| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hansen DA et al. | Identification of a Thioesterase Bottleneck in the Pikromycin Pathway through Full-Module Processing of Unnatural Pentaketides. | 2017 | J. Am. Chem. Soc. | pmid:28836772 |
| Koch AA et al. | A Single Active Site Mutation in the Pikromycin Thioesterase Generates a More Effective Macrocyclization Catalyst. | 2017 | J. Am. Chem. Soc. | pmid:28836768 |
| Pyeon HR et al. | Heterologous expression of pikromycin biosynthetic gene cluster using Streptomyces artificial chromosome system. | 2017 | Microb. Cell Fact. | pmid:28569150 |
| Han S et al. | Structural insights into the binding of lauric acid to CYP107L2 from Streptomyces avermitilis. | 2017 | Biochem. Biophys. Res. Commun. | pmid:27890614 |
| Goldberg VE et al. | Assessment of Erythroid and Granulocytic Hematopoietic Lineages in Patients with Non-Small-Cell Lung Carcinoma. | 2017 | Bull. Exp. Biol. Med. | pmid:28853075 |
| Almutairi MM et al. | Co-produced natural ketolides methymycin and pikromycin inhibit bacterial growth by preventing synthesis of a limited number of proteins. | 2017 | Nucleic Acids Res. | pmid:28934499 |
| Tripathi A et al. | Thioesterase domain swapping of a linear polyketide tautomycetin with a macrocyclic polyketide pikromycin in Streptomyces sp. CK4412. | 2016 | J. Ind. Microbiol. Biotechnol. | pmid:27277081 |
| Chemler JA et al. | Evolution of Efficient Modular Polyketide Synthases by Homologous Recombination. | 2015 | J. Am. Chem. Soc. | pmid:26230368 |
| Li Y et al. | Functional Characterization of a Dehydratase Domain from the Pikromycin Polyketide Synthase. | 2015 | J. Am. Chem. Soc. | pmid:26027428 |
| Hansen DA et al. | Substrate controlled divergence in polyketide synthase catalysis. | 2015 | J. Am. Chem. Soc. | pmid:25730816 |
| Yi JS et al. | Effects of Sucrose, Phosphate, and Calcium Carbonate on the Production of Pikromycin from Streptomyces venezuelae. | 2015 | J. Microbiol. Biotechnol. | pmid:25341465 |
| Dutta S et al. | Structure of a modular polyketide synthase. | 2014 | Nature | pmid:24965652 |
| Whicher JR et al. | Structural rearrangements of a polyketide synthase module during its catalytic cycle. | 2014 | Nature | pmid:24965656 |
| Hansen DA et al. | Biocatalytic synthesis of pikromycin, methymycin, neomethymycin, novamethymycin, and ketomethymycin. | 2013 | J. Am. Chem. Soc. | pmid:23866020 |
| Oh HS and Kang HY | Total synthesis of pikromycin. | 2012 | J. Org. Chem. | pmid:22168449 |
| Bonnett SA et al. | Acyl-CoA subunit selectivity in the pikromycin polyketide synthase PikAIV: steady-state kinetics and active-site occupancy analysis by FTICR-MS. | 2011 | Chem. Biol. | pmid:21944746 |
| Han AR et al. | Biosynthesis of glycosylated derivatives of tylosin in Streptomyces venezuelae. | 2011 | J. Microbiol. Biotechnol. | pmid:21715968 |
| Borisova SA and Liu HW | Characterization of glycosyltransferase DesVII and its auxiliary partner protein DesVIII in the methymycin/picromycin biosynthetic pathway. | 2010 | Biochemistry | pmid:20695498 |
| Kittendorf JD and Sherman DH | The methymycin/pikromycin pathway: a model for metabolic diversity in natural product biosynthesis. | 2009 | Bioorg. Med. Chem. | pmid:19027305 |
| Maharjan S et al. | Identification and functional characterization of an afsR homolog regulatory gene from Streptomyces venezuelae ATCC 15439. | 2009 | J. Microbiol. Biotechnol. | pmid:19307759 |
| Yan J et al. | Functional dissection of a multimodular polypeptide of the pikromycin polyketide synthase into monomodules by using a matched pair of heterologous docking domains. | 2009 | Chembiochem | pmid:19437523 |
| Mortison JD et al. | Synthesis and biochemical analysis of complex chain-elongation intermediates for interrogation of molecular specificity in the erythromycin and pikromycin polyketide synthases. | 2009 | J. Am. Chem. Soc. | pmid:19810731 |
| Buchholz TJ et al. | Structural basis for binding specificity between subclasses of modular polyketide synthase docking domains. | 2009 | ACS Chem. Biol. | pmid:19146481 |
| Lopanik NB et al. | In vivo and in vitro trans-acylation by BryP, the putative bryostatin pathway acyltransferase derived from an uncultured marine symbiont. | 2008 | Chem. Biol. | pmid:19022178 |
| Maharjan S et al. | Heterologous expression of metK1-sp and afsR-sp in Streptomyces venezuelae for the production of pikromycin. | 2008 | Biotechnol. Lett. | pmid:18421418 |
| Gupta S et al. | Generation of novel pikromycin antibiotic products through mutasynthesis. | 2008 | Chembiochem | pmid:18512859 |
| Kittendorf JD et al. | Interrogating the molecular basis for multiple macrolactone ring formation by the pikromycin polyketide synthase. | 2007 | Chem. Biol. | pmid:17719493 |
| Akey DL et al. | Structural basis for macrolactonization by the pikromycin thioesterase. | 2006 | Nat. Chem. Biol. | pmid:16969372 |
| Giraldes JW et al. | Structural and mechanistic insights into polyketide macrolactonization from polyketide-based affinity labels. | 2006 | Nat. Chem. Biol. | pmid:16969373 |
| O'Connor SE | Cyclization of natural products. | 2006 | Nat. Chem. Biol. | pmid:16983382 |
| Venkatraman L et al. | Total synthesis of narbonolide and biotransformation to pikromycin. | 2006 | J. Org. Chem. | pmid:17168607 |
| Lee SK et al. | Neopikromycin and novapikromycin from the pikromycin biosynthetic pathway of Streptomyces venezuelae. | 2006 | J. Nat. Prod. | pmid:16724858 |
| He W et al. | Macrolactonization to 10-deoxymethynolide catalyzed by the recombinant thioesterase of the picromycin/methymycin polyketide synthase. | 2006 | Bioorg. Med. Chem. Lett. | pmid:16249083 |
| Wu J et al. | Polyketide double bond biosynthesis. Mechanistic analysis of the dehydratase-containing module 2 of the picromycin/methymycin polyketide synthase. | 2005 | J. Am. Chem. Soc. | pmid:16332089 |
| Wu J et al. | Chain elongation, macrolactonization, and hydrolysis of natural and reduced hexaketide substrates by the picromycin/methymycin polyketide synthase. | 2005 | Angew. Chem. Int. Ed. Engl. | pmid:16247819 |
| Aldrich CC et al. | Biochemical investigation of pikromycin biosynthesis employing native penta- and hexaketide chain elongation intermediates. | 2005 | J. Am. Chem. Soc. | pmid:15941278 |
| Borisova SA et al. | Characterization of the glycosyltransferase activity of desVII: analysis of and implications for the biosynthesis of macrolide antibiotics. | 2004 | J. Am. Chem. Soc. | pmid:15161264 |
| Hong JS et al. | New olivosyl derivatives of methymycin/pikromycin from an engineered strain of Streptomyces venezuelae. | 2004 | FEMS Microbiol. Lett. | pmid:15358425 |
| Kim BS et al. | An efficient method for creation and functional analysis of libraries of hybrid type I polyketide synthases. | 2004 | Protein Eng. Des. Sel. | pmid:15067106 |
| Lee SK et al. | The role of erythromycin C-12 hydroxylase, EryK, as a substitute for PikC hydroxylase in pikromycin biosynthesis. | 2004 | Bioorg. Chem. | pmid:15530995 |
| Yin Y et al. | Expression and kinetic analysis of the substrate specificity of modules 5 and 6 of the picromycin/methymycin polyketide synthase. | 2003 | J. Am. Chem. Soc. | pmid:12733905 |
| Zhao L et al. | Beta-glucosylation as a part of self-resistance mechanism in methymycin/pikromycin producing strain Streptomyces venezuelae. | 2003 | Biochemistry | pmid:14674753 |
| Beck BJ et al. | Iterative chain elongation by a pikromycin monomodular polyketide synthase. | 2003 | J. Am. Chem. Soc. | pmid:12696866 |
| Watanabe K et al. | Understanding substrate specificity of polyketide synthase modules by generating hybrid multimodular synthases. | 2003 | J. Biol. Chem. | pmid:12923197 |
| Beck BJ et al. | Substrate recognition and channeling of monomodules from the pikromycin polyketide synthase. | 2003 | J. Am. Chem. Soc. | pmid:14531700 |
| Lu H et al. | Expression, site-directed mutagenesis, and steady state kinetic analysis of the terminal thioesterase domain of the methymycin/picromycin polyketide synthase. | 2002 | Biochemistry | pmid:12379101 |
| Kim BS et al. | Biochemical evidence for an editing role of thioesterase II in the biosynthesis of the polyketide pikromycin. | 2002 | J. Biol. Chem. | pmid:12368286 |
| Kim BS et al. | An unexpected interaction between the modular polyketide synthases, erythromycin DEBS1 and pikromycin PikAIV, leads to efficient triketide lactone synthesis. | 2002 | Biochemistry | pmid:12196022 |
| Tsai SC et al. | Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases. | 2002 | Biochemistry | pmid:12379102 |
| Beck BJ et al. | The hidden steps of domain skipping: macrolactone ring size determination in the pikromycin modular polyketide synthase. | 2002 | Chem. Biol. | pmid:12031664 |
| Xue Y and Sherman DH | Biosynthesis and combinatorial biosynthesis of pikromycin-related macrolides in Streptomyces venezuelae. | 2001 | Metab. Eng. | pmid:11162229 |
| Cropp A et al. | Genetic approaches for controlling ratios of related polyketide products in fermentation processes. | 2001 | J. Ind. Microbiol. Biotechnol. | pmid:11774002 |
| Wilson DJ et al. | Characterization and analysis of the PikD regulatory factor in the pikromycin biosynthetic pathway of Streptomyces venezuelae. | 2001 | J. Bacteriol. | pmid:11344155 |
| Chen S et al. | The Streptomyces venezuelae pikAV gene contains a transcription unit essential for expression of enzymes involved in glycosylation of narbonolide and 10-deoxymethynolide. | 2001 | Gene | pmid:11223265 |
| Garzotti M et al. | Coupling of a supercritical fluid chromatography system to a hybrid (Q-TOF 2) mass spectrometer: on-line accurate mass measurements. | 2001 | Rapid Commun. Mass Spectrom. | pmid:11445901 |
| Xue Y et al. | Genetic architecture of the polyketide synthases for methymycin and pikromycin series macrolides. | 2000 | Gene | pmid:10713461 |
| Xue Y and Sherman DH | Alternative modular polyketide synthase expression controls macrolactone structure. | 2000 | Nature | pmid:10676969 |
| Tang L et al. | Formation of functional heterologous complexes using subunits from the picromycin, erythromycin and oleandomycin polyketide synthases. | 2000 | Chem. Biol. | pmid:10662693 |
| Chen S et al. | Mechanisms of molecular recognition in the pikromycin polyketide synthase. | 2000 | Chem. Biol. | pmid:11137814 |
| Tang L et al. | Elucidating the mechanism of chain termination switching in the picromycin/methymycin polyketide synthase. | 1999 | Chem. Biol. | pmid:10421766 |
| Betlach MC et al. | Characterization of the macrolide P-450 hydroxylase from Streptomyces venezuelae which converts narbomycin to picromycin. | 1998 | Biochemistry | pmid:9778370 |
| Graziani EI et al. | Macrolide biosynthesis: a single cytochrome P450, PicK, is responsible for the hydroxylations that generate methymycin, neomethymycin, and picromycin in Streptomyces venezuelae. | 1998 | Bioorg. Med. Chem. Lett. | pmid:9873687 |
| BRODERSEN R et al. | Antibiotic properties of picromycin. | 1953 | Acta Pharmacol Toxicol (Copenh) | pmid:13123945 |
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Pikromycin
Pikromycin is a lipid of Polyketides (PK) class. The involved functions are known as Anabolism, Process, Cytokinesis, Mutation and Biochemical Pathway. Pikromycin often locates in soluble. The associated genes with Pikromycin are SLC7A1 gene, Homologous Gene, Gene Clusters, Polypeptides and THEMIS gene.
Cross Reference
Introduction
To understand associated biological information of Pikromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Pikromycin?
There are no associated biomedical information in the current reference collection.
No disease MeSH terms mapped to the current reference collection.
PubChem Associated disorders and diseases
What pathways are associated with Pikromycin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Pikromycin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Pikromycin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Pikromycin?
There are no associated biomedical information in the current reference collection.
What genes are associated with Pikromycin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Pikromycin?
There are no associated biomedical information in the current reference collection.