| MeSH term | MeSH ID | Detail |
|---|---|---|
| Inflammation | D007249 | 119 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Dog Diseases | D004283 | 5 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Trichostrongyloidiasis | D014252 | 7 associated lipids |
| Poisoning | D011041 | 9 associated lipids |
| Cleft Palate | D002972 | 9 associated lipids |
| Fish Diseases | D005393 | 5 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
Avermectin A1a
Avermectin A1a is a lipid of Polyketides (PK) class. Avermectin a1a is associated with abnormalities such as Ataxia with vitamin E deficiency, Strongyloidiasis, Congenital Transposition, Gigantism and Onchocerciasis. The involved functions are known as DNA Binding, Anabolism, Insertion Mutation, Process and physiological aspects. Avermectin a1a often locates in Chromosomes, Membrane, Clone, soluble and Tissue membrane. The associated genes with Avermectin A1a are Polypeptides, oxytocin, 1-desamino-(O-Et-Tyr)(2)-, Gene Feature, Genome and Gene Clusters. The related lipids are Propionate. The related experimental models are Mouse Model.
Cross Reference
Introduction
To understand associated biological information of Avermectin A1a, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Avermectin A1a?
Avermectin A1a is suspected in Ataxia with vitamin E deficiency, Gigantism, Strongyloidiasis, Congenital Transposition, Onchocerciasis, Tropical Disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Avermectin A1a
PubChem Associated disorders and diseases
What pathways are associated with Avermectin A1a
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Avermectin A1a?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Avermectin A1a?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Avermectin A1a?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Avermectin A1a?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Avermectin A1a?
Mouse Model
Mouse Model are used in the study 'Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the gamma-aminobutyric acid(A) receptor.' (Dawson GR et al., 2000).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Avermectin A1a
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Le Jambre LF et al. | Characterisation of an avermectin resistant strain of Australian Haemonchus contortus. | 1995 | Int. J. Parasitol. | pmid:7657454 |
| Ikeda H and Omura S | Control of avermectin biosynthesis in Streptomyces avermitilis for the selective production of a useful component. | 1995 | J. Antibiot. | pmid:7649850 |
| Arena JP et al. | The mechanism of action of avermectins in Caenorhabditis elegans: correlation between activation of glutamate-sensitive chloride current, membrane binding, and biological activity. | 1995 | J. Parasitol. | pmid:7707209 |
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| Venkatachalam MA et al. | Cytoprotection of kidney epithelial cells by compounds that target amino acid gated chloride channels. | 1996 | Kidney Int. | pmid:8821829 |
| Vercruysse J and Claerebout E | Effect of chemoprophylaxis on immunity to gastrointestinal nematodes in cattle. | 1996 | Verh. K. Acad. Geneeskd. Belg. | pmid:8701602 |
| Cully DF et al. | Identification of a Drosophila melanogaster glutamate-gated chloride channel sensitive to the antiparasitic agent avermectin. | 1996 | J. Biol. Chem. | pmid:8702744 |
| Nari A et al. | The prevalence of anthelmintic resistance in nematode parasites of sheep in southern Latin America: Uruguay. | 1996 | Vet. Parasitol. | pmid:8686167 |
| Löwenstein M et al. | Histology of the skin and determination of blood and serum parameters during the recovery phase of sarcoptic manage in cattle after avermectin (Ivomec) treatment. | 1996 | Appl. Parasitol. | pmid:8688864 |
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| Vassilatis DK et al. | Genetic and biochemical evidence for a novel avermectin-sensitive chloride channel in Caenorhabditis elegans. Isolation and characterization. | 1997 | J. Biol. Chem. | pmid:9407104 |
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| Ikeda H et al. | Cloning of the gene encoding avermectin B 5-O-methyltransferase in avermectin-producing Streptomyces avermitilis. | 1998 | Gene | pmid:9469930 |
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| Zhang YX et al. | Genes encoding acyl-CoA dehydrogenase (AcdH) homologues from Streptomyces coelicolor and Streptomyces avermitilis provide insights into the metabolism of small branched-chain fatty acids and macrolide antibiotic production. | 1999 | Microbiology (Reading, Engl.) | pmid:10517585 |
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| Smit JW et al. | Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure. | 1999 | J. Clin. Invest. | pmid:10562306 |
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| Mosin VA et al. | [Action of avermectins on lymphoid leukemia P-388 cells in vitro]. | 1999 | Antibiot. Khimioter. | pmid:10422573 |
| Gopal RM et al. | Resistance of field isolates of Trichostrongylus colubriformis and Ostertagia circumcincta to ivermectin. | 1999 | Int. J. Parasitol. | pmid:10404276 |
| Turnipseed SB et al. | Confirmation of avermectin residues in food matrices with negative-ion atmospheric pressure chemical ionization liquid chromatography/mass spectrometry. | 1999 | Rapid Commun. Mass Spectrom. | pmid:10204245 |
| Mosin VA et al. | [Cytotoxic and cytostatic effect of avermectines on tumor cells in vitro]. | 2000 | Antibiot. Khimioter. | pmid:11212393 |
| Young KE et al. | Evaluation of anthelmintic activity in captive wild ruminants by fecal egg reduction tests and a larval development assay. | 2000 | J. Zoo Wildl. Med. | pmid:11237142 |
| Jacobson M et al. | Elimination of Sarcoptes scabiei in pig herds by single or double administrations of an avermectin. | 2000 | Acta Vet. Scand. | pmid:11126572 |
| Dawson GR et al. | Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the gamma-aminobutyric acid(A) receptor. | 2000 | J. Pharmacol. Exp. Ther. | pmid:11082440 |
| Hoste H et al. | A questionnaire survey on the practices adopted to control gastrointestinal nematode parasitism in dairy goat farms in France. | 2000 | Vet. Res. Commun. | pmid:11085466 |
| Tsukamoto Y et al. | Avermectin chemistry and action: ester- and ether-type candidate photoaffinity probes. | 2000 | Bioorg. Med. Chem. | pmid:10968260 |
| Novotny MJ et al. | Safety of selamectin in dogs. | 2000 | Vet. Parasitol. | pmid:10940536 |
| Krautmann MJ et al. | Safety of selamectin in cats. | 2000 | Vet. Parasitol. | pmid:10940537 |
| Banks BJ et al. | Avermectins and flea control: structure-activity relationships and the selection of selamectin for development as an endectocide for companion animals. | 2000 | Bioorg. Med. Chem. | pmid:11003146 |
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| Le Jambre LF et al. | Inheritance of avermectin resistance in Haemonchus contortus. | 2000 | Int. J. Parasitol. | pmid:10675751 |
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| Stutzman-Engwall K et al. | Engineering the aveC gene to enhance the ratio of doramectin to its CHC-B2 analogue produced in Streptomyces avermitilis. | 2003 | Biotechnol. Bioeng. | pmid:12599263 |
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| Hwang YS et al. | Cloning and analysis of a DNA fragment stimulating avermectin production in various Streptomyces avermitilis strains. | 2003 | Appl. Environ. Microbiol. | pmid:12571055 |
| Blackhall WJ et al. | Selection at a gamma-aminobutyric acid receptor gene in Haemonchus contortus resistant to avermectins/milbemycins. | 2003 | Mol. Biochem. Parasitol. | pmid:14511812 |
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