| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Neoplasms | D009369 | 13 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
Total
3
Epothilone A
Epothilone a is a lipid of Polyketides (PK) class. Epothilone a is associated with abnormalities such as abnormal fragmented structure and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Polymerization, Mutation, Depolymerization, Musculoskeletal torsion, function and Negative Regulation of Microtubule Depolymerization. Epothilone a often locates in Microtubules, soluble, Nuclear Structure and Microtubule cytoskeleton. The associated genes with Epothilone A are C9 gene, SLC33A1 gene, KIF2C gene and HMHA1 gene.
Cross Reference
Introduction
To understand associated biological information of Epothilone A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Epothilone A?
Epothilone A is suspected in and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Epothilone A
PubChem Associated disorders and diseases
What pathways are associated with Epothilone A
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Epothilone A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Epothilone A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Epothilone A?
There are no associated biomedical information in the current reference collection.
What genes are associated with Epothilone A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Epothilone A?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Epothilone A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Rogalska A et al. | Metformin and epothilone A treatment up regulate pro-apoptotic PARP-1, Casp-3 and H2AX genes and decrease of AKT kinase level to control cell death of human hepatocellular carcinoma and ovary adenocarcinoma cells. | 2018 | Toxicol In Vitro | pmid:29117515 |
| Jiménez VA et al. | Molecular modeling study on the tubulin-binding modes of epothilone derivatives: Insight into the structural basis for epothilones activity. | 2017 | Chem Biol Drug Des | pmid:28632973 |
| Rogalska A et al. | Effects of Epothilone A in Combination with the Antidiabetic Drugs Metformin and Sitagliptin in HepG2 Human Hepatocellular Cancer Cells: Role of Transcriptional Factors NF-κB and p53. | 2016 | Asian Pac. J. Cancer Prev. | pmid:27039825 |
| Ranade AR et al. | Characterizing the Epothilone Binding Site on β-Tubulin by Photoaffinity Labeling: Identification of β-Tubulin Peptides TARGSQQY and TSRGSQQY as Targets of an Epothilone Photoprobe for Polymerized Tubulin. | 2016 | J. Med. Chem. | pmid:26986898 |
| Parajuli P et al. | Enzymatic synthesis of lactosylated and sialylated derivatives of epothilone A. | 2016 | Glycoconj. J. | pmid:26852037 |
| Jiménez VA et al. | Structural insight into epothilones antitumor activity based on the conformational preferences and tubulin binding modes of epothilones A and B obtained from molecular dynamics simulations. | 2015 | J. Biomol. Struct. Dyn. | pmid:24773261 |
| Xiao CF et al. | Investigation of inclusion complex of epothilone A with cyclodextrins. | 2014 | Carbohydr Polym | pmid:24507285 |
| Borrelli S et al. | New class of squalene-based releasable nanoassemblies of paclitaxel, podophyllotoxin, camptothecin and epothilone A. | 2014 | Eur J Med Chem | pmid:25084144 |
| Rogalska A et al. | Induction of apoptosis in human ovarian cancer cells by new anticancer compounds, epothilone A and B. | 2013 | Toxicol In Vitro | pmid:22995584 |
| Prota AE et al. | Molecular mechanism of action of microtubule-stabilizing anticancer agents. | 2013 | Science | pmid:23287720 |
| Yu D et al. | Mechanical and functional properties of epothilone-stabilized microtubules. | 2013 | Cytoskeleton (Hoboken) | pmid:23135951 |
| Shi G et al. | Structural insight into the mechanism of epothilone A bound to beta-tubulin and its mutants at Arg282Gln and Thr274Ile. | 2012 | J. Biomol. Struct. Dyn. | pmid:22731768 |
| Kamel K and Kolinski A | Computational study of binding of epothilone A to β-tubulin. | 2011 | Acta Biochim. Pol. | pmid:21633729 |
| Rusinska-Roszak D et al. | Extended and clustered conformers of epothilone A. | 2011 | J Phys Chem B | pmid:21405036 |
| Ganguly A et al. | Overexpression of mitotic centromere-associated Kinesin stimulates microtubule detachment and confers resistance to paclitaxel. | 2011 | Mol. Cancer Ther. | pmid:21471284 |
| Jiménez VA | Quantum-chemical study on the bioactive conformation of epothilones. | 2010 | J Chem Inf Model | pmid:21077585 |
| Wang YL et al. | Microbial transformation of epothilone A by Aspergillus niger AS 3.739. | 2009 | J Asian Nat Prod Res | pmid:19431017 |
| Pfeiffer B et al. | Synthesis and SAR of C12-C13-oxazoline derivatives of epothilone A. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19433359 |
| Passarella D et al. | Synthesis and biological evaluation of epothilone A dimeric compounds. | 2009 | Bioorg. Med. Chem. | pmid:19804980 |
| Sakaushi S et al. | Differential responses of mitotic spindle pole formation to microtubule-stabilizing agents epothilones A and B at low concentrations. | 2008 | Cell Cycle | pmid:18235240 |
| Zhan W et al. | Design and synthesis of C6-C8 bridged epothilone A. | 2008 | Org. Lett. | pmid:18355076 |
| Erdélyi M et al. | Conformational preferences of natural and C3-modified epothilones in aqueous solution. | 2008 | J. Med. Chem. | pmid:18271516 |
| Reese M et al. | Structural basis of the activity of the microtubule-stabilizing agent epothilone a studied by NMR spectroscopy in solution. | 2007 | Angew. Chem. Int. Ed. Engl. | pmid:17274084 |
| Buey RM et al. | Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites. | 2007 | Nat. Chem. Biol. | pmid:17206139 |
| Cachoux F et al. | Total synthesis and biological assessment of benzimidazole-based analogues of epothilone A: ambivalent effects on cancer cell growth inhibition. | 2006 | Chembiochem | pmid:16345113 |
| Han C et al. | Prostaglandins from a zoanthid: paclitaxel-like neurite-degenerating and microtubule-stabilizating activities. | 2006 | Biosci. Biotechnol. Biochem. | pmid:16556989 |
| Seyb KI et al. | beta-Amyloid and endoplasmic reticulum stress responses in primary neurons: effects of drugs that interact with the cytoskeleton. | 2006 | J. Mol. Neurosci. | pmid:16679552 |
| Ramachandran PV et al. | Studies towards the synthesis of epothilone A via organoboranes. | 2005 | Org. Biomol. Chem. | pmid:16211118 |
| Heinz DW et al. | Much anticipated--the bioactive conformation of epothilone and its binding to tubulin. | 2005 | Angew. Chem. Int. Ed. Engl. | pmid:15714588 |
| Sánchez-Pedregal VM et al. | The INPHARMA method: protein-mediated interligand NOEs for pharmacophore mapping. | 2005 | Angew. Chem. Int. Ed. Engl. | pmid:15929149 |
| Altmann KH et al. | 4. The natural products epothilones A and B as lead structures for anticancer drug discovery: chemistry, biology, and SAR studies. | 2004 | Prog Med Chem | pmid:15003721 |
| Hu W et al. | A high-throughput model for screening anti-tumor agents capable of promoting polymerization of tubulin in vitro. | 2004 | Acta Pharmacol. Sin. | pmid:15169631 |
| Nettles JH et al. | The binding mode of epothilone A on alpha,beta-tubulin by electron crystallography. | 2004 | Science | pmid:15297674 |
| Kingston DG | What makes epothilones stick? | 2004 | Chem. Biol. | pmid:15123274 |
| Ogura H et al. | EpoK, a cytochrome P450 involved in biosynthesis of the anticancer agents epothilones A and B. Substrate-mediated rescue of a P450 enzyme. | 2004 | Biochemistry | pmid:15544342 |
| Carlomagno T et al. | The high-resolution solution structure of epothilone A bound to tubulin: an understanding of the structure-activity relationships for a powerful class of antitumor agents. | 2003 | Angew. Chem. Int. Ed. Engl. | pmid:12800173 |
| Carlomagno T et al. | Derivation of dihedral angles from CH-CH dipolar-dipolar cross-correlated relaxation rates: a C-C torsion involving a quaternary carbon atom in epothilone A bound to tubulin. | 2003 | Angew. Chem. Int. Ed. Engl. | pmid:12800174 |
| Walsh CT et al. | Polyketide-nonribosomal peptide epothilone antitumor agents: the EpoA, B, C subunits. | 2003 | J. Ind. Microbiol. Biotechnol. | pmid:12707798 |
| Wittmann S et al. | Flavopiridol down-regulates antiapoptotic proteins and sensitizes human breast cancer cells to epothilone B-induced apoptosis. | 2003 | Cancer Res. | pmid:12517783 |
| Gerth K et al. | Studies on the biosynthesis of epothilones: hydroxylation of Epo A and B to epothilones E and F. | 2002 | J. Antibiot. | pmid:11918064 |
| Giannakakou P et al. | Enhanced microtubule-dependent trafficking and p53 nuclear accumulation by suppression of microtubule dynamics. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12145320 |
| Liu ZY et al. | Total synthesis of epothilone a through stereospecific epoxidation of the p-methoxybenzyl ether of epothilone C. | 2002 | Chemistry | pmid:12203301 |
| Atadja P et al. | Gene expression profiling of epothilone A-resistant cells. | 2002 | Novartis Found. Symp. | pmid:11990772 |
| Nicolaou KC and Pfefferkorn JA | Solid phase synthesis of complex natural products and libraries thereof. | 2001 | Biopolymers | pmid:11774224 |
| Lichtner RB et al. | Subcellular distribution of epothilones in human tumor cells. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11562452 |
| Hardt IH et al. | New natural epothilones from Sorangium cellulosum, strains So ce90/B2 and So ce90/D13: isolation, structure elucidation, and SAR studies. | 2001 | J. Nat. Prod. | pmid:11473410 |
| Bode JW and Carreira EM | Stereoselective syntheses of epothilones A and B via nitrile oxide cycloadditions and related studies. | 2001 | J. Org. Chem. | pmid:11559194 |
| Chen H et al. | Epothilone biosynthesis: assembly of the methylthiazolylcarboxy starter unit on the EpoB subunit. | 2001 | Chem. Biol. | pmid:11564558 |
| Bode JW and Carreira EM | Stereoselective syntheses of epothilones A and B via directed nitrile oxide cycloaddition. | 2001 | J. Am. Chem. Soc. | pmid:11472140 |
| Stachel SJ et al. | The epothilones, eleutherobins, and related types of molecules. | 2001 | Curr. Pharm. Des. | pmid:11472267 |