| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Du ZQ et al. | Combination of traditional mutation and metabolic engineering to enhance ansamitocin P-3 production in Actinosynnema pretiosum. | 2017 | Biotechnol. Bioeng. | pmid:28782796 |
| Zhao M et al. | Effects of the Methylmalonyl-CoA Metabolic Pathway on Ansamitocin Production in Actinosynnema pretiosum. | 2017 | Appl. Biochem. Biotechnol. | pmid:27787765 |
| Seidel K et al. | Synthesis of Magnetic-Nanoparticle/Ansamitocin Conjugates-Inductive Heating Leads to Decreased Cell Proliferation In Vitro and Attenuation Of Tumour Growth In Vivo. | 2017 | Chemistry | pmid:28585348 |
| Wang LL et al. | A Bio-Chemosynthetic Approach to Superparamagnetic Iron Oxide-Ansamitocin Conjugates for Use in Magnetic Drug Targeting. | 2017 | Chemistry | pmid:27935144 |
| Ning X et al. | Identification and Engineering of Post-PKS Modification Bottlenecks for Ansamitocin P-3 Titer Improvement in Actinosynnema pretiosum subsp. pretiosum ATCC 31280. | 2017 | Biotechnol J | pmid:28881098 |
| Lin J and Zhong JJ | Proteomic studies on anti-tumor agent ansamitocin P-3 producer Actinosynnema pretiosum in response to ammonium and isobutanol. | 2017 | Bioprocess Biosyst Eng | pmid:28382459 |
| Fan Y et al. | Effects of modulation of pentose-phosphate pathway on biosynthesis of ansamitocins in Actinosynnema pretiosum. | 2016 | J. Biotechnol. | pmid:27173582 |
| Fan Y et al. | Enhancement of UDPG synthetic pathway improves ansamitocin production in Actinosynnem pretiosum. | 2016 | Appl. Microbiol. Biotechnol. | pmid:26585444 |
| Li S et al. | Constitutive overexpression of asm18 increases the production and diversity of maytansinoids in Actinosynnema pretiosum. | 2016 | Appl. Microbiol. Biotechnol. | pmid:26572523 |
| Zhang YG et al. | Nocardiopsis ansamitocini sp. nov., a new producer of ansamitocin P-3 of the genus Nocardiopsis. | 2016 | Int. J. Syst. Evol. Microbiol. | pmid:26486850 |
| Li T et al. | Improvement of ansamitocin P-3 production by Actinosynnema mirum with fructose as the sole carbon source. | 2015 | Appl. Biochem. Biotechnol. | pmid:25564203 |
| Fan Y et al. | Process optimization with alternative carbon sources and modulation of secondary metabolism for enhanced ansamitocin P-3 production in Actinosynnema pretiosum. | 2014 | J. Biotechnol. | pmid:25456055 |
| Mancuso L et al. | Preparation of thermocleavable conjugates based on ansamitocin and superparamagnetic nanostructured particles by a chemobiosynthetic approach. | 2014 | Chemistry | pmid:25346489 |
| Martin K et al. | The microtubule-depolymerizing agent ansamitocin P3 programs dendritic cells toward enhanced anti-tumor immunity. | 2014 | Cancer Immunol. Immunother. | pmid:24906866 |
| Gao Y et al. | Enhancement of ansamitocin P-3 production in Actinosynnema pretiosum by a synergistic effect of glycerol and glucose. | 2014 | J. Ind. Microbiol. Biotechnol. | pmid:24174216 |
| Venghateri JB et al. | Ansamitocin P3 depolymerizes microtubules and induces apoptosis by binding to tubulin at the vinblastine site. | 2013 | PLoS ONE | pmid:24124473 |
| Dagger F et al. | Regulatory volume decrease in Leishmania mexicana: effect of anti-microtubule drugs. | 2013 | Mem. Inst. Oswaldo Cruz | pmid:23440120 |
| Pan W et al. | Asm8, a specific LAL-type activator of 3-amino-5-hydroxybenzoate biosynthesis in ansamitocin production. | 2013 | Sci China Life Sci | pmid:23832249 |
| Siyu-Mao et al. | Two novel ansamitocin analogs from Actinosynnema pretiosum. | 2013 | Nat. Prod. Res. | pmid:23061718 |
| Mancuso L et al. | Bioreduction of aryl azides during mutasynthesis of new ansamitocins. | 2013 | Org. Lett. | pmid:23981134 |
| Eichner S et al. | The interplay between mutasynthesis and semisynthesis: generation and evaluation of an ansamitocin library. | 2012 | Angew. Chem. Int. Ed. Engl. | pmid:22135226 |
| Taft F et al. | Combined muta- and semisynthesis: a powerful synthetic hybrid approach to access target specific antitumor agents based on ansamitocin P3. | 2012 | Chemistry | pmid:22170289 |
| Segraves NL et al. | An isolable acyclic hemiacetal of ansamitocin P-3. | 2012 | Magn Reson Chem | pmid:22374862 |
| Lin J et al. | Enhanced production of ansamitocin P-3 by addition of isobutanol in fermentation of Actinosynnema pretiosum. | 2011 | Bioresour. Technol. | pmid:20980145 |
| Jia Y and Zhong JJ | Enhanced production of ansamitocin P-3 by addition of Mg2+ in fermentation of Actinosynnema pretiosum. | 2011 | Bioresour. Technol. | pmid:21907573 |
| Wu Y et al. | N-methylation of the amide bond by methyltransferase asm10 in ansamitocin biosynthesis. | 2011 | Chembiochem | pmid:21681880 |
| Li Y et al. | Dual carbamoylations on the polyketide and glycosyl moiety by asm21 result in extended ansamitocin biosynthesis. | 2011 | Chem. Biol. | pmid:22195559 |
| Knobloch T et al. | Mutational biosynthesis of ansamitocin antibiotics: a diversity-oriented approach to exploit biosynthetic flexibility. | 2011 | Chembiochem | pmid:22238146 |
| Harmrolfs K et al. | Cyclization of synthetic seco-proansamitocins to ansamitocin macrolactams by Actinosynnema pretiosum as biocatalyst. | 2010 | Chembiochem | pmid:21077088 |
| Yao Y et al. | Preparative isolation and purification of anti-tumor agent ansamitocin P-3 from fermentation broth of Actinosynnema pretiosum using high-performance counter-current chromatography. | 2010 | J Sep Sci | pmid:20235129 |
| Wei GZ et al. | A new antitumour ansamitocin from Actinosynnema pretiosum. | 2010 | Nat. Prod. Res. | pmid:20582809 |
| Taft F et al. | Timing of the Delta(10,12)-Delta(11,13) double bond migration during ansamitocin biosynthesis in Actinosynnema pretiosum. | 2009 | J. Am. Chem. Soc. | pmid:19292483 |
| Ng D et al. | Constitutive overexpression of asm2 and asm39 increases AP-3 production in the actinomycete Actinosynnema pretiosum. | 2009 | J. Ind. Microbiol. Biotechnol. | pmid:19609582 |
| Taft F et al. | Highly active ansamitocin derivatives: mutasynthesis using an AHBA-blocked mutant. | 2008 | Chembiochem | pmid:18381586 |
| Zhao P et al. | Amide N-glycosylation by Asm25, an N-glycosyltransferase of ansamitocins. | 2008 | Chem. Biol. | pmid:18721757 |
| Snipes CE et al. | The ansacarbamitocins: polar ansamitocin derivatives. | 2007 | J. Nat. Prod. | pmid:17892263 |
| Goh S et al. | An integrative expression vector for Actinosynnema pretiosum. | 2007 | BMC Biotechnol. | pmid:17956638 |
| Ma J et al. | New amide N-glycosides of ansamitocins identified from Actinosynnema pretiosum. | 2007 | Arch. Pharm. Res. | pmid:17679541 |
| Kubota T et al. | Determination of the cryptic stereochemistry of the first PKS chain-extension step in ansamitocin biosynthesis by Actinosynnema pretiosum. | 2006 | Chembiochem | pmid:16927319 |
| Wenzel SC et al. | On the biosynthetic origin of methoxymalonyl-acyl carrier protein, the substrate for incorporation of "glycolate" units into ansamitocin and soraphen A. | 2006 | J. Am. Chem. Soc. | pmid:17076505 |
| Liu Z et al. | Metabolism studies of the anti-tumor agent maytansine and its analog ansamitocin P-3 using liquid chromatography/tandem mass spectrometry. | 2005 | J Mass Spectrom | pmid:15674857 |
| Lu C et al. | A novel amide N-glycoside of ansamitocins from Actinosynnema pretiosum. | 2004 | J. Antibiot. | pmid:15303496 |
| Liu Z et al. | An API LC/MS/MS quantitation method for ansamitocin P-3 (AP3) and its preclinical pharmacokinetics. | 2004 | J Pharm Biomed Anal | pmid:15533675 |
| Spiteller P et al. | The post-polyketide synthase modification steps in the biosynthesis of the antitumor agent ansamitocin by Actinosynnema pretiosum. | 2003 | J. Am. Chem. Soc. | pmid:14624546 |
| Carroll BJ et al. | Identification of a set of genes involved in the formation of the substrate for the incorporation of the unusual "glycolate" chain extension unit in ansamitocin biosynthesis. | 2002 | J. Am. Chem. Soc. | pmid:11960423 |
| Yu TW et al. | The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12060743 |
| Moss SJ et al. | Identification of asm19 as an acyltransferase attaching the biologically essential ester side chain of ansamitocins using N-desmethyl-4,5-desepoxymaytansinol, not maytansinol, as its substrate. | 2002 | J. Am. Chem. Soc. | pmid:12047169 |
| Havens CG et al. | Cellular effects of leishmanial tubulin inhibitors on L. donovani. | 2000 | Mol. Biochem. Parasitol. | pmid:11071278 |
| Liu C et al. | Eradication of large colon tumor xenografts by targeted delivery of maytansinoids. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8710920 |
| Li Y et al. | Binding selectivity of rhizoxin, phomopsin A, vinblastine, and ansamitocin P-3 to fungal tubulins: differential interactions of these antimitotic agents with brain and fungal tubulins. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1530630 |
Ansamitocin P-3
Ansamitocin P-3 is a lipid of Polyketides (PK) class.
Cross Reference
