MeSH term | MeSH ID | Detail |
---|---|---|
Neoplasms | D009369 | 13 associated lipids |
Lung Neoplasms | D008175 | 171 associated lipids |
Adenocarcinoma | D000230 | 166 associated lipids |
Epothilone a is a lipid of Polyketides (PK) class. Epothilone a is associated with abnormalities such as abnormal fragmented structure and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Polymerization, Mutation, Depolymerization, Musculoskeletal torsion, function and Negative Regulation of Microtubule Depolymerization. Epothilone a often locates in Microtubules, soluble, Nuclear Structure and Microtubule cytoskeleton. The associated genes with Epothilone A are C9 gene, SLC33A1 gene, KIF2C gene and HMHA1 gene.
To understand associated biological information of Epothilone A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Epothilone A is suspected in and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Epothilone A
MeSH term | MeSH ID | Detail |
---|---|---|
Neoplasms | D009369 | 13 associated lipids |
Lung Neoplasms | D008175 | 171 associated lipids |
Adenocarcinoma | D000230 | 166 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Nicolaou KC et al. | Synthesis of epothilones A and B in solid and solution phase. | 1997 | Nature | pmid:9153390 |
Atadja P et al. | Gene expression profiling of epothilone A-resistant cells. | 2002 | Novartis Found. Symp. | pmid:11990772 |
Ramachandran PV et al. | Studies towards the synthesis of epothilone A via organoboranes. | 2005 | Org. Biomol. Chem. | pmid:16211118 |
Zhu B and Panek JS | Total synthesis of epothilone A. | 2000 | Org. Lett. | pmid:10990400 |
Johnson J et al. | Synthesis, structure proof, and biological activity of epothilone cyclopropanes. | 2000 | Org. Lett. | pmid:10841473 |
Zhan W et al. | Design and synthesis of C6-C8 bridged epothilone A. | 2008 | Org. Lett. | pmid:18355076 |
Lichtner RB et al. | Subcellular distribution of epothilones in human tumor cells. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11562452 |
Sinha SC et al. | The antibody catalysis route to the total synthesis of epothilones. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9843936 |
Giannakakou P et al. | Enhanced microtubule-dependent trafficking and p53 nuclear accumulation by suppression of microtubule dynamics. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12145320 |
Giannakakou P et al. | A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10688884 |