis, Congenital Transposition, Gigantism and Onchocerciasis. The involved functions are known as DNA Binding, Anabolism, Insertion Mutation, Process and physiological aspects. Avermectin a1a often locates in Chromosomes, Membrane, Clone, soluble and Tissue membrane. The associated genes with Avermectin A1a are Polypeptides, oxytocin, 1-desamino-(O-Et-Tyr)(2)-, Gene Feature, Genome and Gene Clusters. The related lipids are Propionate. The related experimental models are Mouse Model.
Cross Reference
Introduction
To understand associated biological information of Avermectin A1a, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Avermectin A1a?
Avermectin A1a is suspected in Ataxia with vitamin E deficiency, Gigantism, Strongyloidiasis, Congenital Transposition, Onchocerciasis, Tropical Disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Avermectin A1a
PubChem Associated disorders and diseases
What pathways are associated with Avermectin A1a
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Avermectin A1a?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Avermectin A1a?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Avermectin A1a?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Avermectin A1a?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Avermectin A1a?
Mouse Model
Mouse Model are used in the study 'Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the gamma-aminobutyric acid(A) receptor.' (Dawson GR et al., 2000).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Avermectin A1a
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Wilkins CA et al. | Treatment of psoroptic mange with avermectins. | 1980 | Am. J. Vet. Res. | pmid:7212445 |
| James PS et al. | Insecticidal activity of the avermectins. | 1980 | Vet. Rec. | pmid:7361432 |
| Tolan JW et al. | Determination of avermectins in plasma at nanogram levels using high-performance liquid chromatography with fluorescence detection. | 1980 | J. Chromatogr. | pmid:7380953 |
| Ostlind DA and Cifelli S | Efficacy of thiabendazole, levamisole hydrochloride and the major natural avermectins against Trichostrongylus colubriformis in the gerbil (Meriones unguiculatus). | 1981 | Res. Vet. Sci. | pmid:7323472 |
| Campbell WC | An introduction to the avermectins. | 1981 | N Z Vet J | pmid:7038568 |
| Bowen JM | The avermectin complex: a new horizon in anthelmintic therapy. | 1981 | Vet Med Small Anim Clin | pmid:6908751 |
| Williams M and Risley EA | Interaction of avermectins with [3H]beta-carboline-3-carboxylate ethyl ester and [3H]diazepam binding sites in rat brain cortical membranes. | 1982 | Eur. J. Pharmacol. | pmid:6277673 |
| Denham DA | The effects of some avermectins on the growth of Brugia pahangi. | 1982 | Methods Find Exp Clin Pharmacol | pmid:7121142 |
| Miwa GT et al. | The metabolism of avermectins B1a, H2B1a, and H2B1b by liver microsomes. | 1982 May-Jun | Drug Metab. Dispos. | pmid:6125361 |
| Pivnichny JV et al. | Direct determination of avermectins in plasma at nanogram levels by high-performance liquid chromatography. | 1983 | J Pharm Sci | pmid:6663483 |
| Drexler G and Sieghart W | Evidence for association of a high affinity avermectin binding site with the benzodiazepine receptor. | 1984 | Eur. J. Pharmacol. | pmid:6088254 |
| Kass IS et al. | The effects of avermectin and drugs related to acetylcholine and 4-aminobutyric acid on neurotransmission in Ascaris suum. | 1984 | Mol. Biochem. Parasitol. | pmid:6096713 |
| Drexler G and Sieghart W | [35S]tert.-butylbicyclophosphorothionate and avermectin bind to different sites associated with the gamma- aminobutyric acid-benzodiazepine receptor complex. | 1984 | Neurosci. Lett. | pmid:6093013 |
| Calcott PH and Fatig RO | Inhibition of chitin metabolism by avermectin in susceptible organisms. | 1984 | J. Antibiot. | pmid:6725140 |
| Goodwin LG | Recent advances in research on filariasis. Chemotherapy. | 1984 | Trans. R. Soc. Trop. Med. Hyg. | pmid:6382706 |
| Parrish MD and Roberts RB | Toxicity of avermectin B1 to larval yellowjackets, Vespula maculifrons (Hymenoptera: Vespidae). | 1984 | J. Econ. Entomol. | pmid:6480980 |
| Calcott PH and Fatig RO | Avermectin modulation of GABA binding to membranes of rat brain, brine shrimp and a fungus, Mucor miehei. | 1984 | J. Antibiot. | pmid:6088460 |
| BronshteÄn AM | [Praziquantel and other current preparations and chemotherapy methods in human trematodiases of the liver (opisthorchiasis and clonorchiasis) (a review of the literature)]. | 1984 Nov-Dec | Med Parazitol (Mosk) | pmid:6397686 |
| Onishi JC and Miller TW | The lack of antifungal activity by avermectin B1a. | 1985 | J. Antibiot. | pmid:4077735 |
| Schulman MD et al. | Demethylavermectins. Biosynthesis, isolation and characterization. | 1985 | J. Antibiot. | pmid:4077729 |
| Greene J and Goldberg RB | Isolation and preliminary characterization of lytic and lysogenic phages with wide host range within the streptomycetes. | 1985 | J. Gen. Microbiol. | pmid:2999304 |
| Chalmers AE et al. | The actions of avermectin on crayfish nerve and muscle. | 1986 | Eur. J. Pharmacol. | pmid:2430816 |
| Schulman MD et al. | Avermectin B2 O-methyltransferase activity in "Streptomyces avermitilis" mutants that produce increased amounts of the avermectins. | 1986 | Antimicrob. Agents Chemother. | pmid:3707112 |
| Campbell WC | The chemotherapy of parasitic infections. | 1986 | J. Parasitol. | pmid:3519918 |
| Davies HG and Green RH | Avermectins and milbemycins. | 1986 | Nat Prod Rep | pmid:3526202 |
| Marriner S | Anthelmintic drugs. | 1986 | Vet. Rec. | pmid:3962132 |
| Schulman MD et al. | Biosynthesis of the avermectins by Streptomyces avermitilis. Incorporation of labeled precursors. | 1986 | J. Antibiot. | pmid:3086265 |
| Seaman JT et al. | Avermectin B1 toxicity in a herd of Murray Grey cattle. | 1987 | Aust. Vet. J. | pmid:3426470 |
| Wright DJ | Avermectins: action on target pest species. | 1987 | Biochem. Soc. Trans. | pmid:2435585 |
| Gordnier PM et al. | Chitin metabolism: not a target of avermectin/milbemycin activity in insects. | 1987 | J. Antibiot. | pmid:2951358 |
| Ikeda H et al. | Genetic studies of avermectin biosynthesis in Streptomyces avermitilis. | 1987 | J. Bacteriol. | pmid:3680172 |
| Schulman MD et al. | "Streptomyces avermitilis" mutants defective in methylation of avermectins. | 1987 | Antimicrob. Agents Chemother. | pmid:3606074 |
| Matsumoto K et al. | Actions of avermectins on cultured neurons. | 1988 | Gen. Pharmacol. | pmid:3044917 |
| Ikeda H et al. | Involvement of glucose catabolism in avermectin production by Streptomyces avermitilis. | 1988 | Antimicrob. Agents Chemother. | pmid:3364948 |
| De Chaneet GC et al. | Effect of avermectin B1 and benzimidazole anthelmintics on worm egg output of treated cattle. | 1988 | Aust. Vet. J. | pmid:3401149 |
| Button C et al. | Avermectin toxicity in calves and an evaluation of picrotoxin as an antidote. | 1988 | Aust. Vet. J. | pmid:3401165 |
| Chang V | Toxic baiting of the Western yellowjacket (Hymenoptera: Vespidae) in Hawaii. | 1988 | J. Econ. Entomol. | pmid:3351079 |
| Ammendola D et al. | Anticonvulsant effects of avermectin in DBA/2 mice and rat. | 1988 | Exp Biol | pmid:3268424 |
| Curdová E et al. | The effect of inorganic phosphate on the production of avermectin in Streptomyces avermitilis. | 1989 | J. Basic Microbiol. | pmid:2614673 |
| Robertson B | Actions of anaesthetics and avermectin on GABAA chloride channels in mammalian dorsal root ganglion neurones. | 1989 | Br. J. Pharmacol. | pmid:2478243 |
| Chen TS and Inamine ES | Studies on the biosynthesis of avermectins. | 1989 | Arch. Biochem. Biophys. | pmid:2705778 |
| Blizzard TA et al. | Brine shrimp (Artemia salina) as a convenient bioassay for avermectin analogs. | 1989 | J. Antibiot. | pmid:2759912 |
| Schaeffer JM et al. | A chemiluminescent assay for measuring avermectin binding sites. | 1989 | Anal. Biochem. | pmid:2729548 |
| Chen TS et al. | Directed biosynthesis of avermectins. | 1989 | Arch. Biochem. Biophys. | pmid:2919882 |
| Schulman MD et al. | Purification and identification of dTDP-oleandrose, the precursor of the oleandrose units of the avermectins. | 1990 | J. Biol. Chem. | pmid:2211601 |
| MalanÃková M et al. | Use of thin-layer chromatography for the testing of avermectins produced by Streptomyces avermitilis strains. | 1990 | J. Chromatogr. | pmid:2229244 |
| Holden-Dye L and Walker RJ | Avermectin and avermectin derivatives are antagonists at the 4-aminobutyric acid (GABA) receptor on the somatic muscle cells of Ascaris; is this the site of anthelmintic action? | 1990 | Parasitology | pmid:2175874 |
| Chartrain M et al. | Bioconversion of avermectin into 27-OH avermectin. | 1990 | J. Ind. Microbiol. | pmid:1366995 |
| Arena JP et al. | Avermectin-sensitive chloride currents induced by Caenorhabditis elegans RNA in Xenopus oocytes. | 1991 | Mol. Pharmacol. | pmid:1716730 |