MeSH term | MeSH ID | Detail |
---|---|---|
Adenocarcinoma | D000230 | 166 associated lipids |
Lung Neoplasms | D008175 | 171 associated lipids |
Neoplasms | D009369 | 13 associated lipids |
Epothilone a is a lipid of Polyketides (PK) class. Epothilone a is associated with abnormalities such as abnormal fragmented structure and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Polymerization, Mutation, Depolymerization, Musculoskeletal torsion, function and Negative Regulation of Microtubule Depolymerization. Epothilone a often locates in Microtubules, soluble, Nuclear Structure and Microtubule cytoskeleton. The associated genes with Epothilone A are C9 gene, SLC33A1 gene, KIF2C gene and HMHA1 gene.
To understand associated biological information of Epothilone A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Epothilone A is suspected in and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Epothilone A
MeSH term | MeSH ID | Detail |
---|---|---|
Adenocarcinoma | D000230 | 166 associated lipids |
Lung Neoplasms | D008175 | 171 associated lipids |
Neoplasms | D009369 | 13 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Schinzer D et al. | Synthesis and biological evaluation of aza-epothilones. | 2000 | Chembiochem | pmid:11828400 |
Gerth K et al. | Studies on the biosynthesis of epothilones: hydroxylation of Epo A and B to epothilones E and F. | 2002 | J. Antibiot. | pmid:11918064 |
Atadja P et al. | Gene expression profiling of epothilone A-resistant cells. | 2002 | Novartis Found. Symp. | pmid:11990772 |
Kavallaris M et al. | Anticancer therapy with novel tubulin-interacting drugs. | 2001 | Drug Resist. Updat. | pmid:12030786 |
Giannakakou P et al. | Enhanced microtubule-dependent trafficking and p53 nuclear accumulation by suppression of microtubule dynamics. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12145320 |
Liu ZY et al. | Total synthesis of epothilone a through stereospecific epoxidation of the p-methoxybenzyl ether of epothilone C. | 2002 | Chemistry | pmid:12203301 |
Wittmann S et al. | Flavopiridol down-regulates antiapoptotic proteins and sensitizes human breast cancer cells to epothilone B-induced apoptosis. | 2003 | Cancer Res. | pmid:12517783 |
Li Y et al. | [Diversity of metabolites and their bio-activities in myxobacterium Sorangium cellulosum]. | 2001 | Wei Sheng Wu Xue Bao | pmid:12552829 |
Walsh CT et al. | Polyketide-nonribosomal peptide epothilone antitumor agents: the EpoA, B, C subunits. | 2003 | J. Ind. Microbiol. Biotechnol. | pmid:12707798 |
Carlomagno T et al. | The high-resolution solution structure of epothilone A bound to tubulin: an understanding of the structure-activity relationships for a powerful class of antitumor agents. | 2003 | Angew. Chem. Int. Ed. Engl. | pmid:12800173 |