| MeSH term | MeSH ID | Detail |
|---|---|---|
| Inflammation | D007249 | 119 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Dog Diseases | D004283 | 5 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Trichostrongyloidiasis | D014252 | 7 associated lipids |
| Poisoning | D011041 | 9 associated lipids |
| Cleft Palate | D002972 | 9 associated lipids |
| Fish Diseases | D005393 | 5 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
Avermectin A1a
Avermectin A1a is a lipid of Polyketides (PK) class. Avermectin a1a is associated with abnormalities such as Ataxia with vitamin E deficiency, Strongyloidiasis, Congenital Transposition, Gigantism and Onchocerciasis. The involved functions are known as DNA Binding, Anabolism, Insertion Mutation, Process and physiological aspects. Avermectin a1a often locates in Chromosomes, Membrane, Clone, soluble and Tissue membrane. The associated genes with Avermectin A1a are Polypeptides, oxytocin, 1-desamino-(O-Et-Tyr)(2)-, Gene Feature, Genome and Gene Clusters. The related lipids are Propionate. The related experimental models are Mouse Model.
Cross Reference
Introduction
To understand associated biological information of Avermectin A1a, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Avermectin A1a?
Avermectin A1a is suspected in Ataxia with vitamin E deficiency, Gigantism, Strongyloidiasis, Congenital Transposition, Onchocerciasis, Tropical Disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Proc. Natl. Acad. Sci. U.S.A. (1)
- Stem Cell Reports (1)
- Antimicrob. Agents Chemother. (1)
- Others (3)
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Avermectin A1a
PubChem Associated disorders and diseases
What pathways are associated with Avermectin A1a
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Avermectin A1a?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Avermectin A1a?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Avermectin A1a?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Avermectin A1a?
Related references are published most in these journals:
- Proc. Natl. Acad. Sci. U.S.A. (3)
- Appl. Environ. Microbiol. (3)
- Microbiology (Reading, Engl.) (1)
- Others (5)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Avermectin A1a?
Mouse Model
Mouse Model are used in the study 'Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the gamma-aminobutyric acid(A) receptor.' (Dawson GR et al., 2000).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with Avermectin A1a
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sun Y et al. | Identification of a gene cluster encoding meilingmycin biosynthesis among multiple polyketide synthase contigs isolated from Streptomyces nanchangensis NS3226. | 2003 | Arch. Microbiol. | pmid:12811466 |
| Lamb DC et al. | Cytochrome p450 complement (CYPome) of the avermectin-producer Streptomyces avermitilis and comparison to that of Streptomyces coelicolor A3(2). | 2003 | Biochem. Biophys. Res. Commun. | pmid:12893267 |
| Gaisser S et al. | Direct production of ivermectin-like drugs after domain exchange in the avermectin polyketide synthase of Streptomyces avermitilis ATCC31272. | 2003 | Org. Biomol. Chem. | pmid:12968333 |
| Rohrer SP et al. | Photoaffinity labeling of avermectin binding sites from Caenorhabditis elegans and Drosophila melanogaster. | 1992 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1315055 |
| Chartrain M et al. | Bioconversion of avermectin into 27-OH avermectin. | 1990 | J. Ind. Microbiol. | pmid:1366995 |
| Yates DM et al. | The avermectin receptors of Haemonchus contortus and Caenorhabditis elegans. | 2003 | Int. J. Parasitol. | pmid:13678634 |
| Stong JD et al. | Radical-induced oxidation of oxahydrindene (hexahydrobenzofuran) portion of 22,23-dihydroavermectin B1a: identification of autooxidation products. | 1992 | J Pharm Sci | pmid:1432608 |
| Meinke PT et al. | Affinity probes for the avermectin binding proteins. | 1992 | J. Med. Chem. | pmid:1433197 |
| Blackhall WJ et al. | Selection at a gamma-aminobutyric acid receptor gene in Haemonchus contortus resistant to avermectins/milbemycins. | 2003 | Mol. Biochem. Parasitol. | pmid:14511812 |
| Nagai K et al. | Synthesis and biological activities of novel 4"-alkylidene avermectin derivatives. | 2003 | Bioorg. Med. Chem. Lett. | pmid:14592480 |
| Yoon YJ et al. | Avermectin: biochemical and molecular basis of its biosynthesis and regulation. | 2004 | Appl. Microbiol. Biotechnol. | pmid:14689246 |
| Strabel D et al. | [The use of avermectins in two goats with demodicosis]. | 2003 | Schweiz. Arch. Tierheilkd. | pmid:14725185 |
| Shoop WL | Resistance to avermectins and milbemycins. | 1992 | Vet. Rec. | pmid:1496763 |
| Chen J et al. | Ethanol evolution rate: a new parameter to determine the feeding rate for the production of avermectins by Streptomyces avermitilis. | 2004 | Biotechnol. Lett. | pmid:15000476 |
| Liu J et al. | Genomic organization of an avermectin receptor subunit from Haemonchus contortus and expression of its putative promoter region in Caenorhabditis elegans. | 2004 | Mol. Biochem. Parasitol. | pmid:15003846 |
| Korystov YN et al. | Avermectins inhibit multidrug resistance of tumor cells. | 2004 | Eur. J. Pharmacol. | pmid:15189764 |
| Nagai K et al. | Synthesis and biological evaluation of novel 4"-alkoxy avermectin derivatives. | 2004 | Bioorg. Med. Chem. Lett. | pmid:15261257 |
| Rezanka T et al. | Influence of inhibitors of lipid biosynthesis on the production of avermectins in Streptomyces avermitilis. | 1992 | FEMS Microbiol. Lett. | pmid:1526463 |
| Drinyaev VA et al. | Antitumor effect of avermectins. | 2004 | Eur. J. Pharmacol. | pmid:15464058 |
| MacNeil DJ et al. | Analysis of Streptomyces avermitilis genes required for avermectin biosynthesis utilizing a novel integration vector. | 1992 | Gene | pmid:1547955 |