MeSH term | MeSH ID | Detail |
---|---|---|
Neoplasms | D009369 | 13 associated lipids |
Adenocarcinoma | D000230 | 166 associated lipids |
Lung Neoplasms | D008175 | 171 associated lipids |
Epothilone a is a lipid of Polyketides (PK) class. Epothilone a is associated with abnormalities such as abnormal fragmented structure and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Polymerization, Mutation, Depolymerization, Musculoskeletal torsion, function and Negative Regulation of Microtubule Depolymerization. Epothilone a often locates in Microtubules, soluble, Nuclear Structure and Microtubule cytoskeleton. The associated genes with Epothilone A are C9 gene, SLC33A1 gene, KIF2C gene and HMHA1 gene.
To understand associated biological information of Epothilone A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Epothilone A is suspected in and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Epothilone A
MeSH term | MeSH ID | Detail |
---|---|---|
Neoplasms | D009369 | 13 associated lipids |
Adenocarcinoma | D000230 | 166 associated lipids |
Lung Neoplasms | D008175 | 171 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Giannakakou P et al. | Enhanced microtubule-dependent trafficking and p53 nuclear accumulation by suppression of microtubule dynamics. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12145320 |
Liu ZY et al. | Total synthesis of epothilone a through stereospecific epoxidation of the p-methoxybenzyl ether of epothilone C. | 2002 | Chemistry | pmid:12203301 |
Atadja P et al. | Gene expression profiling of epothilone A-resistant cells. | 2002 | Novartis Found. Symp. | pmid:11990772 |
Nicolaou KC and Pfefferkorn JA | Solid phase synthesis of complex natural products and libraries thereof. | 2001 | Biopolymers | pmid:11774224 |
Lichtner RB et al. | Subcellular distribution of epothilones in human tumor cells. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11562452 |
Hardt IH et al. | New natural epothilones from Sorangium cellulosum, strains So ce90/B2 and So ce90/D13: isolation, structure elucidation, and SAR studies. | 2001 | J. Nat. Prod. | pmid:11473410 |
Bode JW and Carreira EM | Stereoselective syntheses of epothilones A and B via nitrile oxide cycloadditions and related studies. | 2001 | J. Org. Chem. | pmid:11559194 |
Chen H et al. | Epothilone biosynthesis: assembly of the methylthiazolylcarboxy starter unit on the EpoB subunit. | 2001 | Chem. Biol. | pmid:11564558 |
Bode JW and Carreira EM | Stereoselective syntheses of epothilones A and B via directed nitrile oxide cycloaddition. | 2001 | J. Am. Chem. Soc. | pmid:11472140 |
Stachel SJ et al. | The epothilones, eleutherobins, and related types of molecules. | 2001 | Curr. Pharm. Des. | pmid:11472267 |
Gerth K et al. | Studies on the biosynthesis of epothilones: the PKS and Epothilone C/D monooxygenase. | 2001 | J. Antibiot. | pmid:11302486 |
Kavallaris M et al. | Anticancer therapy with novel tubulin-interacting drugs. | 2001 | Drug Resist. Updat. | pmid:12030786 |
Li Y et al. | [Diversity of metabolites and their bio-activities in myxobacterium Sorangium cellulosum]. | 2001 | Wei Sheng Wu Xue Bao | pmid:12552829 |
Molnár I et al. | The biosynthetic gene cluster for the microtubule-stabilizing agents epothilones A and B from Sorangium cellulosum So ce90. | 2000 | Chem. Biol. | pmid:10662695 |
Tang L et al. | Cloning and heterologous expression of the epothilone gene cluster. | 2000 | Science | pmid:10649995 |
Santi DV et al. | An approach for obtaining perfect hybridization probes for unknown polyketide synthase genes: a search for the epothilone gene cluster. | 2000 | Gene | pmid:10773448 |
Martello LA et al. | Taxol and discodermolide represent a synergistic drug combination in human carcinoma cell lines. | 2000 | Clin. Cancer Res. | pmid:10815923 |
Nicolaou KC et al. | Chemical synthesis and biological properties of pyridine epothilones. | 2000 | Chem. Biol. | pmid:11048950 |
Zhu B and Panek JS | Total synthesis of epothilone A. | 2000 | Org. Lett. | pmid:10990400 |
Giannakakou P et al. | A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10688884 |