Avermectin A1a

Avermectin A1a is a lipid of Polyketides (PK) class. Avermectin a1a is associated with abnormalities such as Ataxia with vitamin E deficiency, Strongyloidiasis, Congenital Transposition, Gigantism and Onchocerciasis. The involved functions are known as DNA Binding, Anabolism, Insertion Mutation, Process and physiological aspects. Avermectin a1a often locates in Chromosomes, Membrane, Clone, soluble and Tissue membrane. The associated genes with Avermectin A1a are Polypeptides, oxytocin, 1-desamino-(O-Et-Tyr)(2)-, Gene Feature, Genome and Gene Clusters. The related lipids are Propionate. The related experimental models are Mouse Model.

Cross Reference

Introduction

To understand associated biological information of Avermectin A1a, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Avermectin A1a?

Avermectin A1a is suspected in Ataxia with vitamin E deficiency, Gigantism, Strongyloidiasis, Congenital Transposition, Onchocerciasis, Tropical Disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Avermectin A1a

MeSH term MeSH ID Detail
Inflammation D007249 119 associated lipids
Body Weight D001835 333 associated lipids
Dog Diseases D004283 5 associated lipids
Leukemia P388 D007941 43 associated lipids
Neuroblastoma D009447 66 associated lipids
Trichostrongyloidiasis D014252 7 associated lipids
Poisoning D011041 9 associated lipids
Cleft Palate D002972 9 associated lipids
Fish Diseases D005393 5 associated lipids
Neurotoxicity Syndromes D020258 34 associated lipids
Per page 10 20 | Total 19

PubChem Associated disorders and diseases

What pathways are associated with Avermectin A1a

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Avermectin A1a?

Related references are published most in these journals:

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What functions are associated with Avermectin A1a?


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What lipids are associated with Avermectin A1a?

Related references are published most in these journals:

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What genes are associated with Avermectin A1a?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Avermectin A1a?

Mouse Model

Mouse Model are used in the study 'Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the gamma-aminobutyric acid(A) receptor.' (Dawson GR et al., 2000).

Related references are published most in these journals:

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NCBI Entrez Crosslinks

All references with Avermectin A1a

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Authors Title Published Journal PubMed Link
Kitani S et al. Characterization of a regulatory gene, aveR, for the biosynthesis of avermectin in Streptomyces avermitilis. 2009 Appl. Microbiol. Biotechnol. pmid:19148632
Wang H et al. Rapid method for multi-residue determination of avermectins in bovine liver using high-performance liquid chromatography with fluorescence detection. 2009 Bull Environ Contam Toxicol pmid:19159053
Thompson TS et al. Large volume injection for the direct analysis of ionophores and avermectins in surface water by liquid chromatography-electrospray ionization tandem mass spectrometry. 2009 Anal. Chim. Acta pmid:19110126
dos Santos AR et al. Ivermectin-derived leishmanicidal compounds. 2009 Bioorg. Med. Chem. pmid:19114308
Boina DR et al. Influence of posttreatment temperature on the toxicity of insecticides against Diaphorina citri (Hemiptera: Psyllidae). 2009 J. Econ. Entomol. pmid:19449650
Ci X et al. Avermectin exerts anti-inflammatory effect by downregulating the nuclear transcription factor kappa-B and mitogen-activated protein kinase activation pathway. 2009 Fundam Clin Pharmacol pmid:19453757
Shiwen X et al. Preparation and characterization of monoclonal antibodies against avermectin. 2009 Hybridoma (Larchmt) pmid:19519244
Yang F et al. [Determination of avermectin residues in tea by ultra-performance liquid chromatography-electrospray tandem mass spectrometry]. 2009 Se Pu pmid:19626840
Sung YF et al. Avermectin intoxication with coma, myoclonus, and polyneuropathy. 2009 Clin Toxicol (Phila) pmid:19640241
Inoue K et al. Simultaneous determination of avermectins in bovine tissues by LC-MS/MS. 2009 J Sep Sci pmid:19877150
Zhao X et al. Construction of a doramectin producer mutant from an avermectin-overproducing industrial strain of Streptomyces avermitilis. 2009 Can. J. Microbiol. pmid:20029527
Ji P et al. [Clinical analysis of acute Avermectins poisoning]. 2009 Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi pmid:20039548
Krogh KA et al. Development of an analytical method to determine avermectins in water, sediments and soils using liquid chromatography-tandem mass spectrometry. 2008 J Chromatogr A pmid:18929364
Li M et al. Engineering of avermectin biosynthetic genes to improve production of ivermectin in Streptomyces avermitilis. 2008 Bioorg. Med. Chem. Lett. pmid:18824353
Luft JA et al. Substituent effects on the rearrangements of cyclohexyl to cyclopentyl radicals involving avermectin-related radicals. 2008 J. Org. Chem. pmid:18842059
Zhu J and Tao M [Effect on production of avermectins of spore pigment biosynthesis in Streptomyces avermitilis NRRL8165]. 2008 Sheng Wu Gong Cheng Xue Bao pmid:19149180
Hu J et al. Effects of insecticides on the fluidity of mitochondrial membranes of the diamondback moth, Plutella xylostella, resistant and susceptible to avermectin. 2008 J. Insect Sci. pmid:20345311
Brayden DJ and Griffin J Avermectin transepithelial transport in MDR1- and MRP-transfected canine kidney monolayers. 2008 Vet. Res. Commun. pmid:17578674
Ayers S et al. Anthelmintic macrolactams from Nonomuraea turkmeniaca MA7381. 2008 J. Antibiot. pmid:18408323
Dong JY et al. Ymf 1029A-E, preussomerin analogues from the fresh-water-derived fungus YMF 1.01029. 2008 J. Nat. Prod. pmid:18479163
Kessabi FM et al. Rearrangement of a cyclohexyl radical to a cyclopentylmethyl radical on the avermectin skeleton. 2008 Org. Lett. pmid:18461948
Chen L et al. Characterization of a negative regulator AveI for avermectin biosynthesis in Streptomyces avermitilis NRRL8165. 2008 Appl. Microbiol. Biotechnol. pmid:18560830
Biliavs'ka LO et al. [Effect of pyruvate and valine on avermectin biosynthesis by Streptomyces avermitilis UCM Ac-2179]. 2007 Jul-Aug Mikrobiol. Z. pmid:17977447
Wang XJ et al. [Effect of Avermectins on the secretion function of cultured granulosa cells from rat ovary in vitro.]. 2007 Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi pmid:17945112
Macdonald N and Gledhill A Potential impact of ABCB1 (p-glycoprotein) polymorphisms on avermectin toxicity in humans. 2007 Arch. Toxicol. pmid:17354009
Berendsen BJ et al. The derivatisation of avermectins and milbemycins in milk: new insights and improvement of the procedure. 2007 Anal. Chim. Acta pmid:17386656
Rezanka T et al. Relationship between volatile odorous substances and production of avermectins by Streptomyces avermitilis. 2007 Folia Microbiol. (Praha) pmid:17571791
Lin YW et al. Insecticide susceptibility of surviving Cotesia plutellae (Hym: Braconidae) and Diaeretiella rapae (M'Intosh) (Hym: Aphidiidae) as affected by sublethal insecticide dosages on host insects. 2007 Pest Manag. Sci. pmid:17533655
Hernando MD et al. Fast separation liquid chromatography-tandem mass spectrometry for the confirmation and quantitative analysis of avermectin residues in food. 2007 J Chromatogr A pmid:17524410
Trefzer A et al. Biocatalytic conversion of avermectin to 4''-oxo-avermectin: improvement of cytochrome p450 monooxygenase specificity by directed evolution. 2007 Appl. Environ. Microbiol. pmid:17483257
Li ZZ et al. Adsorption of avermectin on porous hollow silica nanoparticles by supercritical technology. 2007 J Nanosci Nanotechnol pmid:17450791
Tribble ND et al. Identification of the genes encoding for putative gamma aminobutyric acid (GABA) and glutamate-gated chloride channel (GluCl) alpha receptor subunits in sea lice (Lepeophtheirus salmonis). 2007 J. Vet. Pharmacol. Ther. pmid:17348903
Webb L et al. Effects of avermectin residues in cattle dung on yellow dung fly Scathophaga stercoraria (Diptera: Scathophagidae) populations in grazed pastures. 2007 Bull. Entomol. Res. pmid:17411477
Rajkarnikar A et al. Two threonine residues required for role of AfsKav in controlling morphogenesis and avermectin production in Streptomyces avermitilis. 2007 J. Microbiol. Biotechnol. pmid:18062239
Im JH et al. Comparative transcriptome analysis for avermectin overproduction via Streptomyces avermitilis microarray system. 2007 J. Microbiol. Biotechnol. pmid:18050961
Sollai G et al. Effects of avermectins on olfactory responses of Culicoides imicola (Diptera: Ceratopogonidae). 2007 J. Med. Entomol. pmid:17695021
Tao WX et al. [Cloning of bldAa and the effect on morphological differentiation and avermectins production in Streptomyces avermitilis NRRL8165]. 2007 Wei Sheng Wu Xue Bao pmid:17436620
Artho R et al. Avermectin-resistance in gastrointestinal nematodes of Boer goats and Dorper sheep in Switzerland. 2007 Vet. Parasitol. pmid:17088023
Li ZZ et al. Study of UV-shielding properties of novel porous hollow silica nanoparticle carriers for avermectin. 2007 Pest Manag. Sci. pmid:17177171
Hou X et al. Multiresidue analysis of avermectins in cattle liver by liquid chromatography/tandem mass spectrometry. 2006 Jul-Aug J AOAC Int pmid:16915852
Sheehan LS et al. Engineering of the spinosyn PKS: directing starter unit incorporation. 2006 J. Nat. Prod. pmid:17190446
Li ZZ et al. Controlled release of avermectin from porous hollow silica nanoparticles: influence of shell thickness on loading efficiency, UV-shielding property and release. 2006 J Control Release pmid:16388871
Shi W et al. Determination of multiresidue of avermectins in bovine liver by an indirect competitive ELISA. 2006 J. Agric. Food Chem. pmid:16910699
Learmount J et al. A computer model to simulate control of parasitic gastroenteritis in sheep on UK farms. 2006 Vet. Parasitol. pmid:16930844
Rajkarnikar A et al. Catalytic domain of AfsKav modulates both secondary metabolism and morphologic differentiation in Streptomyces avermitilis ATCC 31272. 2006 Curr. Microbiol. pmid:16874544
Danaher M et al. Review of methodology for the determination of macrocyclic lactone residues in biological matrices. 2006 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:16950666
Turnipseed SB et al. No-discharge atmospheric pressure chemical ionization: evaluation and application to the analysis of animal drug residues in complex matrices. 2006 Rapid Commun. Mass Spectrom. pmid:16541409
Beasley CA et al. Identification of impurities in ivermectin bulk material by mass spectrometry and NMR. 2006 J Pharm Biomed Anal pmid:16554137
Wei X et al. Enhancement and selective production of oligomycin through inactivation of avermectin's starter unit in Streptomyces avermitilis. 2006 Biotechnol. Lett. pmid:16786277
Oremus G et al. Effects of mid-season avermectin treatments on pyrethroid resistance in horn fly (Diptera: Muscidae) populations at three locations in Louisiana. 2006 Vet. Parasitol. pmid:16769175
Zhang X et al. Construction of ivermectin producer by domain swaps of avermectin polyketide synthase in Streptomyces avermitilis. 2006 Appl. Microbiol. Biotechnol. pmid:16708195
Zhang C et al. The in vitro characterization of the iterative avermectin glycosyltransferase AveBI reveals reaction reversibility and sugar nucleotide flexibility. 2006 J. Am. Chem. Soc. pmid:17177349
He J et al. Multiresidue analysis of avermectins in bovine liver by immunoaffinity column cleanup procedure and liquid chromatography with fluorescence detector. 2005 Jul-Aug J AOAC Int pmid:16152926
de Macedo DM et al. [Post-embrionic development of Stomoxys calcitrans (Linnaeus,1758) (Diptera: Muscidae)feed in feces of treated bovines with different avermectins]. 2005 Apr-Jun Rev Bras Parasitol Vet pmid:16153344
Walsh CT Natural insights for chemical biologists. 2005 Nat. Chem. Biol. pmid:16408011
Jungmann V et al. Biocatalytic conversion of avermectin to 4"-oxo-avermectin: characterization of biocatalytically active bacterial strains and of cytochrome p450 monooxygenase enzymes and their genes. 2005 Appl. Environ. Microbiol. pmid:16269732
Molnár I et al. Biocatalytic conversion of avermectin to 4"-oxo-avermectin: heterologous expression of the ema1 cytochrome P450 monooxygenase. 2005 Appl. Environ. Microbiol. pmid:16269733
Erzen NK et al. Degradation of abamectin and doramectin on sheep grazed pasture. 2005 Ecotoxicology pmid:16215697
Bowen JM and Vitayavirasak B Contractile activity and motility responses of the dog heartworm Dirofilaria immitis to classical anthelmintics and other compounds. 2005 Vet. Parasitol. pmid:16076531
Wen LX et al. Controlled release of avermectin from porous hollow silica nanoparticles. 2005 Pest Manag. Sci. pmid:15714463
Yong JH and Byeon WH Alternative production of avermectin components in Streptomyces avermitilis by gene replacement. 2005 J. Microbiol. pmid:15995647
Kuzmina TA et al. Analysis of the strongylid nematodes (Nematoda: Strongylidae) community after deworming of brood horses in Ukraine. 2005 Vet. Parasitol. pmid:15979240
Wolstenholme AJ and Rogers AT Glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics. 2005 Parasitology pmid:16569295
Petruk TV et al. [Increasing biosynthesis of avermectins of Streptomyces avermitilis UCM Ac 2161 under the effect N-methyl-N'-nitro-N-nitrosoguanidine]. 2004 Nov-Dec Mikrobiol. Z. pmid:15765867
Korystov YN et al. Avermectins inhibit multidrug resistance of tumor cells. 2004 Eur. J. Pharmacol. pmid:15189764
Nagai K et al. Synthesis and biological evaluation of novel 4"-alkoxy avermectin derivatives. 2004 Bioorg. Med. Chem. Lett. pmid:15261257
Yoon YJ et al. Avermectin: biochemical and molecular basis of its biosynthesis and regulation. 2004 Appl. Microbiol. Biotechnol. pmid:14689246
Driniaev VA et al. [Modification of antitumor effect of vincristine by natural avermectins]. 2004 Antibiot. Khimioter. pmid:15628794
Shi ZH et al. Evaluation of selective toxicity of five pesticides against Plutella xylostella (Lep: Plutellidae) and their side-effects against Cotesia plutellae (Hym: Braconidae) and Oomyzus sokolowskii (Hym: Eulophidae). 2004 Pest Manag. Sci. pmid:15578602
Chen J et al. Ethanol evolution rate: a new parameter to determine the feeding rate for the production of avermectins by Streptomyces avermitilis. 2004 Biotechnol. Lett. pmid:15000476
Liu J et al. Genomic organization of an avermectin receptor subunit from Haemonchus contortus and expression of its putative promoter region in Caenorhabditis elegans. 2004 Mol. Biochem. Parasitol. pmid:15003846
Drinyaev VA et al. Antitumor effect of avermectins. 2004 Eur. J. Pharmacol. pmid:15464058
Gong W et al. Improvement of transformation and electroduction in avermectin high-producer, Streptomyces avermitilis. 2004 Folia Microbiol. (Praha) pmid:15530004
Li CL et al. [Differential acute mortality among the allozyme genotypes of Oxya chinensis by pesticide avermectin]. 2004 Yi Chuan Xue Bao pmid:15651676
BronshteÄ­n AM et al. [Migrating subcutaneous myasis with systemic manifestations caused by gadfly larvae]. 2004 Klin Med (Mosk) pmid:15656401
Driniaev VA et al. [Antitumor effect of natural avermectins]. 2004 Antibiot. Khimioter. pmid:15573897
Zhu HJ et al. [Effects of bkdAB interruption on avermectin biosynthesis]. 2004 Sheng Wu Gong Cheng Xue Bao pmid:15969120
Mironov VA et al. [Dependence of the composition of the avermectin complex of Streptomyces avermitilis on glucose content of the growth medium]. 2003 Mar-Apr Prikl. Biokhim. Mikrobiol. pmid:12722656
Sun Y et al. Identification of a gene cluster encoding meilingmycin biosynthesis among multiple polyketide synthase contigs isolated from Streptomyces nanchangensis NS3226. 2003 Arch. Microbiol. pmid:12811466
Gaisser S et al. Direct production of ivermectin-like drugs after domain exchange in the avermectin polyketide synthase of Streptomyces avermitilis ATCC31272. 2003 Org. Biomol. Chem. pmid:12968333
Yates DM et al. The avermectin receptors of Haemonchus contortus and Caenorhabditis elegans. 2003 Int. J. Parasitol. pmid:13678634
Stutzman-Engwall K et al. Engineering the aveC gene to enhance the ratio of doramectin to its CHC-B2 analogue produced in Streptomyces avermitilis. 2003 Biotechnol. Bioeng. pmid:12599263
Lamb DC et al. Cytochrome p450 complement (CYPome) of the avermectin-producer Streptomyces avermitilis and comparison to that of Streptomyces coelicolor A3(2). 2003 Biochem. Biophys. Res. Commun. pmid:12893267
Hwang YS et al. Cloning and analysis of a DNA fragment stimulating avermectin production in various Streptomyces avermitilis strains. 2003 Appl. Environ. Microbiol. pmid:12571055
Blackhall WJ et al. Selection at a gamma-aminobutyric acid receptor gene in Haemonchus contortus resistant to avermectins/milbemycins. 2003 Mol. Biochem. Parasitol. pmid:14511812
Nagai K et al. Synthesis and biological activities of novel 4"-alkylidene avermectin derivatives. 2003 Bioorg. Med. Chem. Lett. pmid:14592480
Strabel D et al. [The use of avermectins in two goats with demodicosis]. 2003 Schweiz. Arch. Tierheilkd. pmid:14725185
Iovchev M et al. Altered drug resistance and recovery from paralysis in Drosophila melanogaster with a deficient histamine-gated chloride channel. 2002 Oct-Dec J. Neurogenet. pmid:12745634
Sha CK et al. Anionic cyclization approach toward perhydrobenzofuranone: stereocontrolled synthesis of the hexahydrobenzofuran subunit of avermectin. 2002 J. Org. Chem. pmid:11856026
Deger Y et al. Short communication serum copper, zinc, and calcium concentrations in lice-infested sheep. 2002 Biol Trace Elem Res pmid:12117268
Veale PI Resistance to macrocyclic lactones in nematodes of goats. 2002 Aust. Vet. J. pmid:12074315
Viktorov AV et al. [Comparative analysis of degradation of native avermectins and spinosyns by UV-HPLC]. 2002 Antibiot. Khimioter. pmid:12728628
Argentine JA et al. Toxicities of emamectin benzoate homologues and photodegradates to Lepidoptera. 2002 J. Econ. Entomol. pmid:12539830
Martins JR et al. Partial strategic tick control within a herd of European breed cattle in the state of Rio Grande do Sul, southern Brazil. 2002 Exp. Appl. Acarol. pmid:12593589
Rehbein S et al. Efficacy of a new long-acting formulation of ivermectin and other injectable avermectins against induced Psoroptes ovis infestations in cattle. 2002 Parasitol. Res. pmid:12444456
Kim SB and Goodfellow M Streptomyces avermitilis sp. nov., nom. rev., a taxonomic home for the avermectin-producing streptomycetes. 2002 Int. J. Syst. Evol. Microbiol. pmid:12508861
Takahashi Y et al. Streptomyces avermectinius sp. nov., an avermectin-producing strain. 2002 Int. J. Syst. Evol. Microbiol. pmid:12508884
Novik TS et al. [Acute toxicity of aversectin C : various routes of administration and dosage forms]. 2001 Mar-Apr Eksp Klin Farmakol pmid:11548452
Danaher M et al. Extraction and isolation of avermectins and milbemycins from liver samples using unmodified supercritical CO2 with in-line trapping on basic alumina. 2001 J. Chromatogr. B Biomed. Sci. Appl. pmid:11585125
Driniaev VA et al. [Selective cytostatic and cytotoxic effects of avermectins]. 2001 Antibiot. Khimioter. pmid:11558448