| MeSH term | MeSH ID | Detail |
|---|---|---|
| Inflammation | D007249 | 119 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Dog Diseases | D004283 | 5 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Trichostrongyloidiasis | D014252 | 7 associated lipids |
| Poisoning | D011041 | 9 associated lipids |
| Cleft Palate | D002972 | 9 associated lipids |
| Fish Diseases | D005393 | 5 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
Avermectin A1a
Avermectin A1a is a lipid of Polyketides (PK) class. Avermectin a1a is associated with abnormalities such as Ataxia with vitamin E deficiency, Strongyloidiasis, Congenital Transposition, Gigantism and Onchocerciasis. The involved functions are known as DNA Binding, Anabolism, Insertion Mutation, Process and physiological aspects. Avermectin a1a often locates in Chromosomes, Membrane, Clone, soluble and Tissue membrane. The associated genes with Avermectin A1a are Polypeptides, oxytocin, 1-desamino-(O-Et-Tyr)(2)-, Gene Feature, Genome and Gene Clusters. The related lipids are Propionate. The related experimental models are Mouse Model.
Cross Reference
Introduction
To understand associated biological information of Avermectin A1a, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Avermectin A1a?
Avermectin A1a is suspected in Ataxia with vitamin E deficiency, Gigantism, Strongyloidiasis, Congenital Transposition, Onchocerciasis, Tropical Disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Avermectin A1a
PubChem Associated disorders and diseases
What pathways are associated with Avermectin A1a
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Avermectin A1a?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Avermectin A1a?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Avermectin A1a?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Avermectin A1a?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Avermectin A1a?
Mouse Model
Mouse Model are used in the study 'Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the gamma-aminobutyric acid(A) receptor.' (Dawson GR et al., 2000).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Avermectin A1a
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Greene J and Goldberg RB | Isolation and preliminary characterization of lytic and lysogenic phages with wide host range within the streptomycetes. | 1985 | J. Gen. Microbiol. | pmid:2999304 |
| Woerde DJ et al. | Susceptibility of rapidly growing mycobacteria isolated from Australian cats to ivermectin, moxidectin, ceftiofur and florfenicol. | 2015 | J. Feline Med. Surg. | pmid:25572306 |
| Meyers JI et al. | Mosquitocidal properties of IgG targeting the glutamate-gated chloride channel in three mosquito disease vectors (Diptera: Culicidae). | 2015 | J. Exp. Biol. | pmid:25994632 |
| Laughton DL et al. | Reporter gene constructs suggest that the Caenorhabditis elegans avermectin receptor beta-subunit is expressed solely in the pharynx. | 1997 | J. Exp. Biol. | pmid:9192499 |
| Windelspecht M et al. | Survey of malathion resistance and avermectin susceptibility in field populations of Drosophila melanogaster (Diptera: Drosophilidae) and D. simulans. | 1998 | J. Econ. Entomol. | pmid:9887681 |
| Argentine JA et al. | Toxicities of emamectin benzoate homologues and photodegradates to Lepidoptera. | 2002 | J. Econ. Entomol. | pmid:12539830 |
| Boina DR et al. | Influence of posttreatment temperature on the toxicity of insecticides against Diaphorina citri (Hemiptera: Psyllidae). | 2009 | J. Econ. Entomol. | pmid:19449650 |
| Orton CJ et al. | Comparative effectiveness of avermectins and deltamethrin in suppressing oviposition in Lucilia cuprina (Diptera: Calliphoridae). | 1992 | J. Econ. Entomol. | pmid:1607479 |
| Chang V | Toxic baiting of the Western yellowjacket (Hymenoptera: Vespidae) in Hawaii. | 1988 | J. Econ. Entomol. | pmid:3351079 |
| Gao Y et al. | Species displacements are common to two invasive species of leafminer fly in China, Japan, and the United States. | 2011 | J. Econ. Entomol. | pmid:22299335 |
| Huang J et al. | Molecular characterization of the sigma class gutathione S-transferase from Chilo suppressalis and expression analysis upon bacterial and insecticidal challenge. | 2011 | J. Econ. Entomol. | pmid:22299369 |
| Lin YY et al. | Differential susceptibilities of Brontispa longissima (Coleoptera: Hispidae) to insecticides in Southeast Asia. | 2012 | J. Econ. Entomol. | pmid:22812140 |
| Parrish MD and Roberts RB | Toxicity of avermectin B1 to larval yellowjackets, Vespula maculifrons (Hymenoptera: Vespidae). | 1984 | J. Econ. Entomol. | pmid:6480980 |
| Smit JW et al. | Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure. | 1999 | J. Clin. Invest. | pmid:10562306 |
| Danaher M et al. | Extraction and isolation of avermectins and milbemycins from liver samples using unmodified supercritical CO2 with in-line trapping on basic alumina. | 2001 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:11585125 |
| Wu Z et al. | Multi-residue analysis of avermectins in swine liver by immunoaffinity extraction and liquid chromatography-mass spectrometry. | 2001 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:11393726 |
| Danaher M et al. | Review of methodology for the determination of macrocyclic lactone residues in biological matrices. | 2006 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:16950666 |
| Qin Y et al. | Analysis of sulfonamides, tilmicosin and avermectins residues in typical animal matrices with multi-plug filtration cleanup by liquid chromatography-tandem mass spectrometry detection. | 2017 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:28410479 |
| Tao Y et al. | Determination of 17 macrolide antibiotics and avermectins residues in meat with accelerated solvent extraction by liquid chromatography-tandem mass spectrometry. | 2012 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:22542398 |
| MalanÃková M et al. | Use of thin-layer chromatography for the testing of avermectins produced by Streptomyces avermitilis strains. | 1990 | J. Chromatogr. | pmid:2229244 |
| Tolan JW et al. | Determination of avermectins in plasma at nanogram levels using high-performance liquid chromatography with fluorescence detection. | 1980 | J. Chromatogr. | pmid:7380953 |
| Suroto DA et al. | Activation of cryptic phthoxazolin A production in Streptomyces avermitilis by the disruption of autoregulator-receptor homologue AvaR3. | 2017 | J. Biosci. Bioeng. | pmid:28728974 |
| Schulman MD et al. | Purification and identification of dTDP-oleandrose, the precursor of the oleandrose units of the avermectins. | 1990 | J. Biol. Chem. | pmid:2211601 |
| He JM et al. | Direct Involvement of the Master Nitrogen Metabolism Regulator GlnR in Antibiotic Biosynthesis in Streptomyces. | 2016 | J. Biol. Chem. | pmid:27875313 |
| Cully DF et al. | Identification of a Drosophila melanogaster glutamate-gated chloride channel sensitive to the antiparasitic agent avermectin. | 1996 | J. Biol. Chem. | pmid:8702744 |
| Vassilatis DK et al. | Genetic and biochemical evidence for a novel avermectin-sensitive chloride channel in Caenorhabditis elegans. Isolation and characterization. | 1997 | J. Biol. Chem. | pmid:9407104 |
| Payne GT and Soderlund DM | Activation of gamma-aminobutyric acid insensitive chloride channels in mouse brain synaptic vesicles by avermectin B1a. | 1991 | J. Biochem. Toxicol. | pmid:1663556 |
| Türkan F et al. | The toxicological impact of some avermectins on human erythrocytes glutathione S-transferase enzyme. | 2018 | J. Biochem. Mol. Toxicol. | pmid:30091233 |
| Curdová E et al. | The effect of inorganic phosphate on the production of avermectin in Streptomyces avermitilis. | 1989 | J. Basic Microbiol. | pmid:2614673 |
| Ikeda H et al. | Genetic studies of avermectin biosynthesis in Streptomyces avermitilis. | 1987 | J. Bacteriol. | pmid:3680172 |
| Ikeda H et al. | Transposon mutagenesis by Tn4560 and applications with avermectin-producing Streptomyces avermitilis. | 1993 | J. Bacteriol. | pmid:8384619 |
| MacNeil T et al. | Deletion analysis of the avermectin biosynthetic genes of Streptomyces avermitilis by gene cluster displacement. | 1993 | J. Bacteriol. | pmid:8478321 |
| Liu Y et al. | Characterization of SAV7471, a TetR-family transcriptional regulator involved in the regulation of coenzyme A metabolism in Streptomyces avermitilis. | 2013 | J. Bacteriol. | pmid:23893108 |
| Denoya CD et al. | A second branched-chain alpha-keto acid dehydrogenase gene cluster (bkdFGH) from Streptomyces avermitilis: its relationship to avermectin biosynthesis and the construction of a bkdF mutant suitable for the production of novel antiparasitic avermectins. | 1995 | J. Bacteriol. | pmid:7768860 |
| Onishi JC and Miller TW | The lack of antifungal activity by avermectin B1a. | 1985 | J. Antibiot. | pmid:4077735 |
| Hafner EW et al. | Branched-chain fatty acid requirement for avermectin production by a mutant of Streptomyces avermitilis lacking branched-chain 2-oxo acid dehydrogenase activity. | 1991 | J. Antibiot. | pmid:2026560 |
| Dutton CJ et al. | Novel avermectins produced by mutational biosynthesis. | 1991 | J. Antibiot. | pmid:2026561 |
| Blizzard TA et al. | Brine shrimp (Artemia salina) as a convenient bioassay for avermectin analogs. | 1989 | J. Antibiot. | pmid:2759912 |
| Schulman MD et al. | Demethylavermectins. Biosynthesis, isolation and characterization. | 1985 | J. Antibiot. | pmid:4077729 |
| Schulman MD et al. | Biosynthesis of the avermectins by Streptomyces avermitilis. Incorporation of labeled precursors. | 1986 | J. Antibiot. | pmid:3086265 |
| Ohba M et al. | Antiviral effect of theaflavins against caliciviruses. | 2017 | J. Antibiot. | pmid:27756911 |
| Omura S et al. | Selective production of specific components of avermectins in Streptomyces avermitilis. | 1991 | J. Antibiot. | pmid:2061197 |
| Tatsuta K | Celebrating the 2015 Nobel Prize in Physiology or Medicine of Dr Satoshi ÅŒmura. | 2016 | J. Antibiot. | pmid:26486878 |
| Calcott PH and Fatig RO | Inhibition of chitin metabolism by avermectin in susceptible organisms. | 1984 | J. Antibiot. | pmid:6725140 |
| Ikeda H et al. | Construction of a single component producer from the wild type avermectin producer Streptomyces avermitilis. | 1995 | J. Antibiot. | pmid:7622445 |
| Calcott PH and Fatig RO | Avermectin modulation of GABA binding to membranes of rat brain, brine shrimp and a fungus, Mucor miehei. | 1984 | J. Antibiot. | pmid:6088460 |
| Pang CH et al. | Production of 6,8a-seco-6,8a-deoxy derivatives of avermectins by a mutant strain of Streptomyces avermitilis. | 1995 | J. Antibiot. | pmid:7868391 |
| Pang CH et al. | Production of a new methylated 6,8a-seco-6,8a-deoxy derivative of the avermectins by a transformant strain of Streptomyces avermitilis. | 1995 | J. Antibiot. | pmid:7868398 |
| Ikeda H et al. | Direct production of 5-oxo derivatives of avermectins by a recombinant strain of Streptomyces avermitilis. | 1995 | J. Antibiot. | pmid:7868399 |
| Naito S et al. | Milbemycin derivatives: modification at the C-5 position. | 1994 | J. Antibiot. | pmid:8150720 |