Avermectin A1a

Avermectin A1a is a lipid of Polyketides (PK) class. Avermectin a1a is associated with abnormalities such as Ataxia with vitamin E deficiency, Strongyloidiasis, Congenital Transposition, Gigantism and Onchocerciasis. The involved functions are known as DNA Binding, Anabolism, Insertion Mutation, Process and physiological aspects. Avermectin a1a often locates in Chromosomes, Membrane, Clone, soluble and Tissue membrane. The associated genes with Avermectin A1a are Polypeptides, oxytocin, 1-desamino-(O-Et-Tyr)(2)-, Gene Feature, Genome and Gene Clusters. The related lipids are Propionate. The related experimental models are Mouse Model.

Cross Reference

Introduction

To understand associated biological information of Avermectin A1a, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Avermectin A1a?

Avermectin A1a is suspected in Ataxia with vitamin E deficiency, Gigantism, Strongyloidiasis, Congenital Transposition, Onchocerciasis, Tropical Disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Avermectin A1a

MeSH term MeSH ID Detail
Inflammation D007249 119 associated lipids
Body Weight D001835 333 associated lipids
Dog Diseases D004283 5 associated lipids
Leukemia P388 D007941 43 associated lipids
Neuroblastoma D009447 66 associated lipids
Trichostrongyloidiasis D014252 7 associated lipids
Poisoning D011041 9 associated lipids
Cleft Palate D002972 9 associated lipids
Fish Diseases D005393 5 associated lipids
Neurotoxicity Syndromes D020258 34 associated lipids
Per page 10 20 | Total 19

PubChem Associated disorders and diseases

What pathways are associated with Avermectin A1a

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Avermectin A1a?

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Location Cross reference Weighted score Related literatures
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What functions are associated with Avermectin A1a?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Avermectin A1a?

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What genes are associated with Avermectin A1a?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Avermectin A1a?

Mouse Model

Mouse Model are used in the study 'Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the gamma-aminobutyric acid(A) receptor.' (Dawson GR et al., 2000).

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NCBI Entrez Crosslinks

All references with Avermectin A1a

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Per page 10 20 50 100 | Total 477
Authors Title Published Journal PubMed Link
Robertson B Actions of anaesthetics and avermectin on GABAA chloride channels in mammalian dorsal root ganglion neurones. 1989 Br. J. Pharmacol. pmid:2478243
Chen TS and Inamine ES Studies on the biosynthesis of avermectins. 1989 Arch. Biochem. Biophys. pmid:2705778
Blizzard TA et al. Brine shrimp (Artemia salina) as a convenient bioassay for avermectin analogs. 1989 J. Antibiot. pmid:2759912
Schaeffer JM et al. A chemiluminescent assay for measuring avermectin binding sites. 1989 Anal. Biochem. pmid:2729548
Chen TS et al. Directed biosynthesis of avermectins. 1989 Arch. Biochem. Biophys. pmid:2919882
Schulman MD et al. Purification and identification of dTDP-oleandrose, the precursor of the oleandrose units of the avermectins. 1990 J. Biol. Chem. pmid:2211601
Malaníková M et al. Use of thin-layer chromatography for the testing of avermectins produced by Streptomyces avermitilis strains. 1990 J. Chromatogr. pmid:2229244
Holden-Dye L and Walker RJ Avermectin and avermectin derivatives are antagonists at the 4-aminobutyric acid (GABA) receptor on the somatic muscle cells of Ascaris; is this the site of anthelmintic action? 1990 Parasitology pmid:2175874
Chartrain M et al. Bioconversion of avermectin into 27-OH avermectin. 1990 J. Ind. Microbiol. pmid:1366995
Arena JP et al. Avermectin-sensitive chloride currents induced by Caenorhabditis elegans RNA in Xenopus oocytes. 1991 Mol. Pharmacol. pmid:1716730