Avermectin A1a

Avermectin A1a is a lipid of Polyketides (PK) class. Avermectin a1a is associated with abnormalities such as Ataxia with vitamin E deficiency, Strongyloidiasis, Congenital Transposition, Gigantism and Onchocerciasis. The involved functions are known as DNA Binding, Anabolism, Insertion Mutation, Process and physiological aspects. Avermectin a1a often locates in Chromosomes, Membrane, Clone, soluble and Tissue membrane. The associated genes with Avermectin A1a are Polypeptides, oxytocin, 1-desamino-(O-Et-Tyr)(2)-, Gene Feature, Genome and Gene Clusters. The related lipids are Propionate. The related experimental models are Mouse Model.

Cross Reference

Introduction

To understand associated biological information of Avermectin A1a, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Avermectin A1a?

Avermectin A1a is suspected in Ataxia with vitamin E deficiency, Gigantism, Strongyloidiasis, Congenital Transposition, Onchocerciasis, Tropical Disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Avermectin A1a

MeSH term MeSH ID Detail
Inflammation D007249 119 associated lipids
Body Weight D001835 333 associated lipids
Dog Diseases D004283 5 associated lipids
Leukemia P388 D007941 43 associated lipids
Neuroblastoma D009447 66 associated lipids
Trichostrongyloidiasis D014252 7 associated lipids
Poisoning D011041 9 associated lipids
Cleft Palate D002972 9 associated lipids
Fish Diseases D005393 5 associated lipids
Neurotoxicity Syndromes D020258 34 associated lipids
Per page 10 20 | Total 19

PubChem Associated disorders and diseases

What pathways are associated with Avermectin A1a

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Avermectin A1a?

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What functions are associated with Avermectin A1a?


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What lipids are associated with Avermectin A1a?

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What genes are associated with Avermectin A1a?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Avermectin A1a?

Mouse Model

Mouse Model are used in the study 'Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the gamma-aminobutyric acid(A) receptor.' (Dawson GR et al., 2000).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Avermectin A1a

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Authors Title Published Journal PubMed Link
Howells L and Sauer MJ Multi-residue analysis of avermectins and moxidectin by ion-trap LC-MSn. 2001 Analyst pmid:11235096
Danaher M et al. Extraction and isolation of avermectins and milbemycins from liver samples using unmodified supercritical CO2 with in-line trapping on basic alumina. 2001 J. Chromatogr. B Biomed. Sci. Appl. pmid:11585125
Driniaev VA et al. [Selective cytostatic and cytotoxic effects of avermectins]. 2001 Antibiot. Khimioter. pmid:11558448
Driniaev VA et al. [Effect of avermectns on Ca(2+)-dependent chloride currents in plasmalemma of Chara corallina cells]. 2001 Antibiot. Khimioter. pmid:11558454
Anziani OS et al. Avermectin resistance in Cooperia pectinata in cattle in Argentina. 2001 Vet. Rec. pmid:11488345
Martins JR and Furlong J Avermectin resistance of the cattle tick Boophilus microplus in Brazil. 2001 Vet. Rec. pmid:11488352
Swarnkar CP et al. Anthelmintic resistance on an organized sheep farm in India. 2001 Trop Anim Health Prod pmid:11474864
Zakson-Aiken M et al. Systemic activity of the avermectins against the cat flea (Siphonaptera: Pulicidae). 2001 J. Med. Entomol. pmid:11476339
Ikeda H et al. Organization of biosynthetic gene cluster for avermectin in Streptomyces avermitilis: analysis of enzymatic domains in four polyketide synthases. 2001 J. Ind. Microbiol. Biotechnol. pmid:11780788
Barnes EH et al. Selection of different genotype larvae and adult worms for anthelmintic resistance by persistent and short-acting avermectin/milbemycins. 2001 Int. J. Parasitol. pmid:11336754
Drinyaev VA et al. Effect of avermectins on Ca2+-dependent Cl- currents in plasmalemma of Chara corallina cells. 2001 J. Membr. Biol. pmid:11426301
Köhler P The biochemical basis of anthelmintic action and resistance. 2001 Int. J. Parasitol. pmid:11400692
Valenzuela AI et al. Comparison of various liquid chromatographic methods for the analysis of avermectin residues in citrus fruits. 2001 J Chromatogr A pmid:11403456
Ikeda H [Genetic analysis of biosynthesis of polyketide compound in Streptomyces avermitilis]. 2001 Jpn J Antibiot pmid:11392681
Danaher M et al. Development and optimisation of an improved derivatisation procedure for the determination of avermectins and milbemycins in bovine liver. 2001 Analyst pmid:11394296
Miakisheva SN et al. [Proliferation and morphological differentiation of neurblastoma cells in cultured under the effect of avermectins]. 2001 Morfologiia pmid:12016760
Chen Z et al. [Effect of gene disruption of aveD on avermectins production in Streptomyces avermitilis]. 2001 Wei Sheng Wu Xue Bao pmid:12552909
Mosin VA et al. [Cytotoxic and cytostatic effect of avermectines on tumor cells in vitro]. 2000 Antibiot. Khimioter. pmid:11212393
Young KE et al. Evaluation of anthelmintic activity in captive wild ruminants by fecal egg reduction tests and a larval development assay. 2000 J. Zoo Wildl. Med. pmid:11237142
Jacobson M et al. Elimination of Sarcoptes scabiei in pig herds by single or double administrations of an avermectin. 2000 Acta Vet. Scand. pmid:11126572
Dawson GR et al. Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the gamma-aminobutyric acid(A) receptor. 2000 J. Pharmacol. Exp. Ther. pmid:11082440
Hoste H et al. A questionnaire survey on the practices adopted to control gastrointestinal nematode parasitism in dairy goat farms in France. 2000 Vet. Res. Commun. pmid:11085466
Tsukamoto Y et al. Avermectin chemistry and action: ester- and ether-type candidate photoaffinity probes. 2000 Bioorg. Med. Chem. pmid:10968260
Novotny MJ et al. Safety of selamectin in dogs. 2000 Vet. Parasitol. pmid:10940536
Krautmann MJ et al. Safety of selamectin in cats. 2000 Vet. Parasitol. pmid:10940537
Banks BJ et al. Avermectins and flea control: structure-activity relationships and the selection of selamectin for development as an endectocide for companion animals. 2000 Bioorg. Med. Chem. pmid:11003146
Gianelli L et al. Mass spectrometry of avermectins: structural determination of two new derivatives of Ivermectin B(1a). 2000 Rapid Commun. Mass Spectrom. pmid:10918377
Le Jambre LF et al. Inheritance of avermectin resistance in Haemonchus contortus. 2000 Int. J. Parasitol. pmid:10675751
Sangster NC et al. Haemonchus contortus: sequence heterogeneity of internucleotide binding domains from P-glycoproteins. 1999 Exp. Parasitol. pmid:10072327
Zhang YX et al. Genes encoding acyl-CoA dehydrogenase (AcdH) homologues from Streptomyces coelicolor and Streptomyces avermitilis provide insights into the metabolism of small branched-chain fatty acids and macrolide antibiotic production. 1999 Microbiology (Reading, Engl.) pmid:10517585
Novik TS et al. [Assessment of the mutagenic activity of aversectin C]. 1999 Antibiot. Khimioter. pmid:10494378
Sangster NC Pharmacology of anthelmintic resistance in cyathostomes: will it occur with the avermectin/milbemycins? 1999 Vet. Parasitol. pmid:10485365
Geary TG et al. Frontiers in anthelmintic pharmacology. 1999 Vet. Parasitol. pmid:10456419
Ikeda H et al. Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:10449723
Smit JW et al. Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure. 1999 J. Clin. Invest. pmid:10562306
Kokoz YM et al. Selective cytostatic and neurotoxic effects of avermectins and activation of the GABAalpha receptors. 1999 Biosci. Rep. pmid:10841270
Sangster NC and Gill J Pharmacology of anthelmintic resistance. 1999 Parasitol. Today (Regul. Ed.) pmid:10322335
Mosin VA et al. [Action of avermectins on lymphoid leukemia P-388 cells in vitro]. 1999 Antibiot. Khimioter. pmid:10422573
Gopal RM et al. Resistance of field isolates of Trichostrongylus colubriformis and Ostertagia circumcincta to ivermectin. 1999 Int. J. Parasitol. pmid:10404276
Turnipseed SB et al. Confirmation of avermectin residues in food matrices with negative-ion atmospheric pressure chemical ionization liquid chromatography/mass spectrometry. 1999 Rapid Commun. Mass Spectrom. pmid:10204245
Lankas GR et al. Placental P-glycoprotein deficiency enhances susceptibility to chemically induced birth defects in mice. 1998 Jul-Aug Reprod. Toxicol. pmid:9717696
Roudaut B Multiresidue method for the determination of avermectin and moxidectin residues in the liver using HPLC with fluorescence detection. 1998 Analyst pmid:10435295
Meinke PT et al. Synthesis of gem-difluoro-avermectin derivatives: potent anthelmintic and anticonvulsant agents. 1998 Bioorg. Med. Chem. Lett. pmid:9934486
Delany NS et al. Cloning and localisation of an avermectin receptor-related subunit from Haemonchus contortus. 1998 Mol. Biochem. Parasitol. pmid:9879896
Windelspecht M et al. Survey of malathion resistance and avermectin susceptibility in field populations of Drosophila melanogaster (Diptera: Drosophilidae) and D. simulans. 1998 J. Econ. Entomol. pmid:9887681
Shao Y et al. [Determination of avermictin in avermictin tablet by high performance liquid chromatography]. 1998 Se Pu pmid:11324492
Ikeda H et al. Cloning of the gene encoding avermectin B 5-O-methyltransferase in avermectin-producing Streptomyces avermitilis. 1998 Gene pmid:9469930
Marsden AF et al. Engineering broader specificity into an antibiotic-producing polyketide synthase. 1998 Science pmid:9422686
Gill JH and Lacey E Avermectin/milbemycin resistance in trichostrongyloid nematodes. 1998 Int. J. Parasitol. pmid:9673866
Gill JH et al. Evidence of multiple mechanisms of avermectin resistance in haemonchus contortus--comparison of selection protocols. 1998 Int. J. Parasitol. pmid:9650059
Lonneux JF et al. The relationship between parasite counts, lesions, antibody titres and daily weight gains in Psoroptes ovis infested cattle. 1998 Vet. Parasitol. pmid:9653998
Lonneux JF et al. Antibody response after treatment in cattle infected with Psoroptes ovis. 1997 Jul-Aug Res. Vet. Sci. pmid:9368957
Vassilatis DK et al. Genetic and biochemical evidence for a novel avermectin-sensitive chloride channel in Caenorhabditis elegans. Isolation and characterization. 1997 J. Biol. Chem. pmid:9407104
Laughton DL et al. Reporter gene constructs suggest that the Caenorhabditis elegans avermectin receptor beta-subunit is expressed solely in the pharynx. 1997 J. Exp. Biol. pmid:9192499
Gray AK Avermectin toxicity in the dog. 1997 Vet. Rec. pmid:9185316
Scarff DH Avermectin toxicity in the dog. 1997 Vet. Rec. pmid:9185317
Pomes A et al. Target size analysis of an avermectin binding site from Drosophila melanogaster. 1997 Biochim. Biophys. Acta pmid:9187243
Doody GM Avermectin toxicity in the dog. 1997 Vet. Rec. pmid:9203324
Krieger RI et al. Adult and infant abamectin exposures following Avert 310 and pressurized gel crack and crevice treatment. 1997 Bull Environ Contam Toxicol pmid:9115128
Vassilatis DK et al. Evolutionary relationship of the ligand-gated ion channels and the avermectin-sensitive, glutamate-gated chloride channels. 1997 J. Mol. Evol. pmid:9115174
Barnes TM and Hekimi S The Caenorhabditis elegans avermectin resistance and anesthetic response gene unc-9 encodes a member of a protein family implicated in electrical coupling of excitable cells. 1997 J. Neurochem. pmid:9375655
Mironov VA et al. [Biosynthesis of avermectins: physiological and technological aspects]. 1997 Antibiot. Khimioter. pmid:9265465
Herd R Ecotoxicity of the avermectins: a reply to Forbes. 1996 Int. J. Parasitol. pmid:8818740
Venkatachalam MA et al. Cytoprotection of kidney epithelial cells by compounds that target amino acid gated chloride channels. 1996 Kidney Int. pmid:8821829
Vercruysse J and Claerebout E Effect of chemoprophylaxis on immunity to gastrointestinal nematodes in cattle. 1996 Verh. K. Acad. Geneeskd. Belg. pmid:8701602
Cully DF et al. Identification of a Drosophila melanogaster glutamate-gated chloride channel sensitive to the antiparasitic agent avermectin. 1996 J. Biol. Chem. pmid:8702744
Nari A et al. The prevalence of anthelmintic resistance in nematode parasites of sheep in southern Latin America: Uruguay. 1996 Vet. Parasitol. pmid:8686167
Löwenstein M et al. Histology of the skin and determination of blood and serum parameters during the recovery phase of sarcoptic manage in cattle after avermectin (Ivomec) treatment. 1996 Appl. Parasitol. pmid:8688864
Titchener RN and Purnell RE Duration of persistence of injectable avermectins against sucking lice of cattle. 1996 Vet. Rec. pmid:8903014
McKellar QA and Benchaoui HA Avermectins and milbemycins. 1996 J. Vet. Pharmacol. Ther. pmid:8905567
Shoop WL et al. Efficacy in sheep and pharmacokinetics in cattle that led to the selection of eprinomectin as a topical endectocide for cattle. 1996 Int. J. Parasitol. pmid:9024866
Shoop WL et al. Eprinomectin: a novel avermectin for use as a topical endectocide for cattle. 1996 Int. J. Parasitol. pmid:9024867
Clark JM et al. Resistance to avermectins: extent, mechanisms, and management implications. 1995 Annu. Rev. Entomol. pmid:7810984
Le Jambre LF et al. Characterisation of an avermectin resistant strain of Australian Haemonchus contortus. 1995 Int. J. Parasitol. pmid:7657454
Ikeda H and Omura S Control of avermectin biosynthesis in Streptomyces avermitilis for the selective production of a useful component. 1995 J. Antibiot. pmid:7649850
Arena JP et al. The mechanism of action of avermectins in Caenorhabditis elegans: correlation between activation of glutamate-sensitive chloride current, membrane binding, and biological activity. 1995 J. Parasitol. pmid:7707209
Sergeev AV et al. [Effect of nitrogen-containing compounds on the biosynthesis of avermectins]. 1995 Antibiot. Khimioter. pmid:8645056
Mironov VA et al. [Activity of threonine deaminase and biosynthesis of avermectins in the culture of Streptomyces avermitilis]. 1995 Antibiot. Khimioter. pmid:8713429
Gill JH and Redwin JM Cryopreservation of the first-stage larvae of trichostrongylid nematode parasites. 1995 Int. J. Parasitol. pmid:8719953
MacNeil DJ Avermectins. 1995 Biotechnology pmid:8688633
Shoop WL et al. Structure and activity of avermectins and milbemycins in animal health. 1995 Vet. Parasitol. pmid:7483237
Ikeda H et al. Construction of a single component producer from the wild type avermectin producer Streptomyces avermitilis. 1995 J. Antibiot. pmid:7622445
Gill JH et al. Avermectin inhibition of larval development in Haemonchus contortus--effects of ivermectin resistance. 1995 Int. J. Parasitol. pmid:7635622
Pang CH et al. Production of 6,8a-seco-6,8a-deoxy derivatives of avermectins by a mutant strain of Streptomyces avermitilis. 1995 J. Antibiot. pmid:7868391
Pang CH et al. Production of a new methylated 6,8a-seco-6,8a-deoxy derivative of the avermectins by a transformant strain of Streptomyces avermitilis. 1995 J. Antibiot. pmid:7868398
Ikeda H et al. Direct production of 5-oxo derivatives of avermectins by a recombinant strain of Streptomyces avermitilis. 1995 J. Antibiot. pmid:7868399
Denoya CD et al. A second branched-chain alpha-keto acid dehydrogenase gene cluster (bkdFGH) from Streptomyces avermitilis: its relationship to avermectin biosynthesis and the construction of a bkdF mutant suitable for the production of novel antiparasitic avermectins. 1995 J. Bacteriol. pmid:7768860
MacNeil DJ et al. Correlation of the avermectin polyketide synthase genes to the avermectin structure. Implications for designing novel avermectins. 1994 Ann. N. Y. Acad. Sci. pmid:8010663
Cully DF et al. Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans. 1994 Nature pmid:7935817
Rohrer SP et al. Immunoaffinity purification of avermectin-binding proteins from the free-living nematode Caenorhabditis elegans and the fruitfly Drosophila melanogaster. 1994 Biochem. J. pmid:8092985
Evans M et al. Characterization of a Streptomyces-lividans-type site-specific DNA modification system in the avermectin-producer Streptomyces avermitilis permits investigation of two novel giant linear plasmids, pSA1 and pSA2. 1994 Microbiology (Reading, Engl.) pmid:8081502
Schulman M et al. Microbial conversion of avermectins by Saccharopolyspora erythraea: hydroxylation at C-27. 1994 J. Antibiot. pmid:8175491
Khalkova Zh [An experimental evaluation of the cutaneous action of the preparation Bulmektin]. 1994 Probl Khig pmid:7845982
Naito S et al. Milbemycin derivatives: modification at the C-5 position. 1994 J. Antibiot. pmid:8150720
MacNeil T et al. Deletion analysis of the avermectin biosynthetic genes of Streptomyces avermitilis by gene cluster displacement. 1993 J. Bacteriol. pmid:8478321
Novák J et al. Instability of the production of avermectins, sporulation, and pigmentation in Streptomyces avermitilis. 1993 Can. J. Microbiol. pmid:8467423
Special issue: Environmental impact of avermectin usage in livestock. 1993 Vet. Parasitol. pmid:8346625
Ridsdill-Smith TJ Effects of avermectin residues in cattle dung on dung beetle (Coleoptera: Scarabaeidae) reproduction and survival. 1993 Vet. Parasitol. pmid:8346627
King KL The potential for avermectins to affect the nutrient economy of grazed pastures. 1993 Vet. Parasitol. pmid:8346639
McCracken DI The potential for avermectins to affect wildlife. 1993 Vet. Parasitol. pmid:8346640