| MeSH term | MeSH ID | Detail |
|---|---|---|
| Neoplasms | D009369 | 13 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
Total
3
Epothilone A
Epothilone a is a lipid of Polyketides (PK) class. Epothilone a is associated with abnormalities such as abnormal fragmented structure and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Polymerization, Mutation, Depolymerization, Musculoskeletal torsion, function and Negative Regulation of Microtubule Depolymerization. Epothilone a often locates in Microtubules, soluble, Nuclear Structure and Microtubule cytoskeleton. The associated genes with Epothilone A are C9 gene, SLC33A1 gene, KIF2C gene and HMHA1 gene.
Cross Reference
Introduction
To understand associated biological information of Epothilone A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Epothilone A?
Epothilone A is suspected in and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Epothilone A
PubChem Associated disorders and diseases
What pathways are associated with Epothilone A
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Epothilone A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Epothilone A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Epothilone A?
There are no associated biomedical information in the current reference collection.
What genes are associated with Epothilone A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Epothilone A?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Epothilone A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Walsh CT et al. | Polyketide-nonribosomal peptide epothilone antitumor agents: the EpoA, B, C subunits. | 2003 | J. Ind. Microbiol. Biotechnol. | pmid:12707798 |
| Ranade AR et al. | Characterizing the Epothilone Binding Site on β-Tubulin by Photoaffinity Labeling: Identification of β-Tubulin Peptides TARGSQQY and TSRGSQQY as Targets of an Epothilone Photoprobe for Polymerized Tubulin. | 2016 | J. Med. Chem. | pmid:26986898 |
| Erdélyi M et al. | Conformational preferences of natural and C3-modified epothilones in aqueous solution. | 2008 | J. Med. Chem. | pmid:18271516 |
| Seyb KI et al. | beta-Amyloid and endoplasmic reticulum stress responses in primary neurons: effects of drugs that interact with the cytoskeleton. | 2006 | J. Mol. Neurosci. | pmid:16679552 |
| Hardt IH et al. | New natural epothilones from Sorangium cellulosum, strains So ce90/B2 and So ce90/D13: isolation, structure elucidation, and SAR studies. | 2001 | J. Nat. Prod. | pmid:11473410 |
| Bode JW and Carreira EM | Stereoselective syntheses of epothilones A and B via nitrile oxide cycloadditions and related studies. | 2001 | J. Org. Chem. | pmid:11559194 |
| Ganguly A et al. | Overexpression of mitotic centromere-associated Kinesin stimulates microtubule detachment and confers resistance to paclitaxel. | 2011 | Mol. Cancer Ther. | pmid:21471284 |
| Buey RM et al. | Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites. | 2007 | Nat. Chem. Biol. | pmid:17206139 |
| Cowden CJ and Paterson I | Synthetic chemistry. Cancer drugs better than taxol? | 1997 | Nature | pmid:9153384 |
| Nicolaou KC et al. | Synthesis of epothilones A and B in solid and solution phase. | 1997 | Nature | pmid:9153390 |