Pikromycin

Pikromycin is a lipid of Polyketides (PK) class. The involved functions are known as Anabolism, Process, Cytokinesis, Mutation and Biochemical Pathway. Pikromycin often locates in soluble. The associated genes with Pikromycin are SLC7A1 gene, Homologous Gene, Gene Clusters, Polypeptides and THEMIS gene.

Cross Reference

Introduction

To understand associated biological information of Pikromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Pikromycin?

There are no associated biomedical information in the current reference collection.

No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with Pikromycin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Pikromycin?

Related references are published most in these journals:

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What functions are associated with Pikromycin?


Related references are published most in these journals:

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What lipids are associated with Pikromycin?

There are no associated biomedical information in the current reference collection.

What genes are associated with Pikromycin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Pikromycin?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Pikromycin

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Authors Title Published Journal PubMed Link
pmid:
Buchholz TJ et al. Structural basis for binding specificity between subclasses of modular polyketide synthase docking domains. 2009 ACS Chem. Biol. pmid:19146481
BRODERSEN R et al. Antibiotic properties of picromycin. 1953 Acta Pharmacol Toxicol (Copenh) pmid:13123945
Wu J et al. Chain elongation, macrolactonization, and hydrolysis of natural and reduced hexaketide substrates by the picromycin/methymycin polyketide synthase. 2005 Angew. Chem. Int. Ed. Engl. pmid:16247819
Han S et al. Structural insights into the binding of lauric acid to CYP107L2 from Streptomyces avermitilis. 2017 Biochem. Biophys. Res. Commun. pmid:27890614
Borisova SA and Liu HW Characterization of glycosyltransferase DesVII and its auxiliary partner protein DesVIII in the methymycin/picromycin biosynthetic pathway. 2010 Biochemistry pmid:20695498
Lu H et al. Expression, site-directed mutagenesis, and steady state kinetic analysis of the terminal thioesterase domain of the methymycin/picromycin polyketide synthase. 2002 Biochemistry pmid:12379101
Zhao L et al. Beta-glucosylation as a part of self-resistance mechanism in methymycin/pikromycin producing strain Streptomyces venezuelae. 2003 Biochemistry pmid:14674753
Betlach MC et al. Characterization of the macrolide P-450 hydroxylase from Streptomyces venezuelae which converts narbomycin to picromycin. 1998 Biochemistry pmid:9778370
Tsai SC et al. Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases. 2002 Biochemistry pmid:12379102