Epothilone A

Epothilone a is a lipid of Polyketides (PK) class. Epothilone a is associated with abnormalities such as abnormal fragmented structure and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Polymerization, Mutation, Depolymerization, Musculoskeletal torsion, function and Negative Regulation of Microtubule Depolymerization. Epothilone a often locates in Microtubules, soluble, Nuclear Structure and Microtubule cytoskeleton. The associated genes with Epothilone A are C9 gene, SLC33A1 gene, KIF2C gene and HMHA1 gene.

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Introduction

To understand associated biological information of Epothilone A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Epothilone A?

Epothilone A is suspected in and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Epothilone A

PubChem Associated disorders and diseases

What pathways are associated with Epothilone A

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Epothilone A?

Related references are published most in these journals:

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What functions are associated with Epothilone A?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Epothilone A?

There are no associated biomedical information in the current reference collection.

What genes are associated with Epothilone A?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Epothilone A?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Epothilone A

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Authors Title Published Journal PubMed Link
Schinzer D et al. Synthesis and biological evaluation of aza-epothilones. 2000 Chembiochem pmid:11828400
Gerth K et al. Studies on the biosynthesis of epothilones: hydroxylation of Epo A and B to epothilones E and F. 2002 J. Antibiot. pmid:11918064
Atadja P et al. Gene expression profiling of epothilone A-resistant cells. 2002 Novartis Found. Symp. pmid:11990772
Kavallaris M et al. Anticancer therapy with novel tubulin-interacting drugs. 2001 Drug Resist. Updat. pmid:12030786
Giannakakou P et al. Enhanced microtubule-dependent trafficking and p53 nuclear accumulation by suppression of microtubule dynamics. 2002 Proc. Natl. Acad. Sci. U.S.A. pmid:12145320
Liu ZY et al. Total synthesis of epothilone a through stereospecific epoxidation of the p-methoxybenzyl ether of epothilone C. 2002 Chemistry pmid:12203301
Wittmann S et al. Flavopiridol down-regulates antiapoptotic proteins and sensitizes human breast cancer cells to epothilone B-induced apoptosis. 2003 Cancer Res. pmid:12517783
Li Y et al. [Diversity of metabolites and their bio-activities in myxobacterium Sorangium cellulosum]. 2001 Wei Sheng Wu Xue Bao pmid:12552829
Walsh CT et al. Polyketide-nonribosomal peptide epothilone antitumor agents: the EpoA, B, C subunits. 2003 J. Ind. Microbiol. Biotechnol. pmid:12707798
Carlomagno T et al. The high-resolution solution structure of epothilone A bound to tubulin: an understanding of the structure-activity relationships for a powerful class of antitumor agents. 2003 Angew. Chem. Int. Ed. Engl. pmid:12800173