Epothilone A

Epothilone a is a lipid of Polyketides (PK) class. Epothilone a is associated with abnormalities such as abnormal fragmented structure and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Polymerization, Mutation, Depolymerization, Musculoskeletal torsion, function and Negative Regulation of Microtubule Depolymerization. Epothilone a often locates in Microtubules, soluble, Nuclear Structure and Microtubule cytoskeleton. The associated genes with Epothilone A are C9 gene, SLC33A1 gene, KIF2C gene and HMHA1 gene.

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Introduction

To understand associated biological information of Epothilone A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Epothilone A?

Epothilone A is suspected in and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Epothilone A

PubChem Associated disorders and diseases

What pathways are associated with Epothilone A

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Epothilone A?

Related references are published most in these journals:

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What functions are associated with Epothilone A?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Epothilone A?

There are no associated biomedical information in the current reference collection.

What genes are associated with Epothilone A?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Epothilone A?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Epothilone A

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Authors Title Published Journal PubMed Link
Nicolaou KC et al. Synthesis of epothilones A and B in solid and solution phase. 1997 Nature pmid:9153390
Atadja P et al. Gene expression profiling of epothilone A-resistant cells. 2002 Novartis Found. Symp. pmid:11990772
Ramachandran PV et al. Studies towards the synthesis of epothilone A via organoboranes. 2005 Org. Biomol. Chem. pmid:16211118
Zhu B and Panek JS Total synthesis of epothilone A. 2000 Org. Lett. pmid:10990400
Johnson J et al. Synthesis, structure proof, and biological activity of epothilone cyclopropanes. 2000 Org. Lett. pmid:10841473
Zhan W et al. Design and synthesis of C6-C8 bridged epothilone A. 2008 Org. Lett. pmid:18355076
Lichtner RB et al. Subcellular distribution of epothilones in human tumor cells. 2001 Proc. Natl. Acad. Sci. U.S.A. pmid:11562452
Sinha SC et al. The antibody catalysis route to the total synthesis of epothilones. 1998 Proc. Natl. Acad. Sci. U.S.A. pmid:9843936
Giannakakou P et al. Enhanced microtubule-dependent trafficking and p53 nuclear accumulation by suppression of microtubule dynamics. 2002 Proc. Natl. Acad. Sci. U.S.A. pmid:12145320
Giannakakou P et al. A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells. 2000 Proc. Natl. Acad. Sci. U.S.A. pmid:10688884