MeSH term | MeSH ID | Detail |
---|---|---|
Neoplasms | D009369 | 13 associated lipids |
Lung Neoplasms | D008175 | 171 associated lipids |
Adenocarcinoma | D000230 | 166 associated lipids |
Epothilone a is a lipid of Polyketides (PK) class. Epothilone a is associated with abnormalities such as abnormal fragmented structure and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Polymerization, Mutation, Depolymerization, Musculoskeletal torsion, function and Negative Regulation of Microtubule Depolymerization. Epothilone a often locates in Microtubules, soluble, Nuclear Structure and Microtubule cytoskeleton. The associated genes with Epothilone A are C9 gene, SLC33A1 gene, KIF2C gene and HMHA1 gene.
To understand associated biological information of Epothilone A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Epothilone A is suspected in and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Epothilone A
MeSH term | MeSH ID | Detail |
---|---|---|
Neoplasms | D009369 | 13 associated lipids |
Lung Neoplasms | D008175 | 171 associated lipids |
Adenocarcinoma | D000230 | 166 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Carlomagno T et al. | Derivation of dihedral angles from CH-CH dipolar-dipolar cross-correlated relaxation rates: a C-C torsion involving a quaternary carbon atom in epothilone A bound to tubulin. | 2003 | Angew. Chem. Int. Ed. Engl. | pmid:12800174 |
Altmann KH et al. | 4. The natural products epothilones A and B as lead structures for anticancer drug discovery: chemistry, biology, and SAR studies. | 2004 | Prog Med Chem | pmid:15003721 |
Kingston DG | What makes epothilones stick? | 2004 | Chem. Biol. | pmid:15123274 |
Hu W et al. | A high-throughput model for screening anti-tumor agents capable of promoting polymerization of tubulin in vitro. | 2004 | Acta Pharmacol. Sin. | pmid:15169631 |
Nettles JH et al. | The binding mode of epothilone A on alpha,beta-tubulin by electron crystallography. | 2004 | Science | pmid:15297674 |
Ogura H et al. | EpoK, a cytochrome P450 involved in biosynthesis of the anticancer agents epothilones A and B. Substrate-mediated rescue of a P450 enzyme. | 2004 | Biochemistry | pmid:15544342 |
Heinz DW et al. | Much anticipated--the bioactive conformation of epothilone and its binding to tubulin. | 2005 | Angew. Chem. Int. Ed. Engl. | pmid:15714588 |
Sánchez-Pedregal VM et al. | The INPHARMA method: protein-mediated interligand NOEs for pharmacophore mapping. | 2005 | Angew. Chem. Int. Ed. Engl. | pmid:15929149 |
Ramachandran PV et al. | Studies towards the synthesis of epothilone A via organoboranes. | 2005 | Org. Biomol. Chem. | pmid:16211118 |
Cachoux F et al. | Total synthesis and biological assessment of benzimidazole-based analogues of epothilone A: ambivalent effects on cancer cell growth inhibition. | 2006 | Chembiochem | pmid:16345113 |