| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Neoplasms | D009369 | 13 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
Total
3
Epothilone A
Epothilone a is a lipid of Polyketides (PK) class. Epothilone a is associated with abnormalities such as abnormal fragmented structure and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Polymerization, Mutation, Depolymerization, Musculoskeletal torsion, function and Negative Regulation of Microtubule Depolymerization. Epothilone a often locates in Microtubules, soluble, Nuclear Structure and Microtubule cytoskeleton. The associated genes with Epothilone A are C9 gene, SLC33A1 gene, KIF2C gene and HMHA1 gene.
Cross Reference
Introduction
To understand associated biological information of Epothilone A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Epothilone A?
Epothilone A is suspected in and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Epothilone A
PubChem Associated disorders and diseases
What pathways are associated with Epothilone A
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Epothilone A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Epothilone A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Epothilone A?
There are no associated biomedical information in the current reference collection.
What genes are associated with Epothilone A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Epothilone A?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Epothilone A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Bornscheuer UT et al. | Directed evolution of an esterase for the stereoselective resolution of a key intermediate in the synthesis of epothilones. | 1998 | Biotechnol. Bioeng. | pmid:10099292 |
| Hamel E et al. | The coral-derived natural products eleutherobin and sarcodictyins A and B: effects on the assembly of purified tubulin with and without microtubule-associated proteins and binding at the polymer taxoid site. | 1999 | Biochemistry | pmid:10220336 |
| Tang L et al. | Cloning and heterologous expression of the epothilone gene cluster. | 2000 | Science | pmid:10649995 |
| Molnár I et al. | The biosynthetic gene cluster for the microtubule-stabilizing agents epothilones A and B from Sorangium cellulosum So ce90. | 2000 | Chem. Biol. | pmid:10662695 |
| Giannakakou P et al. | A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10688884 |
| Santi DV et al. | An approach for obtaining perfect hybridization probes for unknown polyketide synthase genes: a search for the epothilone gene cluster. | 2000 | Gene | pmid:10773448 |
| Altmann KH et al. | Epothilones and related structures--a new class of microtubule inhibitors with potent in vivo antitumor activity. | 2000 | Biochim. Biophys. Acta | pmid:10799747 |
| Martello LA et al. | Taxol and discodermolide represent a synergistic drug combination in human carcinoma cell lines. | 2000 | Clin. Cancer Res. | pmid:10815923 |
| Johnson J et al. | Synthesis, structure proof, and biological activity of epothilone cyclopropanes. | 2000 | Org. Lett. | pmid:10841473 |