Methymycin

Methymycin is a lipid of Polyketides (PK) class. Methymycin is associated with abnormalities such as abnormal fragmented structure. The involved functions are known as Anabolism.

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Introduction

To understand associated biological information of Methymycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Methymycin?

Methymycin is suspected in and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with Methymycin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Methymycin?

There are no associated biomedical information in the current reference collection.

What functions are associated with Methymycin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Methymycin?

There are no associated biomedical information in the current reference collection.

What genes are associated with Methymycin?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with Methymycin?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Methymycin

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Authors Title Published Journal PubMed Link
pmid:
Wu J et al. Chain elongation, macrolactonization, and hydrolysis of natural and reduced hexaketide substrates by the picromycin/methymycin polyketide synthase. 2005 Angew. Chem. Int. Ed. Engl. pmid:16247819
Ding R et al. New methymycin derivatives of Streptomyces venezuelae ATCC 15439 and their inhibitory effects on human T cell proliferation mediated by PMA/ionomycin. 2012 Arch. Pharm. Res. pmid:23054713
Borisova SA and Liu HW Characterization of glycosyltransferase DesVII and its auxiliary partner protein DesVIII in the methymycin/picromycin biosynthetic pathway. 2010 Biochemistry pmid:20695498
Lu H et al. Expression, site-directed mutagenesis, and steady state kinetic analysis of the terminal thioesterase domain of the methymycin/picromycin polyketide synthase. 2002 Biochemistry pmid:12379101
Zhao L et al. Beta-glucosylation as a part of self-resistance mechanism in methymycin/pikromycin producing strain Streptomyces venezuelae. 2003 Biochemistry pmid:14674753
Kittendorf JD and Sherman DH The methymycin/pikromycin pathway: a model for metabolic diversity in natural product biosynthesis. 2009 Bioorg. Med. Chem. pmid:19027305
Chang CW and Liu HW Synthesis of TDP-3-amino-3,4,6-trideoxy-alpha-D-xylo-hexopyranose--the immediate precursor of TDP-alpha-D-desosamine. 2002 Bioorg. Med. Chem. Lett. pmid:12031327
He W et al. Macrolactonization to 10-deoxymethynolide catalyzed by the recombinant thioesterase of the picromycin/methymycin polyketide synthase. 2006 Bioorg. Med. Chem. Lett. pmid:16249083
Graziani EI et al. Macrolide biosynthesis: a single cytochrome P450, PicK, is responsible for the hydroxylations that generate methymycin, neomethymycin, and picromycin in Streptomyces venezuelae. 1998 Bioorg. Med. Chem. Lett. pmid:9873687