| MeSH term | MeSH ID | Detail |
|---|---|---|
| Inflammation | D007249 | 119 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Dog Diseases | D004283 | 5 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Trichostrongyloidiasis | D014252 | 7 associated lipids |
| Poisoning | D011041 | 9 associated lipids |
| Cleft Palate | D002972 | 9 associated lipids |
| Fish Diseases | D005393 | 5 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
Avermectin A1a
Avermectin A1a is a lipid of Polyketides (PK) class. Avermectin a1a is associated with abnormalities such as Ataxia with vitamin E deficiency, Strongyloidiasis, Congenital Transposition, Gigantism and Onchocerciasis. The involved functions are known as DNA Binding, Anabolism, Insertion Mutation, Process and physiological aspects. Avermectin a1a often locates in Chromosomes, Membrane, Clone, soluble and Tissue membrane. The associated genes with Avermectin A1a are Polypeptides, oxytocin, 1-desamino-(O-Et-Tyr)(2)-, Gene Feature, Genome and Gene Clusters. The related lipids are Propionate. The related experimental models are Mouse Model.
Cross Reference
Introduction
To understand associated biological information of Avermectin A1a, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Avermectin A1a?
Avermectin A1a is suspected in Ataxia with vitamin E deficiency, Gigantism, Strongyloidiasis, Congenital Transposition, Onchocerciasis, Tropical Disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Avermectin A1a
PubChem Associated disorders and diseases
What pathways are associated with Avermectin A1a
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Avermectin A1a?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Avermectin A1a?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Avermectin A1a?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Avermectin A1a?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Avermectin A1a?
Mouse Model
Mouse Model are used in the study 'Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the gamma-aminobutyric acid(A) receptor.' (Dawson GR et al., 2000).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Avermectin A1a
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chen LP et al. | Direct interaction of avermectin with epidermal growth factor receptor mediates the penetration resistance in Drosophila larvae. | 2016 | Open Biol | pmid:27249340 |
| Li Y et al. | Preparation, Characterization, and Insecticidal Activity of Avermectin-Grafted-Carboxymethyl Chitosan. | 2016 | Biomed Res Int | pmid:27213156 |
| Godoy P et al. | Characterisation of P-glycoprotein-9.1 in Haemonchus contortus. | 2016 | Parasit Vectors | pmid:26822677 |
| Sultan SP et al. | Characterization of AvaR1, a butenolide-autoregulator receptor for biosynthesis of a Streptomyces hormone in Streptomyces avermitilis. | 2016 | Appl. Microbiol. Biotechnol. | pmid:27541747 |
| Zhu J et al. | AvaR2, a pseudo γ-butyrolactone receptor homologue from Streptomyces avermitilis, is a pleiotropic repressor of avermectin and avenolide biosynthesis and cell growth. | 2016 | Mol. Microbiol. | pmid:27502190 |
| Guo J et al. | Raising the avermectins production in Streptomyces avermitilis by utilizing nanosecond pulsed electric fields (nsPEFs). | 2016 | Sci Rep | pmid:27181521 |
| Sun D et al. | SAV742, a Novel AraC-Family Regulator from Streptomyces avermitilis, Controls Avermectin Biosynthesis, Cell Growth and Development. | 2016 | Sci Rep | pmid:27841302 |
| He JM et al. | Direct Involvement of the Master Nitrogen Metabolism Regulator GlnR in Antibiotic Biosynthesis in Streptomyces. | 2016 | J. Biol. Chem. | pmid:27875313 |
| de Oliveira Ferreira F et al. | On-line solid-phase extraction-ultra high performance liquid chromatography-tandem mass spectrometry for the determination of avermectins and milbemycin in soils. | 2016 | J Chromatogr A | pmid:27745927 |
| Zhang Y et al. | Avermectin Confers Its Cytotoxic Effects by Inducing DNA Damage and Mitochondria-Associated Apoptosis. | 2016 | J. Agric. Food Chem. | pmid:27551889 |
| Tomilova OG et al. | Immune-physiological aspects of synergy between avermectins and the entomopathogenic fungus Metarhizium robertsii in Colorado potato beetle larvae. | 2016 | J. Invertebr. Pathol. | pmid:27546865 |
| Meng L et al. | Enhanced production of avermectin by deletion of type III polyketide synthases biosynthetic cluster rpp in Streptomyces avermitilis. | 2016 | Lett. Appl. Microbiol. | pmid:27538855 |
| Lemos MA et al. | Development, validation, and application of a method for selected avermectin determination in rural waters using high performance liquid chromatography and fluorescence detection. | 2016 | Ecotoxicol. Environ. Saf. | pmid:27513222 |
| Zhang J et al. | Synthesis, biological activities and structure-activity relationships for new avermectin analogues. | 2016 | Eur J Med Chem | pmid:27318119 |
| Dos Anjos MR et al. | Multiresidue method for simultaneous analysis of aflatoxin M1, avermectins, organophosphate pesticides and milbemycin in milk by ultra-performance liquid chromatography coupled to tandem mass spectrometry. | 2016 | Food Addit Contam Part A Chem Anal Control Expo Risk Assess | pmid:27144891 |
| Chen J et al. | Different fates of avermectin and artemisinin in China. | 2016 | Sci China Life Sci | pmid:27132020 |
| Hopwood DA | Satoshi ÅŒmura. | 2016 | J. Ind. Microbiol. Biotechnol. | pmid:26186906 |
| Długońska H | The Nobel Prize 2015 in physiology or medicine for highly effective antiparasitic drugs. | 2015 | Ann Parasitol | pmid:26878630 |
| Tambo E et al. | Nobel prize for the artemisinin and ivermectin discoveries: a great boost towards elimination of the global infectious diseases of poverty. | 2015 | Infect Dis Poverty | pmid:26708575 |
| Shen B | A New Golden Age of Natural Products Drug Discovery. | 2015 | Cell | pmid:26638061 |
| Jin L et al. | Selective targeting of nuclear receptor FXR by avermectin analogues with therapeutic effects on nonalcoholic fatty liver disease. | 2015 | Sci Rep | pmid:26620317 |
| Zhang J et al. | Designed biosynthesis of 25-methyl and 25-ethyl ivermectin with enhanced insecticidal activity by domain swap of avermectin polyketide synthase. | 2015 | Microb. Cell Fact. | pmid:26400541 |
| Godinez O et al. | Targeting the Osmotic Stress Response for Strain Improvement of an Industrial Producer of Secondary Metabolites. | 2015 | J. Microbiol. Biotechnol. | pmid:26139611 |
| Kwon YJ et al. | Selective Inhibition of SIN3 Corepressor with Avermectins as a Novel Therapeutic Strategy in Triple-Negative Breast Cancer. | 2015 | Mol. Cancer Ther. | pmid:26078298 |
| Huang J et al. | Gene Replacement for the Generation of Designed Novel Avermectin Derivatives with Enhanced Acaricidal and Nematicidal Activities. | 2015 | Appl. Environ. Microbiol. | pmid:26025902 |
| Liu W et al. | Increasing Avermectin Production in Streptomyces avermitilis by Manipulating the Expression of a Novel TetR-Family Regulator and Its Target Gene Product. | 2015 | Appl. Environ. Microbiol. | pmid:26002902 |
| Meyers JI et al. | Mosquitocidal properties of IgG targeting the glutamate-gated chloride channel in three mosquito disease vectors (Diptera: Culicidae). | 2015 | J. Exp. Biol. | pmid:25994632 |
| Omansen TF et al. | In-vitro activity of avermectins against Mycobacterium ulcerans. | 2015 | PLoS Negl Trop Dis | pmid:25742173 |
| Wang F et al. | Structural and functional analysis of the loading acyltransferase from avermectin modular polyketide synthase. | 2015 | ACS Chem. Biol. | pmid:25581064 |
| Efferth T et al. | Nobel Prize for artemisinin brings phytotherapy into the spotlight. | 2015 | Phytomedicine | pmid:26563851 |
| Molyneux DH and Ward SA | Reflections on the Nobel Prize for Medicine 2015--The Public Health Legacy and Impact of Avermectin and Artemisinin. | 2015 | Trends Parasitol. | pmid:26552892 |
| Liu C et al. | Avermectin induced autophagy in pigeon spleen tissues. | 2015 | Chem. Biol. Interact. | pmid:26541719 |
| Boden R | Editorial: on artemisinin, avermectins and Nobel Prizes. | 2015 | FEMS Microbiol. Lett. | pmid:26486159 |
| Owens B | 2015 Nobel Prize goes to antiparasitic drug discoverers. | 2015 | Lancet | pmid:26466031 |
| Agbedanu PN et al. | Doxycycline as an inhibitor of p-glycoprotein in the alpaca for the purpose of maintaining avermectins in the CNS during treatment for parelaphostrongylosis. | 2015 | Vet. Parasitol. | pmid:26371853 |
| Yang R et al. | The PhoP transcription factor negatively regulates avermectin biosynthesis in Streptomyces avermitilis. | 2015 | Appl. Microbiol. Biotechnol. | pmid:26298701 |
| Dalzell AM et al. | Characterization of multidrug transporter-mediated efflux of avermectins in human and mouse neuroblastoma cell lines. | 2015 | Toxicol. Lett. | pmid:25865432 |
| Li X et al. | Fast and Online Determination of Five Avermectin Residues in Foodstuffs of Plant and Animal Origin Using Reusable Polymeric Monolithic Extractor Coupled with LC-MS/MS. | 2015 | J. Agric. Food Chem. | pmid:25865176 |
| Rúbies A et al. | Determination of avermectins: a QuEChERS approach to the analysis of food samples. | 2015 | Food Chem | pmid:25794721 |
| Li D et al. | Synergistic effect of non-ionic surfactants Tween 80 and PEG6000 on cytotoxicity of insecticides. | 2015 | Environ. Toxicol. Pharmacol. | pmid:25699500 |
| Chen C et al. | The synergistic toxicity of the multiple chemical mixtures: implications for risk assessment in the terrestrial environment. | 2015 | Environ Int | pmid:25667058 |
| Sun P et al. | 1,19-seco-Avermectin analogues from a ΔaveCDE mutant Streptomyces avermectinius strain. | 2015 | J. Nat. Prod. | pmid:25611131 |
| Woerde DJ et al. | Susceptibility of rapidly growing mycobacteria isolated from Australian cats to ivermectin, moxidectin, ceftiofur and florfenicol. | 2015 | J. Feline Med. Surg. | pmid:25572306 |
| Qu J et al. | Autophagy is upregulated in brain tissues of pigeons exposed to avermectin. | 2015 | Ecotoxicol. Environ. Saf. | pmid:25497772 |
| Wang Y et al. | Ternary toxicological interactions of insecticides, herbicides, and a heavy metal on the earthworm Eisenia fetida. | 2015 | J. Hazard. Mater. | pmid:25463238 |
| Guo J et al. | Two adjacent and similar TetR family transcriptional regulator genes, SAV577 and SAV576, co-regulate avermectin production in Streptomyces avermitilis. | 2014 | PLoS ONE | pmid:24915523 |
| Li M et al. | Exploring the electron transfer pathway in the oxidation of avermectin by CYP107Z13 in Streptomyces ahygroscopicus ZB01. | 2014 | PLoS ONE | pmid:24905717 |
| Huang WK et al. | Efficacy evaluation of fungus Syncephalastrum racemosum and nematicide avermectin against the root-knot nematode Meloidogyne incognita on cucumber. | 2014 | PLoS ONE | pmid:24586982 |
| Guo H et al. | Reversal of meticillin resistance in Staphylococcus aureus by the anthelmintic avermectin. | 2014 | Int. J. Antimicrob. Agents | pmid:25123810 |
| Thuan NH et al. | Recent advances in biochemistry and biotechnological synthesis of avermectins and their derivatives. | 2014 | Appl. Microbiol. Biotechnol. | pmid:25104027 |