Epothilone A

Epothilone a is a lipid of Polyketides (PK) class. Epothilone a is associated with abnormalities such as abnormal fragmented structure and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Polymerization, Mutation, Depolymerization, Musculoskeletal torsion, function and Negative Regulation of Microtubule Depolymerization. Epothilone a often locates in Microtubules, soluble, Nuclear Structure and Microtubule cytoskeleton. The associated genes with Epothilone A are C9 gene, SLC33A1 gene, KIF2C gene and HMHA1 gene.

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Introduction

To understand associated biological information of Epothilone A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Epothilone A?

Epothilone A is suspected in and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Epothilone A

PubChem Associated disorders and diseases

What pathways are associated with Epothilone A

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Epothilone A?

Related references are published most in these journals:

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What functions are associated with Epothilone A?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Epothilone A?

There are no associated biomedical information in the current reference collection.

What genes are associated with Epothilone A?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Epothilone A?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Epothilone A

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Authors Title Published Journal PubMed Link
Giannakakou P et al. Enhanced microtubule-dependent trafficking and p53 nuclear accumulation by suppression of microtubule dynamics. 2002 Proc. Natl. Acad. Sci. U.S.A. pmid:12145320
Liu ZY et al. Total synthesis of epothilone a through stereospecific epoxidation of the p-methoxybenzyl ether of epothilone C. 2002 Chemistry pmid:12203301
Atadja P et al. Gene expression profiling of epothilone A-resistant cells. 2002 Novartis Found. Symp. pmid:11990772
Nicolaou KC and Pfefferkorn JA Solid phase synthesis of complex natural products and libraries thereof. 2001 Biopolymers pmid:11774224
Lichtner RB et al. Subcellular distribution of epothilones in human tumor cells. 2001 Proc. Natl. Acad. Sci. U.S.A. pmid:11562452
Hardt IH et al. New natural epothilones from Sorangium cellulosum, strains So ce90/B2 and So ce90/D13: isolation, structure elucidation, and SAR studies. 2001 J. Nat. Prod. pmid:11473410
Bode JW and Carreira EM Stereoselective syntheses of epothilones A and B via nitrile oxide cycloadditions and related studies. 2001 J. Org. Chem. pmid:11559194
Chen H et al. Epothilone biosynthesis: assembly of the methylthiazolylcarboxy starter unit on the EpoB subunit. 2001 Chem. Biol. pmid:11564558
Bode JW and Carreira EM Stereoselective syntheses of epothilones A and B via directed nitrile oxide cycloaddition. 2001 J. Am. Chem. Soc. pmid:11472140
Stachel SJ et al. The epothilones, eleutherobins, and related types of molecules. 2001 Curr. Pharm. Des. pmid:11472267
Gerth K et al. Studies on the biosynthesis of epothilones: the PKS and Epothilone C/D monooxygenase. 2001 J. Antibiot. pmid:11302486
Kavallaris M et al. Anticancer therapy with novel tubulin-interacting drugs. 2001 Drug Resist. Updat. pmid:12030786
Li Y et al. [Diversity of metabolites and their bio-activities in myxobacterium Sorangium cellulosum]. 2001 Wei Sheng Wu Xue Bao pmid:12552829
Molnár I et al. The biosynthetic gene cluster for the microtubule-stabilizing agents epothilones A and B from Sorangium cellulosum So ce90. 2000 Chem. Biol. pmid:10662695
Tang L et al. Cloning and heterologous expression of the epothilone gene cluster. 2000 Science pmid:10649995
Santi DV et al. An approach for obtaining perfect hybridization probes for unknown polyketide synthase genes: a search for the epothilone gene cluster. 2000 Gene pmid:10773448
Martello LA et al. Taxol and discodermolide represent a synergistic drug combination in human carcinoma cell lines. 2000 Clin. Cancer Res. pmid:10815923
Nicolaou KC et al. Chemical synthesis and biological properties of pyridine epothilones. 2000 Chem. Biol. pmid:11048950
Zhu B and Panek JS Total synthesis of epothilone A. 2000 Org. Lett. pmid:10990400
Giannakakou P et al. A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells. 2000 Proc. Natl. Acad. Sci. U.S.A. pmid:10688884