MeSH term | MeSH ID | Detail |
---|---|---|
Adenocarcinoma | D000230 | 166 associated lipids |
Lung Neoplasms | D008175 | 171 associated lipids |
Neoplasms | D009369 | 13 associated lipids |
Epothilone a is a lipid of Polyketides (PK) class. Epothilone a is associated with abnormalities such as abnormal fragmented structure and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Polymerization, Mutation, Depolymerization, Musculoskeletal torsion, function and Negative Regulation of Microtubule Depolymerization. Epothilone a often locates in Microtubules, soluble, Nuclear Structure and Microtubule cytoskeleton. The associated genes with Epothilone A are C9 gene, SLC33A1 gene, KIF2C gene and HMHA1 gene.
To understand associated biological information of Epothilone A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Epothilone A is suspected in and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Epothilone A
MeSH term | MeSH ID | Detail |
---|---|---|
Adenocarcinoma | D000230 | 166 associated lipids |
Lung Neoplasms | D008175 | 171 associated lipids |
Neoplasms | D009369 | 13 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Bollag DM et al. | Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action. | 1995 | Cancer Res. | pmid:7757983 |
Xiao CF et al. | Investigation of inclusion complex of epothilone A with cyclodextrins. | 2014 | Carbohydr Polym | pmid:24507285 |
Sakaushi S et al. | Differential responses of mitotic spindle pole formation to microtubule-stabilizing agents epothilones A and B at low concentrations. | 2008 | Cell Cycle | pmid:18235240 |
Jiménez VA et al. | Molecular modeling study on the tubulin-binding modes of epothilone derivatives: Insight into the structural basis for epothilones activity. | 2017 | Chem Biol Drug Des | pmid:28632973 |
Chen H et al. | Epothilone biosynthesis: assembly of the methylthiazolylcarboxy starter unit on the EpoB subunit. | 2001 | Chem. Biol. | pmid:11564558 |
Molnár I et al. | The biosynthetic gene cluster for the microtubule-stabilizing agents epothilones A and B from Sorangium cellulosum So ce90. | 2000 | Chem. Biol. | pmid:10662695 |
Nicolaou KC et al. | Chemical synthesis and biological properties of pyridine epothilones. | 2000 | Chem. Biol. | pmid:11048950 |
Kingston DG | What makes epothilones stick? | 2004 | Chem. Biol. | pmid:15123274 |
Finney NS | Enantioselective epoxide hydrolysis: catalysis involving microbes, mammals and metals. | 1998 | Chem. Biol. | pmid:9571210 |
Cachoux F et al. | Total synthesis and biological assessment of benzimidazole-based analogues of epothilone A: ambivalent effects on cancer cell growth inhibition. | 2006 | Chembiochem | pmid:16345113 |