Ansamitocin P-3

Ansamitocin P-3 is a lipid of Polyketides (PK) class.

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Current reference collection contains 418 references associated with Ansamitocin P-3 in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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pmid:
Havens CG et al. Cellular effects of leishmanial tubulin inhibitors on L. donovani. 2000 Mol. Biochem. Parasitol. pmid:11071278
Carroll BJ et al. Identification of a set of genes involved in the formation of the substrate for the incorporation of the unusual "glycolate" chain extension unit in ansamitocin biosynthesis. 2002 J. Am. Chem. Soc. pmid:11960423
Moss SJ et al. Identification of asm19 as an acyltransferase attaching the biologically essential ester side chain of ansamitocins using N-desmethyl-4,5-desepoxymaytansinol, not maytansinol, as its substrate. 2002 J. Am. Chem. Soc. pmid:12047169
Yu TW et al. The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum. 2002 Proc. Natl. Acad. Sci. U.S.A. pmid:12060743
Spiteller P et al. The post-polyketide synthase modification steps in the biosynthesis of the antitumor agent ansamitocin by Actinosynnema pretiosum. 2003 J. Am. Chem. Soc. pmid:14624546
Okamoto K et al. Therapeutic effect of ansamitocin targeted to tumor by a bispecific monoclonal antibody. 1992 Jpn. J. Cancer Res. pmid:1517150
Lu C et al. A novel amide N-glycoside of ansamitocins from Actinosynnema pretiosum. 2004 J. Antibiot. pmid:15303496
Li Y et al. Binding selectivity of rhizoxin, phomopsin A, vinblastine, and ansamitocin P-3 to fungal tubulins: differential interactions of these antimitotic agents with brain and fungal tubulins. 1992 Biochem. Biophys. Res. Commun. pmid:1530630
Liu Z et al. An API LC/MS/MS quantitation method for ansamitocin P-3 (AP3) and its preclinical pharmacokinetics. 2004 J Pharm Biomed Anal pmid:15533675
Liu Z et al. Metabolism studies of the anti-tumor agent maytansine and its analog ansamitocin P-3 using liquid chromatography/tandem mass spectrometry. 2005 J Mass Spectrom pmid:15674857
Kubota T et al. Determination of the cryptic stereochemistry of the first PKS chain-extension step in ansamitocin biosynthesis by Actinosynnema pretiosum. 2006 Chembiochem pmid:16927319
Wenzel SC et al. On the biosynthetic origin of methoxymalonyl-acyl carrier protein, the substrate for incorporation of "glycolate" units into ansamitocin and soraphen A. 2006 J. Am. Chem. Soc. pmid:17076505
Li Y et al. Interaction of phomopsin A with porcine brain tubulin. Inhibition of tubulin polymerization and binding at a rhizoxin binding site. 1992 Biochem. Pharmacol. pmid:1739410
Ma J et al. New amide N-glycosides of ansamitocins identified from Actinosynnema pretiosum. 2007 Arch. Pharm. Res. pmid:17679541
Snipes CE et al. The ansacarbamitocins: polar ansamitocin derivatives. 2007 J. Nat. Prod. pmid:17892263
Goh S et al. An integrative expression vector for Actinosynnema pretiosum. 2007 BMC Biotechnol. pmid:17956638
Taft F et al. Highly active ansamitocin derivatives: mutasynthesis using an AHBA-blocked mutant. 2008 Chembiochem pmid:18381586
Zhao P et al. Amide N-glycosylation by Asm25, an N-glycosyltransferase of ansamitocins. 2008 Chem. Biol. pmid:18721757
Taft F et al. Timing of the Delta(10,12)-Delta(11,13) double bond migration during ansamitocin biosynthesis in Actinosynnema pretiosum. 2009 J. Am. Chem. Soc. pmid:19292483

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