Epothilone A

Epothilone a is a lipid of Polyketides (PK) class. Epothilone a is associated with abnormalities such as abnormal fragmented structure and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Polymerization, Mutation, Depolymerization, Musculoskeletal torsion, function and Negative Regulation of Microtubule Depolymerization. Epothilone a often locates in Microtubules, soluble, Nuclear Structure and Microtubule cytoskeleton. The associated genes with Epothilone A are C9 gene, SLC33A1 gene, KIF2C gene and HMHA1 gene.

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Introduction

To understand associated biological information of Epothilone A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Epothilone A?

Epothilone A is suspected in and other diseases in descending order of the highest number of associated sentences.

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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Epothilone A

PubChem Associated disorders and diseases

What pathways are associated with Epothilone A

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

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What cellular locations are associated with Epothilone A?

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What functions are associated with Epothilone A?


Related references are published most in these journals:

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What lipids are associated with Epothilone A?

There are no associated biomedical information in the current reference collection.

What genes are associated with Epothilone A?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Epothilone A?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Epothilone A

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Authors Title Published Journal PubMed Link
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Bornscheuer UT et al. Directed evolution of an esterase for the stereoselective resolution of a key intermediate in the synthesis of epothilones. 1998 Biotechnol. Bioeng. pmid:10099292
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Tang L et al. Cloning and heterologous expression of the epothilone gene cluster. 2000 Science pmid:10649995
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Liu ZY et al. Total synthesis of epothilone a through stereospecific epoxidation of the p-methoxybenzyl ether of epothilone C. 2002 Chemistry pmid:12203301
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Carlomagno T et al. The high-resolution solution structure of epothilone A bound to tubulin: an understanding of the structure-activity relationships for a powerful class of antitumor agents. 2003 Angew. Chem. Int. Ed. Engl. pmid:12800173
Carlomagno T et al. Derivation of dihedral angles from CH-CH dipolar-dipolar cross-correlated relaxation rates: a C-C torsion involving a quaternary carbon atom in epothilone A bound to tubulin. 2003 Angew. Chem. Int. Ed. Engl. pmid:12800174
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Kingston DG What makes epothilones stick? 2004 Chem. Biol. pmid:15123274
Hu W et al. A high-throughput model for screening anti-tumor agents capable of promoting polymerization of tubulin in vitro. 2004 Acta Pharmacol. Sin. pmid:15169631
Nettles JH et al. The binding mode of epothilone A on alpha,beta-tubulin by electron crystallography. 2004 Science pmid:15297674
Ogura H et al. EpoK, a cytochrome P450 involved in biosynthesis of the anticancer agents epothilones A and B. Substrate-mediated rescue of a P450 enzyme. 2004 Biochemistry pmid:15544342
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Ramachandran PV et al. Studies towards the synthesis of epothilone A via organoboranes. 2005 Org. Biomol. Chem. pmid:16211118
Cachoux F et al. Total synthesis and biological assessment of benzimidazole-based analogues of epothilone A: ambivalent effects on cancer cell growth inhibition. 2006 Chembiochem pmid:16345113
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Sakaushi S et al. Differential responses of mitotic spindle pole formation to microtubule-stabilizing agents epothilones A and B at low concentrations. 2008 Cell Cycle pmid:18235240
Erdélyi M et al. Conformational preferences of natural and C3-modified epothilones in aqueous solution. 2008 J. Med. Chem. pmid:18271516
Zhan W et al. Design and synthesis of C6-C8 bridged epothilone A. 2008 Org. Lett. pmid:18355076
Wang YL et al. Microbial transformation of epothilone A by Aspergillus niger AS 3.739. 2009 J Asian Nat Prod Res pmid:19431017
Pfeiffer B et al. Synthesis and SAR of C12-C13-oxazoline derivatives of epothilone A. 2009 Bioorg. Med. Chem. Lett. pmid:19433359
Passarella D et al. Synthesis and biological evaluation of epothilone A dimeric compounds. 2009 Bioorg. Med. Chem. pmid:19804980