MeSH term | MeSH ID | Detail |
---|---|---|
Neoplasms | D009369 | 13 associated lipids |
Adenocarcinoma | D000230 | 166 associated lipids |
Lung Neoplasms | D008175 | 171 associated lipids |
Epothilone a is a lipid of Polyketides (PK) class. Epothilone a is associated with abnormalities such as abnormal fragmented structure and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Polymerization, Mutation, Depolymerization, Musculoskeletal torsion, function and Negative Regulation of Microtubule Depolymerization. Epothilone a often locates in Microtubules, soluble, Nuclear Structure and Microtubule cytoskeleton. The associated genes with Epothilone A are C9 gene, SLC33A1 gene, KIF2C gene and HMHA1 gene.
To understand associated biological information of Epothilone A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Epothilone A is suspected in and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Epothilone A
MeSH term | MeSH ID | Detail |
---|---|---|
Neoplasms | D009369 | 13 associated lipids |
Adenocarcinoma | D000230 | 166 associated lipids |
Lung Neoplasms | D008175 | 171 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Pfeiffer B et al. | Synthesis and SAR of C12-C13-oxazoline derivatives of epothilone A. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19433359 |
Passarella D et al. | Synthesis and biological evaluation of epothilone A dimeric compounds. | 2009 | Bioorg. Med. Chem. | pmid:19804980 |
Jiménez VA | Quantum-chemical study on the bioactive conformation of epothilones. | 2010 | J Chem Inf Model | pmid:21077585 |
Kamel K and Kolinski A | Computational study of binding of epothilone A to β-tubulin. | 2011 | Acta Biochim. Pol. | pmid:21633729 |
Rusinska-Roszak D et al. | Extended and clustered conformers of epothilone A. | 2011 | J Phys Chem B | pmid:21405036 |
Ganguly A et al. | Overexpression of mitotic centromere-associated Kinesin stimulates microtubule detachment and confers resistance to paclitaxel. | 2011 | Mol. Cancer Ther. | pmid:21471284 |
Shi G et al. | Structural insight into the mechanism of epothilone A bound to beta-tubulin and its mutants at Arg282Gln and Thr274Ile. | 2012 | J. Biomol. Struct. Dyn. | pmid:22731768 |
Rogalska A et al. | Induction of apoptosis in human ovarian cancer cells by new anticancer compounds, epothilone A and B. | 2013 | Toxicol In Vitro | pmid:22995584 |
Prota AE et al. | Molecular mechanism of action of microtubule-stabilizing anticancer agents. | 2013 | Science | pmid:23287720 |
Yu D et al. | Mechanical and functional properties of epothilone-stabilized microtubules. | 2013 | Cytoskeleton (Hoboken) | pmid:23135951 |